Inconsistent effects of the proline12 → alanine variant of the peroxisome proliferator-activated receptor-γ2 gene on body mass index in children and adolescent girls

Fertility and Sterility

Volumn 76, Issue 4, 2001, Pages 741-747

  Witchel, Selma F ^a,c   White, Carlie ^a   Siegel, Michael E ^a   Aston, Christopher E ^b  

^a Division of Endocrinology   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c Pittsburgh Conference   (United States)

Author keywords

Body mass index; Hyperandrogenism; Obesity; Polycystic ovary syndrome; PPAR; Premature pubarche

Indexed keywords

ALANINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE; CELL RECEPTOR; TRANSCRIPTION FACTOR;

ALLELE; ARTICLE; BODY MASS; CHILD; FEMALE; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HORMONE DETERMINATION; HUMAN; HYPERANDROGENISM; MAJOR CLINICAL STUDY; MALE; OBESITY; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; AMINO ACID SEQUENCE; GENETICS; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD;

AMINO ACID SEQUENCE; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYPERANDROGENISM; MALE; OBESITY; PUBERTY, PRECOCIOUS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 0034741154     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(01)01982-3     Document Type: Article

References (47)

1. Differential activation of adipogenesis by multiple PPAR isoforms
2. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
3. The organization, promoter analysis, and expression of the human PPAR gamma gene
4. An anti-diabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptorγ (PPAR-γ)
5. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
6. Effects of troglitazone: A new hypoglycemic agent in patients with NIDDM poorly controlled by diet therapy
7. PPAR-α and PPAR-γ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
8. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPAR-γ) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR-γ2 missense mutation
9. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
10. Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma 2 on thiazolidinedione-induced adipogenesis
11. Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women
12. The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans
13. Impact of the peroxisome proliferator activated receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
14. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
15. The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes
16. The peroxisome proliferator-activated receptor γ2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose
17. Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): Divergent modulating effects on body mass index in obese and lean Caucasian men
18. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
19. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR-γ
20. Hyperinsulinemia and decreased insulin-like growth factor-binding protein-1 are common features in prepubertal and pubertal girls with a history of premature pubarche
21. Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism
22. Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: Relevance to the developmental phase of polycystic ovary syndrome
23. No association between body mass index and β3-adrenergic receptor variant (W64R) in children with premature pubarche and adolescent girls with hyperandrogenism
24. Standardized percentile curves of body mass index for children and adolescents
25. Reference data for obesity: 85th and 95th percentiles of body mass index (wt/ht2) and triceps skinfold thickness
26. Body mass index reference curves for the UK, 1990
27. Impact of age on weight goals
28. Tracking of body mass index in children in relation to overweight in adulthood
29. Predicting obesity in young adulthood from childhood and parental obesity
30. Congenital leptin deficiency is associated with severe early-onset obesity in humans
31. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
32. A frameshift mutation in MC4R associated with dominantly inherited human obesity
33. A frameshift mutation in human MC4R is associated with a dominant form of obesity
34. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
35. Summary of human linkage and association studies
36. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
37. Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects
38. Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-γ in human adipocytes
39. Evidence for gene-nutrient interaction at the PPARγ locus
40. Peroxisome proliferator-activated receptor γ, the ultimate liaison between fat and transcription
41. Dominant negative mutation in human PPAR-γ associated with severe insulin resistance, diabetes mellitus, and hypertension
42. Peroxisome proliferator-activated receptor-γ2 P12A and type 2 diabetes in Canadian Oji-Cree
43. PPAR-γ is required for placental, cardiac, and adipose tissue development
44. PPAR-γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
45. Improved insulin-sensitivity in mice heterozygous for PPAR - Deficiency
46. Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935
47. Health consequences of obesity in youth: Childhood predictors of adult disease