Extreme functional sensitivity to conservative amino acid changes on enzyme exteriors

Journal of Molecular Biology

Volumn 301, Issue 3, 2000, Pages 585-595

  Axe, Douglas D ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Exposed residues; Molecular evolution; Neutral theory; Protein homologues; Sequence space

Indexed keywords

BARNASE; BETA LACTAMASE; RIBONUCLEASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; GENE CONSTRUCT; GENE DISRUPTION; GENETIC CONSERVATION; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEUS MIRABILIS; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); MIRABILIS; PROTEUS MIRABILIS;

EID: 0034682868     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3997     Document Type: Article

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