Structure-activity relationship and rational design of 3,4-dephostatin derivatives as protein tyrosine phosphatase inhibitors

Tetrahedron

Volumn 56, Issue 5, 2000, Pages 741-752

  Watanabe, Takumi ^a   Suzuki, Takayuki ^b   Umezawa, Yoji ^a   Takeuchi, Tomio ^a   Otsuka, Masami ^c   Umezawa, Kazuo ^b  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Enzyme inhibitors; Molecular design; Molecular modeling mechanics; Structure activity

Indexed keywords

3,4 DEPHOSTATIN METHYL ESTER; DEPHOSTATIN DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0034723277     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(99)01058-3     Document Type: Article

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