메뉴 건너뛰기




Volumn 452, Issue 2, 2000, Pages 149-162

P53 null mice: Damaging the hypothesis?

Author keywords

Mice; p53; Tumour suppressor gene

Indexed keywords

PROTEIN P53;

EID: 0034683566     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00089-0     Document Type: Review
Times cited : (24)

References (81)
  • 1
    • 0029845760 scopus 로고    scopus 로고
    • Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
    • C Harris C. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J. Natl. Cancer Inst. 88(20):1996;442-1455.
    • (1996) J. Natl. Cancer Inst. , vol.88 , Issue.20 , pp. 442-1455
    • C. Harris, C.1
  • 2
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 387(6630):1997;296-299.
    • (1997) Nature , vol.387 , Issue.6630 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 5
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C., Hall P.A. The p53 pathway. J. Pathol. 187(1):1999;112-126.
    • (1999) J. Pathol. , vol.187 , Issue.1 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 6
    • 0029013273 scopus 로고
    • P53 and its 14 Kda C-terminal domain recognize primary DNA-damage in the form of insertion deletion mismatches
    • Lee S., Elenbaas B., Levinea A., Griffith J. P53 and its 14 Kda C-terminal domain recognize primary DNA-damage in the form of insertion deletion mismatches. Cell. 81(7):1995;1013-1020.
    • (1995) Cell , vol.81 , Issue.7 , pp. 1013-1020
    • Lee, S.1    Elenbaas, B.2    Levinea, A.3    Griffith, J.4
  • 8
    • 0016836493 scopus 로고    scopus 로고
    • Commitment to senescence: A model for the finite growth of diploid and transformed human fibroblasts
    • L Kirkwood T.B., Holiday R. Commitment to senescence: a model for the finite growth of diploid and transformed human fibroblasts. J. Theor. Biol. 53:1996;481-496.
    • (1996) J. Theor. Biol. , vol.53 , pp. 481-496
    • L. Kirkwood, T.B.1    Holiday, R.2
  • 12
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris C.C., Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N. Engl. J. Med. 329(18):1993;1318-1327.
    • (1993) N. Engl. J. Med. , vol.329 , Issue.18 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 14
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
    • Srivastava S., Zou Z.Q., Pirollo K., Blattner W., Chang E.H., Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome Nature. 348(6303):1990;747-749.
    • (1990) Nature , vol.348 , Issue.6303 , pp. 747-749
    • Srivastava, S.1    Zou, Z.Q.2    Pirollo, K.3    Blattner, W.4    Chang, E.H.5
  • 15
    • 0031987265 scopus 로고    scopus 로고
    • Mouse models dissect the role of p53 in cancer and development
    • Loazano G., Lui G. Mouse models dissect the role of p53 in cancer and development. Semin. Cancer Biol. 8:1998;337-344.
    • (1998) Semin. Cancer Biol. , vol.8 , pp. 337-344
    • Loazano, G.1    Lui, G.2
  • 16
    • 0033028043 scopus 로고    scopus 로고
    • The role of p53 in tumour suppression: Lessons from mouse models
    • Attardi L.D., Jacks T. The role of p53 in tumour suppression: lessons from mouse models. Cell. Mol. Life Sci. 55(1):1999;48-63.
    • (1999) Cell. Mol. Life Sci. , vol.55 , Issue.1 , pp. 48-63
    • Attardi, L.D.1    Jacks, T.2
  • 17
    • 0029918992 scopus 로고    scopus 로고
    • Effects of p53 mutation on tumor progression: Recent insights from mouse tumor models
    • Donehower L.A. Effects of p53 mutation on tumor progression: recent insights from mouse tumor models. Biochim. Et Biophys. Acta-Rev. Cancer. 1242(3):1996;171-176.
    • (1996) Biochim. et Biophys. Acta-Rev. Cancer , vol.1242 , Issue.3 , pp. 171-176
    • Donehower, L.A.1
  • 20
    • 0000727065 scopus 로고
    • Spontaneous testicular teratomas in an inbred strain of mice
    • Stevens L.C., Little C.C. Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. U. S. A. 40:1954;1080-1087.
