Serum-free induced neuronal apoptosis-like cell death is independent of caspase activity

Molecular Brain Research

Volumn 78, Issue 1-2, 2000, Pages 186-191

  Hamabe, Wakako ^a   Fukushima, Nobuyuki ^a   Yoshida, Akira ^a   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Caspase independent; Nuclear fragmentation; Primary culture

Indexed keywords

AURINTRICARBOXYLIC ACID; CAMPTOTHECIN; CASPASE; CASPASE INHIBITOR; DNA FRAGMENT; PROTEINASE; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CORTEX; CELL NUCLEUS; CHROMATIN CONDENSATION; CONTROLLED STUDY; NERVE CELL NECROSIS; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA, SERUM-FREE; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; NEURONS; OLIGOPEPTIDES; RATS;

EID: 0034738054     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00074-7     Document Type: Article

References (37)

1. G. Barbin, I. Selak, M. Manthorpe, S. Varon, Use of central neuronal cultures for the detection of neuronotrophic agents, Neuroscience 12 (1984) 33-43.
2. A. Batistatou, L.A. Greene, Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity, J. Cell Biol. 115 (1991) 461-471.
3. G.M. Cohen, Caspases: the executioners of apoptosis, Biochem. J. 326 (1997) 1-16.
4. V. Cryns, J. Yuan, Proteases to die for, Genes Dev. 12 (1998) 1551-1570.
5. R. Dal Toso, O. Giorgi, C. Soranzo, G. Kirschner, G. Ferrari, M. Favaron, D. Benvegnu, D. Presti, S. Vicini, G. Toffano et al., Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF), J. Neurosci. 8 (1988) 733-745.
6. M. Deshmukh, J. Vasilakos, T.L. Deckwerth, P.A. Lampe, B.D. Shivers, E.M. Johnson Jr., Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases, J. Cell. Biol. 135 (1996) 1341-1354.
7. M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, S. Nagata, A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD, Nature 391 (1998) 43-50.
8. F.J. Gottron, H.S. Ying, D.W. Choi, Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death, Mol. Cell Neurosci. 9 (1997) 159-169.
9. H.K. Lorenzo, A.S. Susin, J. Penninger, G. Kroemer, Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death, Cell Death Differ. 6 (1999) 516-524.
10. J. Hartikka, F. Hefti, Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes, J. Neurosci. 8 (1988) 2967-2985.
11. L.M. Kaufman, S.R. Barry, J.N. Barrett, Characterization of tissue-derived macromolecules affecting transmitter synthesis in rat spinal cord neurons, J. Neurosci. 5 (1985) 5160-5166.
12. S.A. Kaufman, S.W. Lowe, J.M. Penninger, T.W. Mak, R. Hakem, A. Hakem, G.S. Duncan, J.T. Henderson, M. Woo, M.S. Soengas, A. Elia, J.L. de la Pompa, D. Kagi, W Khoo, J. Potter, R. Yoshida, Differential requirement for caspase-9 in apoptotic pathways in vivo, Cell 94 (1998) 339-352.
13. R.W. Keane, A. Srinivasan, L.M. Foster, M.P. Testa, T. Ord, D. Nonner, H.G. Wang, J.C. Reed, D.E. Bredesen, C. Kayalar, Activation of CPP32 during apoptosis of neurons and astrocytes, J. Neurosci. Res. 48 (1997) 168-180.
14. J.F. Kerr, B. Harmon, J. Searle, An electron-microscope study of cell deletion in the anuran tadpole tail during spontaneous metamorphosis with special reference to apoptosis of striated muscle fibers, J. Cell Sci. 14 (1974) 571-585.
15. A.J. Krohn, E. Preis, J.H. Prehn, Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector, J. Neurosci. 208 (1998) 186-197.
16. K. Kuida, T.F. Haydar, C.Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M.S. Su, P. Rakic, R.A. Flavell, Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9, Cell 94 (1998) 325-337.
17. K. Kuida, T.S. Zheng, S. Na, C. Kuan, D. Yang, H. Karsuyama, P. Rakic, R.A. Flavell, Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice, Nature 384 (1996) 368-372.
