Methylation of CpG dinucleotides in the lacI gene of the Big Blue® transgenic mouse

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 420, Issue 1-3, 1998, Pages 55-65

  You, Young Hyun ^a   Halangoda, Asanga ^a   Buettner, Victoria ^a   Hill, Kathleen ^a   Sommer, Steve ^a   Pfeifer, Gerd ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

CpG; lacI gene; Methylation; Mutation; Transgenic mouse

Indexed keywords

5 METHYLCYTOSINE; CYTOSINE; DINUCLEOTIDE; DNA METHYLTRANSFERASE; METHYLTRANSFERASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA BINDING; GENE MUTATION; LACTOSE OPERON; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; THYMUS; THYMUS LYMPHOMA; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; DINUCLEOSIDE PHOSPHATES; DNA; DNA METHYLATION; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI PROTEINS; FEMALE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; TESTIS; THYMOMA; THYMUS GLAND;

ESCHERICHIA COLI; MAMMALIA; MUS MUSCULUS;

EID: 0032406223     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(98)00147-8     Document Type: Article

References (49)

1. Schaaper R.M., Danforth B.N., Glickman B.W. Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene. J. Mol. Biol. 189:1986;273-284.
2. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Putman D.L., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. USA. 88:1991;7958-7962.
3. Gu M., Ahmed A., Wei C., Gorelick N., Glickman B.W. Development of a lambda-based complementation assay for the preliminary localization of lacI mutants from the Big Blue mouse: implications for a DNA-sequencing strategy. Mut. Res. 307:1994;533-540.
4. Nishino H., Buettner V.L., Haavik J., Schaid D.J., Sommer S.S. Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ. Mol. Mutagen. 28:1996;299-312.
5. Gossen J.A., Vijg J. Transgenic mice as model systems for studying gene mutations in vivo. Trends Genet. 9:1993;27-31.
6. Ashby J., Tinwell H. Use of transgenic mouse lacI/Z mutation assays in genetic toxicology. Mutagenesis. 9:1994;179-181.
7. Gorelick N.J. Validation issues for the use of transgenic mouse mutation assays in risk assessment. Prog. Clin. Biol. Res. 395:1996;81-108.
8. J.G. de Boer, H.L. Erfle, D. Walsh, J. Holcroft, B.W. Glickman, The use of lacI transgenic mice in genetic toxicology, in: G.P. Pfeifer (Ed.), Technologies for Detection of DNA Damage and Mutations, Plenum, New York (1996) pp. 411-429.
9. Knöll A., Jacobson D.P., Kretz P.L., Lundberg K.S., Short J.M., Sommer S.S. Spontaneous mutations in lacI-containing lambda lysogens derived from transgenic mice: the observed patterns differ in liver and spleen. Mut. Res. 311:1994;57-67.
10. Buettner V.L., Nishino H., Haavik J., Knöll A., Hill K., Sommer S.S. Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the guardian of the genome hypothesis in the Big Blue transgenic mouse mutation detection system. Mut. Res. 379:1997;13-20.
11. de Boer J.G., Erfle H., Walsh D., Holcroft J., Provost J.S., Rogers B., Tindall K.R., Glickman B.W. Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ. Mol. Mutagen. 30:1997;273-286.
12. Razin A., Riggs A.D. DNA methylation and gene function. Science. 210:1980;604-610.
13. Pfeifer G.P., Spiess E., Grünwald S., Boehm T.L.J., Drahovsky D. Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes. EMBO J. 4:1985;2879-2884.
14. Duncan B.K., Miller J.H. Mutagenic deamination of cytosine residues in DNA. Nature. 287:1980;560-561.
15. Skopek T., Marino D., Kort K., Miller J., Trumbauer M., Gopal S., Chen H. Effect of target gene CpG content on spontaneous mutation in transgenic mice. Mut. Res. 400:1998;77-88.
16. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A., Butel J.S., Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 356:1992;215-221.
17. Nishino H., Knöll A., Buettner V.L., Frish C.S., Maruta Y., Haavik J., Sommer S.S. p53 wild-type and p53 nullizygous Big Blue® transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain. Oncogene. 11:1995;263-270.
18. Nishino H., Herath J.F., Jenkins R.B., Sommer S.S. Fluorescence in situ hybridization for rapid differentiation of zygosity in transgenic mice. BioTechniques. 19:1995;587.
19. Provost G.S., Short J.M. Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc. Natl. Acad. Sci. USA. 91:1994;6564-6568.
20. Maxam A.M., Gilbert W. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:1980;499-560.
21. Pfeifer G.P., Singer-Sam J., Riggs A.D. PCR assays for methylation and chromatin structure. Methods Enzymol. 225:1993;567-583.
