Effects of modest anemia on systemic and coronary circulation of septic sheep

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 6 46-6, 1999, Pages

  Bloos, Frank ^a,b   Martin, Claudio M ^a   Ellis, Chris G ^a   Sibbald, William J ^a,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Hemodilution; Hypoxia; Transfusion

Indexed keywords

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE OXYGEN CONSUMPTION; HEART OUTPUT; HEMODILUTION; HYPERMETABOLISM; HYPOXIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SEPSIS; SHEEP; SPLANCHNIC BLOOD FLOW;

EID: 0033401246     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.6.h2195     Document Type: Article

References (43)

1. Abel, F. L. Relative importance of cardiac output and arterial pressure in determining myocardial oxygen consumption and coronary blood flow. Circ. Shock 24: 85-97, 1988.
2. American College of Physicians. Practice strategies for elective red blood cell transfusion. Ann. Intern. Med. 116: 403-406, 1992.
3. Berstein, D., and D. F. Teitel. Myocardial and systemic oxygenation during severe hypoxemia in ventilated lambs. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H1856-H1864, 1990.
4. Bersten, A. D., and W. J. Sibbald. Circulatory disturbances in multiple systems organ failure. In: Critical Care Clinics, edited by B. Cohen. Philadelphia, PA: Saunders, 1989, vol. 5, p. 223-254.
5. Bersten, A. D., W. J. Sibbald, M. Hersch, H. Cheung, and F. S. Rutledge. Interaction of sepsis and sepsis plus sympathomimetics on myocardial oxygen availability. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1164-H1173, 1992.
6. Bloos, F., H. M. Morisaki, A. Neal, C. M. Martin, C. Ellis, and W. J. Sibbald. Sepsis depresses the metabolic oxygen reserve of the coronary circulation in mature sheep. Am. J. Respir. Crit. Care Med. 153: 1577-1584, 1996.
7. 2 extraction in hyperdynamic sepsis (Abstract). Chest 104: 152S, 1993.
8. Bone, R. C., C. J. Fisher, Jr., T. P. Clemmer, G. J. Slotman, C. A. Metz, and R. A. Balk. Sepsis syndrome: a valid clinical entity. Crit. Care Med. 17: 389-393, 1989.
9. Cane, R. D. Hemoglobin: how much is enough? Crit. Care Med. 18: 1046, 1990.
10. Chapler, C. K., and S. M. Cain. The physiologic reserve in oxygen carrying capacity: studies in experimental hemodilution. Can. J. Physiol. Pharmacol. 64: 7-12, 1986.
11. Conzen, P. F., H. Habazetti, B. Vollmar, M. Christ, H. Baier, and K. Peter. Coronary microcirculation during halothane, enflurane, isoflurane, and adenosine in dogs. Anesthesiology 76: 261-270, 1992.
12. Cook, J. P., and P. S. Tsao. Cytoprotective effects of nitric oxide. Circulation 88: 2451-2454, 1993.
13. Crystal, G. J. Coronary hemodynamic responses during local hemodilution in canine hearts. Am. J. Physiol. 254 (Heart Circ. Physiol. 23): H525-H531, 1988.
14. 2 uptake during hemodilution and adrenergic stimulation. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1769-H1777, 1993.
15. Darbonne, W. C., G. C. Rice, M. A. Mohler, T. Apple, C. A. Hebert, A. J. Valente, and J. B. Baker. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. J. Clin. Invest. 88: 1362-1369, 1991.
16. Fox, G. A., A. Bersten, C. Lam, A. Neal, F. S. Rutledge, K. Inman, and W. J. Sibbald. Hematocrit modifies the circulatory control of systemic and myocardial oxygen utilization in septic sheep. Crit. Care Med. 22: 470-479, 1994.
17. Fox, G. A., C. J. Lam, W. B. Darragh, A. M. Neal, K. J. Inman, F. S. Rutledge, and W. J. Sibbald. Circulatory sequelae of administering CPAP in hyperdynamic sepsis are time dependent. J. Appl. Physiol. 81: 976-984, 1996.
18. Gill, R. S., K. Donais, W. J. Sibbald, G. Doig, and C. G. Ellis. Oxygen delivery and extraction in the septic microcirculation (Abstract). Am. J. Respir. Crit. Care Med. 151: A324, 1995.
19. Groeneveld, A. B. J., A. A. van Lambalgen, G. C. van den Bos, W. Bronsveld, J. J. P. Nauta, and L. G. Thijs. Maldistribution of heterogeneous coronary blood flow during canine endotoxin shock. Cardiovasc. Res. 25: 80-88, 1991.
