Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep

Intensive Care Medicine

Volumn 24, Issue 1, 1998, Pages 48-54

  Bone, H G ^a   Waurick, R ^a   Van Aken, H ^a   Booke, M ^a   Prien, T ^a   Meyer, J ^a  

^a Klin Poliklin F A   (Germany)

Author keywords

Endotoxaemia; Haemoglobin; Nitric oxide; Sepsis

Indexed keywords

ARGININE METHYL ESTER; ENDOTOXIN; HEMOGLOBIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; ENDOTOXEMIA; FEMALE; HEART INDEX; HEMODYNAMICS; HYPOTENSION; LUNG VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; NONHUMAN; SALMONELLA TYPHI; SHEEP;

ANIMALS; ENDOTOXEMIA; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; HEMOGLOBINS; NG-NITROARGININE METHYL ESTER; OXYGEN CONSUMPTION; POLYETHYLENE GLYCOLS; SALMONELLA TYPHI; SHEEP; TYPHOID FEVER;

EID: 0031895705     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001340050514     Document Type: Article

References (37)

1. Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercier JC, Offenstadt G, Régnier B, for the French ICU Group for Severe Sepsis (1995) Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. JAMA 274: 968-974
2. Le Gall JR, Lemeshow S, Leleu G, Klar J, Huillard J, Rué M, Teres D, Artigas A, for the Intensive Care Unit Scoring Group (1995) Customized probability models for early severe sepsis in adult intensive care patients. JAMA 273: 644-650
3. Pinner RV (1996) Trends in infectious disease mortality in the United States. JAMA 275: 189-193
4. Bone RC (1996) Why sepsis trials fail. JAMA 276: 565-566
5. Eidelman LA, Pizov R, Sprung CL (1996) New therapeutic approaches in sepsis: a critical review. Intensive Care Med 21: S269-S272
6. Evans T, Carpenter A, Kinderman H, Cohen J (1993) Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 41: 77-81
7. Palmer RM (1993) The discovery of nitric oxide in the vessel wall. A unifying concept in the pathogenesis of sepsis. Arch Surg 128: 396-401
8. Szabo C (1995) Alterations in nitric oxide production in various forms of circulatory shock. New Horizons 3: 2-32
9. Meyer J, Lentz CW, Stothert JC, Traber LD, Herndon DN, Traber DL (1994) Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia. Crit Care Med 22: 306-312
10. Petros A, Bennett D, Vallance P (1991) Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338: 1557-1558
11. Kiehl MG, Ostermann H, Meyer J, Kienast J (1997) Nitric oxide synthase inhibition by L-NAME in leukocytopenic patients with severe septic shock. Intensive Care Med 23: 561-566
12. Alayash AI, Cashon RE (1994) Reactions of nitric oxide ann hydrogen peroxide with hemoglobin-based blood substitutes. Ann NY Acad Sci 738: 378-381
13. Crowley JP, Metzger J, Gray A, Pivacek LE, Cassidy G, Valeri CR (1993) Infusion of stroma-free cross-linked hemoglobin during acute gram-negative bacteremia. Circ Shock 41: 144-149
14. Aranow JS, Wang H, Zhuang J, Fink MP (1996) Effect of human hemoglobin on systemic and regional hemodynamics in a porcine model of endotoxemic shock. Crit Care Med 24: 807-814
15. Mourelatos MG, Enzer N, Ferguson JL, Rypins EB, Burhop KE, Law WR (1996) The effects of diaspirin cross-linked hemoglobin in sepsis. Shock 5: 141-148
16. Bone HG, Schenarts PJ, Booke M, McGuire R, Harper D, Traber LD, Traber DL (1997) Pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep. Crit Care Med 25: 1010-1018
17. Martich GD, Boujoukos AJ, Suffredini AF (1993) Response of man to endotoxin. Immunobiology 187: 403-416
18. Szabo C, Mitchell JA, Thiemermann C, Vane JR (1993) Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 108: 786-792
19. Minnard EA, Shou J, Naama H, Cech A, Gallagher H, Daly JM (1994) Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch Surg 129: 142-147
20. Lingnau W, McGuire R, Dehring DJ, Traber LD, Traber DL (1996) Changes in regional hemodynamics after nitric oxide inhibition during ovine bacteremia. Am J Physiol 270: R207-R216
21. Kida Y, Maeda M, Iwata S, Iwashita Y, Goto K, Nishi K (1995) Effects of pyridoxalated hemoglobin polyoxyethylene conjugate and other hemoglobin-related substances on arterial blood pressure in anesthetized and conscious rats. Artif Org 19: 117-128
22. Nakai K, Matsuda N, Amano M, Ohta T, Tokuyama S, Akama K, Kawakami E, Tauchida E, Sekiguchi S (1994) Acellular and cellular hemoglobin solutions as vasoconstrictive factor. Artif Cell Blood Sub 22: 559-564
23. Katsuyama SS, Cole DJ, Drummond JC, Bradley K (1994) Nitric oxide mediates the hypertensive response to a modified hemoglobin solution (DCLHb) in rats. Artif Cell Blood Sub 22: 1-7
24. Gulati A, Rebello S (1994) Role of adrenergic mechanisms in the pressor effect of diaspirin cross-linked hemoglobin. J Lab Clin Med 124: 125-133
25. Schultz SC, Grady B, Cole F, Hamilton I, Burhop K, Malcolm DS (1993) A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin. J Lab Clin Med 122: 301-308
26. Parrillo JE, Parker MM, Natanson C. Suffredini AF, Danner RL, Cunnion RE, Ognibene FP (1990) Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 113: 227-242
27. Thijs LG, Schneider AJ, Groeneveld AB (1990) The haemodynamics of septic shock. Intensive Care Med 16: S182-S186
28. Lorente JA, Landin L, Renes E, De Pablo R, Jorge P, Rodena E, Liste D (1993) Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med 21: 759-767
29. Booke M, Hinder F, McGuire R, Traber LD, Traber DL (1996) Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: effects on regional blood flow. Shock 5: 362-370
30. Zappellini A, Moreno JNH, Antunes E, de Nucci G (1997) Dissociation between the increase in systemic vascular resistance induced by acute nitric oxide synthesis inhibition and the decrease in cardiac output in anesthetized dogs. J Cardiovasc Pharmacol 29: 45-48
31. Klabunde RE, Ritger RC, Helgren MC (1991) Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation/release in anesthetized dogs. Eur J Pharmacol 199: 51-59
32. Cohen RI, Chen L, Scharf SM (1996) The effects of high dose NG-nitro-L-arginine-methyl ester on myocardial blood flow and left ventricular function in dogs. J Crit Care 11: 206-213
33. Hughes GS, Antal EJ, Locker PK, Francom SF, Adams WJ, Jacobs EE (1996) Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit Care Med 24: 756-764
34. Hess JR, Macdonald VW, Brinkley WW (1993) Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 74: 1769-1778
35. Heyland DK, Cook DJ, King D, Kernermann P, Brun-Buisson C (1996) Maximizing oxygen delivery in critically ill patients: a methodologic appraisal of the evidence. Crit Care Med 24: 517-524
36. Gattinoni L, Brazzi L, Pelosi P (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 333: 1025-1032
37. Hayes MA, Timmins AC, Yau EH, Palazzo M, Watson D, Hinds CJ (1997) Oxygen transport patterns in patients with sepsis syndrome or septic shock: influence of treatment and relationship to outcome. Crit Care Med 25: 926-936