Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: Evidence for cooperativity with c-Myb

Journal of Virology

Volumn 70, Issue 8, 1996, Pages 5618-5629

  Zaiman, Ari L ^a   Lenz, Jack ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENHANCER REGION; GENE EXPRESSION; MOUSE; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; RETROVIRUS; TRANSCRIPTION REGULATION; VIRUS TRANSCRIPTION;

EID: 0030015294     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.8.5618-5629.1996     Document Type: Article

References (108)

1. Aziz, N., M. R. Miglarese, R. C. Hendrickson, J. Shabanowitz, T. W. Sturgill, D. F. Hunt, and T. P. Bender. 1995. Modulation of c-myb-induced transcription activation by a phosphorylation site near the negative regulatory domain. Proc. Natl. Acad. Sci. USA 92:6429-6433.
2. Bae, S., E. Takahashi, Y. W. Zhang, E. Ogawa, K. Shigesada, Y. Namba, M. Satake, and Y. ItO. 1995. Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian runt domain. Gene 159:245-248.
3. Bae, S. C., E. Ogawa, M. Maruyama, H. Oka, M. Satake, K. Shigesada, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and Y. Ito. 1994. PEBP2αB/ mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol. Cell. Biol. 14:3242-3252.
4. Bae, S. C., Y. Yamaguchi-Iwai, E. Ogawa, M. Maruyama, M. Inuzuka, H. Kagoshima, K. Shigesada, M. Satake, and Y. Ito. 1993. Isolation of PEBP2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene 8:809-814.
5. Ben-David, Y., and A. Bernstein. 1991. Friend virus-induced erythroleukemia and the multistage nature of cancer. Cell 66:831-834.
6. Boral, A. L., S. A. Okenquist, and J. Lenz. 1989. Identification of the SL3-3 virus enhancer core as a T-lymphoma cell-specific element. J. Virol. 63:76-84.
7. Bradsbaw, M. S., S. Y. Tsai, X. Leng, A. D. W. Dobson, O. M. Conneely, B. W. O'Malley, and M. Tsai. 1991. Studies on the mechanism of functional cooperativity between progesterone and estrogen receptors. J. Biol. Chem. 266:16684-16690.
8. Brightman, B. K., C. Farmer, and H. Fan. 1993. Escape from in vivo restriction of Moloney mink cell focus-inducing viruses driven by the Mo+PyF101 long terminal repeat (LTR) by LTR alterations. J. Virol. 67:7140-7148.
9. Brightman, B. K., A. Rein, D. J. Trepp, and H. Fan. 1991. An enhancer variant of Moloney murine leukemia virus defective in leukemogenesis does not generate mink cell focus-inducing virus in vivo. Proc. Natl. Acad. Sci. USA 88:2264-2268.
10. Brown, T. A., and S. L. McKnight. 1992. Specificities of protein-protein and protein-DNA interaction of GABPα and two newly defined ets-related proteins. Genes Dev. 6:2502-2512.
11. Calabi, F., M. Rhodes, P. Williamson, and Y. Boyd. 1995. Identification and chromosomal mapping of a third mouse runt-like locus. Genomics 26:607-610.
12. Cameron, S., D. S. Taylor, E. C. TePas, N. A. Speck, and B. Mathey-Prevot. 1994. Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting. Blood 83:2851-2859.
13. Celander, D., and W. A. Haseltine. 1984. Tissue-specific transcription preference as a determinant of cell tropism and leukaemogenic potential of murine retroviruses. Nature (London) 312:159-162.
14. Chatis, P. A., C. A. Holland, J. W. Hartley, W. P. Rowe, and N. Hopkins. 1983. Role for the 3′ end of the genome in determining disease specificity of Friend and Moloney murine leukemia viruses. Proc. Natl. Acad. Sci. USA 80:4408-4411.
15. Chatis, P. A., C. A. Holland, J. E. Silver, T. N. Frederickson, N. Hopkins, and J. W. Hartley. 1984. A 3′-end fragment encompassing the transcriptional enhancers of nondefective Friend virus confers erythroleukemogenicity on Moloney leukemia virus. J. Virol. 52:248-254.
16. Chi, T., P. Lieberman, K. Ellwood, and M. Carey. 1995. A general mechanism for transcriptional synergy by eukaryotic activators. Nature (London) 377:254-257.
