Modulation of tight junction structure and function by cytokines

Advanced Drug Delivery Reviews

Volumn 41, Issue 3, 2000, Pages 303-313

  Walsh, Shaun V ^a   Hopkins, Ann M ^a   Nusrat, Asma ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

Actin; Cytokine; Tight junction; ZO 1

Indexed keywords

CELLS; MECHANICAL PERMEABILITY; PROTEINS;

CYTOKINES; TIGHT JUNCTIONS;

CONTROLLED DRUG DELIVERY;

ACTIN; ALPHA CATENIN; BETA CATENIN; CYTOKINE; F ACTIN; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; OCCLUDIN; PHOSPHOLIPASE C; PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SOMATOMEDIN B; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; VASCULOTROPIN;

HUMAN; MODULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TIGHT JUNCTION;

EID: 0034733782     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00048-X     Document Type: Article

References (82)

1. Mitic L.L., Anderson J.M. Molecular architecture of tight junctions. Annu. Rev. Physiol. 60:1998;121-142.
2. Madara J.L. Regulation of the movement of solutes across tight junctions. Annu. Rev. Physiol. 60:1998;143-159.
3. Madara J.L., Pappenheimer J.R. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100:1987;149-164.
4. Hecht G., Pothoulakis C., LaMont J.T., Madara J.L. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J. Clin. Invest. 82:1988;1516-1524.
5. Hecht G., Koutsouris A., Pothoulakis C., LaMont J.T., Madara J.L. Clostridium difficile toxin B disrupts the barrier function of T84 monolayers. Gastroenterology. 102:1992;416-423.
6. Madara J.L., Stafford J., Dharmsathaphorn K., Carlson S. Structural analysis of a human intestinal epithelial cell line. Gastroenterology. 92:1987;1133-1145.
7. Furuse M., Hirase T., Itoh M., Nagafuchi A., Yonemura S., Tsukita S., Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions [see comments]. J. Cell Biol. 123:1993;1777-1788.
8. Furuse M., Fujita K., Hiiragi T., Fujimoto K., Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141:1998;1539-1550.
9. Billiau A., Heremans H., Vermeire K., Matthys P. Immunomodulatory properties of interferon-gamma. An update. Ann. New York Acad. Sci. 856:1998;22-32.
10. Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15:1997;749-795.
11. Besancon F., Przewlocki G., Baro I., Hongre A.S., Escande D., Edelman A. Interferon-gamma downregulates CFTR gene expression in epithelial cells. Am. J. Physiol. 267:1994;C1398-C1404.
12. Madara J.L., Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Invest. 83:1989;724-727.
13. Breese E., Braegger C.P., Corrigan C.J., Walker-Smith J.A., MacDonald T.T. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology. 78:1993;127-131.
14. Bjarnason I.C.O.M., Levi A.J., Peters T.J. Absorption of 51chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology. 85:1983;318-322.
15. Unno N., Fink M.P. Intestinal epithelial hyperpermeability. Mechanisms and relevance to disease. Gastroenterol. Clin. 27:1998;289-307.
16. Adams R.B., Planchon S.M., Roche J.K. IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding. J. Immunol. 150:1993;2356-2363.
17. Fish S.M., Proujansky R., Reenstra W.W. Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function. Gut. 45:1999;191-198.
18. Planchon S.M., Martins C.A., Guerrant R.L., Roche J.K. Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine. J. Immunol. 153:1994;5730-5739.
19. Youakim A., Ahdieh M. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am. J. Physiol. 276:1999;G1279-G1288.
20. Tsukamoto T., Nigam S.K. Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am. J. Physiol. 276:1999;F737-F750.
