Molecular and structural advances in tissue factor-dependent coagulation

Trends in Cardiovascular Medicine

Volumn 7, Issue 8, 1997, Pages 316-324

  Kirchhofer, Daniel ^a,b   Banner, David W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 9A; THROMBIN; THROMBOPLASTIN; TRYPSIN;

ANTICOAGULANT THERAPY; BLOOD CLOTTING; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HEMOSTASIS; HUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; THROMBOSIS; THROMBOSIS PREVENTION;

EID: 0030666922     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(97)00094-7     Document Type: Article

References (78)

1. Annex BH, Denning SM, Channon KM, et al.: 1995. Differential expression of tissue factor protein in directional atherectomy specimens from patients with stable and unstable coronary syndromes. Circulation 91:619-622.
2. Arbini AA, Bodkin D, Lopaciuk S, Bauer KA: 1994. Molecular analysis of Polish patients with factor VII deficiency. Blood 84:2214-2220.
3. Ashton AW, Kemball-Cook G, Johnson DJD, et al.: 1995. Factor VIIa and the extracellular domains of human tissue factor form a compact complex: a study by X-ray and neutron solution scattering. FEBS Lett 374:141-146.
4. Bacon DJ, Anderson WF: 1988. A fast algorithm for rendering space-filling molecule pictures. J Mol Graph 6:219-220.
5. Banner DW, Hadváry P: 1991. Crystallographic analysis at 3.0-Å resolution of the binding to human thrombin of four active site-directed inhibitors. J Biol Chem 266:20,085-20,093.
6. Banner DW, D'Arcy A, Chène C, et al.: 1996. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380:41-46.
7. Bazan JF: 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87: 6934-6938.
8. 334Ser→Pro). Hum Mol Genet 3:1175-1177.
9. Bernardi F, Liney DL, Patracchini P, et al.: 1994b. Molecular defects in CRM+ factor VII deficiencies: modelling of missense mutations in the catalytic domain of FVII. Br J Haematol 86:610-618.
10. Bharadwaj D, Iino M, Knotoyianni M, Smith KJ, Foster DC, Kisiel W: 1996. Factor VII central: a novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. J Biol Chem 271:30,685-30,691.
11. Brandstetter H, Bauer M, Huber R, Lollar P, Bode W: 1995. X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. Proc Natl Acad Sci USA 92:9796-9800.
12. Brandstetter H, Kühne A, Bode W, et al.: 1996. X-ray structure of active site-inhibited clotting factor Xa-Implications for drug design and substrate recognition. J Biol Chem 271: 29,988-29,992.
13. Bromberg ME, Konigsberg WH, Madison JF, Pawashe A, Garen A: 1995. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 92:8205-8209.
14. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem 271:29,034-29,042.
15. Camerer E, Kolstø A-B, Prydz H: 1996b. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res 81:1-41.
16. Chaing S, Clarke B, Sridhara S, et al.: 1994. Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor. Blood 83:3524-3535.
17. Chang J-Y, Stafford DW, Straight DL: 1995. The roles of factor VIIs structural domains in tissue factor binding. Biochemistry 34:12,227-12,232.
18. Clarke BJ, Ofosu FA, Sridhara S, Bona RD, Rickles FR, Blajchman MA: 1992. The first epidermal growth factor domain of human coagulation factor VII is essential for binding with tissue factor. FEBS Lett 298:206-210.
19. De Vos AM, Ultsch M, Kossiakoff AA: 1992. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255:306-312.
20. Dickinson CD, Kelly CR, Ruf W: 1996. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. Proc Natl Acad Sci USA 93:14,379-14,384.
21. Gibbs CS, McCurdy SN, Leung LLK, Paborsky LR: 1994. Identification of the factor VIIa binding site on tissue factor by homologous loop swap and alanine scanning mutagenesis. Biochemistry 33:14,003-14,010.
22. Harlos K, Martin DMA, O'Brien DP, et al.: 1994. Crystal structure of the extracellular region of human tissue factor. Nature 370:662-666.
23. Higashi S, Nishimura H, Aita K, Iwanaga S: 1994. Identification of regions of bovine factor VII essential for binding to tissue factor. J Biol Chem 269:18,891-18,898.
24. Higashi S, Matsumoto N, Iwanaga S: 1996. Molecular mechanism of tissue factor-mediated acceleration of factor VIIa activity. J Biol Chem 271:26,569-26,574.
25. 166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J Biol Chem 271:21,752-21,757.
26. Huber R, Bode W: 1978. Structural basis of the activation and action of trypsin. Ace Chem Res 11:114-122