18. S. Kure, T. Tominaga, T. Yoshimoto, K. Tada, K. Narisawa, Glutamate triggers internucleosomal DNA cleavage in neuronal cells, Biochem. Biophys. Res. Commun. 179 (1991) 39-45.
19. M.A. Lagarkova, O.V. larovaia, S.V. Razin, Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers, J. Biol. Chem. 270 (1995) 20 239-20 241.
20. S. Leonidas, C.M. Troy, H. Qi, M.L. Shelanski, L.A. Greene, Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity, J. Neurosci. 22 (1998) 9204-9215.
21. P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, X. Wang, Cytochrome c and dATP-dependent formation of Apaf-1-caspase-9 complex initiates an apoptotic protease cascade, Cell 91 (1997) 479-489.
22. X. Liu, C.N. Kim, J. Yang, R. Jemmerson, X. Wang, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell 86 (1996) 147-157.
23. R.E. Mains, P.H. Patterson, Primary cultures of dissociated sympathetic neurons. I. Establishment of long-term growth in culture and studies of differentiated properties, J. Cell Biol. 59 (1973) 329-345.
24. C.E. Milligan, D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim, L.M. Schwartz, Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro, Neuron 15 (1995) 385-393.
25. R. Nath, K.J. Raser, K. McGinnis, R. Nadimpalli, D. Stafford, K.K. Wang, Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis, Neuroreport 8 (1996) 249-255.
26. D.W. Nicholson, N.A. Thornberry, Caspases: killer proteases, Trends Biochem. Sci. 22 (1997) 299-306.
27. F. Oberhammer, J.W. Wilson, C. Dive, I.D. Morris, J.A. Hickman, A.E. Wakeling, P.R. Walker, M. Sikorska, Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation, EMBO J. 12 (1993) 3679-3684.
28. S. Rabizadeh, D.J. LaCount, P.D. Friesen, D.E. Bredesen, Expression of the baculovirus p35 gene inhibits mammalian neural cell death, J. Neurochem. 61 (1993) 2318-2321.
29. M.C. Raff, B.A. Barres, J.F. Burne, H.S. Coles, Y Ishizaki, M.D. Jacobson, Programmed cell death and the control of cell survival: lessons from the nervous system, Science 262 (1993) 695-700.
30. A. Rana Anjum, M. Ali, Z. Begum, J. Vanaja, A. Khar, Selective involvement of caspase-3 in ceramide induced apoptosis in AK-5 tumor cells, FEBS Lett. 439 (1998) 81-84.
31. K. Samejima, S. Tone, T.J. Kottke, M. Enari, H. Sakahira, C.A. Cooke, F. Durrieu, L.M. Martins, S. Nagata, S.H. Kaufmann, W.C. Earnshaw, Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution, J. Cell Biol. 143 (1998) 225-239.
32. A.S. Susin, H.K. Lorenzo, N. Zamzami, I. Marzo, B.E. Snow, G.M. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D.R. Goodlett, R. Aebersold, D.P. Siderovski, J.M. Penninger, G. Kroemer, Molecular characterization of mitochondrial apoptosis-inducing factor, Nature 397 (1999) 441-446.
33. Y. Sasaki, N. Fukushima, A. Yoshida, H. Ueda, Low-density induced apoptosis of cortical neurons is inhibited by serum factors, Cell Mol. Neurobiol. 18 (1998) 487-496.
34. A.M. Trbovich, P.M. Hughes Jr., G.I. Perez, K. Kugu, K.I. Tilly, J.A. Cidlowski, J.L. Tilly, High and low-molecular-weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays, Cell Death Differ. 5 (1998) 38-49.
35. H. Ueda, N. Fukushima, A. Yoshida, K. Mizuno, W. Hamabe, Neuronal cell death inhibitor and its signal transduction. In: T. Kato (Ed.), Frontiers of the Mechanisms of Memory and Dementia, Elsevier, Amsterdam, 2000, pp. 83-86.
36. J. Yuan, Transducing signals of life and death, Curr. Opin. Cell Biol. 9 (1997) 247-251.
37. K. Vekrellis, M.J. McCarthy, A. Watson, J. Whitfield, L.L. Rubin, J. Ham, Bax promotes neuronal cell death and is downregulated during the development of the nervous system, Development 124 (1997) 1239-1249.