Effect of short-term treatment of SHR with the novel calcium channel antagonist mibefradil on function of small arteries

American Journal of Hypertension

Volumn 10, Issue 1, 1997, Pages 94-100

  Li, Jin S ^a   Schiffrin, Ernesto L ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

antihypertensive therapy; endothelial dependent contracting factor; endothelial dependent relaxing factor; hypertension; nitric oxide; resistance arteries

Indexed keywords

ACETYLCHOLINE; CALCIUM ANTAGONIST; MIBEFRADIL; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL FUNCTION; CONTROLLED STUDY; DRUG EFFECT; ESSENTIAL HYPERTENSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM;

ANIMALS; ARTERIES; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; HYPERTENSION; MIBEFRADIL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TETRAHYDRONAPHTHALENES; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 0031036702     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(96)00294-4     Document Type: Article

References (33)

1. Mulvany MJ, Hansen PK, Aalkjaer C. Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers. Circ Res. 43:1978;854-864.
2. Mulvany MJ, Korsgaard N. Correlations and otherwise between blood pressure, cardiac mass and resistance vessel characteristics in hypertensive, normotensive and hypertensive/normotensive hybrid rats. J Hypertens. 1:1983;235-244.
3. Mulvany MJ, Baandrup U, Gundersen HJG. Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a 3-dimensional dissector. Circ Res. 57:1985;794-800.
4. Baumbach GL, Heistad DD. Remodeling of cerebral arterioles in chronic hypertension. Hypertension. 13:1989;968-972.
5. Deng LY, Schiffrin EL. Effects of endothelin-1 and vasopressin on small arteries of spontaneously hypertensive rats. Am J Hypertens. 5:1992;817-822.
6. Li J-S, Schiffrin EL. Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension. 25:((Part 1)):1995;495-500.
7. Izzard AS, Heagerty AM. Hypertension and the vasculature: arterioles and the myogenic response. J Hypertens. 13:1995;1-4.
8. Christensen KL, Jespersen LT, Mulvany MJ. Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-term treatment related to vascular structure. J Hypertens. 7:1989;83-90.
9. Harrap SB, Van der Merwe WM, Griffin SA, et al. Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure longterm. Hypertension. 16:1990;603-614.
10. Mulvany MJ, Persson AEG, Andresen J. No persistent effect of angiotensin converting enzyme inhibitor treatment in Milan hypertensive rats despite regression of vascular structure. J Hypertens. 9:1991;589-593.
11. Lee RMKW, Berecek KH, Tsoporis J, et al. Prevention of hypertension and vascular changes by captopril treatment. Hypertension. 17:1991;141-150.
12. Hajdu MA, Heistad DD, Baumbach GL. Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats. Hypertension. 17:1991;308-316.
13. Thybo NK, Korsgaard N, Eriksen S, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure. Hypertension. 23:1994;659-666.
14. Li J-S, Schiffrin EL. Effect of calcium channel blockade or angiotensin converting enzyme inhibition on structure of coronary, renal and other small arteries in SHR. J Cardiovasc Pharmacol. 28:1996;68-74.
15. Mulvany MJ, Aalkjaer C. Structure and function of small arteries. Physiol Rev. 70:1990;921-971.
16. Schiffrin EL. Reactivity of small blood vessels in hypertension. Relationship with structural changes. Hypertension. 19:((suppl II)):1992;II-1-II-9.
17. Clozel M. Mechanism of action of angiotensin converting enzyme inhibitors on endothelial function in hypertension. Hypertension. 18:((suppl II)):1991;II-37-II-42.
18. Takase H, Moreau P, Küng CF, et al. Antihypertensive therapy prevents endothelial dysfunction in chronic nitric oxide deficiency - effect of verapamil and trandolapril. Hypertension. 27:1996;25-31.
19. Schiffrin EL, Deng LY. Comparison of effects of angiotensin I-converting enzyme inhibition and beta blockade on function of small arteries from hypertensive patients. Hypertension. 25:((Part 2)):1995;699-703.
20. 2+ channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol. 13:1989;754-759.
21. 2+ channels by Ro 40-5967. Circ Res. 75:1994;144-148.
22. Li J-S, Schiffrin EL. Chronic endothelin receptor antagonist treatment of young spontaneously hypertensive rats. J Hypertens. 13:1995;647-652.
23. Li JS, Larivière R, Schiffrin EL. Effect of a nonselective endothelin antagonist on vascular remodeling in DOCA-salt hypertensive rats. Hypertension. 24:1994;183-188.
24. Deng LY, Schiffrin EL. Effects of endothelin on small arteries of DOCA-salt hypertensive rats. Am J Physiol. 262:1992;H1782-H1787.
25. Tschudi MR, Criscione L, Novosel D, et al. Antihypertensive therapy augments endothelium-dependent relaxations in coronary arteries of spontaneously hypertensive rats. Circulation. 1994;2212-2218.
26. Dohi Y, Criscione L, Pfeiffer K, Lüscher TF. Angiotensin blockade or calcium antagonists improve endothelial dysfunction in hypertension: studies in perfused mesenteric resistance arteries. J Cardiovasc Pharmacol. 24:1994;372-379.
27. Lockette W, Otsuka Y, Carretero O. The loss of endothelium-dependent vascular relaxation in hypertension. Hypertension. 8:((suppl II)):1986;II-61-II-66.
28. Lüscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension. 8:1986;344-348.
29. Diederich DA, Yang Z, Bühler FR, Lüscher TF. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve the cyclooxygenase pathway. Am J Physiol (Heart Circ Physiol). 258:1990;H445-H451.
30. Lüscher TF, Aarhus LL, Vanhoutte PM. Indomethacin enhances the impaired endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat. Am J Hypertens. 3:1990;55-58.
31. Deng LY, Li J-S, Schiffrin EL. Endothelium-dependent relaxation of small arteries from essential hypertensive patients. Clin Sci. 88:1995;611-622.
32. Küng CF, Tschudi MR, Noll G, et al. Differential effects of the calcium antagonist mibefradil in epicardial and intramyocardial coronary arteries. J Cardiovasc Pharmacol. 26:1995;312-318.
33. Tschudi MR, Mesaros S, Lüscher TF, Malinski T. Direct in situ measurement of nitric oxide in mesenteric resistance arteries - increased decomposition by superoxide in hypertension. Hypertension. 27:1996;32-35.