The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes

Journal of Clinical Investigation

Volumn 97, Issue 8, 1996, Pages 1942-1951

  Sitrin, R G ^a,c   Todd III, R F ^a   Petty, H R ^b   Brock, T G ^a   Shollenberger, S B ^a   Albrecht, E ^b   Gyetko, M R ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

adhesion; integrin; macrophage 1 antigen; monocyte; urokinase

Indexed keywords

CD11 ANTIGEN; CD18 ANTIGEN; COMPLEMENT COMPONENT C3 RECEPTOR; INTEGRIN; UROKINASE;

ARTICLE; COMPLEX FORMATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 0030000470     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118626     Document Type: Article

References (63)

1. Beekhuizen, H., and R vanFurth. 1993. Monocyte adherence to human vascular endothelium. J. Leukocyte Biol 54:363-378
2. Detmers, P., S. Wright. E. Olsen, B. Kimball, and Z. Cohn. 1987. Aggregation of complement receptors on human neutrophds in the absence of ligand J. Cell Biol 105:1137-1145.
3. Hermanowski-Vosatka. A, P Detmers. O Gotze, S. Silverstein, and S Wright. 1988. Clustering of ligand on the surface of a particle enhances adhesion to receptor-bearing cells. J Biol. Chem 263:17822-17827.
4. Wright, S., R. Ramos, A. Hermanowski-Vosatka. P. Rockwell, and P. Detmers. 1991. Activation of the adhesive capacity of CR3 on neutrophils by endotoxin dependence on lipopolysaccharide binding protein and CD 14. J. Exp. Med. 173:1281-1286.
5. Detmers, P., S. Lo. E Olsen-Egbcrt, A. Walz, M. Baggiolini. and Z. Cohn. 1990. Neutrophil activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J. Exp. Med. 171:1155-1162.
6. Diamond, M., and T. Springer. 1993. A subpopulation of Mac-1 (CD11b/ CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen J. Cell Biol. 120:545-556.
7. Buyon. J., S. Slade. J. Reibman, S Abramson, M. Philips. G. Weissmann, and R Winchester. 1990. Constitutive and induced phosphorylation of the α-and β-chaius of the CD11/CD18 leukocyte integrin framily: relationship to adhesion-dependent function. J Immunol. 144:191-197.
8. Chatila, T., R. Geha, and M. Arnaout. 1989. Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules J. Cell Biol 109:3435-3444.
9. Altieri, D. 1991. Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion. J. Immunol. 147:1891-1898.
10. Hermanowski-Vosatka, A., J VanStrijp, W. Swiggard, and S Wright. 1992. Integrin modulating factor-1: a lipid that alters the function of leukocyte integrins Cell. 68:341-352.
11. Zhou, M., R. Todd III, J. vandeWinkel, and H Petty. 1993. Cocapping of the leuko-adhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fcg receptor III on human neutrophils Possible role of lectin-like molecules. J. Immnnol. 150:3030-3041.
12. Sehgal, G., K. Zhang, R. Todd III, L. Boxer, and H. Petty. 1993. Lectin-like inhibition of immune complex receptor-mediated stimulation of neutrophils: Effects on cytosolic calcium release and superoxide production J Immunol. 150 4571-4580.
13. Bohuslav, J., V. Horejsi, C Hansmann, J. Stöckl, U. Weidle, O. Majdic, I. Barke, W. Knapp, and H. Stockinger. 1995. Urokinase plasminogen activator receptor, β2 integrins, and src-kinases within a single receptor complex of human monocytes. J. Exp. Med 181:1381-1390.
14. Petty, H., and R. Todd III. 1993. Receptor-receptor interactions of complement receptor type 3 in neutrophil membranes. J. Leuk. Biol. 54.492-494
15. Xue, W., A. Kindzelskii, R. Todd III, and H. Petty 1994 Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes. J. Immunol. 152:4630-4640.
16. Detmers, P., D. Zhou, and D. Powell. 1994. Different signaling pathways for CD18-mediated adhesion and Fc-mediated phagocytosis. J. Immunol. 153:2137-2145.
17. Krauss, J., H. Poo, W. Xue, L Mayo-Bond, R. Todd III, and H. Petty 1994. Reconstitution of antibody-dependent phagocytosis in fibroblasts expressing Fcγ Receptor IIIB and the complement receptor type 3. J Immunol. 153.1769-1777.
18. Cao, D., I. Mizukami, B. Garni-Wagner, A. Kindzelskii, R. Todd III. L. Boxer, and H. Petty. 1995. Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release: possible roles of complement receptor type III and calcium. J Immunol. 154:1817-1829.