21. Colgan S.P., Parkos C.A., Matthews J.B.L.D.A., Awtrey C.S., Lichtman A.H., Delp-Archer C., Madara J.L. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am. J. Physiol. 267:1994;C402-C410.
22. Madara J.L., Moore R., Carlson S. Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am. J. Physiol. 253:1987;C854-C861.
23. Madara J.L., Dharmsathaphorn K. Occluding junction structure-function relationships in a cultured epithelial monolayer. J. Cell Biol. 101:1985;2124-2133.
24. Coers W., Vos J.T., Van der Meide P.H., Van der Horst M.L., Huitema S., Weening J.J. Interferon-gamma (IFN-gamma) and IL-4 expressed during mercury-induced membranous nephropathy are toxic for cultured podocytes [see comments]. Clin. Exp. Immunol. 102:1995;297-307.
25. Blum M.S., Toninelli E., Anderson J.M., Balda M.S., Zhou J.L.O.D., Pardi R., Bender J.R. Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. Am. J. Physiol. 273:1997;H286-H294.
26. Fenyves A.M., Behrens J., Spanel-Borowski K. Cultured microvascular endothelial cells (MVEC) differ in cytoskeleton, expression of cadherins and fibronectin matrix. A study under the influence of interferon-gamma. J. Cell Sci. 106:1993;879-890.
27. Martin-Padura I., Lostaglio S., Schneemann M., Williams L., Romano M., Fruscella P., Panzeri C., Stoppacciaro A., Ruco L., Villa A., Simmons D., Dejana E. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J. Cell Biol. 142:1998;117-127.
28. Ozaki H., Ishii K., Horiuchi H., Arai H., Kawamoto T., Okawa K., Iwamatsu A., Kita T. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 163:1999;553-557.
29. 2+ stores. Cell. Signal. 11:1999;101-110.
30. Birchmeier C., Gherardi E. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell. Biol. 8:1998;404-410.
31. Jiang W.G., Hiscox S. Hepatocyte growth factor/scatter factor, a cytokine playing multiple and converse roles. Histol. Histopathol. 12:1997;537-555.
32. Gherardi E., Sharpe M., Lane K., Sirulnik A., Stoker M. Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells. Symp. Soc. Exp. Biol. 47:1993;163-181.
33. Nusrat A., Parkos C.A., Bacarra A.E., Godowski P.J., Delp-Archer C., Rosen E.M., Madara J.L. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J. Clin. Invest. 93:1994;2056-2065.
34. Gumbiner B., Stevenson B., Grimaldi A. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J. Cell Biol. 107:1988;1575-1587.
35. Pasdar M., Li Z., Marreli M., Nguyen B.T., Park M., Wong K. Inhibition of junction assembly in cultured epithelial cells by hepatocyte growth factor/scatter factor is concomitant with increased stability and altered phosphorylation of the soluble junctional molecules. Cell Growth Differ. 8:1997;451-462.
36. Tsukamoto T., Nigam S.K. Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome. J. Biol. Chem. 274:1999;24579-24584.
37. Hiscox S., Jiang W.G. Hepatocyte growth factor/scatter factor disrupts epithelial tumour cell-cell adhesion: involvement of beta-catenin. Anticancer Res. 19:1999;509-517.
38. Grisendi S., Arpin M., Crepaldi T. Effect of hepatocyte growth factor on assembly of zonula occludens-1 protein at the plasma membrane. J. Cell. Physiol. 176:1998;465-471.
39. Potempa S., Ridley A.J. Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol. Biol. Cell. 9:1998;2185-2200.
40. Rink L., Kirchner H. Recent progress in the tumor necrosis factor-alpha field. Int. Arch. Allergy Immunol. 111:1996;199-209.
41. Heller R.A., Kronke M. Tumor necrosis factor receptor-mediated signaling pathways. J. Cell Biol. 126:1994;5-9.
42. Schmitz H., Fromm M., Bentzel C.J., Scholz P., Detjen K., Mankertz J., Bode H., Epple H.J., Riecken E.O., Schulzke J.D. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J. Cell Sci. 112:1999;137-146.
