Degeneracy in T-cell antigen recognition - Implications for the pathogenesis of autoimmune diseases

Journal of Neuroimmunology

Volumn 107, Issue 2, 2000, Pages 148-153

  Hemmer, Bernhard ^a   Jacobsen, Marc ^a   Sommer, Norbert ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antigen recognition; Autoimmunity; Combinatorial peptide libraries; T cell receptor; T cells

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; AUTOIMMUNITY; COMPLEX FORMATION; CONFERENCE PAPER; CROSS REACTION; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; MOLECULAR MIMICRY; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIGEN PRESENTATION; DEMYELINATING AUTOIMMUNE DISEASES, CNS; HUMANS; T-LYMPHOCYTES;

EID: 0034710359     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00226-5     Document Type: Conference Paper

References (23)

1. Brocker T. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 18:1997;1223-1232.
2. Demotz S., Grey H.M.S., Sette A. The minimal number of class II MHC-antigen complexes needed for T-cell activation. Science. 249:1990;1028-1030.
3. Evavold B.D., Sloan-Lancaster J., Wilson K.J., Rothbard J.B., Allen P.M. Specific T-cell recognition of minimally homologous peptides: evidence for endogenous ligands. Immunity. 2:1995;655-663.
4. Fujinami R.S., Oldstone M.B.A. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science. 230:1985;1043-1045.
5. Garcia K.C., Teyton L., Wilson I.A. Structural basis of T-cell recognition. Annu. Rev. Immunol. 17:1999;369-397.
6. Germain R.N., Stefanova I. The dynamics of T-cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol. 17:1999;467-522.
7. Gundlach B.R., Wiesmüller K.-H., Junt T., Kienle S., Jung G., Walden P. Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL. J. Immunol. 156:1996;3645-3651.
8. Hemmer B., Fleckenstein B.T., Vergelli M., Jung G., McFarland H., Martin R., Wiesmuller K.H. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T-cell clone. J. Exp. Med. 185:1997;1651-1659.
9. Hemmer B., Vergelli M., Gran B., Ling N., Conlon P., Pinilla C., Houghten R., McFarland H.F., Martin R. Cutting edge: predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. J. Immunol. 160:1998;3631-3636.
10. Hemmer B., Vergelli M., Pinilla C., Houghten R., Martin R. Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol. Today. 19:1998;163-168.
11. Hemmer B., Gran B., Zhao Y., Marques A., Pinilla C., Pascal J., Tzou A., Kondo T., Cortese I., Bielekova B., Straus S., McFarland H.F., Houghten R., Simon R., Martin R. Identification of candidate T-Cell epitopes and molecular mimics in chronic Lyme disease. Nature Med. 5:1999;1375-1382.
12. Hiemstra H.S., van Veelen P.A., Schloot N.C., Geluk A., van Meijgaarden K.E., Willemen S.J., Leunissen J.A., Benckhuijsen W.E., Amons R., de Vries R.R., Roep B.O., Ottenhoff T.H., Drijfhout J.W. Definition of natural T-cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries. J. Immunol. 161:1998;4078-4082.
13. Hunt D.F., Henderson R.A., Sharanowitz J., Sakaguchi K., Michel H., Sevilir N., Cox A.L., Appella E., Engelhard V.H. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science. 255:1992;1261-1263.
14. Kersh G.J., Allen P.M. Essential flexibility in the T-cell recognition of antigen. Nature. 380:1996;495-498.
15. Kirberg J., Berns A., von Boehmer H. Peripheral T-cell survival requires continual ligation of the T-cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186:1997;1269-1275.
16. Lehmann P.V., Forsthuber T., Miller A., Sercarz E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature. 358:1992;155-157.
17. Mason D. A very high level of cross-reactivity is an essential feature of the T-cell receptor. Immunol. Today. 19:1998;395-404.
18. Robey E., Fowlke B.J. Selective events in T-cell development. Annu. Rev. Immunol. 12:1994;675-705.
19. Sykulev Y., Joo M., Vturina I., Tsomides T.J., Eisen H.N. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T-cell response. Immunity. 4:1996;565-571.
20. Tanchot C., Lemonnier F.A., Perarnau B., Freitas A.A., Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T-cells. Science. 276:1997;2057-2062.
21. Udaka K., Wiesmüller K.-H., Kienle S., Jung G., Walden P. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries. J. Exp. Med. 181:1995;2097-2108.
22. Vergelli M., Hemmer B., Kalbus M., Vogt A.B., Ling N., Conlon P., Coligan J.E., McFarland H., Martin R. Modifications of peptide ligands enhancing T-cell responsiveness imply large numbers of stimulatory ligands for autoreactive T-cells. J. Immunol. 158:1997;3746-3752.
23. Wucherpfennig K.W., Strominger J.L. Molecular mimicry in T-cell-mediated autoimmunity: viral peptides activate human T-cell clones specific for myelin basic protein. Cell. 80:1995;695-705.