The final maturation of at least some single-positive CD4(hi) thymocytes does not require T cell receptor-major histocompatibility complex contact

Journal of Experimental Medicine

Volumn 190, Issue 6, 1999, Pages 757-764

  Dyall, Ruben ^a   Nikolić Žugić, Janko ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

CD4 thymocytes; Major histocompatibility complex class II; T cell development; T cell receptor

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CONTROLLED STUDY; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SUPPRESSOR CELL; THYMOCYTE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CELL DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS;

EID: 0344500762     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.6.757     Document Type: Article

References (34)

1. Nikolić-Žugić, J. 1994. Intrathymic T-Cell Development. R.G. Landes Co., Austin, TX. 1-172.
2. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29-47.
3. Aguila, H.L., K. Akashi, J. Domen, K.L. Gandy, E. Lagasse, R.E. Mebius, S.J. Morrison, J. Shizuru, S. Strober, N. Uchida, et al. 1997. From stem cells to lymphocytes: biology and transplantation. Immunol. Rev. 157:13-40.
4. Sprent, J., and S.R. Webb. 1987. Function and specificity of T cell subsets in the mouse. Adv. Immunol. 41:39-133.
5. Scollay, R., E. Butcher, and I. Weissman. 1980. Thymus migration: quantitative studies on the rate of migration of cells from the thymus to the periphery in mice. Eur. J. Immunol. 10:210-218.
6. Scollay, R., A. Wilson, A. D'Amico, K. Kelly, M. Egerton, M. Pearse, L. Wu, and K. Shortman. 1988. Developmental status and reconstitution potential of subpopulations of murine thymocytes. Immunol. Rev. 104:81-120.
7. Gabor, M.J., D.I. Godfrey, and R. Scollay. 1997. Recent thymic emigrants are distinct from most medullary thymocytes. Eur. J. Immunol. 27:2010-2015.
8. Rocha, B., N. Dautigny, and P. Pereira. 1989. Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immunol. 19:905-911.
9. + single-positive thymocytes requires the thymus to produce long-lived, functional T cells. J. Exp. Med. 181:235-245.
10. Ernst, B., C. Surh, and J. Sprent. 1995. Thymic selection and cell division. J. Exp. Med. 182:961-971.
11. Penit, C., and F. Vasseur. 1997. Expansion of mature thymocyte subsets before emigration to the periphery. J. Immunol. 159:4848-4856.
12. Nikolić-Žugić, J., and M.J. Bevan. 1990. Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus. Int. Immunol. 2:135-141.
13. - thymocytes are functionally immature. J. Immunol. 147:1779-1785.
14. Vernachio, J., M. Li, A.D. Donnenberg, and M.J. Soloski. 1989. Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset. J. Immunol. 142:48-56.
15. Lucas, B., F. Vasseur, and C. Penit. 1994. Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153:53-62.
16. Grusby, M.J., R.S. Johnson, V.E. Papaioannou, and L.H. Glimcher. 1991. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science. 253: 1417-1420.
17. Markowitz, J.S., H. Auchincloss, M.J. Grusby, and L.H. Glimcher. 1993. Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice. Proc. Natl. Acad. Sci. USA. 90:2779-2783.
18. Rahemtulla, A., W.P. Fung-Leung, M.W. Schilham, T.M. Kundig, S.R. Sambhara, A. Narendran, A. Arabian, A. Wakeham, C.J. Paige, R.M. Zinkernagel, et al. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 353:180-184.
19. Shen, F.-W. 1981. Monoclonal antibodies to mouse lymphocyte differentiation alloantigens. In Monoclonal Antibodies and T Cell Hybridomas. U.H. Hammerling, editor. Elsevier Science B.V., Amsterdam. 25-31.
20. Goldschneider, I., K.I. Komschlies, and D.L. Greiner. 1986. Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors. J. Exp. Med. 163:1-17.
21. Nikolić-Žugić, J., and M.J. Bevan. 1988. Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection. Proc. Natl. Acad. Sci. USA. 85:8663-8667.
22. Rooke, R., C. Waltzinger, C. Benoist, and D. Mathis. 1997. Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity. 7:123-134.
23. Guidos, C.J., J.S. Danska, C.G. Fathman, and I.L. Weissman. 1990. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J. Exp. Med. 172:835-845.
24. + thymocytes: increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection. J. Exp. Med. 181:193-202.
25. Lucas, B., and R.N. Germain. 1996. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity. 5:461-467.
26. Hare, K.J., E.J. Jenkinson, and G. Anderson. 1999. CD69 expression discriminates MHC-dependent and -independent stages of thymocyte positive selection. J. Immunol. 162:3978-3983.
27. Tanchot, C., F.A. Lemonnier, B. Perarnau, A.A. Freitas, and B. Rocha. 1997. Differential requirements for survival are proliferation of CD8 naive or memory T cells. Science. 276: 2057-2062.
28. Nesic, D., and S. Vukmanovic. 1998. MHC class I is required for peripheral accumulation of CD8+ thymic emigrants. J. Immunol. 160:3705-3712.
29. von Boehmer, H., and K. Hafen. 1993. The life span of naive α/β T cells in secondary lymphoid organs. J. Exp. Med. 177: 891-896.
30. Benoist, C., and D. Mathis. 1997. Selection for survival? Science. 276:2000-2001.
31. Takeda, S., H.-R. Rodewald, J. Arakawa, H. Bluethmann, and T. Shimizu. 1996. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity. 5:217-228.
32. Brocker, T. 1997. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 186:1223-1232.
33. Kirberg, J., A. Berns, and H. von Boehmer. 1997. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186:1269-1275.
34. Viret, C., F.S. Wong, and C.A. Janeway, Jr. 1999. Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity. 10:559-568.