A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing

Protein Engineering

Volumn 9, Issue 10, 1996, Pages 895-904

  Roguska, Michael A ^a,c   Pedersen, Jan T ^a,b,d   Henry, Andrew H ^a,b,f   Searle, Stephen M J ^a,b   Michelle Roja, C ^a   Avery, Brian ^a   Hoffee, Mary ^a   Cook, Sherri ^a   Lambert, John M ^a   Blättler, Walter A ^a   Rees, Anthony R ^a,b   Guild, Braydon C ^a,e  

^a IMMUNOGEN INC   (United States)

^b University of Bath   (United Kingdom)

^c BASF Bioresearch Corporation   (United States)

^d UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^e GENOME THERAPEUTICS CORPORATION   (United States)

^f Oxford Biomaterials Ltd   (United Kingdom)

Author keywords

Antibody; Immunotherapy; Reshaping; Resurfacing

Indexed keywords

MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGENICITY; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALIA; MURINAE; RODENTIA;

EID: 10344237543     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/9.10.895     Document Type: Article

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