Mibefradil- and ω-conotoxin GVIA-induced inhibition of noradrenaline release from the sympathetic nerves of the human heart

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 6, 1997, Pages 860-863

  Gothert M ^a   Molderings, G J ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Calcium channels; Human atrial appendages; L type Ca2+ channels; Mibefradil; N type Ca2+ channels; Nifedipine; Sympathetic nerves; Conotoxin GVIA

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CONOTOXIN; CORTICOSTERONE; DESIPRAMINE; MIBEFRADIL; NIFEDIPINE; NORADRENALIN;

ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; NORADRENALIN RELEASE; NORMAL HUMAN; SYMPATHETIC NERVE;

EID: 0030735228     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005130     Document Type: Article

References (16)

1. Bakx ALM, van der Wall EE, Braun S, Emanuelsson H, Bruschke AVG, Kobrin I (1995) Effects of the new calcium antagonist mibefradil (Ro 40-5967) on exercise duration in patients with chronic stable angina pectoris: A multicenter, placebo-controlled study. Am Heart J 130:748-757
2. Bernink PJ, Prager G, Schelling A, Kobrin I (1996) Antihypertensive properties of the novel calcium antagonist mibefradil (Ro 40-5967). A new generation of calcium antagonists? Mibefradil International Study Group. Hypertension 27:426-432
3. 2+ channel antagonist mibefradil (Ro 40-5967). Mol Pharmacol 48:540-549
4. Braun S, van der Wall EE, Emanuelsson H, Kobrin I (1996) Effects of a new calcium antagonist, mibefradil (Ro 40-5967), in silent ischemia in patients with stable chronic angina pectoris: a multicenter placebo-controlled study. The Mibefradil International Study Group. J Am Coll Cardiol 27:317-322
5. Clozel J-P, Osterrieder W, Kleinbloesem CH, Welker HA, Schläppi B, Tudor R, Hefti F, Schmitt R, Eggers H (1991) Ro 40-5967: a new nondihydropyridine calcium antagonist. Cardiovasc Drug Rev 9:4-17
6. 2+ channels by amlodipine. Br J Pharmacol 121:1136-1140
7. 2+], in human cerebral synaptosomes. Naunyn-Schmiedeberg's Arch Pharmacol 356 [Suppl]:R6
8. Haustein KO, Assmann I, Huller G (1990) Interaction between nifedipine and cardioactivedrugs. Int J Pharmacol Ther Toxicol 28:458-461
9. +-and veratridine-induced increases of cytosolic calcium concentration in rat cerebral cortical synaptosomes. Naunyn-Schmiedeberg's Arch Pharmacol 356:797-805
10. Miljanich GP, Ramachandran J (1995) Antagonists of neuronal calcium channels: structure,function, and therapeutic implications. Annu Rev Pharmacol Toxicol 35:707-734
11. 2+ channels by Ro 40-5967. Circ Res 75:144-148
12. 1Dα receptors in human atrium. Naunyn-Schmiedeberg's Arch Pharmacol 353:272-280
13. Roux S, Bühler M, Clozel JP (1996) Mechanism of the antiischemic effect of mibefradil, a selective T calcium channel blocker in dogs: comparison with amlodipine. J Cardiovasc Pharmacol 27:132-139
14. Starke K, Schümann HJ (1973) Wirkung von Nifedipine auf die Funktion der sympathischen Nerven des Herzens. Arzneim Forsch 23:193-197
15. Tareilus E, Breer H (1995) Presynaptic calcium channels: pharmacology and regulation. Neurochem Int 26:539-558
16. Wright CE, Angus JA (1996) Effects of N-, P-and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission. Br J Pharmacol 119:49-56