Infection of mice lacking the common cytokine receptor γ-chain (γ(c)) reveals an unexpected role for CD4+ T lymphocytes in early IFN-γ-dependent resistance to Toxoplasma gondii

Journal of Immunology

Volumn 160, Issue 6, 1998, Pages 2565-2569

  Scharton Kersten, Tanya ^a   Nakajima, Hiroshi ^b   Yap, George ^a   Sher, Alan ^a,c   Leonard, Warren J ^a,c  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE RECEPTOR;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; IMMUNE RESPONSE; KILLER CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE ACTIVATION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ACUTE DISEASE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOKINE; TOXOPLASMOSIS, ANIMAL;

EID: 0032520773     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Leonard, W. J. 1996. The molecular basis of X-linked combined immunodeficiency: defective cytokine receptor signaling. Annu. Rev. Med. 47:229.
2. Sugamura, K., H. Asao, M. Kondo, N. Tanaka, N. Ishii, K. Ohbo, M. Nakamura, and T. Takeshita. 1996. The interleukin-2 receptor γ-chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14:179.
3. Lin, J.-X., and W. J. Leonard. 1997. IL-2 signaling from the membrane to the nucleus. Cytokine Growth Factor Rev. In press.
4. Noguchi, M., H. Yi, H. M. Rosenblatt, A. H. Filipovich, S. Adelstein, W. S. Modi, O. W. McBride, and W. J. Leonard. 1993. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in human. Cell 73:147.
5. DiSanto, J. P. W. Müller, D. Guy-Grand, A. Fischer, and K. Rajewsky. 1995. Lymphoid development in mice with a targeted deletion of the interleukin-2 receptor γ chain. Proc. Natl. Acad. Sci. USA 92:377.
6. Cao, X., E. W. Shores, J. Hu-Li, M. R. Anver, B. L. Kelsall, S. M. Russell, J. Drago, M. Noguchi, A. Grinberg, E. T. Bloom, W. E. Paul, S. I. Katz, P. E. Love, and W. J. Leonard. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 2:223.
7. Ohbo, K., T. Suda, M. Hashiyama, A. Mantani, M. Ikebe, K. Miyakawa, M. Moriyama, M. Nakamura, M. Katsuki, K. Takahashi, K-i, Yamamura, and K. Sugamura. 1996. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain. Blood 87:956.
8. Leonard, W. J., E. W. Shores, and P. E. Love. 1996. Role of the common cytokine receptor γ chain in cytokine signaling and lymphoid development. Immunol. Rev. 148:97.
9. Nakajima, H., E. W. Shores, M. Noguchi, and W. J. Leonard. 1997. The common cytokine receptor γ chain plays an essential role in regulating lymphoid homeostasis. J. Exp. Med. 185:189.
10. c-deficient mice. J. Immunol. 159:4737.
11. Scharton-Kersten, T. M., and A. Sher. 1997. Role of natural killer cells in innate resistance to protozoan infections. Curr. Opin. Immunol. 9:44.
12. Mariuz, P., E. M. Bosler, and B. J. Luft. 1994. Toxoplasmosis in individuals with AIDS. Infect. Dis. Clin. North Am. 8:365.
13. Suzuki, Y., M. A. Orellana, R. D. Schreiber, and J. S. Remington. 1988. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 240:516.
14. Gazzinelli R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533.
15. Denkers E. Y., G. Yap, T. Scharton-Kersten, H. Charest, B. A. Butcher, P. Caspar, S. Heiny, and A. Sher. 1997. Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. J. Immunol. 159:1903.
16. + immune T cells against toxoplasmosis in mice. J. Immunol. 144:1954.
17. Grunvald, E., M. Chiaramonte, S. Hieny, M. Wysocka, G. Trinchieri, S. N. Vogel, R. T. Gazzinelli, and A. Sher. 1996. Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii. Infect. Immun. 64:2010.
18. Scharton-Kersten, T. M., T. A. Wynn, E. Y. Denkers, S. Bala, E. Grunvald, S. Hieny, R. T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ. mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045.
19. Dialynas, D. P., D. B. Wilde, P. Marrack, A. Pierres, K. A. Wall, W. Havran, G. Otten, M. R. Loken, M. Pierres, J. Kappler, and F. W. Fitch. 1983. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-restriction. Immunol. Rev. 74:29.
20. Sarmiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
21. Hunter, C. A., C. S. Subauste, V. H. Van Cleave, and J. S. Remington. 1994. Production of γ interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor α. Infect. Immun. 62:2818.
22. Gazzinelli, R. T., S. Hieny, T. Wynn, S. Wolf, and A. Sher. 1993. IL-12 is required for the T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.