17. Crute, B. E., and N. A. Speck. 1994. Unpublished results.
18. Daga, A., J. E. Tighe, and F. Calabi. 1992. Leukaemia/Drosophila homology. Nature (London) 356:484.
19. Davis, B., B. K. Brightman, K. G. Chandy, and H. Fan. 1987. Characterization of a preleukemic state induced by Moloney murine leukemia virus: evidence for two infection events during leukemogenesis. Proc. Natl. Acad. Sci. USA 84:4875-4879.
20. DesGroseillers, L., and P. Jolicoeur. 1984. The tandem direct repeats within the long terminal repeat of murine leukemia viruses are the primary determinant of their leukemogenic potential. J. Virol. 52:945-952.
21. DesGroseillers, L., E. Rassart, and P. Jolicoeur. 1983. Thymotropism of murine leukemia virus is conferred by its long terminal repeat. Proc. Natl. Acad. Sci. USA 80:4203-4207.
22. Dubendorff, J., L. Whittaker, J. Eltman, and J. Lipsick. 1992. Carboxyterminal elements of c-Myb negatively regulate transcriptional activation in cis and in trans. Genes Dev. 6:2524-2535.
23. Dudek, H., R. V. Tantravahi, V. N. Rao, S. P. Reddy, and E. P. Reddy. 1992. Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter. Proc. Natl. Acad. Sci. USA 89:1291-1295.
24. Erickson, P., J. Gao, K.-S. Chang, T. Look, E. Whisenant, S. Raimondi, R. Lasher, J. Trujillo, J. Rowley, and H. Drabkin. 1992. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825-1831.
25. Fan, H. 1990. Influences of the long terminal repeats on retrovirus pathogenicity. Semin. Virol. 1:165-174.
26. Giese, K., C. Kingsley, J. R. Kirshner, and R. Grosschedl. 1995. Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9:995-1008.
27. Golemis, E., Y. Li, T. N. Fredrickson, J. W. Hartley, and N. Hopkins. 1989. Distinct segments within the enhancer region collaborate to specify the type of leukemia induced by nondefective Friend and Moloney viruses. J. Virol. 63:328-337.
28. Golemis, E. A., N. A. Speck, and N. Hopkins. 1990. Alignment of U3 sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design. J. Virol. 64:534-542.
29. Golub, T. R., G. F. Barker, S. K. Bohlander, S. W. Hiebert, D. C. Ward, P. Bray-Ward, E. Morgan, S. C. Raimondi, J. D. Rowley, and D. G. Gilliland. 1995. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 92:4917-4921.
30. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
31. Gottschalk, L. R., and J. M. Leiden. 1990. Identification and functional characterization of the human T-cell receptor β gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor α and β genes. Mol. Cell. Biol. 10: 5486-5495.
32. Gunther, C. V., and B. J. Graves. 1994. Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer. Mol. Cell. Biol. 14:7569-7580.
33. Hajra, A., P. P. Liu, N. A. Speck, and F. S. Collins. 1995. Overexpression of core-binding factor α (CBFα) reverses cellular transformation by the CBFβ-smooth muscle myosin heavy chain chimeric oncoprotein. Mol. Cell. Biol. 15:4980-4989.
34. Hallberg, B., and T. Grundström. 1988. Tissue specific sequence motifs in the enhancer of the leukaemogenic mouse retrovirus SL3-3. Nucleic Acids Res. 16:5927-5944.
35. Hallberg, B., J. Schmidt, A. Luz, F. S. Pedersen, and T. Grundström. 1991. SL3-3 enhancer factor 1 transcriptional activators are required for tumor formation by SL3-3 murine leukemia virus. J. Virol. 65:4177-4181.
36. Hernandez-Munain, C., and M. S. Krangel. 1994. Regulation of the T-cell receptor δ enhancer by functional cooperation between c-Myb and core-binding factors. Mol. Cell. Biol. 14:473-483.
37. Hernandez-Munain, C., and M. S. Krangel. 1995. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor δ enhancer. Mol. Cell. Biol. 15:3090-3099.
38. Holland, C. A., C. Y. Thomas, S. K. Chattopadhyay, C. Koehne, and P. V. O'Donnell. 1989. Influence of enhancer sequences on thymotropism and leukemogenicity of mink cell focus-forming viruses. J. Virol. 63:1284-1292.
