Differences in the regulation of CD4 and CD8 T-cell clones during immune responses

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 355, Issue 1395, 2000, Pages 401-406

  Beverley, Peter C L ^a   Maini, Mala K ^b  

^a NIHR Biomedical Researcg Centre   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

CD4; CD8; Clone; Life span; T cell; Telomere

Indexed keywords

CD4 T CELL CLONE; CD8 T CELL CLONE; CELL CLONE; CELL PROLIFERATION; EPSTEIN BARR VIRUS; GENETIC REGULATION; IN VIVO STUDY; INFECTIOUS MONONUCLEOSIS; T LYMPHOCYTE; TELOMERASE;

HUMAN HERPESVIRUS 4;

EID: 0034728607     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2000.0580     Document Type: Article

References (59)

1. Akbar, A. N., Borthwick, N. J., Salmon, M., Gombert, W., Bofil, M., Shamsadeen, N., Pilling, D., Pett, S., Grundy, J. E. & Janossy, G. 1993 The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J. Exp. Med. 178, 427-438.
2. Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J. & Davis, M. M. 1996 Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94-96.
3. Bell, E. B. & Sparshott, S. M. 1990 Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 348, 163-166.
4. Beverley, P. C. L. 1996 Generation of T cell memory. Curr. Opin. Immunol. 8, 327-330.
5. Boursalian, T. E. & Bottomly, K. 1999 Stability of naive and memory phenotypes on resting CD4 T cells in vivo. J. Immunol. 162, 9-16.
6. Bruno, L., Kirberg, J. & Von Boehmer, H. 1995 On the cellular basis of immunological T cell memory. Immunity 2, 37-43.
7. Buckton, K. E., Court Brown, W. M. & Smith, P. G. 1967 Lymphocyte survival in men treated with X-rays for anky-losing spondylitis. Nature 214, 470-473.
8. Callahan, J. E., Kappler, J. W. & Marrack, P. 1993 Unexpected expansions of CD8-bearing cells in old mice. J. Immunol. 151, 6657-6669.
9. Callan, M. F., Steven, N., Krausa, P., Wilson. J. D., Moss, P. A., Gillespie, G. M., Bell, J. I., Rickinson, A. B. & McMichael, A. J. 1996 Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nature Med. 2, 906-911.
10. Callan, M. F., Tan, L., Annels, N., Ogg, G. S., Wilson, J. D. K., O'Callaghan, C. A., Steven, N., McMichael, A. J. & Rickinson, A. B. 1998 Direct visualisation of antigen-specific CD8+ T cells during the primary immune response to Epstein Barr virus in vivo. J. Exp. Med. 187, 1395-1402.
11. Chambers, C. A., Sullivan, T. J. & Allison, J. P. 1997 Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity 7, 885-895.
12. Cochet, M., Pannetier, C., Regnault, A., Darche, S., Leclerc, C. & Kourilsky, P. 1992 Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur. J. Immunol. 22, 2639-2647.
13. Doherty, P. C., Topham, D. J. & Tripp, R. A. 1996 Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory. Immunol. Rev. 150, 23-44.
14. Ehl, S., Hoffmann-Rohrer, U., Nagata, S., Hengartner, H. & Zinkernagel, R. 1996 Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo. J. Immunol. 156, 2357-2360.
15. Gullberg, M. & Smith. K. A. 1980 Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. J. Exp. Med. 163, 270-284.
16. Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R. & Van Lier, R. A. W. 1997 Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 186, 1407-1418.
17. Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K. & Allshire, R. C. 1990 Telomere reduction in human colorectal carcinoma and with aging. Nature 346, 866-868.
18. Hellerstein, M., Hanley, M. B., Cesar, D., Papageorgopoulos, C., Weider, E., Schmidt, D., Hoh, R., Neese, R., Macallan, D., Decks, S. & McCune, J. M. 1999 Direct measurement of T lymphocyte kinetics in humans using a stable isotope-mass spectrometric technique: effects of HIV-1 infection and anti-retroviral therapy. Nature Med. 5, 83-89.
