The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity

Journal of Virology

Volumn 72, Issue 4, 1998, Pages 2890-2895

  Rezende, Lisa F ^a   Curr, Kenneth ^a   Ueno, Takamasa ^b   Mitsuya, Hiroaki ^b   Prasad, Vinayaka R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; DIDANOSINE; RNA DIRECTED DNA POLYMERASE; ZALCITABINE;

ANTIVIRAL ACTIVITY; ARTICLE; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; VIRUS GENE;

EID: 0031897968     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.4.2890-2895.1998     Document Type: Article

References (37)

1. Abbotts, J., K. Bebenek, T. A. Kunkel, and S. H. Wilson. 1993. Mechanism of HIV-1 reverse transcriptase. J. Biol. Chem. 268:10312-10323.
2. Beard, W. A., and S. H. Wilson. 1993. Kinetic analysis of template-primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry 32:9745-9753.
3. Bebenek, K., J. Abbotts, J. D. Roberts, S. H. Wilson, and T. A. Kunkel. 1989. Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J. Biol. Chem. 264:16948-16956.
4. Bebenek, K., J. Abbotts, S. H. Wilson, and T. A. Kunkel. 1993. Error-prone polymerization by HIV-1 reverse transcriptase. J. Biol. Chem. 268:10324-10334.
5. Bebenek, K., W. A. Beard, J. R. Casas-Finet, H. R. Kim, T. A. Darden, S. H. Wilson, and T. A. Kunkel. 1995. Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. J. Biol. Chem. 270:19516-19523.
6. Bebenek, K., and T. A. Kunkel. 1995. Analyzing fidelity of DNA polymerases. Methods Enzymol. 262:217-232.
7. Bebenek, K., and T. A. Kunkel. 1993. The fidelity of retroviral reverse transcriptase, p. 85-102. In A. M. Skalka and S. P. Goff (ed.), Reverse transcriptase. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
8. Collier, A. C., R. W. Coombs, D. A. Schoenfeld, R. Bassett, A. Baruch, and L. Corey. 1996. Combination therapy with zidovudine, didanosine and saquinavir. Antiviral Res. 29:99.
9. Drosopoulos, W. C., and V. R. Prasad. 1996. Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase. J. Virol. 70:4834-4838.
10. Eckert, K. A., and T. A. Kunkel. 1993. Fidelity of DNA synthesis catalyzed by human DNA polymerase α and HIV-1 reverse transcriptase: effect of reaction pH. Nucleic Acids Res. 21:5212-5220.
11. Essink, B. B. O., N. K. T. Back, and B. Berkhout. 1997. Increased polymerase fidelity of the 3TC-resistam variants of HIV-1 reverse transcriptase. Nucleic Acids Res. 25:3212-3217.
12. Georgiadis, M. M, S. M. Jessen, C. M. Ogata, A. Telesnitsky, S. P. Goff, and W. A. Hendrickson. 1995. Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase. Structure 3:879-892.
13. Iversen, A. K. N., R. W. Shafer, K. Wehrly, M. A. Winters, J. I. Mullins, B. Chesebro, and T. C. Merigan. 1996. Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy. J. Virol. 70:1086-1090.
14. Jaju, M., W. A. Beard, and S. H. Wilson. 1995. Human immunodeficiency virus tvpe 1 reverse transcriptase. J. Biol. Chem. 270:9740-9747.
15. Johnson, V. A. 1996. Combination therapy for HIV-1 infection-overview: preclinical and clinical analysis of antiretroviral combinations. Antiviral Res. 29:35-39.
16. Larder, B. A. 1993. Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance, p. 205-222. In A. M. Skalka and S. P. Goff (ed.), Reverse transcriptase. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
17. Mansky, L. M. 1996. The mutation rate of human immunodeficiency virus type 1 is influenced by the vpr gene. Virology 222:391-400.
