메뉴 건너뛰기




Volumn 1, Issue 1, 1997, Pages 47-53

Synthetic strategies in combinatorial chemistry

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC CHEMISTRY; REVIEW;

EID: 0031152053     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1367-5931(97)80107-x     Document Type: Article
Times cited : (58)

References (38)
  • 1
    • 0028243847 scopus 로고
    • Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries
    • Gallop MA, Barrett RW, Dower WJ, Fodor SPA, Gordon EM: Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 1994, 37:1233-1251.
    • (1994) J Med Chem , vol.37 , pp. 1233-1251
    • Gallop, M.A.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.A.4    Gordon, E.M.5
  • 2
    • 0028318863 scopus 로고
    • Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screeening strategies, and future directions
    • Gordon EM, Barrett RW, Dower WJ, Fodor SPA, Gallop MA: Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screeening strategies, and future directions. J Med Chem 1994, 37:1385-1401.
    • (1994) J Med Chem , vol.37 , pp. 1385-1401
    • Gordon, E.M.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.A.4    Gallop, M.A.5
  • 3
    • 0029065615 scopus 로고
    • Combinatorial synthesis - The design of compound libraries and their application to drug discovery
    • Terrett NK, Gardner M, Gordon DW, Kobylecki RJ, Steele J: Combinatorial synthesis - the design of compound libraries and their application to drug discovery. Tetrahedron 1995, 51:8135-8173.
    • (1995) Tetrahedron , vol.51 , pp. 8135-8173
    • Terrett, N.K.1    Gardner, M.2    Gordon, D.W.3    Kobylecki, R.J.4    Steele, J.5
  • 4
    • 0029930278 scopus 로고    scopus 로고
    • Solid-phase organic reactions: A review of the recent literature
    • Hermkens PHH, Ottenheijm HCJ, Rees D: Solid-phase organic reactions: a review of the recent literature. Tetrahedron 1996, 52:4527-4554. A tabular presentation of organic transformations performed on solid-phase which is organized according to reaction class.
    • (1996) Tetrahedron , vol.52 , pp. 4527-4554
    • Hermkens, P.H.H.1    Ottenheijm, H.C.J.2    Rees, D.3
  • 5
    • 33748237769 scopus 로고    scopus 로고
    • Organic chemistry on solid supports
    • Fruchtel JS, Jung G: Organic chemistry on solid supports. Angew Chem Int Ed 1996, 35:17-42. Elaborates on many practical issues of solid-phase organic synthesis, such as resin types, linkers and cleavage schemes.
    • (1996) Angew Chem Int Ed , vol.35 , pp. 17-42
    • Fruchtel, J.S.1    Jung, G.2
  • 6
    • 7044263277 scopus 로고    scopus 로고
    • Synthesis and applications of small molecule libraries
    • Thompson LA, Ellman JA: Synthesis and applications of small molecule libraries. Chem Rev 1996, 96:555-600. An overview of the field by one of the pioneering research groups in combinatorial organic chemistry.
    • (1996) Chem Rev , vol.96 , pp. 555-600
    • Thompson, L.A.1    Ellman, J.A.2
  • 7
    • 2842561522 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of small-molecule libraries
    • Ellman JA: Design, synthesis, and evaluation of small-molecule libraries. Accounts Chem Res 1996, 29:132-143.
    • (1996) Accounts Chem Res , vol.29 , pp. 132-143
    • Ellman, J.A.1
  • 8
    • 0030477258 scopus 로고    scopus 로고
    • Combinatorial synthesis of small organic molecules
    • Balkenhohl F, von dem Bussche-Hynnefeld C, Lansky A, Zechel C: Combinatorial synthesis of small organic molecules. Angew Chem Int Ed 1996, 35:2288-2337. A tour de force compilation of small-molecule libraries, which includes strategic analysis as well as coverage of the patent literature and conference proceedings.
