-
1
-
-
0028988325
-
On the cellular basis of immunological T cell memory
-
of outstanding interest. This is an elegant use of TCR transgenic cells to examine the fate and properties of adoptively transferred naive and memory cells. The data establish clearly that the behaviour of the subsets differs in the absence of antigen and following antigenic stimulation.
-
Bruno L, Kirberg J, Von Boehmer H. On the cellular basis of immunological T cell memory. of outstanding interest Immunity. 2:1995;37-43 This is an elegant use of TCR transgenic cells to examine the fate and properties of adoptively transferred naive and memory cells. The data establish clearly that the behaviour of the subsets differs in the absence of antigen and following antigenic stimulation.
-
(1995)
Immunity
, vol.2
, pp. 37-43
-
-
Bruno, L.1
Kirberg, J.2
Von Boehmer, H.3
-
2
-
-
0027960893
-
Locus-specific somatic hypermutation in germinal centre T cells
-
Zheng B, Xue W, Kelsoe G. Locus-specific somatic hypermutation in germinal centre T cells. Nature. 372:1994;556-559.
-
(1994)
Nature
, vol.372
, pp. 556-559
-
-
Zheng, B.1
Xue, W.2
Kelsoe, G.3
-
3
-
-
0030024279
-
Immunology taught by viruses
-
of special interest. This paper reviews how viruses interact with the immune system. A clear distinction is drawn between the the way in which the immune system needs to respond to cytopathic and non-cytopathic viruses.
-
Zinkernagel RM. Immunology taught by viruses. of special interest Science. 271:1996;173-178 This paper reviews how viruses interact with the immune system. A clear distinction is drawn between the the way in which the immune system needs to respond to cytopathic and non-cytopathic viruses.
-
(1996)
Science
, vol.271
, pp. 173-178
-
-
Zinkernagel, R.M.1
-
4
-
-
0028452851
-
Cytotoxic T-cell memory without antigen
-
+ CTLs and polymerase chain reaction analysis is used in cell transfers to an adoptive host, to establish that antigen is not required for maintenance of CTL memory.
-
+ CTLs and polymerase chain reaction analysis is used in cell transfers to an adoptive host, to establish that antigen is not required for maintenance of CTL memory.
-
(1994)
Nature
, vol.369
, pp. 648-652
-
-
Lau, L.L.1
Jamieson, B.D.2
Somasundaram, T.3
Ahmed, R.4
-
5
-
-
0028305255
-
+ T-cell memory determined by clonal burst size
-
2-microglobulin-negative hosts to eliminate the possibility of presentation of antigen by MHC class I. The conclusion is drawn that antigen is not required for persistence of memory.
-
2-microglobulin-negative hosts to eliminate the possibility of presentation of antigen by MHC class I. The conclusion is drawn that antigen is not required for persistence of memory.
-
(1994)
Nature
, vol.369
, pp. 652-654
-
-
Hou, S.1
Hyland, L.2
Ryan, K.W.3
Portner, A.4
Doherty, P.C.5
-
6
-
-
0025331311
-
Analysis of recent thymic emigrants with subset and maturity-related makers
-
Kelly DA, Scollay R. Analysis of recent thymic emigrants with subset and maturity-related makers. Int Immunol. 2:1990;419-425.
-
(1990)
Int Immunol.
, vol.2
, pp. 419-425
-
-
Kelly, D.A.1
Scollay, R.2
-
7
-
-
0028267677
-
Turnover of naive- and memory-phenotype T cells
-
of outstanding interest. Combined labelling of dividing cells with BrdU and surface markers is used to establish the population dynamics of naive and memory cells and show that both populations contain dividing and non-dividing cells.
-
Tough DF, Sprent J. Turnover of naive- and memory-phenotype T cells. of outstanding interest J Exp Med. 179:1994;1127-1135 Combined labelling of dividing cells with BrdU and surface markers is used to establish the population dynamics of naive and memory cells and show that both populations contain dividing and non-dividing cells.
-
(1994)
J Exp Med.
