Differential kinetics of [123I]β-CIT binding to dopamine and serotonin transporters

European Journal of Nuclear Medicine

Volumn 23, Issue 4, 1996, Pages 431-436

  Fujita, Masahiro ^a,d   Takatoku, Keizo ^b   Matoba, Yoshinori ^b   Nishiura, Masaru ^b   Kobayashi, Kaoru ^c   Inoue, Osamu ^a   Nishimura, Tsunehiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b Daiichi Radioisot Labs Ltd   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3 (4 iodophenyl)tropane 2 carboxylic acid; Dopamine transporter; Serotonin transporter; Single photon emission tomography

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CARRIER PROTEIN; COCAINE; DIAGNOSTIC AGENT; DOPAMINE TRANSPORTER; DRUG DERIVATIVE; MEMBRANE PROTEIN; NERVE PROTEIN; RADIOACTIVE IODINE; SEROTONIN; SEROTONIN TRANSPORTER; SLC6A3 PROTEIN, RAT; SLC6A4 PROTEIN, RAT; CARBOXYLIC ACID; DOPAMINE; IODINE 123; LIGAND;

ANIMAL; ARTICLE; BRAIN LEVEL; KINETICS; MALE; METABOLISM; RAT; TISSUE DISTRIBUTION; ANIMAL TISSUE; BINDING KINETICS; CEREBELLUM; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; HYPOTHALAMUS; NONHUMAN; OCCIPITAL CORTEX; SEROTONINERGIC SYSTEM; TRANSPORT KINETICS;

ANIMALS; BRAIN CHEMISTRY; CARRIER PROTEINS; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; IODINE RADIOISOTOPES; KINETICS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE DISTRIBUTION;

EID: 0029664493     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01247372     Document Type: Article

References (37)