43. Marano C.W., Lewis S.A., Garulacan L.A., Soler A.P., Mullin J.M. Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line. J. Membr. Biol. 161:1998;263-274.
44. Mullin J.M., Snock K.V. Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res. 50:1990;2172-2176.
45. Marano C.W., Laughlin K.V., Russo L.M., Peralta Soler A., Mullin J.M. Long-term effects of tumor necrosis factor on LLC-PK1 transepithelial resistance. J. Cell Physiol. 157:1993;519-527.
46. Heyman M., Darmon N., Dupont C., Dugas B., Hirribaren A., Blaton M.A., Desjeux J.F. Mononuclear cells from infants allergic to cow's milk secrete tumor necrosis factor alpha, altering intestinal function. Gastroenterology. 106:1994;1514-1523.
47. Rodriguez P., Heyman M., Candalh C., Blaton M.A., Bouchaud C. Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers. Cytokine. 7:1995;441-448.
48. Colgan S.P., Resnick M.B., Parkos C.A., Delp-Archer C., McGuirk D., Bacarra A.E., Weller P.F., Madara J.L. IL-4 directly modulates function of a model human intestinal epithelium. J. Immunol. 153:1994;2122-2129.
49. Taylor C.T., Dzus A.L., Colgan S.P. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterology. 114:1998;657-668.
50. Peralta Soler A., Mullin J.M., Knudsen K.A., Marano C.W. Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells. Am. J. Physiol. 270:1996;F869-F879.
51. Tabibzadeh S., Kong Q.F., Kapur S., Satyaswaroop P.G., Aktories K. Tumour necrosis factor-alpha-mediated dyscohesion of epithelial cells is associated with disordered expression of cadherin/beta-catenin and disassembly of actin filaments. Hum. Reprod. 10:1995;994-1004.
52. Wojciak-Stothard B., Entwistle A., Garg R., Ridley A.J. Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J. Cell. Physiol. 176:1998;150-165.
53. Wong R.K., Baldwin A.L., Heimark R.L. Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma-induced permeability in mesenteric venules. Am. J. Physiol. 276:1999;H736-H748.
54. Mullin J.M., Laughlin K.V., Marano C.W., Russo L.M., Soler A.P. Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability. Am. J. Physiol. 263:1992;F915-F924.
55. Soler A.P., Marano C.W., Bryans M., Miller R.D., Garulacan L.A., Mauldin S.K., Stamato T.D., Mullin J.M. Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis. Eur. J. Cell Biol. 78:1999;56-66.
56. Kalogeris T.J., Laroux F.S., Cockrell A., Ichikawa H., Okayama N., Phifer T.J., Alexander J.S., Grisham M.B. Effect of selective proteasome inhibitors on TNF-induced activation of primary and transformed endothelial cells. Am. J. Physiol. 276:1999;C856-C864.
57. Hernandez-Sotomayor S.M., Carpenter G. Epidermal growth factor receptor: elements of intracellular communication. J. Membr. Biol. 128:1992;81-89.
58. Tarnawski A.S., Jones M.K. The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction pathways. J. Clin. Gastroenterol. 27:1998;S12-S20.
59. Soler A.P., Laughlin K.V., Mullin J.M. Effects of epidermal growth factor versus phorbol ester on kidney epithelial (LLC-PK1) tight junction permeability and cell division. Exp. Cell Res. 207:1993;398-406.
60. Van Itallie C.M., Balda M.S., Anderson J.M. Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. J. Cell Sci. 108:1995;1735-1742.
61. Rijken P.J., Post S.M., Hage W.J., van Bergen en Henegouwen P.M., Verkleij A.J., Boonstra J. Actin polymerization localizes to the activated epidermal growth factor receptor in the plasma membrane, independent of the cytosolic free calcium transient. Exp. Cell Res. 218:1995;223-232.
62. Clark D.A., Coker R. Transforming growth factor-beta (TGF-beta). Int. J. Biochem. Cell Biol. 30:1998;293-298.