, vol.179
, pp. 1127-1135
-
-
Tough, D.F.1
Sprent, J.2
-
8
-
-
0028023462
-
Lymphocyte life-span and memory
-
of special interest. This short paper reviews data on population dynamics of T cells and the nature of T- and B-cell memory.
-
Sprent J, Tough DF. Lymphocyte life-span and memory. of special interest Science. 265:1994;1395-1400 This short paper reviews data on population dynamics of T cells and the nature of T- and B-cell memory.
-
(1994)
Science
, vol.265
, pp. 1395-1400
-
-
Sprent, J.1
Tough, D.F.2
-
9
-
-
0026576566
-
+ T cells in vivo. I. Differential regulation of gp90MEL-14 (LECAM-1), Pgp-1, LFA-1 and VLA-4α during the differentiation of CTL induced by allografts
-
+ T cells in vivo. I. Differential regulation of gp90MEL-14 (LECAM-1), Pgp-1, LFA-1 and VLA-4α during the differentiation of CTL induced by allografts. J Immunol. 148:1992;2348-2356.
-
(1992)
J Immunol.
, vol.148
, pp. 2348-2356
-
-
Mobley, J.L.1
Dailey, M.O.2
-
10
-
-
0029123526
-
+ T cells emerge at different stages of an immune response
-
of special interest. This study examines the phenotype of memory CTLs at various times after priming and establishes the kinetics of changes in several cell-surface markers, commonly used to distinguish naive and memory cells.
-
+ T cells emerge at different stages of an immune response. of special interest J Immunol. 155:1995;3443-3452 This study examines the phenotype of memory CTLs at various times after priming and establishes the kinetics of changes in several cell-surface markers, commonly used to distinguish naive and memory cells.
-
(1995)
J Immunol.
, vol.155
, pp. 3443-3452
-
-
Walker, P.1
Ohteki, T.2
Lopez, J.A.3
MacDonald, H.R.4
Maryanski, J.L.5
-
11
-
-
0028153999
-
+ peripheral blood lymphocytes
-
+ peripheral blood lymphocytes. J Exp Med. 179:1994;857-864.
-
(1994)
J Exp Med.
, vol.179
, pp. 857-864
-
-
Roth, M.D.1
-
12
-
-
0025951644
-
+ helper cells which differ in lymphokine secretion pattern and cell surface phenotype
-
+ helper cells which differ in lymphokine secretion pattern and cell surface phenotype. J Immunol. 147:1991;2991-3000.
-
(1991)
J Immunol.
, vol.147
, pp. 2991-3000
-
-
Swain, S.L.1
Huston, G.2
Tonkonogy, S.3
Weinberg, A.D.4
-
13
-
-
0025222698
-
IL-4 directs the development of Th2-like helper effectors
-
Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol. 145:1990;3796-3806.
-
(1990)
J Immunol.
, vol.145
, pp. 3796-3806
-
-
Swain, S.L.1
Weinberg, A.D.2
English, M.3
Huston, G.4
-
14
-
-
0025329959
-
+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro
-
+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro. J Immunol. 144:1990;1788-1799.
-
(1990)
J Immunol.
, vol.144
, pp. 1788-1799
-
-
Swain, S.L.1
Weinberg, A.D.2
English, M.3
-
15
-
-
0028927653
-
Antigen-specific development of primary and memory T cells in vivo
-
+ T cells, to study the kinetics of an antigen specific response in vivo.
-
+ T cells, to study the kinetics of an antigen specific response in vivo.
-
(1995)
Science
, vol.268
, pp. 106-111
-
-
McHeyzer-Williams, M.G.1
Davis, M.M.2
-
18
-
-
0028020588
-
+ effector populations: Reciprocal action of interleukin (IL-4) and IL-12 in promoting type 2 versus type 1 cytokine profiles
-
+ cells stimulated in the presence of polarizing cytokines.
-
+ cells stimulated in the presence of polarizing cytokines.
-
(1994)
J Exp Med.
, vol.180
, pp. 1715-1728
-
-
Croft, M.1
Carter, L.2
Swain, S.L.3
Dutton, R.W.4
-
19
-
-
0029162873
-
+ effector cells
-
+ effector cells favour different pathways of cytolysis.