19. Gyetko, M., R. Todd III, C. Wilkinson, and R. Sitrin. 1994. The urokinase receptor is required for monocyte chemotaxis in vitro. J. Clin. Invest 93: 1380-1387.
20. Kirchheimer, J C, and H.G. Remold 1989 Endogenous receptor bound urokinase mediates tissue invasion of human monocytes. J. Immunol 143:2634-2639
21. Min, II, R Semnani, I Mizukami, K. Watt, R. Todd III, and D. Liu. 1992. cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. J. Immunol. 148:3636-3642.
22. Mizukami, I., B. Garni-Wagner, L. deAngelo, M. Liebert, A. Flint, D Lawrence, R. Cohen, and R. Todd III. 1994 Immunologic detection of the cellular receptor for urokinase plasminogen activator. Clin. Immunol. Immunopathol. 71.96-104.
23. Dana, N., B. Styrt, J. Griffin, R. Todd III, M. Klempner, and M. Arnaout. 1986. Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies. J Immunol. 137:3259-3263.
24. Sanchez-Madrid, F., J. Nagy, E. Robbins, P. Simon, and T. Springer. 1983. A human leukocyte differentiation antigen family with distinct α subunits and a common β subunit: The lymphocyte function-associated antigen (LFA-1). the C3bi complement receptor (OKM-1/Mac-1), and the p150.95 molecule. J. Exp. Med. 158:1785-1803.
25. Vissers, M , S. Lester, and J. Fantone. 1988. Rapid purification of human peripheral blood monocytes by centrifugation through Ficoll-Hypaque and Sepracell-MN. J. Immunol Methods. 110:203-207.
26. Uster, P., and R. Pagano. 1986 Resonance energy transfer microscopy. observations of membrane-bound fluorescent probes in model membranes and living cells. J Cell Biol. 103:1221-1234.
27. Zhou, M., R. Todd III. and H. Petty. 1991. Detection of transmembrane linkages between immunoglobulin or complement receptors and the neutrophil's cortical microfilaments by resonance energy transfer microscopy. J. Mol. Biol. 218:263-268.
28. Zhou, M., H. Poo, R. Todd III, and H. Petty. 1992. Surface-bound immune complexes trigger transmembrane proximity between complement receptor type 3 and the neutrophil's cortical microfilaments. J. Immunol. 148:3550-3553.
29. Maher, R., D. Cao, L. Boxer, and H. Petty 1993. Simultaneous calcium-dependent delivery of neutrophil lactoferrin and reactive oxygen metabolites to erythrocyte targets: evidence supporting granule-dependent triggering of superoxide release. J. Cell Physiol. 156:226-234
30. Shappell, S., C. Toman, D. Andarson, A. Taylor, M. Entman, and C. Smith. 1990. Mac-1 (CD11b/CD18) mediates adherence dependent hydrogen peroxide production by human and canine neutrophils. J. Immunol. 144:2702-2711.
31. Suchard, S., M. Burton, V. Dixit, and L. Boxer. 1991. Human neutrophil adherence to thrombospondin occurs through a CD11/CD18-independent mechanism. J Immunol 146:3945-3952.
32. Riccio, A., G. Grimaldi, P. Verde, G. Sebastio, S. Boast, and F. Blasi, 1985. The human urokinase-plasminogen activator gene and its promoter. Nucleic Acids Res 13:2759-2771.
33. Roldan, A.L., V V. Cubellis, L.R. Lund, K. Danø, E. Appella, and F. Blasi. 1990. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent protcolysis. EMBO (Eur. Mol. Biol Organ.) J. 9:467-474.
34. Stein, C., and J. Cohen. 1989. Phosphorothioate oligonucleotide analogues In Antisense inhibitors of gene expression. CRC Press, Inc, Boca Raton, FL.
35. Wright, S., J. Weitz, A. Huang, S. Levin, S. Silverstein, and J. Loike, 1988. Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc. Natl Acad Sci USA. 85:7734-7738
36. Myones, B., J. Dalzell, N. Hogg, and G. Ross. 1988. Neutrophil and monocyte cell surface p150.95 has iC3b-receptor (CR4) activity resembling CR3. J. Clin. Invest. 82:640-651.
37. Watson, P., R. Pon, and R. Shiu 1992. Inhibition of cell adhesion to plastic substratum by phosphorothioate oligonucleotide. Exp Cell Res. 202: 391-397.
38. Remold-O'Donnell, E , and K. Lewandrowski. 1981. Macrophage surface component gp160: sensitivity to plasmin and other proteases. J Immunol. 128:1541-1544.
39. Albelda, S., C. Smith, and P. Ward. 1994 Adhesion molecules and inflammatory injury. FASEB J. 8:504-512.
40. Gyetko, M., R. Sitrin, J. Fuller, R. Todd, and T. Standiford. 1995. Function of the urokinase receptor (CD87) in PMN chemotaxis. J. Leukocyte Biol. 58:533-538.