20. Jan, K. M., and S. Chien. Effect of hematocrit variations on coronary hemodynamics and oxygen utilization. Am. J. Physiol. 233 (Heart Circ. Physiol. 2): H106-H113, 1977.
21. Jia, L., C. Bonaventura, J. Bonaventura, and J. S. Stamler. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380: 221-226, 1996.
22. Kiel, J. W., and A. P. Shepherd. Optimal hematocrit for canine gastric oxygenation. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H472-H477, 1989.
23. Kleinbaum, D. G., L. L. Kupper, and K. E. Muller. Applied Regression Analysis and Other Multivariable Methods. Boston, MA: PWS-Kent, 1988.
24. Lam, C., K. Tyml, C. Martin, and W. Sibbald. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J. Clin. Invest. 94: 2077-2083, 1994.
25. Levine, B. A., K. R. Sirinek, and H. V. Gaskill III. The radiolabeled microsphere technique in gut blood flow measurement: current practice. J. Surg. Res. 37: 241-255, 1984.
26. Marik, P. E., and W. J. Sibbald. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 269: 3024-3029, 1993.
27. Matthay, M., M. Sadick, M. Reichart, and W. C. Darbonne. Red blood cells function as a major clearance mechanism for chemokines (IL-8, MGSA, Rantes) in critically ill patients (Abstract). Am. J. Respir. Crit. Care Med. 151: A318, 1995.
28. Mesh, C. L., and B. L. Gewertz. The effect of hemodilution on blood flow regulation in normal and postischemic intestine. J. Surg. Res. 48: 183-189, 1990.
29. Morisaki, H., F. Bloos, J. Keys, C. M. Martin, A. Neal, and W. J. Sibbald. Compared with crystalloid, colloid therapy slows progression of extrapulmonary tissue injury in septic sheep. J. Appl. Physiol. 77: 1507-1518, 1994.
30. Morisaki, H., W. Sibbald, C. Martin, G. Doig, and K. Inman. Hyperdynamic sepsis depresses circulatory compensation to normovolemic anemia in conscious rats. J. Appl. Physiol. 80: 656-664, 1996.
31. Moss, M., G. Moreau, and G. Lister. Oxygen transport and metabolism in the conscious lamb: the effects of hypoxemia. Pediatr. Res. 22: 177-183, 1987.
32. 2 uptake during bacteremia in dogs. J. Appl. Physiol. 63: 1487-1492, 1987.
33. 2 uptake during endotoxemia. J. Appl. Physiol. 64: 2410-2419, 1988.
34. Piper, R. D., M. Pitt-Hyde, F. Li, W. J. Sibbald, and R. F. Potter. Microcirculatory changes in rat skeletal muscle in sepsis. Am. J. Respir. Crit. Care Med. 154: 931-937, 1996.
35. Pries, A. R., A. Fritzsche, K. Ley, and P. Gaehtgens. Redistribution of red blood cell flow in microcirculatory networks by hemodilution. Circ. Res. 70: 1113-1121, 1992.
36. Raper, R., and W. J. Sibbald. The effect of coronary artery disease on cardiac function in non-hypotensive sepsis. Chest 95: 507-511, 1988.
37. Suter P. M., and J.-A. Romand. Multiple organ failure due to tissue hypoxia: myth or reality? Réan. Urg. 5: 243-245, 1996.
38. Van Woerkens, E. C. S. M., A. Trouwborst, D. J. G. M. Duncker, M. M. G. Koning, F. Boomsma, and P. D. Verdouw. Catecholamines and regional hemodynamics during isovolemic hemodilution in anesthetized pigs. J. Appl. Physiol. 72: 760-769, 1992.
39. Van Woerkens, E. C., A. Trouwborst, D. J. Duncker, and P. D. Verdouw. Regional cardiac hemodynamics and oxygenation during isovolemic hemodilution in anesthetized pigs. Adv. Exp. Med. Biol. 317: 545-552, 1992.
40. Walley, K. R., C. J. Becker, R. A. Hogan, K. Teplinsky, and L. D. H. Wood. Progressive hypoxemia limits left ventricular oxygen consumption and contractility. Circ. Res. 63: 849-859, 1988.
41. Wichterman, K. A., A. E. Baue, and I. H. Chaudry Sepsis and septic shock. A review of animal models and a proposal. J. Surg. Res. 29: 189-201, 1980.
42. Woodson, R. D., and S. Auerbach. Effects of increased oxygen affinity and anemia on cardiac output and its distribution. J. Appl. Physiol. 53: 1299-1306, 1982.
43. Yu, M., M. M. Levy, P. Smith, S. A. Takiguchi, A. Miyasaki, and S. A. Myers. Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: a prospective, randomized, controlled study. Crit. Care Med. 21: 830-838, 1993.