-
+ effector cells favour different pathways of cytolysis.
-
(1995)
J Immunol.
, vol.155
, pp. 1028-1031
-
-
Carter, L.L.1
Dutton, R.W.2
-
20
-
-
0028919877
-
+ T lymphocyte differentiation in vivo
-
of outstanding interest. This study provides support for the idea that the cytokine profile of effector T cells can be affected by the strength of the signal delivered through the TCR during T-cell priming.
-
+ T lymphocyte differentiation in vivo. of outstanding interest J Exp Med. 181:1995;1569-1574 This study provides support for the idea that the cytokine profile of effector T cells can be affected by the strength of the signal delivered through the TCR during T-cell priming.
-
(1995)
J Exp Med.
, vol.181
, pp. 1569-1574
-
-
Pfeiffer, C.1
Stein, J.2
Southwood, S.3
Ketelaar, H.4
Sette, A.5
Bottomly, K.6
-
21
-
-
0028986256
-
+ T cells and bone marrow-derived mast cells results in the development of Th2 cells
-
of outstanding interest. Although there is evidence for basophil production of IL-4, this study establishes that activation of basophils and T cells in proximity leads to the production of Th2 effectors.
-
+ T cells and bone marrow-derived mast cells results in the development of Th2 cells. of outstanding interest Int Immunol. 7:1995;525-532 Although there is evidence for basophil production of IL-4, this study establishes that activation of basophils and T cells in proximity leads to the production of Th2 effectors.
-
(1995)
Int Immunol.
, vol.7
, pp. 525-532
-
-
Huels, C.1
Germann, T.2
Goedert, S.3
Hoehn, P.4
Koelsch, S.5
Hultner, L.6
Palmer, N.7
Rude, E.8
Schmitt, E.9
-
22
-
-
0025094642
-
Anti-CD3 antibody induces rapid expression of cytokine genes in vivo
-
Scott DE, Gause WC, Finkelman FD, Steinberg AD. Anti-CD3 antibody induces rapid expression of cytokine genes in vivo. J Immunol. 145:1990;2183-2188.
-
(1990)
J Immunol.
, vol.145
, pp. 2183-2188
-
-
Scott, D.E.1
Gause, W.C.2
Finkelman, F.D.3
Steinberg, A.D.4
-
23
-
-
0025266887
-
Anti-CD3 antibodies induce cells from unprimed animals to secrete IL-4 both in vitro and in vivo
-
Flamand V, Abramowicz D, Goldman M, Biernaux C, Huez G, Urbain J, Moser M, Leo O. Anti-CD3 antibodies induce cells from unprimed animals to secrete IL-4 both in vitro and in vivo. J Immunol. 144:1990;2875-2882.
-
(1990)
J Immunol.
, vol.144
, pp. 2875-2882
-
-
Flamand, V.1
Abramowicz, D.2
Goldman, M.3
Biernaux, C.4
Huez, G.5
Urbain, J.6
Moser, M.7
Leo, O.8
-
25
-
-
0028233726
-
+ T cells into IL-4-secreting cells
-
+ T cells into IL-4-secreting cells. J Immunol. 152:1994;5180-5188.
-
(1994)
J Immunol.
, vol.152
, pp. 5180-5188
-
-
Gollob, K.J.1
Coffman, R.L.2
-
26
-
-
0029582927
-
+ TCRβ intermediate liver lymphocytes are down-regulated by Listeria monocytogenes
-
of outstanding interest. It has long been known that certain infections promote Th1 or Th2 responses and these experiments suggest at least one mechanism for this.
-
+ TCRβ intermediate liver lymphocytes are down-regulated by Listeria monocytogenes. of outstanding interest Eur J Immunol. 25:1995;3321-3325 It has long been known that certain infections promote Th1 or Th2 responses and these experiments suggest at least one mechanism for this.
-
(1995)
Eur J Immunol.
, vol.25
, pp. 3321-3325
-
-
Emoto, M.1
Emoto, Y.2
Kaufmann, S.H.E.3
-
27
-
-
0029122495
-
+ cells: New clues to their origin, specificity and function
-
+ cells.
-
+ cells.