41. Szöllösi, J., S. Damjanovich, S. Mulhern, and L Tron. 1987. Fluorescence energy transfer and membrane potential measurements monitor dynamic properties of cell membranes, a critical review. Prog. Biophys. Mol. Biol 49:65-87.
42. Graham, I., H. Gresham, and E. Brown. 1989. An immobile subset of plasma membrane CD11b/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors. J. Immunol. 142:2352-2358.
43. Pavalko, F., and S. LaRochc. 1993. Activation of human neutrophils induces an interaction between the integrin β2-subunit (CD18) and the actin binding protein a-actinm J. Immunol. 151:3795-3807.
44. Ciambrone, G , and P. McKeown-Longos. 1992. Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells. J. Biol Chem. 267:13617.
45. Takahashi, K., K. Ikeo, T. Gojobori, and M. Tanifuji. 1990. Local function of urokinase receptor at the adhesion contact sites of a metastatic tumor cell. Thromb. Res. Suppl. X:55-61.
46. Kindzelskit, A., W. Xue, R. Todd, L. Boxer, and H. Petty. 1994. Aberrant capping of membrane proteins on neutrophils from patients with leukocyte adhesion deficiency Blood. 83:1650-1655.
47. Francis, J., R. Todd III, L. Boxer, and H. Petty 1989. Sequential expression of cell surface C3bi receptors during neutrophil locomotion. J. Cell Physiol. 140:519-523.
48. Wei, Y., D. Waltz, N. Rao, R. Drummond, S. Rosenberg, and H. Chapman. 1994. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem. 269:32380-32388.
49. Loike, J., B. Sodetk, L. Cao, S. Leucona, J. Weitz, P. Detmers, S. Wright, and S. Silverstein. 1991. CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the Aa chain of fibrinogen. Proc Natl. Acad Sci. USA. 88:1044-1048.
50. Vassalli, J.-D., A. Wohlwend, and D. Beim. 1992. Urokinase-catalyzed plasminogen activation at the monocyte/macrophage cell surface: a localized and regulated proteolytic system Curr. Topics Microbiol. Immunol. 181:65-86
51. Picone, R., E.L. Kajtaniak, L.S. Nielsen, N. Behrendt, M.R Mastrontcola, M.V. Cubellis, M.P. Stoppelli, S. Pedersen, K. Danø, and F. Blasi. 1989. Regulation of urokinase receptors in monocytehke U937 cells by phorbol ester phorbol myristateacetate. J. Cell Biol. 108:693-702
52. Olson, D., J. Pöllanen; G. Høyer-Hansen, E. Rønne, K. Sakaguchi, T. Wun, E. Appella. K Danø, and F. Blasi. 1992. Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor. J. Biol. Chem 267.9129-9133.
53. Cubeilis, M., T. Wun, and F. Blasi. 1990. Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1 EMBO (Eur. Mol. Biol Organ.) J. 9:1079-1085.
54. Chapman, H.A., O.L. Stone, and Z. Vavrin. 1984. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. J Clin. Invest. 73: 806-815.
55. Mochan, E., and T. Keler. 1984. Plasmin degradation of cartilage proteoglycan Biochim. Biophys. Acta. 800.312-315.
56. Murphy, G., and A Doherty. 1992. The matrix metalloproteinases and their regulation Am. J. Respir. Cell Mol. Biol. 7:120-125.
57. Carlos, T., A. Dobrina, R. Ross, and J. Harlan. 1990. Multiple receptors on human monocytes are involved in adhesion to cultured human endothelial cells. J Leukocyte Biol. 48:451-456
58. Carlos, T., N. Kovach, B. Sehwartz, M. Rosa, B. Newman, E. Wayner, C. Benjamin, L. Osborn, R. Lobb, and J. Harlan. 1991. Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells. endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood. 77:2266-2271.
59. Xue, W., B. Garni-Wagner, R. Todd. and H. Petty. 1995. Colocalization of uPAR with β1 and β3 integrins on tumor cells adherent to specific extracellular matrices. Proceedings of the 9th International Congress of Immunology. 3208.
60. Waltz, D., L Sailor, and H. Chapman 1993. Cytokines induce urokinase-dependent adhesion of human myeloid cells A regulatory role for plasminogen activator inhibitors. J. Clin Invest. 91:1541-1552.
61. Waltz, D., and H. Chapman. 1994. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy J. Biol Chem. 269:14746-14750.
62. Høyer-Hansen, G., E. Rønne, H. Solberg, N. Behrendt. M. Ploug, L. Lund, V. Ellis, and K. Danø. 1992. Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain. J. Biol. Chem. 267: 18224-18229.
63. Fan, S., and T. Edgington. 1993. Integrin regulation of leukocyte inflammatory functions: CD11b/CD18 enhancement of the tumor necrosis factor-α responses of monocytes. J Immunol 150:2972-2980.