Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth

Histology and Histopathology

Volumn 16, Issue 4, 2001, Pages 1263-1274

  Belloni, A S ^a   Albertin, G ^a   Forneris, M L ^a   Nussdorfer, G G ^a  

^a Section of Anatomy   (Italy)

Author keywords

Adrenomedullin; Apoptosis; Cell proliferation; Neoplastic growth; Organogenesis; Proadrenomedullin N terminal 20 peptide

Indexed keywords

ADENYLATE CYCLASE; ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PROADRENOMEDULLIN; PROTEIN TYROSINE KINASE;

APOPTOSIS; ARTERY INTIMA PROLIFERATION; AUTOCRINE EFFECT; BLOOD PRESSURE REGULATION; BLOOD VESSEL; CANCER CELL CULTURE; CARDIOVASCULAR SYSTEM; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; DNA SYNTHESIS INHIBITION; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; FIBROBLAST; GENE EXPRESSION; GLOMERULOSA CELL; GROWTH REGULATION; HEART MUSCLE CELL; HOMEOSTASIS; HUMAN; MESANGIUM CELL; MOLECULAR BIOLOGY; NONHUMAN; ORGAN GROWTH; ORGANOGENESIS; PARACRINE SIGNALING; PROTEIN ANALYSIS; PROTEIN SYNTHESIS INHIBITION; REVIEW; SKIN EPITHELIUM; SMOOTH MUSCLE FIBER; TISSUE DIFFERENTIATION; TISSUE GRAFT; TUMOR CELL LINE; TUMOR GROWTH; VASCULAR SMOOTH MUSCLE; ZONA GLOMERULOSA;

AMINO ACID SEQUENCE; ANIMALS; AUTOCRINE COMMUNICATION; CELL DIVISION; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; PARACRINE COMMUNICATION; PEPTIDES; PREGNANCY; PROTEIN PRECURSORS; PROTEINS;

EID: 0034777265     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (106)

