Augmented age-associated innate immune responses contribute to negative inotropic and lusitropic effects of lipopolysaccharide and interferon γ

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 10, 2001, Pages 1849-1859

  Rosas, Gisele O ^a   Zieman, Susan J ^a   Donabedian, Maral ^a   Vandegaer, Koenraad ^a   Hare, Joshua M ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Aging; Innate immune system; L NIL; L NMMA; Nitric oxide; Sepsis

Indexed keywords

CD14 ANTIGEN; CYCLIC AMP; GAMMA INTERFERON; ISOPRENALINE; LIPOPOLYSACCHARIDE; LYSINE; NITRIC OXIDE SYNTHASE; TOLL LIKE RECEPTOR 4;

ADRENERGIC STIMULATION; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; IMMUNE RESPONSE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPSIS;

ANIMALIA;

EID: 0034781712     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2001.1448     Document Type: Article

References (52)

1. Innate immunity
2. Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility
3. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity
4. Cardiodepressant effects of interferon-γ and endotoxin reversed by inhibition of NO synthase in rat myocardium
5. Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice
6. Tumor necrosis factor alpha and interleukin-1 beta are responsible for in vitro myocardial cell depression induced by human septic shock serum
7. Elevated soluble CD14 receptors and altered cytokines in chronic heart failure
8. LPS-induced TNF-α release from and apoptosis in rat cardiomyocytes: Obligatory role for CD14 in mediating the LPS response
9. CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin
10. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
11. The human Toll signaling pathway: Divergence of NF-κB and JNK/SAPK activation upstream of TRAF6
12. MyD88 is an adapter protein in the hToll/IL-1 receptor family signaling pathways
13. G-methylarginine hydrochloride (546C88) in patients with septic shock
14. Nitric oxide inhibits the contractile response to β-adrenergic stimulation in humans with left ventricular dysfunction
15. Increased sensitivity to nitric oxide synthase inhibition in patients with heart failure: Potentiation of β-adrenergic inotropic responsiveness
16. Upregulation of the nitric oxide-cGMP pathway in aged myocardium: Physiologic response to L-arginine
17. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing
18. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon γ and lipopolysaccharide
19. Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-alpha, and interferon-gamma in the serum of patients with septic shock
20. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura
21. cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: Potential role for S-nitrosylation
22. 6-(1-Iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase
23. Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart
24. Cardiovascular regulatory mechanisms in advanced age
25. Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling
26. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium
27. Cytokine-inducible nitric-oxide synthase (iNOS) expression in cardiac myocytes: Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro
28. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ
29. Increased cytokine production in mononuclear cells of eldery people
30. Sepsis and its complications: Clinical definitions and therapeutic prospects
31. Endotoxaemia in patients with severe sepsis or septic shock
32. Is presentation of bacteremia in the eldery the same as in younger patients
33. Septic shock in bacteremic patients: Risk factors, features and prognosis
34. Myocardial contractile dysfunction in the systemic inflammatory response syndrome: Role of a cytokine-inducible nitric oxide synthase in cardiac myocytes
35. Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure
36. Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals
37. Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo
38. Interferon-gamma in healthy subjects: Selective modulation of inflammatory mediators
39. Bacterial Iipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: Role of NF-kappa B activation
40. Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans
41. Negative inotropic effects of cytokines on the heart mediated by nitric oxide
42. Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase
43. Nitric oxide produced via neuronal NOS may impair vasodilation in septic rat skeletal muscle
44. Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice
45. The mannose receptor is a pattern recognition receptor involved in host defense
46. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
47. CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes
48. Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14
49. Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway
50. STAT1 combines signals derived from INF-gamma and LPS receptors during macrophage activation
51. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14
52. Role of macrophage scavenger receptor in endotoxin shock