Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats

British Journal of Pharmacology

Volumn 134, Issue 3, 2001, Pages 529-534

  Lutfy, Kabirullah ^a   Hossain, Syed M ^a   Khaliq, Imran ^a   Maidment, Nigel T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antinociception; CA3 region; Hippocampus; Morphine; Orphanin FQ nociceptin; Rat hot plate test; Tolerance

Indexed keywords

MORPHINE; NOCICEPTIN; OPIATE RECEPTOR; OPIATE RECEPTOR LIKE RECEPTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; HIPPOCAMPUS; HOT PLATE TEST; LEARNING; LONG TERM POTENTIATION; MALE; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; HIPPOCAMPUS; MALE; MORPHINE; OPIOID PEPTIDES; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS;

EID: 0034774632     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704279     Document Type: Article

References (57)

1. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells
2. Delta-opioid receptor-mediated increase in cortical extracellular levels of cholecystokinin-like material by subchronic morphine in rats
3. mu-Opioid receptor downregulation and cAMP-dependent protein kinase phosphorylation in a mouse model of chronic morphine tolerance
4. Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay
5. Effect of nociceptin/orphanin FQ on the rewarding properties of morphine
6. Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro
7. The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line
8. Drug tolerance and physical dependence
9. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion
10. Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence
11. Regulation of mu binding sites after chronic administration of antibodies directed against specific anti-opiate peptides
12. Opiate tolerance and dependence: Receptors, G-proteins, and antiopiates
13. Morphine activates opioid receptors without causing their rapid internalization
14. The role of adenyl cyclase in opiate tolerance and dependence
15. Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons
16. Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor
17. Loss of opiate receptor activity in neuroblastoma X glioma NG108-15 hybrid cells after chronic opiate treatment. A multiple-step process
18. Extracellular cholecystokinin levels in the rat spinal cord following chronic morphine exposure: An in vivo microdialysis study
19. Blockade of morphine-induced analgesia and tolerance in mice by MK-801
20. Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test
21. Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat
22. Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test
23. FMRF-NH2-like mammalian octapeptide: Possible role in opiate dependence and abstinence
24. Increases in protein kinase C gamma immunoreactivity in the spinal cord of rats associated with tolerance to the analgesic effects of morphine
25. Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat
26. Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes
27. The development of morphine tolerance and dependence is associated with translocation of protein kinase C
28. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
29. Orphanin FQ is a functional anti-opioid peptide
30. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization
31. Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ
32. Orphanin FQ/nociceptin blocks acquisition of morphine place preference
33. Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse
34. Neuraxial infusion in patients with chronic intractable cancer and noncancer pain
35. Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: A useful model for the study of tolerance at mu opioid receptors
36. Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor
37. The nociceptin/orphanin FQ receptor antagonist, [Nphel]NC(1-13)NH2, potentiates morphine analgesia
38. Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats
39. Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
40. Morphine analgesic tolerance: Its situation specificity supports a Pavlovian conditioning model
41. Involvement of intracellular calcium in morphine tolerance in mice
42. Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment
43. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat
44. Endogenous orphanin FQ: Evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture
45. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
46. Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene
47. Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones
48. Effects of orphanin FQ on endomorphin-1 induced analgesia
49. Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent
50. Tolerance to morphine at the muopioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine
51. Modulation of free intracellular calcium levels [(Ca++)i] in brain and spinal cord of morphine-tolerant rats and mice
52. The evaluation of analgesic action of pethidine hydrochloride (demerol)
53. Opioid receptor regulation in mice
54. Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation
55. Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus
56. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats