Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: Application to prolyl endopeptidase and thermolysin

Biopolymers

Volumn 54, Issue 1, 2000, Pages 64-79

  Aita, Takuyo ^a,b   Uchiyama, Hidefumi ^b,c   Inaoka, Tetsuya ^b,d   Nakajima, Motowo ^b   Kokubo, Toshio ^b,d   Husimi, Yuzuru ^a  

^a SAITAMA UNIVERSITY   (Japan)

^b NOVARTIS PHARMA K K   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d BAYER YAKUHIN LTD   (Japan)

Author keywords

Fitness landscape; Mutational additivity; Prolyl endopeptidase; Protein sequence space; Thermolysin

Indexed keywords

LEAST SQUARES APPROXIMATIONS; MATHEMATICAL MODELS; THERMODYNAMIC STABILITY;

PROLYL ENDOPEPTIDASE; PROTEIN SEQUENCE SPACE; THERMOLYSIN;

PROTEINS;

BIOPOLYMER; MUTANT PROTEIN; PROLYL ENDOPEPTIDASE; THERMOLYSIN;

AMINO ACID SEQUENCE; ARTICLE; BIOENGINEERING; ENZYME ACTIVITY; ENZYME STABILITY; MODEL; POLYMERIZATION;

AMINO ACID SEQUENCE; BIOPOLYMERS; COMPUTER SIMULATION; ENZYME STABILITY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; SERINE ENDOPEPTIDASES; THERMODYNAMICS; THERMOLYSIN;

EID: 0034082141     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(200007)54:1<64::AID-BIP70>3.0.CO;2-R     Document Type: Article

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