    • (1954) Proc. Natl. Acad. Sci. U. S. A. , vol.40 , pp. 1080-1087
    • Stevens, L.C.1    Little, C.C.2
  • 21
    • 0028937476 scopus 로고
    • Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin
    • Harvey M., Vogel H., Lee E.Y.H.P., Bradley A., Donehower L.A. Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res. 55(5):1995;1146-1151.
    • (1995) Cancer Res. , vol.55 , Issue.5 , pp. 1146-1151
    • Harvey, M.1    Vogel, H.2    Lee, E.Y.H.P.3    Bradley, A.4    Donehower, L.A.5
  • 22
    • 0028988697 scopus 로고
    • Effects of heterozygosity for the Rb-1(T19neo) allele in the mouse
    • Harrison D.J., Hooper M.L., Armstrong J.F., Clarke A.R. Effects of heterozygosity for the Rb-1(T19neo) allele in the mouse. Oncogene. 10(8):1995;1615-1620.
    • (1995) Oncogene , vol.10 , Issue.8 , pp. 1615-1620
    • Harrison, D.J.1    Hooper, M.L.2    Armstrong, J.F.3    Clarke, A.R.4
  • 23
    • 0027109075 scopus 로고
    • P53: Guardian of the genome
    • Lane D.P. P53: guardian of the genome. Nature. 358:1992;15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 24
    • 0032543343 scopus 로고    scopus 로고
    • Apoptotic repair of genotoxic tissue damage and the role of p53 gene
    • Kondo S. Apoptotic repair of genotoxic tissue damage and the role of p53 gene. Mut. Res.-Fundam. Mol. Mech. Mutagen. 402(1-2):1998;311-319.
    • (1998) Mut. Res.-Fundam. Mol. Mech. Mutagen. , vol.402 , Issue.12 , pp. 311-319
    • Kondo, S.1
  • 25
  • 26
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination and cancer biology
    • Modrich P., Lahue R. Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu. Rev. Biochem. 65:1996;101-133.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 28
    • 0033027549 scopus 로고    scopus 로고
    • P53 in embryonic development: Maintaining a fine balance
    • Choi J., Donehower L.A. P53 in embryonic development: maintaining a fine balance. Cell. Mol. Life Sci. 55(1):1999;38-47.
    • (1999) Cell. Mol. Life Sci. , vol.55 , Issue.1 , pp. 38-47
    • Choi, J.1    Donehower, L.A.2
  • 29
    • 0029347164 scopus 로고
    • High-frequency developmental abnormalities in p53-deficient mice
    • Armstrong J.F., Kaufman M.H., Harrison D.J., Clarke A.R. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol. 5(8):1995;931-936.
    • (1995) Curr. Biol. , vol.5 , Issue.8 , pp. 931-936
    • Armstrong, J.F.1    Kaufman, M.H.2    Harrison, D.J.3    Clarke, A.R.4
  • 32
    • 0031600949 scopus 로고    scopus 로고
    • No female embryonic lethality in mice nullizygous for Msh2 and p53
    • Toft N.J., Arends M.J., Wyllie A.H., Clarke A.R. No female embryonic lethality in mice nullizygous for Msh2 and p53. Nature Genet. 18(1):1998;17.
    • (1998) Nature Genet. , vol.18 , Issue.1 , pp. 17
    • Toft, N.J.1    Arends, M.J.2    Wyllie, A.H.3    Clarke, A.R.4
  • 33
    • 0029874308 scopus 로고    scopus 로고
    • P53 dependent apoptosis suppresses radiation induced teratogenesis
    • Norimura T., Nomuta S., Katsuki M., Gondo Y., Kondo S. P53 dependent apoptosis suppresses radiation induced teratogenesis. Nature Med. 2:1996;581.
    • (1996) Nature Med. , vol.2 , pp. 581
    • Norimura, T.1    Nomuta, S.2    Katsuki, M.3    Gondo, Y.4    Kondo, S.5
  • 34
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones S.N., Roe A.E., Donehower L.A., Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 378(6553):1995;206-208.
    • (1995) Nature , vol.378 , Issue.6553 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 35
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in Mdm2-deficient mice by deletion of p53
    • Luna R.M.D., Wagner D.S., Lozano G. Rescue of early embryonic lethality in Mdm2-deficient mice by deletion of p53. Nature. 378(6553):1995;203-206.
    • (1995) Nature , vol.378 , Issue.6553 , pp. 203-206
    • Luna, R.M.D.1    Wagner, D.S.2    Lozano, G.3
  • 37
    • 0031008749 scopus 로고    scopus 로고
    • P53, mutation frequency and apoptosis in the murine small intestine
    • Clarke A.R., Howard L.A., Harrison D.J., Winton D.J. P53, mutation frequency and apoptosis in the murine small intestine. Oncogene. 14(17):1997;2015-2018.
    • (1997) Oncogene , vol.14 , Issue.17 , pp. 2015-2018
    • Clarke, A.R.1    Howard, L.A.2    Harrison, D.J.3    Winton, D.J.4
  • 38
    • 0033602263 scopus 로고    scopus 로고
    • P53-dependent and -independent links between DNA-damage apoptosis and mutation frequency in ES cell
    • Corbet S.W., Clarke A.R., Gledhills S., Wyllie A.H. P53-dependent and -independent links between DNA-damage apoptosis and mutation frequency in ES cell. Oncogene. 18(8):1999;1537-1544.
    • (1999) Oncogene , vol.18 , Issue.8 , pp. 1537-1544
    • Corbet, S.W.1    Clarke, A.R.2    Gledhills, S.3    Wyllie, A.H.4
  • 39
    • 0031911745 scopus 로고    scopus 로고
    • Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa
    • Jasani B., Campbell F., Navabi N., Schmid K.W., Williams G.T. Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa. J. Pathol. 184:1999;144-147.
    • (1999) J. Pathol. , vol.184 , pp. 144-147
    • Jasani, B.1    Campbell, F.2    Navabi, N.3    Schmid, K.W.4    Williams, G.T.5
  • 40
    • 0031987280 scopus 로고    scopus 로고
    • Estimation of mutation frequencies in normal mammalian cells and the development of cancer
    • Turker M.S. Estimation of mutation frequencies in normal mammalian cells and the development of cancer. Semin. Cancer Biol. 8(6):1998;407-419.
    • (1998) Semin. Cancer Biol. , vol.8 , Issue.6 , pp. 407-419
    • Turker, M.S.1
  • 41
    • 0023894101 scopus 로고
    • A clonal marker induced by mutation in mouse intestinal epithelium
    • Winton D.J., Blount M.A., Ponder B.A.J. A clonal marker induced by mutation in mouse intestinal epithelium. Nature. 333(6172):1988;463-466.
    • (1988) Nature , vol.333 , Issue.6172 , pp. 463-466
    • Winton, D.J.1    Blount, M.A.2    Ponder, B.A.J.3
  • 42
    • 0029156729 scopus 로고
    • P53 wild-type and p53 nullizygous Big-Blue transgenic mice have similar frequencies and patterns of observed mutation in liver spleen and brain
    • Nishino H., Knoll A., Buettner V.L., Frisk C.S., Maruta Y., Haavik J., Sommer S.S. P53 wild-type and p53 nullizygous Big-Blue transgenic mice have similar frequencies and patterns of observed mutation in liver spleen and brain. Oncogene. 11(2):1995;263-270.
    • (1995) Oncogene , vol.11 , Issue.2 , pp. 263-270
    • Nishino, H.1    Knoll, A.2    Buettner, V.L.3    Frisk, C.S.4    Maruta, Y.5    Haavik, J.6    Sommer, S.S.7
  • 43
    • 0032965173 scopus 로고    scopus 로고
    • A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo
    • Cosentino I., Heddle J.A. A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo. Mutagenesis. 14(1):1999;113-119.