18. Mansky, L. M., and M. Temin. 1995. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 69:5087-5094.
19. Martin, J. L., J. E. Wilson, R. B. Haynes, and P. A. Furman. 1993. Mechanism of resistance of human immunodeficiency virus type 1 to 2′,3′-dideoxyinosine. Proc. Natl. Acad. Sci. USA 90:6135-6139.
20. Mendelman, L. V., M. S. Boosalis, J. Petruska, and M. F. Goodman. 1989. Nearest neighbor influences on DNA polymerase insertion fidelity. J. Biol. Chem. 264:14415-14423.
21. Pandey, V. N., N. Kaushik, N. Rege, S. G. Sarafianos, P. N. S. Yadav, and M. J. Modak. 1996. Role of methionine 184 in human immunodeficiency virus type 1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis. Biochemistry 35:2168-2179.
22. Perrin, L., and B. Hirschel. 1996. Combination therapy in primary HIV infection. Antiviral Res. 29:87-89.
23. Poch, O., I. Sauvaget, M. Delarue, and N. Tordo. 1989. Identification of four conserved motifs among the RNA-dependent encoding elements. EMBO J. 8:3867-3874.
24. Preston, B. D., B. J. Poiesz, and L. A. Loeb. 1988. Fidelity of HIV-1 reverse transcriptase. Science 242:1168-1171.
25. Rezende, L. F., et al. Unpublished observations.
26. Ricchetti, M., and H. Buc. 1990. Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent. EMBO J. 9:1583-1593.
27. Richman, D. D. 1992. HIV drug resistance. AIDS Res. Hum. Retroviruses 8: 1065-1071.
28. Roberts, J. D., K. Bebenek, and T. A. Kunkel. 1988. The accuracy of reverse transcriptase from HIV-1. Science 242:1171-1173.
29. Rubinek, T., M. Bakhanashvili, and A. Hizi. 1997. The fidelity of 3′ misinsertion and mispair extension during DNA synthesis exhibited by two drug-resistant mutants of the reverse transcriptase of human immunodeficiency virus type 1 with Leu74Val and Glu89Gly. Eur. J. Biochem. 247:238-247.
30. Sarafianos, S. G., V. N. Pandey, N. Kaushik, and M. J. Modak. 1995. Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase. Biochemistry 34:7207-7216.
31. Shafer, R. W., M. J. Kozal, M. A. Winters, A. K. N. Iversen, D. A. Katzenstein, M. V. Ragnei, W. A. Meyer III, P. Gupta, S. Rasheed, R. Coombs, M. Katzman, S. Fiscus, and T. C. Merrigan. 1994. Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations. J. Infect. Dis. 169:722-729.
32. Shirasaka, T., M. F. Kavlick, T. Ueno, W. Gao, E. Kojima, M. L. Alcaide, S. Chokekijchai, B. M. Roy, E. Arnold, R. Yarchoan, and H. Mitsuya. 1995. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc. Natl. Acad. Sci. USA 92:2398-2402.
33. Shirasaka, T., R. Yarchoan, M. C. O'Brien, R. N. Husson, B. D. Anderson, E. Kojima, T. Shimada, S. Border, and H. Mitsuya. 1993. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Proc. Natl. Acad. Sci. USA 90:562-566.
34. Temin, H. M. 1993. Retrovirus variation and reverse transcription: abnormal transfers result in retrovirus genetic variation. Proc. Natl. Acad. Sci. USA 90: 6900-6903.
35. Ueno, T., and H. Mitsuya. 1997. Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay. Biochemistry 36:1092-1099.
36. Ueno, T., T. Shirasaka, and H. Mitsuya. 1995. Enzymatic characterization of human immunodeficiency virus reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates. J. Biol. Chem. 270:23605-23611.
37. Wainberg, M. A., W. C. Drosopoulos, H. Salomon, M. Hsu, G. Borkow, M. A. Parniak, Z. Gu, Q. Song, J. Manne, S. Islam, G. Castriota, and V. R. Prasad. 1996. Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science 271:1282-1285.