39. Hsiang, Y. H., J. P. Goldman, and D. H. Raulet. 1995. The role of c-myb or a related factor in regulating the T cell receptor gamma gene enhancer. J. Immunol. 154:5195-5204.
40. Hu, Y., R. Ramsay, C. Kanei-Ishii, S. Ishii, and T. Gonda. 1991. Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain. Oncogene 6:1549-1553.
41. Ishimoto, A., M. Takimoto, A. Adachi, M. Kakuyama, S. Kato, K. Kakimi, K. Fukuoka, T. Ogiu, and M. Matsuyama. 1987. Sequences responsible for erythroid and lymphoid leukemia in the long terminal repeats of Friend mink cell focus-forming and Moloney murine leukemia viruses. J. Virol. 61:1861-1866.
42. Janknecht, J., and A. Nordheim. 1993. Gene regulation by Ets proteins. Biochim. Biophys. Acta 1155:346-356.
43. Kagoshima, H., K. Shigesada, M. Satake, Y. Ito, H. Miyoshi, M. Ohki, M. Pepling, and P. Gergen. 1993. The Runt domain identifies a new family of heteromeric transcriptional regulators. Trends Genet. 9:338-341.
44. Kalkbrenner, F., S. Guehmann, and K. Moelling. 1990. Transcriptional activation by human c-myb and v-myb genes. Oncogene 5:657-661.
45. Kamachi, Y., E. Ogawa, M. Asano, S. Ishida, Y. Murakami, M. Satake, Y. Ito, and K. Shigesada. 1990. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J. Virol. 64:4808-4819.
46. Kanei-Ishii, C., E. MacMillan, T. Nomura, A. Sarai, R. Ramsay, S. Aimoto, S. Ishii, and T. Gonda. 1992. Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure. Proc. Natl. Acad. Sci. USA 89:3088-3092.
47. Kania, M. A., A. S. Bonner, J. B. Duffy, and J. P. Gergen. 1990. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 4:1701-1713.
48. Khoury, G., and P. Gruss. 1983. Enhancer elements. Cell 33:313-314.
49. Lawrenz-Smith, S. C., A. C. Massey, D. J. Innes, and C. Y. Thomas. 1994. Pathogenic determinants in the U3 region of recombinant murine leukemia viruses isolated from CWD and HRS/J mice. J. Virol. 68:5174-5183.
50. Lenz, J., D. Celander, R. L. Crowther, R. Patarca, D. W. Perkins, and W. A. Haseltine. 1984. Determination of the leukemogenicity of a murine retrovirus by sequences within the long terminal repeat. Nature (London) 308: 467-470.
51. Levanon, D., V. Negreanu, Y. Bernstein, I. Bar-Am, L. Avivi, and Y. Groner. 1994. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23:425-432.
52. Li, Y., E. Golemis, J. W. Hartley, and N. Hopkins. 1987. Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides. J. Virol. 61:693-700.
53. Liu, P., S. A. Tarlé, A. Hajra, D. F. Claxton, P. Marlton, M. Freedman, M. J. Siciliano, and F. S. Collins. 1993. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 261:1041-1044.
54. LoSardo, J., and J. Lenz. 1995. Unpublished results.
55. LoSardo, J. E., A. L. Boral, and J. Lenz. 1990. Relative importance of elements within the SL3-3 virus enhancer for T-cell specificity. J. Virol. 64:1756-1763.
56. Martin, K. J., J. W. Lillie, and M. R. Green. 1990. Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets. Nature (London) 346:147-152.
57. Melnikova, I. A., B. E. Crute, S. Wang, and N. A. Speck. 1993. Sequence specificity of the core-binding factor. J. Virol. 67:2408-2411.
58. Melotti, P., and B. Calabretta. 1994. Ets-2 and c-myb act independently in regulating expression of the hematopoietic stem cell antigen CD34. J. Biol. Chem. 269:25303-25309.
59. Meyers, S., J. R. Downing, and S. W. Hiebert. 1993. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DJNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336-6345.
60. Meyers, S., N. Lenny, and S. W. Hiebert. 1995. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol. Cell. Biol. 15:1974-1982.
61. Mitani, K., S. Ogawa, T. Tanaka, H. Miyoshi, M. Kurokawa, H. Mano, Y. Yazaki, M. Onki, and H. Hirai. 1994. Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J. 13:504-510.