-
(1995)
J Exp Med.
, vol.182
, pp. 633-638
-
-
MacDonald, H.R.1
-
28
-
-
0028984172
-
+ T cells isolated from different mouse strains
-
of special interest. There are as yet few examples documented of opposing effects of cytokines on responding T cells, but such a mechanism may be expected to contribute to strain-specific disease susceptibility.
-
+ T cells isolated from different mouse strains. of special interest J Immunol. 155:1995;3788-3793 There are as yet few examples documented of opposing effects of cytokines on responding T cells, but such a mechanism may be expected to contribute to strain-specific disease susceptibility.
-
(1995)
J Immunol.
, vol.155
, pp. 3788-3793
-
-
Hoehn, P.1
Goedert, S.2
Germann, T.3
Koelsch, S.4
Jin, S.5
Palm, N.6
Ruede, E.7
Schmitt, E.8
-
29
-
-
0029149596
-
+ effector fate: Transforming growth factor β1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion
-
of special interest. A large amount of literature has shown the polarizing effects of cytokines or cytokine combinations, but this paper shows that combinations may also synergize in promoting growth and survival of activated effectors.
-
+ effector fate: transforming growth factor β1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. of special interest J Exp Med. 182:1995;699-709 A large amount of literature has shown the polarizing effects of cytokines or cytokine combinations, but this paper shows that combinations may also synergize in promoting growth and survival of activated effectors.
-
(1995)
J Exp Med.
, vol.182
, pp. 699-709
-
-
Zhang, X.1
Giangreco, L.2
Broome, H.E.3
Dargan, C.M.4
Swain, S.L.5
-
30
-
-
0028979063
-
The cytokines IL-4 IFN-γ, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro
-
of special interest. The extent of polarization among memory cells is not known. It is shown here that a polyclonal memory population may still respond in a Th1 or Th2 mode when exposed to appropriate cytokines.
-
Bradley LM, Yoshimoto K, Swain SL. The cytokines IL-4 IFN-γ, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. of special interest J Immunol. 155:1995;1713-1724 The extent of polarization among memory cells is not known. It is shown here that a polyclonal memory population may still respond in a Th1 or Th2 mode when exposed to appropriate cytokines.
-
(1995)
J Immunol.
, vol.155
, pp. 1713-1724
-
-
Bradley, L.M.1
Yoshimoto, K.2
Swain, S.L.3
-
31
-
-
0028518985
-
Generation and in vivo persistence of polarized Th1 and Th2 memory cells
-
of outstanding interest. When polarized effectors are 'parked' in vivo they remain polarized when restimulated in vitro, providing evidence that commitment to the Th1 or Th2 state is not readily reversed.
-
Swain SL. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. of outstanding interest Immunity. 1:1994;543-552 When polarized effectors are 'parked' in vivo they remain polarized when restimulated in vitro, providing evidence that commitment to the Th1 or Th2 state is not readily reversed.
-
(1994)
Immunity
, vol.1
, pp. 543-552
-
-
Swain, S.L.1
-
32
-
-
0028265155
-
Interleukin-12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 clones
-
Manetti R, Gerosa F, Giudizi MG, Biagliotti R, Parronchi P, Piccinni M-P, Sampognaro S, Maggi E, Romagnani S, Trinchieri G. Interleukin-12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 clones. J Exp Med. 179:1994;1273-1285.
-
(1994)
J Exp Med.
, vol.179
, pp. 1273-1285
-
-
Manetti, R.1
Gerosa, F.2
Giudizi, M.G.3
Biagliotti, R.4
Parronchi, P.5
Piccinni, M.-P.6
Sampognaro, S.7
Maggi, E.8
Romagnani, S.9
Trinchieri, G.10
-
33
-
-
0028299065
-
The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis
-
Salmon M, Pilling D, Borthwick N, Viner N, Bacon P, Janossy G, Akbar A. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol. 24:1994;892-899.
-
(1994)
Eur J Immunol.
