Effects of complementarity determining region mutations on the affinity of an α/β t cell receptor: Measuring the energy associated with CD4/CD8 repertoire skewing

Journal of Experimental Medicine

Volumn 189, Issue 3, 1999, Pages 461-470

  Manning, Thomas C ^a   Parke, Evan A ^a   Teyton, Luc ^b   Kranz, David M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Affinity; CD4 CD8; Complementarity determining region; Peptide major histocompatibility complex; T cell receptor

Indexed keywords

ALANINE; CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIGEN BINDING; ARTICLE; BINDING KINETICS; COMPLEMENTARITY DETERMINING REGION; DOWN REGULATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; THYMOCYTE;

ALANINE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GENE REARRANGEMENT, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; LIGANDS; MODELS, IMMUNOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PROTEIN BINDING; RECEPTORS, ANTIGEN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SERINE; THERMODYNAMICS;

EID: 0033081248     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.3.461     Document Type: Article

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