Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii

Journal of Medicinal Chemistry

Volumn 39, Issue 9, 1996, Pages 1836-1845

  Gangjee, Aleem ^a   Zhu, Yuanming ^a   Queener, Sherry F ^b   Francom, Paula ^c   Broom, Arthur D ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 [(2 CHLORO N METHYLANILINO)METHYL]PYRIDO[3,2 D]PYRIMIDINE; 2,4 DIAMINO 6 [(2,4,6 TRICHLOROANILINO)METHYL]PYRIDO[3,2 D]PYRIMIDINE; 2,4 DIAMINO 6 [(3,4,5 TRIMETHOXYANILINO)METHYL]PYRIDO[3,2 D]PYRIMIDINE; DIHYDROFOLATE REDUCTASE INHIBITOR; PYRIMIDINE DERIVATIVE; TRIMETREXATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; LIVER; NONHUMAN; PNEUMOCYSTIS CARINII; RAT; TOXOPLASMA GONDII;

ANIMALS; FOLIC ACID; FOLIC ACID ANTAGONISTS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; PNEUMOCYSTIS; RATS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, ULTRAVIOLET; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA;

EID: 0029881975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950918e     Document Type: Article

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