27. Husten EJ, Esmon CT, Johnson AE: 1987. The active site of blood coagulation factor Xa: its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem 262:12,953-12,961.
28. Jang Y, Guzman LA, Lincoff M, et al.: 1995. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral artery injury model. Circulation 92:3041-3050.
29. Kazama Y, Patuszyn A, Wildgoose P, Hamamoto T, Kisiel W: 1993. Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit tissue factor-enhanced amidolytic activity of factor VIIa. J Biol Chem 268:16,231-16,240.
30. Kelley RF, Costas KE, O'Connell MP, Lazarus RA: 1995. Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding. Biochemistry 34: 10,383-10,392.
31. Kelley RF, O'Connell MP, Modi N, Refino CJ, Pater C, Bunting SJ: 1997. A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent. Blood 89(9):3219-3227.
32. 44 regulates catalytic function of the bound proteinase factor VIIa. Biochem J 315:145-151.
33. Kirchhofer D, Guha A, Nemerson Y, et al.: 1995. Activation of blood coagulation factor VIIa with cleaved tissue factor extracellular domain and crystallization of the active complex. Proteins 22:419-425.
34. Kraulis PJ: 1991. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 24:946-950.
35. Lu R, Esmon NL, Esmon CT, Johnson AE: 1989. The active site of the thrombin-thombomodulin complex: a fluorescence energy transfer measurement of its distance above the membrane surface. J Biol Chem 264: 12,956-12,962.
36. Marchetti G, Patracchini P, Gemmati D, et al.: 1992. Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7). Hum Genet 89:497-502.
37. Marmur JD, Rossikhina M, Guha A, et al: 1993. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest 91:2253-2259.
38. Marmur JD, Thiruvikraman SV, Fyfe BS, et al.: 1996. Identification of active tissue factor in human coronary atheroma. Circulation 94: 1226-1232.
39. Martin DMA, O'Brien DP, Tuddenham EGD, Byfield PGH: 1993. Synthesis and characterization of wild-type and variant γ-carboxyglutamic acid-containing domains of factor VII. Biochemistry 32:13,949-13,955.
40. Matsushita T, Kojima T, Emi N, Takahashi I, Saito H: 1994. Impaired human tissue factor-mediated activity in blood clotting factor VII-Nagoya (Arg304→Trp): evidence that a region in the catalytic domain of factor VII is important for the association with tissue factor. J Biol Chem 269:7355-7363.
41. McCallum CD, Hapak RC, Neuenschwander PF, Morrissey JH, Johnson AE: 1996. The location of the active site of blood coagulation factor VIIa above the membrane surface and its reorientation upon association with tissue factor: a fluorescence energy transfer study. J Biol Chem 271:28,168-28,175.
42. Merritt EA, Murphy MEP: 1994. Raster#D version 2.0: a program for photorealistic molecular graphics. Acta Crystollagr D 50:869-873
43. Muller YA, Ultsch MH, Kelley RF, de Vos AM: 1994. Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. Biochemistry 33:10,864-10,870.
44. Mutucumarana VP, Duffy EJ, Lollar P, Johnson AE: 1992. The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor Villa: a fluorescence study. J Biol Chem 267:17,012-17,021.
45. Nemerson Y: 1988. Tissue factor and hemostasis. Blood 71:1-8.
46. Neuenschwander PF, Morrissey JH: 1995. Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: Importance of amino acid residue K192. Biochemistry 34:8701-8707.
47. O'Brien DP, Gale KM, Anderson JS, et al.: 1991. Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male. Blood 78:132-140.
48. O'Brien DP, Kemball-Cook G, Hutchinson AM, et al.: 1994. Surface plasmon resonance studies of the interaction between factor VII and tissue factor: demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q). Biochemistry 33:14,162-14,169.
49. Paborsky LR, Law VS, Mao CT, Leung LLK, Gibbs CS: 1995. A peptide derived from a tissue factor loop region functions as a tissue factor-factor VIIa antagonist. Biochemistry 34:15,328-15,333.
50. Padmanabhan K, Padmanabhan KP, Tulinsky A, et al.: 1993. Structure of human Des(1-45) factor Xa at 2.2 resolution. J Mol Biol 232: 947-966.
51. Petersen LC, Schiødt J, Christensen U. 1994. Involvement of the hydrophobic stack residues 39-44 of factor VIIa in tissue factor interactions. FEBS Lett 347:73-79.
52. Rapaport SI, Rao LVM: 1995. The tissue factor pathway: how it has become a "prima ballerina." Thromb Haemost 74:7-17.