19. Ku, C. C., Kotwin, B., Kappler, J. & Marrack, P. 1997 CD8+ T-cell clones in old mice. Immunol. Rev. 160, 139-144.
20. Lundblad, V. & Wright, W. E. 1996 Telomeres and telomerase: a simple picture becomes complex. Cell 87, 369-375.
21. Macallan, D. C., Fullerton, C. A., Neese, R., Haddock, K., Park, S. & Hellerstein, M. K. 1998 Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: studies in vitro, in animals and in humans. Proc. Natl Acad. Sci. 95, 708-713.
22. McHeyzer-Williams, M. G. & Davis, M. M. 1995 Antigen-specific development of primary and memory T cells in vivo. Science 268, 106-111.
23. Mackall, C. L., Bare, C. V., Titus, J. A., Sharrow, S. O., Granger, L. A. & Gress, R. E. 1996 Thymic-independent T cell regeneration occurs via antigen driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J. Immunol. 156, 4609-4616.
24. Mackay, C. R., Marston, W. L. & Dudler, L. 1990 Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 171, 801-817.
25. McLean, A. & Michie, C. A. 1995 In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl Acad. Sci. 92, 3797-3711.
26. Maini, M. K., Wedderburn, L. R., Hall, F. C., Wack, A., Casorati, G. & Beverley, P. C. L. 1998 A comparison of two techniques for the molecular tracking of specific T-cell responses: CD4+ T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8- population. Immunology 94, 529-535.
27. Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N. & Beverley, P. C. L. 1999 Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence. J. Immunol. 162, 4541-4516.
28. Maini, M. K., Gudgeon, G., Wedderburn, L. R., Rickinson, A. B. & Beverley, P. C. L. 2000 Global longitudinal molecular analysis of clonality in CD4 and CD8 T cells in EBV infection. (In preparation.)
29. Masnko, K., Kato, T., Ikeda, Y., Okubo, M., Mizushima, Y., Nishioka, K. & Yamamoto, K. 1994 Dynamic changes of accumulated T cell clonotypes during antigenic stimulation in vivo and in vitro. Int. Immunol. 6, 1959-1966.
30. Merkenschlager, M. & Beverley, P. C. L. 1990 Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1). Int. Immunol 1, 50-59.
31. Merkenschlager, M., Terry, L., Eduards, R. & Beverley, P. C. L. 1988 Limiting dilution analysis of proliferativw responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation. Eur. J. Immunol. 18, 1653-1661.
32. Michie, C. A., McLean, A., Alcock, C. & Beverley, P. C. L. 1992 Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264-265.
33. Minutello, M. A., Pileri, P., Unutmaz, D., Censini, S., Kuo, G., Houghton, M., Brunetto, M. R., Bonino, F. & Abrignani, S. 1993 Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of Hepatitis C virus in patients with chronic Hepatitis C. J. Exp. Med. 178, 17-25.
34. Murali-Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. & Ahmed, R. 1998 Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177-187.
35. Pawelee, G., Rehbein, A., Haehnel, K., Merl, A. & Adibzadeh, M. 1997 Human T cell clones in long term culture as a model of immunosenescence. Immunol Rev. 160, 31-42.
36. Posnett, D. N., Sinha, R., Kabak, S. & Russo, C. 1994 Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammopathy?'. J. Exp. Med. 179, 609-618.
37. Ramalho, A. T., Curado, M. P. & Natarajan, A. T. 1995 Lifespan of human lymphocytes estimated during a six year cytogenetic follow-up of individuals accidentally exposed in the 1987 radiological accident in Brazil. Mutat. Rev. 331, 17-54.
38. Rocha, B., Dautigny, N. & Pereira, P. 1989 Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immunol. 19, 905-914.