1. Perry EK, Marshall EF, Blessed G, Tomlinson BE, Perry RH. Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry 1983; 142: 188-192.
2. Crow TJ, Cross AJ, Cooper SJ, Deakin JFW, Ferrier IN, Johnson JA, Joseph MH, Owen F, Poulter M, Lofthouse R, Corsellis JAN, Chambers DR, Blessed G, Perry EK, Perry EH. Neurotransmitter receptors and monoamine metabolites in the patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 1984; 23: 1561-1569.
3. 3H-cathecolamine uptake by rat brain synaptosomes. Life Sci 1977; 21:1117-1122.
4. Kilty JE, Lorang D, Amara SG. Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 1991; 254: 578-579.
5. Shimada S, Kitayama S, Lin CL, Patel A, Nanthakumar E, Gregor P, Kuhar M, Uhl G. Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 1991; 254: 576-578.
6. Blakely RD, Berson HE, Fremeau RJ, Caron MG, Peek MM, Prince HK, Bradley CC. Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991; 354: 66-70.
7. Hoffman BJ, Mezey E, Brownstein MJ. Cloning of a serotonin transporter affected by antidepressants. Science 1991; 254: 579-580.
8. Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 1991; 350: 350-354.
9. Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, Macgregor RR, Hitzemann R, Logan J, Bendriem B, Galley SJ, Christman D. Mapping cocaine binding sites in human and baboon brain in vivo. Synapse 1989; 4: 371-377.
10. 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol 1993; 34: 423-431.
11. Innis RB, Seibyl JP, Scanley BE, Laruelle M, Abi-Dargham A, Wallace E, Baldwin RM, Zea PY, Zoghbi S, Wang S, Gao Y, Neumeyer JL, Charney DS, Hoffer PB, Marek KL. Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. Proc Natl Acad Sci USA 1993; 90: 11965-11969.
12. Kuikka JT, Bergstrom KA, Vanninen E, Laulumaa V, Hartikainen P, Lansimies E. Initial experience with single-photon emission tomography using iodine-123-labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane in human brain. Eur J Nucl Med 1993;20:783-786.
13. Neumeyer JL, Wang S, Gao Y, Milius RA, Kula NS, Campbell A, Baldessarini RJ, Zea PY, Baldwin RM, Innis RB. N-Omega-fluoroalkyl analogs of (1R)-2β-carbomethoxy-3β-(4-iodophenyl)-tropane (β-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters. J Med Chem 1994; 37: 1558-1561.
14. 123I]N-ω-fluoroalkyl-2β-carboxy-3β-(4-iodophenyl) nortropane esters in baboons. Nucl Med Biol 1995; 22: 211-219.
15. Kuikka JT, Akerman K, Bergstrom KA, Karhu J, Hiltunen J, Haukka J, Heikkinen J, Tiihonen J, Wang S, Neumeyer JL. Iodine-123 labelled N-(2-fluoroethyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain. Eur J Nucl Med 1995; 22: 682-686.
16. 123I]β-CIT. Binding kinetics in the human brain. J Neural Transm Gen Sect 1993; 94: 137-146.
17. 123I]β-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse 1993; 13: 295-309.
18. Kuikka JT, Tiihonen J, Bergstrom KA, Karhu J, Hartikainen P, Viinamuki H, Lansimies E, Lehtonen J, Hakola P. Imaging of serotonin and dopamine transporters in the living human brain. Eur J Nucl Med 1995; 22: 346-350.
19. Kuikka JT, Tiihonen J, Bergstrom KA, Karhu J, Viinamaki H, Lehtonen J, Hakola P, Lansimies E. Altered serotonin and dopamine transporter densities associated with impulse violent behaviour. J Nucl Med 1995; Suppl 36: 31P.
20. Marquardt DW. An algorithm for least square estimation of non-linear parameters. J Soc Indust Appl Math 1963; 11: 431-441.
21. Mintun MA, Raichle ME, Kilbourn MR, Woolen GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15: 217-227.
22. 125I]RTI-55 to dopamine and serotonin transporters in rat brain. Synapse 1992; 12: 27-36.
23. 125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain. J Neurochem 1993; 61: 1996-2006.
24. 125I]RTI-55. J Chem Neuroanat 1994; 7: 13-23.
25. 125I]RTI-55: in vitro binding and autoradiographic characterization. J Neurochem 1994; 62: 549-556.
26. 125I]RTI-55, an in vivo label for the serotonin transporter. Synapse 1992; 11: 134-139.
27. 3H-paroxetine binding sites in rat brain. J Pharmacol Toxicol Methods 1992; 27: 209-216.
28. Suhara T, Fukuda H, Inoue O, Itoh T, Suzuki K, Yamasaki T, Tateno Y. Age-related changes in human D, dopamine receptors measured by positron emission tomography. Psychopharmacology 1991; 103: 41-45.
29. Wong DF, Gjedde A, Wagner HN Jr. Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands. J Cereb Blood Flow Metab 1986; 6: 137-146.
30. 11C]-carfentanil binding to opiate receptors in humans measured by positron emission tomography. J Cereb Blood Flow Metab 1989; 9: 398-409.
31. 3H]SCH 23390 in vivo. Neuropharmacology 1992; 31: 115-121.
32. 3H]SCH 23390 induced by MK-801 the mouse striatum. Neuropharmacology 1993; 32: 341-348.
33. Friedman E, Fung F, Gershon S. Antidepressant drugs and dopamine uptake in different brain regions. Eur J Pharmacol 1977; 42: 47-51.
34. Kinnier WJ, Tabor RD, Norrell LY. Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake. Biochem Pharmacol 1984; 33: 3001-3005.
35. 123I]β-CIT binding to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab 1994; 14: 982-994.
36. Waelbroeck M, Tastenoy M, Camus J, Christophe J. Binding kinetics of quinuclidinyl benzilate and methyl-quinuclidinyl benzilate enantiomers at neuronal (M1), cardiac (M2), and pancreatic (M3) muscarinic receptors. Mol Pharmacol 1991; 40: 413-420.
37. 3H]-methylscopolamine afford differential labelling and localization of M1, M2, and M3 muscarinic receptor subtypes in primate brain. Synapse 1993; 14: 283-296.