, vol.24
, pp. 892-899
-
-
Salmon, M.1
Pilling, D.2
Borthwick, N.3
Viner, N.4
Bacon, P.5
Janossy, G.6
Akbar, A.7
-
34
-
-
0026629870
-
Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen
-
Oehen S, Waldner H, Kundig TM, Hengartner H, Zinkernagel RM. Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J Exp Med. 176:1992;1273-1281.
-
(1992)
J Exp Med.
, vol.176
, pp. 1273-1281
-
-
Oehen, S.1
Waldner, H.2
Kundig, T.M.3
Hengartner, H.4
Zinkernagel, R.M.5
-
35
-
-
0027972541
-
The long term maintenance of cytotoxic T cell memory does not require persistence of antigen
-
of outstanding interest. This paper uses adoptive transfer to show that memory persists in the absence of antigen. Cells transferred long after priming to adoptive hosts and restimulated gave secondary kinetics of response only if the priming and boosting virus were cross-reactive.
-
Mullbacher A. The long term maintenance of cytotoxic T cell memory does not require persistence of antigen. of outstanding interest J Exp Med. 179:1994;317-321 This paper uses adoptive transfer to show that memory persists in the absence of antigen. Cells transferred long after priming to adoptive hosts and restimulated gave secondary kinetics of response only if the priming and boosting virus were cross-reactive.
-
(1994)
J Exp Med.
, vol.179
, pp. 317-321
-
-
Mullbacher, A.1
-
36
-
-
0028200629
-
Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses
-
of special interest. The thesis that cross-reactiviy may maintain virus-specific memory receives some support from this study.
-
Selin LK, Nahill SR, Welsh RM. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. of special interest J Exp Med. 179:1994;1933-1943 The thesis that cross-reactiviy may maintain virus-specific memory receives some support from this study.
-
(1994)
J Exp Med.
, vol.179
, pp. 1933-1943
-
-
Selin, L.K.1
Nahill, S.R.2
Welsh, R.M.3
-
37
-
-
0028779228
-
Memories are made of this?
-
Matzinger P. Memories are made of this? Nature. 369:1994;605-606.
-
(1994)
Nature
, vol.369
, pp. 605-606
-
-
Matzinger, P.1
-
38
-
-
0028893078
-
Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation
-
Ju S-T, Panka DJ, Cui H, Ettinger R, El-Khatib M, Sherr DH, Stanger BZ, Marshak-Rothstein A. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature. 373:1995;444-448.
-
(1995)
Nature
, vol.373
, pp. 444-448
-
-
Ju, S.-T.1
Panka, D.J.2
Cui, H.3
Ettinger, R.4
El-Khatib, M.5
Sherr, D.H.6
Stanger, B.Z.7
Marshak-Rothstein, A.8
-
40
-
-
0030067103
-
L bit not pro-apoptotic (bax, bcl-xs) gene expression
-
of outstanding interest
-
L bit not pro-apoptotic (bax, bcl-xs) gene expression. of outstanding interest Eur J Immunol. 1996; Cell survival and cell death are intimately linked. This study begins to unravel the molecular mechanisms that are involved in the decision between death or survival.
-
(1996)
Eur J Immunol.
-
-
Akbar, A.N.1
Borthwick, N.J.2
Wickremasinghe, G.3
Panayiotidis, P.4
Pilling, D.5
Bofill, M.6
Krajewski, S.7
Reed, J.C.8
Salmon, M.9
-
41
-
-
0027512573
-
The selective ablation of interleukin 2-producing cells isolated from transgenic mice
-
Minasi L-AE, Kamogawa Y, Carding S, Bottomly K, Flavell RA. The selective ablation of interleukin 2-producing cells isolated from transgenic mice. J Exp Med. 177:1993;1451-1459.
-
(1993)
J Exp Med.
, vol.177
, pp. 1451-1459
-
-
Minasi, L.-A.E.1
Kamogawa, Y.2
Carding, S.3
Bottomly, K.4
Flavell, R.A.5
-
42
-
-
0028201732
-
Tolerance, danger and the extended family
-
Matzinger P. Tolerance, danger and the extended family. Annu Rev Immunol. 12:1994;991-1045.
-
(1994)
Annu Rev Immunol.
, vol.12
, pp. 991-1045
-
-
Matzinger, P.1
|