    • (1996) Angew Chem Int Ed , vol.35 , pp. 2288-2337
    • Balkenhohl, F.1    Von Dem Bussche-Hynnefeld, C.2    Lansky, A.3    Zechel, C.4
  • 9
    • 0025911415 scopus 로고
    • The logic of chemical synthesis: Multistep synthesis of complex carbogenic molecules (Nobel lecture)
    • Corey EJ: The logic of chemical synthesis: multistep synthesis of complex carbogenic molecules (Nobel lecture). Angew Chem Int Ed 1991, 30:455-612.
    • (1991) Angew Chem Int Ed , vol.30 , pp. 455-612
    • Corey, E.J.1
  • 10
    • 0000512227 scopus 로고    scopus 로고
    • Multiple component condensation strategies for combinatorial library synthesis
    • Armstrong RW, Combs AP, Tempest PA, Brown SD, Keating TA: Multiple component condensation strategies for combinatorial library synthesis. Accounts Chem Res 1996, 29:123-131. Overview of this important synthetic approach in combinatorial chemistry.
    • (1996) Accounts Chem Res , vol.29 , pp. 123-131
    • Armstrong, R.W.1    Combs, A.P.2    Tempest, P.A.3    Brown, S.D.4    Keating, T.A.5
  • 11
    • 0027068161 scopus 로고
    • A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives
    • Bunin BA, Ellman JA: A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives. J Am Chem Soc 1992, 114:10997-10998.
    • (1992) J am Chem Soc , vol.114 , pp. 10997-10998
    • Bunin, B.A.1    Ellman, J.A.2
  • 13
    • 0028928237 scopus 로고
    • Solid-phase synthesis of structurally diverse 1,4-benzodiazepine derivatives using the Stille coupling reaction
    • Plunkett MJ, Ellman JA: Solid-phase synthesis of structurally diverse 1,4-benzodiazepine derivatives using the Stille coupling reaction. J Am Chem Soc 1995, 117:3306-3307.
    • (1995) J am Chem Soc , vol.117 , pp. 3306-3307
    • Plunkett, M.J.1    Ellman, J.A.2
  • 14
    • 0030064961 scopus 로고    scopus 로고
    • Solid-supported combinatorial synthesis of structurally diverse β-lactams
    • Ruhland B, Bhandari A, Gordon EM, Gallop MA: Solid-supported combinatorial synthesis of structurally diverse β-lactams. J Am Chem Soc 1996, 118:253-254.
    • (1996) J am Chem Soc , vol.118 , pp. 253-254
    • Ruhland, B.1    Bhandari, A.2    Gordon, E.M.3    Gallop, M.A.4
  • 18
    • 0029988589 scopus 로고    scopus 로고
    • Azatides: Solution and liquid phase syntheses of a new peptidomimetic
    • Han H, Janda KD: Azatides: Solution and liquid phase syntheses of a new peptidomimetic. J Am Chem Soc 1996, 118:2539-2544.
    • (1996) J am Chem Soc , vol.118 , pp. 2539-2544
    • Han, H.1    Janda, K.D.2
  • 19
  • 20
    • 0002656809 scopus 로고    scopus 로고
    • Designing chemical libraries for lead discovery
    • Ferguson AM, Patterson DE, Garr CD, Underiner TL: Designing chemical libraries for lead discovery. J Biomol Screen 1996, 1:65-73. Description of informatics-based approaches to the design of optimally diverse libraries.
    • (1996) J Biomol Screen , vol.1 , pp. 65-73
    • Ferguson, A.M.1    Patterson, D.E.2    Garr, C.D.3    Underiner, T.L.4
  • 21
    • 33748235487 scopus 로고
    • A novel procedure for the synthesis of libraries containing small organic molecules
    • Carell T, Wintner EA, Bashir-Hashemi A, Rebek J: A novel procedure for the synthesis of libraries containing small organic molecules. Angew Chem Int Ed 1994, 33:2059-2061.
    • (1994) Angew Chem Int Ed , vol.33 , pp. 2059-2061
    • Carell, T.1    Wintner, E.A.2    Bashir-Hashemi, A.3    Rebek, J.4
  • 22
    • 33748813410 scopus 로고
    • A solution-phase screening procedure for the isolation of active compounds from a library of molecules
    • Carell T, Wintner EA, Rebek J: A solution-phase screening procedure for the isolation of active compounds from a library of molecules. Angew Chem Int Ed 1994, 33:2061-2064.
