trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines: Mixed dopamine D2/D4 receptor antagonists as potential antipsychotic agents

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3923-3932

  Zhang, X ^a   Hodgetts, K ^a   Rachwal, S ^a   Zhao, H ^a   Wasley, J W F ^a   Craven, K ^a   Brodbeck, R ^a   Kieltyka, A ^a   Hoffman, D ^a   Bacolod, M D ^a   Girard, B ^a   Tran, J ^a   Thurkauf, A ^a  

^a NEUROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 PHENYLCYCLOPROPYL)METHYL] 4 (2,4 DICHLOROPHENYL)PIPERAZINE; 1 [(2 PHENYLCYCLOPROPYL)METHYL] 4 (2,4 DIMETHYLPHENYL)PIPERAZINE; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; AROMATIC COMPOUND; CLOZAPINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; RECEPTOR SUBUNIT; REMOXIPRIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; PSYCHOSIS; RECEPTOR AFFINITY;

ANIMALS; ANTIPSYCHOTIC AGENTS; CHO CELLS; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; DOPAMINE ANTAGONISTS; HUMANS; MALE; MICROSOMES, LIVER; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034687217     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990562x     Document Type: Article

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