Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT)

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 16, 1998, Pages 2149-2150

  Roller, Peter P ^a   Wu, Li ^b   Zhang, Zhong Yin ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; MALONIC ACID DERIVATIVE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SULFIDE; TYROSINE DERIVATIVE;

ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME INHIBITION; MOLECULAR MIMICRY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; INDICATORS AND REAGENTS; KINETICS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0032544162     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00376-X     Document Type: Article

References (11)

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11. 2-OH using Fmoc chemistry. Peptide 4 was characterized by analytical HPLC, FABMS and amino acid analysis.