22. Tornaletti S., Pfeifer G.P. Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. Oncogene. 10:1995;1493-1499.
23. S. Tornaletti, G.P. Pfeifer, Ligation-mediated PCR for analysis of UV damage, in: G.P. Pfeifer (Ed.), Technologies for Detection of DNA Damage and Mutations, Plenum, New York (1996) pp. 199-209.
24. Törmänen V.T., Pfeifer G.P. Mapping of UV photoproducts within ras protooncogenes in UV-irradiated cells: correlation with mutations in human skin cancer. Oncogene. 7:1992;1729-1736.
25. Pfeifer G.P., Steigerwald S.D., Mueller P.R., Wold B., Riggs A.D. Genomic sequencing and methylation analysis by ligation mediated PCR. Science. 246:1989;810-813.
26. Frommer M., McDonald M.E., Millar D.S., Collis C.M., Watt F., Grigg G.W., Molloy P.L., Paul C.L. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA. 89:1992;1827-1831.
27. Cross S.H., Bird A.P. CpG islands and genes. Curr. Opin. Genet. Dev. 5:1995;309-314.
28. Pfeifer G.P., Steigerwald S.D., Hansen R.S., Gartler S.M., Riggs A.D. Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc. Natl. Acad. Sci. USA. 87:1990;8252-8256.
29. Pfeifer G.P., Tanguay R.L., Steigerwald S.D., Riggs A.D. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. Genes Dev. 4:1990;1277-1287.
30. Ferguson-Smith A.C., Sasaki H., Cattanach B.M., Surani M.A. Parental-origin-specific epigenetic modification of the mouse H19 gene. Nature. 362:1993;751-755.
31. Jones P.A., Wolkowicz M.J., Rideout W.M., Gonzales F.A., Marziasz C.M., Coetzee G.A., Tapscott S.J. De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc. Natl. Acad. Sci. USA. 87:1990;6117-6121.
32. Antequera F., Boyes J., Bird A. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell. 62:1990;503-514.
33. Merlo A., Herman J.G., Mao L., Lee D.J., Gabrielson E., Burger P.C., Baylin S.B., Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nature Med. 1:1995;686-692.
34. Nur I., Pascale E., Furano A.V. The left end of rat L1 (L1Rn, long interspersed repeated) DNA which is a CpG island can function as a promoter. Nucleic Acids Res. 16:1988;9233-9251.
35. Woodcock D.M., Crowther P.J., Diver W.P., Graham M., Bateman C., Baker D.J., Smith S.S. RglB facilitated cloning of highly methylated eukaryotic DNA: the human L1 transposon, plant DNA, and DNA methylated in vitro with human DNA methyltransferase. Nucleic Acids Res. 16:1988;4465-4482.
36. Brandeis M., Frank D., Keshet I., Siegfried Z., Mendelsohn M., Nemes A., Temper V., Razin A., Cedar H. Sp1 elements protect a CpG island from de novo methylation. Nature. 371:1994;435-438.
37. Macleod D., Charlton J., Mullins J., Bird A.P. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8:1994;2282-2292.
38. Yoder J.A., Walsh C.P., Bestor T.H. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13:1997;335-340.
39. Jones P.A. DNA methylation errors and cancer. Cancer Res. 56:1996;2463-2467.
40. Neddermann P., Gallinari P., Lettieri T., Schmid D., Truong O., Hsuan J.J., Wiebauer K., Jiricny J. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. J. Biol. Chem. 271:1996;12767-12774.
41. Ketterling R.P., Vielhaber E., Sommer S.S. The rates of G:C→T:A and G:C→C:G transversions at CpG dinucleotides in the human factor IX gene. Am. J. Hum. Genet. 54:1994;831-835.
42. Denissenko M.F., Chen J.X., Tang M.S., Pfeifer G.P. Cytosine methylation determines hot spots of DNA damage in the human P53 gene. Proc. Natl. Acad. Sci. USA. 94:1997;3893-3898.
43. Skopek T.R., Kort K.L., Marino D.R., Mittal L.V., Umbenhauer D.R., Laws G.M., Adams S.P. Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice. Environ. Mol. Mutagen. 28:1996;376-384.
44. Jiao J., Douglas G.R., Gingerich J.D., Soper L.M. Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice. Carcinogenesis. 18:1997;2239-2245.
45. Harris C.C. p53: at the crossroads of molecular carcinogenesis and risk assessment. Science. 262:1993;1980-1981.
46. Denissenko M.F., Pao A., Tang M.-s., Pfeifer G.P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science. 274:1996;430-432.
47. Tommasi S., Denissenko M.F., Pfeifer G.P. Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases. Cancer Res. 57:1997;4727-4730.
48. Drouin R., Therrien J.-P. UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53. Photochem. Photobiol. 66:1997;719-726.
49. Chen J.X., Zheng Y., West M., Tang M.-s. Carcinogens preferentially bind to human cancer mutational hotspots at cytosine methylated CpG sequences. Cancer Res. 58:1998;2070-2075.