53. Rehemtulla A, Ruf W, Edgington TS: 1991. The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. J Biol Chem 266:10,294-10,299.
54. Rezaie AR, Neuenschwander PF, Morrissey JH, Esmon CT: 1993. Analysis of the functions of the first epidermal growth factor-like domain of factor X. J Biol Chem 268:8176-8180.
55. 2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor. J Biol Chem 270:4650-4660.
56. Roy S, Hass PE, Bourell JH, Henzel WJ, Vehar GA: 1991. Lysine residues 165 and 166 are essential for the cofactor function of tissue factor. J Biol Chem 266:22,063-22,066.
57. 290 is required for efficient activation of the macromolecular substrate factor X. Biochemistry 33:11,631-11,636.
58. Ruf W, Kalnik MW, Lund-Hansen T, Edgington TS: 1991. Characterization of factor VII association with tissue factor in solution: high and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J Biol Chem 266:15,719-15,725.
59. Ruf W, Miles DJ, Rehemtulla A, Edgington TS: 1992a. Tissue factor residues 157-167 are required for efficient proteolytic activation of factor X and Factor VII. J Biol Chem 267: 22,206-22,210.
60. Ruf W, Miles DJ, Rehemtulla A, Edgington TS: 1992b. Cofactor residues Lys 165 and 166 are critical for protein substrate recognition by the tissue factor: factor VIIa protease complex. J Biol Chem 267:6375-6381.
61. Ruf W, Schullek JR, Stone MJ, Edgington TS: 1994. Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. Biochemistry 33: 1565-1572.
62. Ruf W, Kelly CR, Schullek JR, et al.: 1995. Energetic contributions and topographical organization of ligand binding residues of tissue factor. Biochemistry 34:6310-6315.
63. 2+-binding site in the serine protease domain of human factor VIIa and its role in tissue factor binding and development of catalytic activity. J Biol Chem 270:15,523-15,530.
64. Sakai T, Lund-Hansen T, Thim L, Kisiel, W: 1990. The γ-carboxyglutamic acid domain of human factor VIIa is essential for its interaction with cell surface tissue factor. J Biol Chem 265:1890-1894.
65. Speidel CM, Eisenberg PR, Ruf W, Edgington TS, Abendschein DR: 1995. Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits. Circulation 92:3323-3330.
66. Takamiya O, Kemball-Cook G, Martin DMA, et al: 1993. Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII. Hum Mol Genet 2:1355-1359.
67. Shinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79. Haemostasis 25:89-97.
68. Toomey JR, Smith KJ, Stafford DW: 1991. Localization of the human tissue factor recognition determinant of human factor VIIa. J Biol Chem 266:19,198-19,202.
69. Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A: 1994. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci 3:2254-2271.
70. Walter J, Steigemann W, Singh TP, Bartunik H, Bode W, Huber R. 1982. On the disordered activation domain in trypsinogen: chemical labelling and low-temperature crystallography. Acta Crystallogr B 38:1462-1472.
71. Walter MR, Windsor WT, Nagabhushan TL, et al.: 1995. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor. Nature 376:230-235.
72. Wang D, Bode W, Huber R. 1985. Bovine chymotrypsinogen A: x-ray crystal structure analysis and refinement of a new crystal form at 1.8Å resolution. J Mol Biol 185:595-624.
73. Waxman E, Laws WR, Laue TM, Nemerson Y, Ross JBA: 1993. Human factor VIIa and its complex with soluble tissue factor: evaluation of asymmetry and conformational dynamics by ultracentrifugation and fluorescence anisotropy decay methods. Biochemistry 32:3005-3012.
74. Wilcox JN, Smith KM, Schwartz SM, Gordon D: 1989. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 86:2839-2843.
75. Wildgoose P, Foster D, Schiodt J, Wiberg FC, Birktoft JJ, Petersen LC: 1993. Identification of a calcium binding site in the protease domain of human blood coagulation factor VII: evidence for its role in factor VII-tissue factor interaction. Biochemistry 32:114-119.
76. Zhang Y, Deng Y, Luther T, et al.: 1994. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 94:1320-1327.
77. Zheng D-Q, Shurafa M, James HL: 1996. Factor VII G331D: a variant molecule involving replacement of a residue in the substrate-binding region of the catalytic domain. Blood Coagul Fibrinolysis 7:93-96.
78. Zhong D, Smith KJ, Birktoft JJ, Bajaj SP: 1994. First epidermal growth factor-like domain of human blood coagulation factor DC is required for its activation by factor VIIa/tissue factor but not by factor XIa. Proc Natl Acad Sci USA 91:3574-3578.