Structure, specificity and CDR mobility of a class II restricted single- chain T-cell receptor

Nature Structural Biology

Volumn 6, Issue 6, 1999, Pages 574-581

  Hare, Brian J ^a   Wyss, Daniel F ^b,c   Osburne, Marcia S ^b,d   Kern, Petra S ^e,f   Reinherz, Ellis L ^e   Wagner, Gerhard ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Procept Inc   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d ARIAD PHARMACEUTICALS INC   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f Eurocor SA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; ARTICLE; COMPLEMENTARITY DETERMINING REGION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SOLUBILITY; THERMODYNAMICS;

EID: 0033017466     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/9359     Document Type: Article

References (11)

1. Meuer, S.C., Acuto, O., Hercend, T., Schlossman, S.F., Reinherz, E.L The human T-cell receptor. Annu. Rev. Immunol. 2, 23-50 (1984).
2. Marrack, P. & Kappler, J. The antigen-specific, major histocompatibility complex-restricted receptor on T cells. Adv. Immunol. 38, 1-30 (1986).
3. Zinkernagel, R.M. & Doherty, P.C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248, 701-702 (1974).
4. Meuer, S.C., Schlossman, S.F. & Reinherz, E.L. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc. Natl. Acad. Sci. USA 79, 4395-4399 (1982).
5. Biddison, W.E. Rao, P.E., Talle, M.A., Goldstein, G. & Shaw, S. Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens. J. Exp. Med. 156, 1065-1076 (1982).
6. Krensky, A.M. Reiss, C.S., Mier, J.W., Strominger, J.L. & Burakoff, S.J. Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. Proc. Natl. Acad. Sci. USA 79, 2365-2369 (1982).
7. Meuer, S.C. et al. Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science 218, 471-473 (1982).
8. Utsunomiya, Y. et al. Analysis of a monoclonal rat antibody directed to the alpha-chain variable region (V alpha 3) of the mouse T cell antigen receptor. J. Immunol. 143, 2602-2608 (1989).
9. Garboczi, D.N. et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384, 134-141 (1996).
10. Garcia, K.C. et al. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279, 1166-1172 (1998).
11. Ding, Y.-H. et al. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8, 403-411 (1998).