62. Miyoshi, H., T. Kozu, K. Shimizu, K. Enomoto, N. Maseki, Y. Kaneko, N. Kamada, and M. Ohki. 1993. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 12:2715-2721.
63. Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1991. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. USA 88:10431-10434.
64. Morrison, H. L., B. Soni, and J. Lenz. 1995. Long terminal repeat enhancer core sequences in proviruses adjacent to c-myc in T-cell lymphomas induced by a murine retrovirus. J. Virol. 69:446-455.
65. Mucenski, M. L., K. McLain, A. B. Kier, S. H. Swerdlow, C. M. Schreiner, T. A. Miller, D. W. Pietryga, W. J. Scott, and S. Potter. 1991. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677-689.
66. Nieves, A., and J. Lenz. 1996. Unpublished results.
67. Numura, T., N. Sakai, A. Sarai, T. Sudo, C. Kanei-Ishii, R. Ramsay, D. Favier, T. Gonda, and S. Ishii. 1993. Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper. J. Biol. Chem. 268:21914-21923.
68. Nuchprayoon, I., S. Meyers, L. M. Scott, J. Suzow, S. Hiebert, and A. D. Friedman. 1994. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol. Cell. Biol. 14:5558-5568.
69. Nucifora, G., C. R. Begy, P. Erickson, H. A. Drabkin, and J. D. Rowley. 1993. The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. Proc. Natl. Acad. Sci. USA 90:7784-7788.
70. Nucifora, G., D. J. Birn, K. Espinosa III, P. Erickson, M. M. LeBeau, D. Roulston, T. W. McKeithan, H. Drabkin, and J. D. Rowley. 1993. Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood 81:2728-2734.
71. Ogawa, E., M. Inuzuka, M. Maruyama, M. Satake, M. Fujimoto-Naito, Y. Ito, and K. Shigesada. 1993. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314-331.
72. Ogawa, E., M. Maruyama, H. Kagoshima, M. Inuzuka, J. Lu, M. Satake, K. Shigesada, and Y. Ito. 1993. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc. Natl. Acad. Sci. USA 90:6859-6863.
73. Okuda, T., J. van Deursen, S. W. Hiebert, G. Grosveld, and J. R. Downing. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-330.
74. Pederson, F. S., R. L. Crowther, D. L. Tenney, A. M. Reimhold, and W. A. Haseltine. 1981. Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour. Nature (London) 292:167-170.
75. Prosser, H. M., D. Wotton, J. Gegonne, J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1992. A phorbol ester response element within the human T-cell receptor β-chain enhancer. Proc. Natl. Acad. Sci. USA 89:9934-9938.
76. Ramsay, R., S. Ishii, and T. Gonda. 1991. Increase in specific DNA binding by carboxyl truncation suggests a mechanism for activation of Myb. Oncogene 6:1875-1879.
77. Romana, S. P., M. Mauchauffe, M. Le Conat, I. Chumakov, D. Le Paslier, R. Berger, and O. A. Bernard. 1995. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662-3670.
78. Rosen, C. A., W. A. Haseltine, J. Lenz, R. Ruprecht, and M. W. Cloyd. 1985. Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. J. Virol. 55:862-866.
79. Rubin, C. M., R. A. Larson, J. Anastasi, J. N. Winter, M. Thangavelu, J. W. Vardiman, J. D. Rowley, and M. M. LeBeau. 1990. t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood 76:2594-2598.
80. Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. Ga17-VP16 is an unusually potent transcriptional activator. Nature (London) 335:563-564.
81. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL(1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539.
82. Saikumar, P., R. Murali, and E. P. Reddy. 1990. Role of tryptophan repeats and flanking amino acids in myb-DNA interaction. Proc. Natl. Acad. Sci. USA 87:8452-8456.
83. Sakura, H., C. Kanei-Ishii, T. Nagase, H. Nakagoshi, T. J. Gonda, and S. Ishii. 1989. Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proc. Natl. Acad. Sci. USA 86:5758-5762.
84. Shapiro, L. H. 1995. Myb and Ets proteins cooperate to transactivate an early myeloid gene. J. Biol. Chem. 270:8763-8771.
85. Short, M. K., S. A. Okenquist, and J. Lenz. 1987. Correlation of leukemogenic potential of murine retroviruses with transcriptional tissue preference of the viral long terminal repeats. J. Virol. 61:1067-1072.
86. Speck, N. A., and D. Baltimore. 1987. Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer. Mol. Cell. Biol. 7:1101-1110.
87. Speck, N. A., B. Renjifo, E. Golemis, T. Fredrickson, J. Hartley, and N. Hopkins. 1990. Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. Genes Dev. 4:233-242.
88. Subramaniam, A., J. Gulick, and J. Robbins. 1990. Analysis of the upstream regulatory region of a chicken skeletal myosin heavy chain. J. Biol. Chem. 265:13986-13994.
89. Sun, W., B. J. Graves, and N. A. Speck. 1995. Transactivation of the Moloney murine leukemia virus and T-cell receptor β-chain enhancers by cbf and ets requires intact binding sites for both proteins. J. Virol. 69:4941-4949.
90. Suzow, J., and A. D. Friedman. 1993. The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Mol. Cell. Biol. 13:2141-2151.
91. Tanaka, T., K., Tanaka, S. Ogawa, M. Kurokawa, K. Mitani, J. Nishida, Y. Shibata, Y. Yazaki, and H. Hirai. 1995. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J. 14:341-350.
92. Thiesen, H.-J., Z. Bosze, L. Henry, and P. Charnay. 1988. A DNA element responsible for the different tissue specificities of Friend and Moloney retroviral enhancers. J. Virol. 62:614-618.
93. Thornell, A., B. Hallberg, and T. Grundström. 1988. Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3. Mol. Cell. Biol. 8:1625-1637.
94. Thornell, A., B. Hallberg, and T. Grundström. 1991. Binding of SL3-3 enhancer factor I transcriptional activators to viral and chromosomal enhancer sequences. J. Virol. 65:42-50.
95. Thornell, A., M. Holm, and T. Grundström. 1913. Purification of SEF1 proteins binding to transcriptional enhancer elements active in T lymphocytes. J. Biol. Chem. 268:21946-21954.
96. Tsai, S. Y., M. Tsai, and B. W. O'Malley. 1989. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at the target enhancer elements. Cell 57:443-448.
97. Tsichlis, P. N., and P. A. Lazo. 1991. Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses. Curr. Top. Microbiol. Immunol. 171:95-171.
98. Vogt, M., C. Haggblom, S. Swift, and M. Haas. 1985. Envelope gene and long terminal repeat determine the different biological properties of Rauscher, Friend, and Moloney mink cell focus-inducing viruses. J. Virol. 55: 184-192.
99. Wang, S., Q. Wang, B. E. Crute, I. N. Melnikova, S. R. Keller, and N. A. Speck. 1993. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol. Cell. Biol. 13:3324-3339.
100. Wasylyk, B., S. Hahn, and A. Giovane. 1993. The ets family of transcription factors. Eur. J. Biochem. 211:7-18.
101. Weiher, H., M. König, and P. Gruss. 1983. Multiple point mutations affecting the simian virus 40 enhancer. Science 219:626-631.
102. Wijmenga, C., N. A. Speck, N. C. Dracopoli, M. H. Hofker, P. Liu, and F. S. Collins. 1995. Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog CBFA, to chromosome Ip35-pter. Genomics 26:611-614.
103. Wotton, D., J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1994. Cooperative binding of Ets-1 and core binding factor to DNA. Mol. Cell. Biol. 14:840-850.
104. Yamamoto, K., A. Tojo, N. Aoki, and M. Shibuya. 1993. Characterization of the promoter region of the human c-kit proto-oncogene. Jpn. J. Cancer Res. 84:1136-1144.
105. Yoshimura, F. K., B. Davison, and K. Chaffin. 1985. Murine leukemia virus long terminal repeat sequences can enhance activity in a cell-type-specific manner. Mol. Cell. Biol. 5:2832-2835.
106. Zaiman, A., A. Nieves, and J. Lenz. 1995. Unpublished results.
107. Zaiman, A. L., A. F. Lewis, B. E. Crute, N. A. Speck, and J. Lenz. 1995. Transcriptional activity of core binding factor α (AML1) and β subunits on murine leukemia virus enhancer cores. J. Virol. 69:2898-2906.
108. Zhang, D., K. Fujioka, C. J. Hetherington, L. H. Shapiro, H. Chen, A. K. Look, and D. G. Tenen. 1994. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and hinds PEBP2/CBF (AML1). Mol. Cell. Biol. 14:8085-8095.