Theory of evolutionary molecular engineering through simultaneous accumulation of advantageous mutations

Journal of Theoretical Biology

Volumn 207, Issue 4, 2000, Pages 543-556

  Aita, Takuyo ^a,b   Husimi, Yuzuru ^b  

^a NOVARTIS PHARMA K K   (Japan)

^b SAITAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE MUTATION; GENETIC ENGINEERING; GENETIC SCREENING; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; MUTANT; POINT MUTATION; PRIORITY JOURNAL;

EID: 0034700419     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2000.2195     Document Type: Article

References (23)

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6. Protein-protein interactions: Additivity of the free energies of association of amino acid residues
7. Directed evolution of enzyme catalysts
8. Affinity maturation of human growth hormone by monovalent phage display
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13. γ repressor recognizes the approximately 2-fold symmetric half-operator sequences asymmetrically
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15. Potential use of additivity of mutational effects in simplifying protein engineering
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23. Molecular evolution by staggered extension process (StEP) in vitro recombination