Evidence against an action of mibefradil at N-type voltage-operated calcium channels

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 364, Issue 5, 2001, Pages 430-436

  Xi, Q ^a   Angus, J A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Conotoxin GVIA; Left atrium; Mibefradil; N type calcium channels; Rat vas deferens

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; BENEXTRAMINE; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL T TYPE; MIBEFRADIL; OMEGA CONOTOXIN GVIA; POTASSIUM; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC FIELD; GUINEA PIG; HEART ATRIUM; HYPOTHESIS; INOTROPISM; NERVE POTENTIAL; NERVE STIMULATION; NONHUMAN; RAT; RECEPTOR DOWN REGULATION; SYMPATHETIC NERVE; VAS DEFERENS;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; ELECTRIC STIMULATION; GUINEA PIGS; HEART ATRIA; MALE; MIBEFRADIL; MUSCLE CONTRACTION; OMEGA-CONOTOXIN GVIA; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHETIC NERVOUS SYSTEM; VAS DEFERENS;

EID: 0034749672     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100100470     Document Type: Article

References (42)

1. Refractory period field stimulation of right atria: A method for studying presynaptic receptors in cardiac autonomic transmission
2. Role of autoinhibitory feedback in cardiac sympathetic transmission
3. Antihypertensive properties of the novel calcium antagonist mibefradil (Ro 40-5967): A new generation of calcium antagonists?
4. 2+ channel antagonist mibefradil (Ro 40-5967)
5. Potent vasodilatory with minor cardiodepressant actions of mibefradil in human cardiac tissue
6. 2+ channel blockers on noradrenaline release and purinergic neuroeffector transmission in rat tail artery
7. 2+ channels and heart failure
8. Mibefradil in the treatment of chronic stable angina pectoris: Comparative studies with other calcium antagonists
9. 2+ channels and pharmacological blockade: Potential pathophysiological relevance
10. Mibefradil- and omega-conotoxin GVIA-induced inhibition of noradrenaline release from the sympathetic nerves of the human heart
11. The withdrawal of mibefradil (Posicor)
12. Role of T channels in cardiovascular function
13. ATP as a cotransmitter in perivascular sympathetic nerves
14. A family of gamma-like calcium channel subunits
15. Serious interaction between mibefradil and tacrolimus
16. Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues
17. Effect of short-term treatment of SHR with the novel calcium channel antagonist mibefradil on function of small arteries
18. Mibefradil block of cloned T-type calcium channels
19. Mibefradil in the treatment of systemic hypertension: Comparative studies with other calcium antagonists
20. +- and veratridine-induced increases of cytosolic calcium concentration in rat cerebral cortical synaptosomes
21. +- and veratridine-induced increase of cytosolic calcium concentration in human cerebral cortical synaptosomes
22. ++ channels
23. 2+ channels by Ro 40-5967
24. Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium
25. N-Type calcium channels control sympathetic neurotransmission in human heart atrium
26. Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers
27. Noradrenaline contracts arteries by activating voltage-dependent calcium channels
28. Anti-hypertensive effects of mibefradil in the treatment of mild-to-moderate systemic hypertension
29. 2+ channel blocker with potent vasodilator but weak inotropic action
30. Omega-conotoxin GVIA is a potent inhibitor of sympathetic neurogenic responses in rat small mesenteric arteries
31. Calcium channel blockade limits cardiac remodelling and improves cardiac function in myocardial infarction-induced heart failure in rats
32. Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists
33. Mibefradil prevents neointima formation after vascular injury in rats. Possible role of the blockade of the T-type voltage-operated calcium channel
34. Prevention of neointima formation by mibefradil after vascular injury in rats: Comparison with ACE inhibition
35. Two stable cell lines for screening of calcium channel blockers
36. Role of N-type calcium channels in autonomic neurotransmission in guinea-pig isolated left atria
37. Pharmacokinetic interaction between oral cyclosporin and mibefradil in stabilized post-renal-transplant patients
38. Inhibitory effect of mibefradil on contractions induced by sympathetic neurotransmitter release in the rat tail artery
39. Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones
40. Expression of the L-type calcium channel with two different beta subunits and its modulation by Ro 40-5967
41. Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission
42. Evidence that mibefradil is not a N-type calcium channel antagonist in functional assays