    • (1999) Mutagenesis , vol.14 , Issue.1 , pp. 113-119
    • Cosentino, I.1    Heddle, J.A.2
  • 44
    • 0030855899 scopus 로고    scopus 로고
    • Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: A test of the guardian of the genome hypothesis in the Big Blue(R) transgenic mouse mutation detection system
    • Buettner V.L., Nishino H., Haavik J., Knoll A., Hill K., Sommer S.S. Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the guardian of the genome hypothesis in the Big Blue(R) transgenic mouse mutation detection system. Mut. Res.-Fundam. Mol. Mech. Mutagen. 379(1):1997;13-20.
    • (1997) Mut. Res.-Fundam. Mol. Mech. Mutagen. , vol.379 , Issue.1 , pp. 13-20
    • Buettner, V.L.1    Nishino, H.2    Haavik, J.3    Knoll, A.4    Hill, K.5    Sommer, S.S.6
  • 46
    • 0026719791 scopus 로고
    • Application of galactose-sensitive Escherichia-coli strains as selective hosts for lacZ-plasmid
    • Gossen J.A., Molijn A.C., Douglas G.R., Vijg J. Application of galactose-sensitive Escherichia-coli strains as selective hosts for lacZ-plasmid. Nucleic Acids Res. 20(12):1992;3254.
    • (1992) Nucleic Acids Res. , vol.20 , Issue.12 , pp. 3254
    • Gossen, J.A.1    Molijn, A.C.2    Douglas, G.R.3    Vijg, J.4
  • 47
    • 0028177266 scopus 로고
    • The accumulation and persistence of somatic mutations in-vivo
    • Tao K.S., Heddle J.A. The accumulation and persistence of somatic mutations in-vivo. Mutagenesis. 9(3):1994;187-191.
    • (1994) Mutagenesis , vol.9 , Issue.3 , pp. 187-191
    • Tao, K.S.1    Heddle, J.A.2
  • 49
    • 0030331124 scopus 로고    scopus 로고
    • Spontaneous mutation in Big Blue(R) transgenic mice: Analysis of age, gender, and tissue type
    • Nishino H., Buettner V.L., Haavik J., Schaid D.J., Sommer S.S. Spontaneous mutation in Big Blue(R) transgenic mice: analysis of age, gender, and tissue type. Environ. Mol. Mutagen. 28(4):1996;299-312.
    • (1996) Environ. Mol. Mutagen. , vol.28 , Issue.4 , pp. 299-312
    • Nishino, H.1    Buettner, V.L.2    Haavik, J.3    Schaid, D.J.4    Sommer, S.S.5
  • 53
    • 0030458031 scopus 로고    scopus 로고
    • Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53 Big Blue double transgenic mice
    • Buettner V.L., Hill K.A., Nishino H., Schaid D.J., Frisk C.S., Sommer S.S. Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53 Big Blue double transgenic mice. Oncogene. 13(11):1996;2407-2413.
    • (1996) Oncogene , vol.13 , Issue.11 , pp. 2407-2413
    • Buettner, V.L.1    Hill, K.A.2    Nishino, H.3    Schaid, D.J.4    Frisk, C.S.5    Sommer, S.S.6
  • 54
    • 0031972522 scopus 로고    scopus 로고
    • Foundations in cancer research: cancer cells exhibit a mutator phenotype
    • L.A. Loeb, Foundations in cancer research: cancer cells exhibit a mutator phenotype, Adv. Cancer Res. (1998) 25-26.
    • (1998) Adv. Cancer Res. , pp. 25-26
    • Loeb, L.A.1
  • 55
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong J.G., Costanzo A., Yang H.Q., Melino G., Kaelin W.G., Levrero M., Wang J.Y.L. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 399(6738):1999;806-809.
    • (1999) Nature , vol.399 , Issue.6738 , pp. 806-809
    • Gong, J.G.1    Costanzo, A.2    Yang, H.Q.3    Melino, G.4    Kaelin, W.G.5    Levrero, M.6    Wang, J.Y.L.7
  • 58
    • 0027319521 scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. P53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362(6423):1993;847-849.
    • (1993) Nature , vol.362 , Issue.6423 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 60
    • 0028301094 scopus 로고
    • P53 dependence or early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation
    • Clarke A.R., Gledhill S., Hooper M.L., Bird C.C., Wyllie A.H. P53 dependence or early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene. 9(6):1994;1767-1773.
    • (1994) Oncogene , vol.9 , Issue.6 , pp. 1767-1773
    • Clarke, A.R.1    Gledhill, S.2    Hooper, M.L.3    Bird, C.C.4    Wyllie, A.H.5
  • 61
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal-tract of normal and p53-deficient mice
    • Merritt A.J., Potten C.S., Kemp C.J., Hickman J.A., Balmain A., Lane D.P., Hall P.A. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal-tract of normal and p53-deficient mice. Cancer Res. 54(3):1994;614-617.
    • (1994) Cancer Res. , vol.54 , Issue.3 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 62
    • 0030812174 scopus 로고    scopus 로고
    • Apoptosis in small intestinal epithelia from p53-null mice: Evidence for a delayed p53-independent G2/M-associated cell death after gamma-irradiation
    • Merritt A.J., Allen T.D., Potten C.S., Hickman J.A. Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene. 14(23):1997;2759-2766.
    • (1997) Oncogene , vol.14 , Issue.23 , pp. 2759-2766
    • Merritt, A.J.1    Allen, T.D.2    Potten, C.S.3    Hickman, J.A.4
  • 63
    • 0025224214 scopus 로고
    • A comprehensive study of the radiobiological response of the murine (Bdf1) small-intestine
    • C.S. Potten, A comprehensive study of the radiobiological response of the murine (Bdf1) small-intestine, Int. J. Radiat. Biol. 58 (6) (1990).
    • (1990) Int. J. Radiat. Biol. , vol.58 , Issue.6
    • Potten, C.S.1
  • 65
    • 0030895235 scopus 로고    scopus 로고
    • Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium
    • Potten C.S. Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. Stem Cells. 15(2):1997;82-93.
    • (1997) Stem Cells , vol.15 , Issue.2 , pp. 82-93
    • Potten, C.S.1
  • 66
    • 0030987665 scopus 로고    scopus 로고
    • The intestinal epithelial stem cell: The mucosal governor
    • Potten C.S., Booth C., Pritchard D.M. The intestinal epithelial stem cell: the mucosal governor. Int. J. Exp. Pathol. 78(4):1997;219-243.
    • (1997) Int. J. Exp. Pathol. , vol.78 , Issue.4 , pp. 219-243
    • Potten, C.S.1    Booth, C.2    Pritchard, D.M.3
  • 67
    • 0028937044 scopus 로고
    • Deduction of the clonogen content of intestinal crypts - A direct comparison of 2-dose and multiple-dose methodologies
    • Roberts S.A., Hendry J.H., Potten C.S. Deduction of the clonogen content of intestinal crypts - a direct comparison of 2-dose and multiple-dose methodologies. Radiat. Res. 141(3):1995;303-308.
    • (1995) Radiat. Res. , vol.141 , Issue.3 , pp. 303-308
    • Roberts, S.A.1    Hendry, J.H.2    Potten, C.S.3
  • 68
    • 0028298595 scopus 로고
    • Clonogen content of intestinal crypts - its deduction using a microcolony assay on whole-mount preparations and its dependence on radiation-dose
    • Roberts S.A., Potten C.S. Clonogen content of intestinal crypts - its deduction using a microcolony assay on whole-mount preparations and its dependence on radiation-dose. Int. J. Radiat. Biol. 65(4):1994;477-481.
    • (1994) Int. J. Radiat. Biol. , vol.65 , Issue.4 , pp. 477-481
    • Roberts, S.A.1    Potten, C.S.2
  • 69
    • 0030779865 scopus 로고    scopus 로고
    • P53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine
    • Hendry J.H., Cai W.B., Roberts S.A., Potten C.S. P53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine. Radiat. Res. 148(3):1997;254-259.