1. Evidence for a paracrine role of adrenomedullin in the physiological resetting of aldosterone secretion by rat adrenal zona glomerulosa
2. Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits proliferation of human neuroblastoma TGW cells
3. Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: Receptor subtype involved and signaling mechanism
4. Rapid regulation of adrenomedullin in metabolically compromised vascular smooth muscle cells
5. Inhibitory effect of adrenomedullin (ADM) on the aldosterone response of human adrenocortical cells to angiotensin-II: Role of ADM(22-52)-sensitive receptors
6. 2+-dependent agonist-stimulated secretion of human adrenal glands
7. 0-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism
8. Mitogenic signaling via G protein-coupled receptors
9. The MAP kinase cascade
10. CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues
11. Structure-activity relationships of adrenomedullin in the circulation and adrenal gland
12. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway
13. Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway
14. Significance of quiescent smooth muscle cell migration in the injured rat carotic artery
15. Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats
16. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity
17. Mechanisms of neointima formation and remodeling in the porcine coronary artery
18. Adrenomedullin gene delivery attenuates hypertensions, cardiac remodeling, and renal injury in deoxycorticosterone acetate-salt hypertensive rats
19. Endothelin-1 promotes neointima formation after balloon angioplasty in the rat
20. Nitric oxide inhibits angiotensin-II-induced migration of rat aortic smooth muscle cells
21. New insight into the control of MAP kinase pathways
22. Regulation of the MAPK family members: Role of subcellular localization and architectural organization
23. RAMPs: Accessory proteins for seven transmembrane domain receptors
24. Organization and regulation of mitogen-activated protein kinase signaling pathways
25. Intimal hyperplasia, vascular modeling, and the restenosis problem
26. The role of protein kinase A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation
27. Inhibition of adrenal cell aldosterone synthesis by endogenous nitric oxide
28. Adrenomedullin, a multifunctional regulatory peptide
29. Adrenomedullin as a novel antimigration factor of vascular smooth muscle cells
30. Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: Stimulation by interleukin-1β and tumor necrosis factor-α
31. Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts
32. Adrenomedullin production in fibroblasts: Its possible function as a growth regulator of Swiss 3T3 cells
33. Adrenomedullin suppresses interleukin-1β-induced tumor necrosis factor-α production in Swiss 3T3 cells
34. Adrenomedullin as a novel growth-promoting factor for cultured vascular smooth muscle cells: Role of tyrosine kinase-mediated mitogen-activated protein kinase activation
35. Adrenomedullin stimulates proline-rich tyrosine kinase 2 in vascular smooth muscle cells
36. Adrenomedullin: Potential in physiology and pathophysiology
37. Adrenomedullin as a novel antiproliferative factor of vascular smooth msucle cells
38. Adrenomedullin has mitogenic effects on human oral keratinocytes: Involvement of cyclic AMP
39. Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells
40. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
41. Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP)
42. The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma
43. Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells
44. Induction by lysophosphatidylcholine, a major phospholipid component of atherogenic lipoproteins, of human coronary artery smooth muscle cell migration
45. Nitric oxide inhibits aldosteronogenesis guanylyl cyclase stimulation
46. Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blood monocytes
47. A cascade model for restenosis: A special case of atherosclerosis progression
48. Expression of adrenomedullin in normal human lung and in pulmonary tumors
49. Expression of adrenomedullin and its receptor in normal and malignant human skin: A potential pluripotent role in the integument
50. Adrenomedullin receptor expression in human lung and in pulmonary tumors
51. Expression pattern of adrenomedullin during pancreatic development in the rat reveals a common precursor with other endocrine cell types
52. Distribution, functional role and signaling mechanism of adrenomedullin receptors in the rat adrenal gland
53. Restenosis after successful coronary angioplasty: Pathophysiology and prevention
54. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
55. Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells
56. Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor
57. Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action
58. Coordinate expression of transforming growth factor-β1 and adrenomedullin in rodent embryogenesis
59. Adrenomedullin binds with high affinity, elevates cyclic AMP, and stimulates c-fos mRNA in C6 glioma cells
60. Proadrenomedullin NH2-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells
61. Expression of adrenomedullin and adrenomedullin mRNA in ectopic ACTH-secreting tumors
62. Cytophysiology of the adrenal cortex
63. Paracrine control of adrenal cortical function by medullary chromaffin cells
64. Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary-adrenal axis
65. Role of adrenomedullin and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis
66. Autocrine-paracrine endothelin system in the physiology and pathology of steroid secreting tissues
67. The p38 signal transduction pathway. Activation and function
68. SB203580 reverse adrenomedullins effect on proliferation and apoptosis in cultured mesangial cells
69. Desensitization and resensitization of adrenomedullin-sensitive receptor in rat mesangial cells
70. Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells
71. PAMP enhances proliferation of rat zona glomerulosa cells by activating MAPK cascade
72. Stimulation of endogenous nitric oxide production is involved in the inhibitory effect of adrenomedullin on aldosterone secretion in the rat
73. Adrenomedullin
74. Expression of adrenomedullin and peptide amidation in human prostate cancer and human prostate cancer cell lines
75. The pathogenesis of atherosclerosis: An uptodate
76. The pathogenesis of atherosclerosis: A perspective for the 1990s
77. Early signals in the mitogenic response
78. Adrenomedullin and the control of fluid and electrolyte homeostasis
79. Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism
80. Adrenomedullin induces expression of c-fos and AP-1 activity in rat vascular smooth muscle cells and cardiomyocytes
81. Adrenomedullin: A newly discovered hormone controlling fluid and electrolyte homeostasis
82. Inhibitory effect of adrenomedullin on rat mesangial cell mitogenesis
83. Andrenomedulin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinase-dependent cascade
84. Adrenomedullin receptor antagonism by calcitonin gene-related peptide (8-37) inhibits carotid artery neointimal hyperplasia after baloon injury
85. Atrial natriuretic peptide induces the expression of MKP-1, a mitogen-activated protein kinase phosphatase, in glomerular mesangial cells
86. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-α
87. Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells
88. MKP-1 (3CH134), an immediate early gene gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
89. Production and secretion of adrenomedullin from glial cell tumors and its effects on cAMP production
90. Expression of adrenomedullin mRNA in adrenocortical tumors and secretion of adrenomedullin by cultured adrenocortical carcinoma cells
91. Production and secretion of two vasoactive peptides, adrenomedullin and endothelin-1, by cultured human adrenocortical carcinoma cells
92. Secretion of endothelin-1 and adrenomedullin by SW-13 human adrenocortical carcinoma cells
93. Circulating level of cytokines and their endogenous modulators in patients with mild severe congestive heart failure due to coronary artery disease or hypertension
94. Interleukin-1β modulates the growth and phenotype of neonatal rat cardiac myocytes
95. Beraprost sodium, an analogue of prostacyclin, induces the expression of mitogen-activated protein kinase phosphatase and inhibits the proliferation of cultured mesangial cells
96. Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro
97. Adrenomedullin: A possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes
98. An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth
99. Adrenomedullin expression and growth inhibitory effects in distinct pulmonary artery smooth muscle cell subpopulations
100. s/mitogen-activated protein kinase pathway in mutant S49 cells
101. Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells
102. Tumor necrosis factor-α provokes a hypertropic growth response in adult cardiac myocytes
103. Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rat administered monocrotaline
104. Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse
105. Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis, and renal damage in hypertensive Dahl salt-sensitive rats
106. PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium