Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 9, 1999, Pages 1227-1232

  Adang, Anton E P ^a   Peters, Co A M ^a   Gerritsma, Siene ^a   De Zwart, Edwin ^a   Veeneman, Gerrit ^a  

^a Research and Development   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARGATROBAN; BLOOD CLOTTING FACTOR 10A; PIPERIDINE DERIVATIVE; PROTEINASE INHIBITOR; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; BLOOD CLOTTING; CHEMICAL ANALYSIS; CHEMICAL REACTION; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEINASE INHIBITION; SOLID STATE; STEREOSPECIFICITY;

BLOOD COAGULATION FACTORS; CARBOXYLIC ACIDS; FACTOR XA; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; PIPERIDINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THIAZOLES; THROMBIN;

EID: 0033519182     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00179-1     Document Type: Article

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