    • (1994) Angew Chem Int Ed , vol.33 , pp. 2061-2064
    • Carell, T.1    Wintner, E.A.2    Rebek, J.3
  • 23
    • 0029987185 scopus 로고    scopus 로고
    • Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries
    • Boger DL, Tarby CM, Myers PL, Caporale LH: Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries. J Am Chem Soc 1996, 118:2109-2110. Example similar to [21,22] of a library built around a novel, nonpharmacophoric template.
    • (1996) J am Chem Soc , vol.118 , pp. 2109-2110
    • Boger, D.L.1    Tarby, C.M.2    Myers, P.L.3    Caporale, L.H.4
  • 24
    • 0029926720 scopus 로고    scopus 로고
    • Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
    • Cheng S, Comer DD, Williams JP, Meyers PL, Boger DL: Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules. J Am Chem Soc 1996, 118:2567-2573. Example similar to [21,22] of a library built around a novel, nonpharmacophoric template.
    • (1996) J am Chem Soc , vol.118 , pp. 2567-2573
    • Cheng, S.1    Comer, D.D.2    Williams, J.P.3    Meyers, P.L.4    Boger, D.L.5
  • 25
    • 0030072662 scopus 로고
    • Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid
    • Dankwardt SM, Phan TM, Krstenansky JL: Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid. Mol Divers 1995, 1:113-120.
    • (1995) Mol Divers , vol.1 , pp. 113-120
    • Dankwardt, S.M.1    Phan, T.M.2    Krstenansky, J.L.3
  • 26
    • 3743084024 scopus 로고
    • 'Analogous' organic synthesis of small-compound libraries: Validation of combinatorial chemistry in small-molecule synthesis
    • Chen C, Ahlberg Randall LA, Miller RB, Jones AD, Kurth MJ: 'Analogous' organic synthesis of small-compound libraries: validation of combinatorial chemistry in small-molecule synthesis. J Am Chem Soc 1994, 116:2661-2662.
    • (1994) J am Chem Soc , vol.116 , pp. 2661-2662
    • Chen, C.1    Ahlberg Randall, L.A.2    Miller, R.B.3    Jones, A.D.4    Kurth, M.J.5
  • 27
    • 0029142607 scopus 로고
    • Solid-phase synthesis of highly substituted peptoid 1(2H)-isoquinolines
    • Goff DA, Zuckermann RN: Solid-phase synthesis of highly substituted peptoid 1(2H)-isoquinolines. J Org Chem 1995, 60:5748-5749.
    • (1995) J Org Chem , vol.60 , pp. 5748-5749
    • Goff, D.A.1    Zuckermann, R.N.2
  • 28
    • 33748220036 scopus 로고    scopus 로고
    • Solid-phase, parallel synthesis by ugi multicomponent condensation
    • Tempest PA, Brown SD, Armstrong RW: Solid-phase, parallel synthesis by ugi multicomponent condensation. Angew Chem Int Ed 1996, 35:640-642.
    • (1996) Angew Chem int Ed , vol.35 , pp. 640-642
    • Tempest, P.A.1    Brown, S.D.2    Armstrong, R.W.3
  • 29
    • 0028827034 scopus 로고
    • A solid phase protocol of the Biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry
    • Wipf P, Cunningham A: A solid phase protocol of the Biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry. Tetrahedron Lett 1995, 36:7819-7822.
    • (1995) Tetrahedron Lett , vol.36 , pp. 7819-7822
    • Wipf, P.1    Cunningham, A.2
  • 30
    • 0001363457 scopus 로고
    • Molecular diversity via a convertible isocyanide in the Ugi four-component condensation
    • Keating TA, Armstrong RW: Molecular diversity via a convertible isocyanide in the Ugi four-component condensation. J Am Chem Soc 1995, 117:7842-7843.
    • (1995) J am Chem Soc , vol.117 , pp. 7842-7843
    • Keating, T.A.1    Armstrong, R.W.2
  • 31
    • 0030443529 scopus 로고    scopus 로고
    • A remarkable two-step synthesis of diverse 1,4-benzodia2epine-2,5-dlones using the Ugi four-component condensation
    • Keating TA, Armstrong RW: A remarkable two-step synthesis of diverse 1,4-benzodia2epine-2,5-dlones using the Ugi four-component condensation. J Org Chem 1996, 61:8935-8939. Example of a short reaction sequence capable of enormous diversity.
    • (1996) J Org Chem , vol.61 , pp. 8935-8939
    • Keating, T.A.1    Armstrong, R.W.2
  • 33
    • 84955066834 scopus 로고
    • Solid phase synthesis of bicyclo[2.2.2]octane derivatives via tandem Michael addition reactions and subsequent reductive amination
    • Ley SV, Mynett DM, Koot WJ: Solid phase synthesis of bicyclo[2.2.2]octane derivatives via tandem Michael addition reactions and subsequent reductive amination. Synlett 1995, 1017-1020. One of the few examples of library synthesis involving construction of complex carbocyclic molecules.
    • (1995) Synlett , pp. 1017-1020
    • Ley, S.V.1    Mynett, D.M.2    Koot, W.J.3
  • 34
    • 0029042575 scopus 로고
    • Combinatorial organic synthesis of highly functionalized pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library
    • Murphy MM, Schullek JR, Gordon EM, Gallop MA: Combinatorial organic synthesis of highly functionalized pyrrolidines: identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library. J Am Chem Soc 1995, 117:7029-7030.
    • (1995) J am Chem Soc , vol.117 , pp. 7029-7030
    • Murphy, M.M.1    Schullek, J.R.2    Gordon, E.M.3    Gallop, M.A.4
  • 35
    • 0028873745 scopus 로고
    • Design of novel, nonpeptidic thrombin inhibitors and structure of a thrombin-inhibitor complex
    • Obst U, Gramlich V, Diederich F, Weber L: Design of novel, nonpeptidic thrombin inhibitors and structure of a thrombin-inhibitor complex. Angew Chem Int Ed 1995, 34:1739-1742. A structure-based design effort that led to a nonpharmacophoric core, anticipating the concept of the prospecting library.
    • (1995) Angew Chem Int Ed , vol.34 , pp. 1739-1742
    • Obst, U.1    Gramlich, V.2    Diederich, F.3    Weber, L.4
  • 36
    • 0000770773 scopus 로고    scopus 로고
    • Synthesis of 2-azatricyclo[5.2.1.04,10]decanes and 2,5-diazatricyclo[5.2.1.04,10] decanes by intramolecular azomethine ylide cycloadditions
    • Overman LE, Tellew JE: Synthesis of 2-azatricyclo[5.2.1.04,10]decanes and 2,5-diazatricyclo[5.2.1.04,10] decanes by intramolecular azomethine ylide cycloadditions. J Org Chem 1996, 61:8338-8340. A solution-phase example employing the azomethine ylide cycloaddition to formulate complex products.
    • (1996) J Org Chem , vol.61 , pp. 8338-8340
    • Overman, L.E.1    Tellew, J.E.2
  • 37
    • 0031549105 scopus 로고    scopus 로고
    • Synthetic design for combinatorial chemistry. Solution and polymersupported synthesis of polycyclcic lactams by intramolecular cyclization of azomethine ylides
    • Marx MA, Grillot AL, Louer CT, Beaver KA, Bartlett PA: Synthetic design for combinatorial chemistry. Solution and polymersupported synthesis of polycyclcic lactams by intramolecular cyclization of azomethine ylides. J Am Chem Soc 1997, in press. Development of solution-phase and solid-phase applications of intramolecular azomethine ylide cycloadditions to generate novel ring systems appropriate for prospecting libraries.
    • (1997) J am Chem Soc
    • Marx, M.A.1    Grillot, A.L.2    Louer, C.T.3    Beaver, K.A.4    Bartlett, P.A.5
  • 38
    • 7044235263 scopus 로고    scopus 로고
    • Domino reactions in organic synthesis
    • Tietze LF: Domino reactions in organic synthesis. Chem Rev 1996, 96:115-136.
    • (1996) Chem Rev , vol.96 , pp. 115-136
    • Tietze, L.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.