    • (1997) Radiat. Res. , vol.148 , Issue.3 , pp. 254-259
    • Hendry, J.H.1    Cai, W.B.2    Roberts, S.A.3    Potten, C.S.4
  • 70
    • 0032404145 scopus 로고    scopus 로고
    • The relationships between p53-dependent apoptosis inhibition of proliferation and 5-fluorouracil-induced histopathology in murine intestinal epithelia
    • Pritchard D.M., Potten C.S., Hickman J.A. The relationships between p53-dependent apoptosis inhibition of proliferation and 5-fluorouracil-induced histopathology in murine intestinal epithelia. Cancer Res. 58(23):1998;5453-5465.
    • (1998) Cancer Res. , vol.58 , Issue.23 , pp. 5453-5465
    • Pritchard, D.M.1    Potten, C.S.2    Hickman, J.A.3
  • 71
    • 0028533694 scopus 로고
    • DNA-damage tolerance, mismatch repair and genome instability
    • Karran P., Bignami M. DNA-damage tolerance, mismatch repair and genome instability. Bioessays. 16(11):1994;833-839.
    • (1994) Bioessays , vol.16 , Issue.11 , pp. 833-839
    • Karran, P.1    Bignami, M.2
  • 72
    • 0034094390 scopus 로고    scopus 로고
    • 6-benzlguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit p450-dependent activation of dacarbazine
    • 6-benzlguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit p450-dependent activation of dacarbazine. Carcinogenesis. 21(4):2000;593-598.
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 593-598
    • Toft, N.J.1    J. Sansom, O.2    Brookes, R.A.3    Arends, M.J.4    Wood, M.5    Margiston, G.P.6    Winton, D.J.7    Clarke, A.R.8
  • 74
    • 0031012977 scopus 로고    scopus 로고
    • Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53
    • Hundley J.E., Koester S.K., Troyer D.A., Hilsenbeck S.G., Subler M.A., Windle J.J. Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53. Mol. Cell. Biol. 17(2):1997;723-731.
    • (1997) Mol. Cell. Biol. , vol.17 , Issue.2 , pp. 723-731
    • Hundley, J.E.1    Koester, S.K.2    Troyer, D.A.3    Hilsenbeck, S.G.4    Subler, M.A.5    Windle, J.J.6
  • 76
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin C.Y., Knudson C.M., Korsmeyer S.J., VanDyke T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature. 385(6617):1997;637-640.
    • (1997) Nature , vol.385 , Issue.6617 , pp. 637-640
    • Yin, C.Y.1    Knudson, C.M.2    Korsmeyer, S.J.3    Vandyke, T.4
  • 77
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., Giaccia A.J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379(6560):1996;88-91.
    • (1996) Nature , vol.379 , Issue.6560 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 78
    • 0028792347 scopus 로고
    • Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy
    • Clarke A.R., Cummings C., Harrison D.J. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. Oncogene. 11(9):1995;1913-1920.
    • (1995) Oncogene , vol.11 , Issue.9 , pp. 1913-1920
    • Clarke, A.R.1    Cummings, C.2    Harrison, D.J.3
  • 79
    • 0031987296 scopus 로고    scopus 로고
    • P53 dependent cell cycle control: Response to genotoxic stress
    • Schwartz D., Rotter V. P53 dependent cell cycle control: response to genotoxic stress. Semin. Cancer Biol. 8:1998;325-336.
    • (1998) Semin. Cancer Biol. , vol.8 , pp. 325-336
    • Schwartz, D.1    Rotter, V.2
  • 80
    • 0032954092 scopus 로고    scopus 로고
    • Insights into cancer from transgenic mouse models
    • Macleod K.F., Jacks T. Insights into cancer from transgenic mouse models. J. Pathol. 187(1):1999;43-60.
    • (1999) J. Pathol. , vol.187 , Issue.1 , pp. 43-60
    • MacLeod, K.F.1    Jacks, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.