39. Rocha, B., Penit, C., Baron, C., Nasscur, F.. Dautigny, N. & Freitas, A. A. 1990 Accumulation of bromodeoxyuridine-labelled cells in central and peripheral organs: minimal estimates of production and turnover rales of mature lymphocytes. Eur. J. Immunol. 20, 1697-1708.
40. Rothstein, D. M., Yamada, A., Schlossman, S. F. & Morimoto, C. 1991 Cyclic regulation of CD45 isoform expression in a long term human CD4-CD45RA+ T cell line. J. Immunol. 146, 4175-4183.
41. Schwab, R., Szabo, P., Manavalan, J. S., Weksler, M. E., Posnett, D. N., Pannetier, C., Kourilsky, P. & Even. J. 1997 Expanded CD4+ and CD8+T cell clones in elderly humans. J. Immunol. 158, 4493-4499.
42. Selin, L. K., Nahill, S. R. & Welsh, R. M. 1994 Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179, 1933-1943.
43. Silins, S. L., Cross, S. M., Elliott, S. L., Pye, S. J., Burrows, S. R., Burrows. J. M., Moss, D. J., Argaet, V. P. & Misko, I. S. 1996 Development of Epstein Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis. J. Exp. Med. 184, 1813-1821.
44. Singer, G. G. & Abbas, A. K. 1991 The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371.
45. Sparshott, S. M. & Bell, E. B. 1994 Membrane CD45R isoform exchange on CD4 T cells is rapid, frequent and dynamic in vivo. Eur. J. Immunol. 24, 2573-2578.
46. Sprent, J., Schaefer, M., Hurd, M., Suth, C. D. & Yacov, R. 1991 Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype. J. Exp. Med. 174, 717-728.
47. Sprent, J., Tough, D. & Sun, S. Q. 1997 Factors controlling the turnover of memory cells. Immunol. Rev. 156, 79-85.
48. Sytwu, H. K., Liblau, R. S. & McDevitt, H. O. 1996 The roles of fas/APO-I and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 5, 17-30.
49. Tough, D. F., Borrow, P. & Sprent, J. 1996 Induction of bystander T cell proliferation by viruses and type 1 interferon in vivo. Science 272, 1947-1950.
50. Tough, D. F. & Sprent, J. 1994 Turnover of naive-and memory-phenotype T cells. J Exp. Med 179, 1127-1135.
51. Naziri, H., Schachter, F., Uchida, I., Wei, L., Zhu, X., Effros, R., Cohen, D. & Harley, C. B. 1993 Loss of telomeric DNA during aging of normal and trisomy-21 human lymphocytes. Am. J. Hum. Genet. 52, 661-667.
52. Wack, A., Montagna, D., Delabonna, P. & Casorati, G. 1996 An improved PCR-heteroduplex method permits high-sensitvity detection of clonal expansions in complex T cell populations. J. Immunol. Meth. 196, 181-192.
53. Wack, A., Cossarizza, A., Heltai, S., Barbietri, D., D'Addato, S., Fransceschi, C., Dellabona, P. & Casorati, G. 1998 Age-related modifications of the human ab T cell repertoire due to different clonal expansions in the CD4 and CD8+ subsets. Int. Immunol. 10, 1281-1288.
54. Wedderburn, L. R., O'Hehir, R. E., Hewitt, C. R. A., Lamb, J. R. & Owen, M. J. 1993 In-vivo clonal dominance and limited T-cell receptor usage in human CD4(+) T-cell recognition of house dust mite allergens. Proc. Natl Acad. Sci. 90, 8214-8218.
55. Weng, N., Levine, B. L., June, C. H. & Hodes, R. J. 1996 Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183, 2471-2479.
56. Weng, N. P., Granger, L. & Hodes, R. J. 1997 Telomere lengthening and telomerase activation during human B cell differentiation. Proc. Natl Acad. Sci. 94, 10827-10832.
57. Young, A. J. & Hay, J. B. 1995 Rapid turnover of the recirculating pool in vivo. Int. Immunol. 7, 1607-1615.
58. Zimmermann, C., Brduscha-Riem, K., Blaser, C., Zinkernagel, R. M. & Pircher, H. 1996a Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts. J. Exp. Med. 183, 1367-1375.
59. Zimmermann, C., Rawiel, M., Blaser, C., Kaufmann, M. & Pircher, H. 1996b Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of fas (CD95). Eur. J. Immunol. 26, 2903-2910.