63. Herrera R.E. The growth-inhibitory effects of TGF beta. Prog. Mol. Subcellul. Biol. 20:1998;11-24.
64. Dignass A.U., Podolsky D.K. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology. 105:1993;1323-1332.
65. McKay D.M., Singh P.K. Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: inhibition of increased permeability, but not diminished secretory responses by TGF-beta2. J. Immunol. 159:1997;2382-2390.
66. Beltinger J., McKaig B.C., Makh S., Stack W.A., Hawkey C.J., Mahida Y.R. Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response. Am. J. Physiol. 277:1999;C271-C279.
67. Planchon S., Fiocchi C., Takafuji V., Roche J.K. Transforming growth factor-beta1 preserves epithelial barrier function: identification of receptors, biochemical intermediates, and cytokine antagonists. J. Cell. Physiol. 181:1999;55-66.
68. Danielpour D. Transdifferentiation of NRP-152 rat prostatic basal epithelial cells toward a luminal phenotype: regulation by glucocorticoid, insulin-like growth factor-I and transforming growth factor-beta. J. Cell Sci. 112:1999;169-179.
69. Woo P.L., Cha H.H., Singer K.L., Firestone G.L. Antagonistic regulation of tight junction dynamics by glucocorticoids and transforming growth factor-beta in mouse mammary epithelial cells. J. Biol. Chem. 271:1996;404-412.
70. Coomber B.L. Cytoskeleton in TFG-beta- and bFGF-modulated endothelial monolayer repair. Exp. Cell Res. 194:1991;42-47.
71. Merwin J.R., Anderson J.M., Kocher O., Van Itallie C.M., Madri J.A. Transforming growth factor beta 1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis. J. Cell. Physiol. 142:1990;117-128.
72. Hurst V.I., Goldberg P.L., Minnear F.L., Heimark R.L., Vincent P.A. Rearrangement of adherens junctions by transforming growth factor-beta1: role of contraction. Am. J. Physiol. 276:1999;L582-L595.
73. Marcus B.C., Wyble C.W., Hynes K.L., Gewertz B.L. Cytokine-induced increases in endothelial permeability occur after adhesion molecule expression. Surgery. 120:1996;411-416. discussion 416-417.
74. Bolton S.J., Anthony D.C., Perry V.H. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience. 86:1998;1245-1257.
75. Nilsson M., Husmark J., Bjorkman U., Ericson L.E. Cytokines and thyroid epithelial integrity: interleukin-1alpha induces dissociation of the junctional complex and paracellular leakage in filter-cultured human thyrocytes. J. Clin. Endocrinol. Metab. 83:1998;945-952.
76. Berin M.C., Yang P.C., Ciok L., Waserman S., Perdue M.H. Role for IL-4 in macromolecular transport across human intestinal epithelium. Am. J. Physiol. 276:1999;C1046-C1052.
77. Zund G., Madara J.L., Dzus A.L., Awtrey C.S., Colgan S.P. Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion. J. Biol. Chem. 271:1996;7460-7464.
78. Buse P., Woo P.L., Alexander D.B., Reza A., Firestone G.L. Glucocorticoid-induced functional polarity of growth factor responsiveness regulates tight junction dynamics in transformed mammary epithelial tumor cells. J. Biol. Chem. 270:1995;28223-28227.
79. McRoberts J.A., Riley N.E. Role of insulin and insulin-like growth factor receptors in regulation of T84 cell monolayer permeability. Am. J. Physiol. 267:1994;G883-G891.
80. Kevil C.G., Payne D.K., Mire E., Alexander J.S. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. J. Biol. Chem. 273:1998;15099-15103.
81. Antonetti D.A., Barber A.J., Hollinger L.A., Wolpert E.B., Gardner T.W. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J. Biol. Chem. 274:1999;23463-23467.
82. Madsen K.L., Lewis S.A., Tavernini M.M., Hibbard J., Fedorak R.N. Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology. 113:1997;151-159.