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Volumn 44, Issue 7, 1998, Pages 534-549

Imaging of the serotonergic system: Interactions of neuroanatomical and functional abnormalities of depression

Author keywords

Depression; Positron emission tomography; Serotonin receptors; Serotonin transporter; Single photon emission computed tomography; Tryptophan hydroxylase

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (2 FLUOROETHYL)SPIPERONE; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; FANANSERIN; FENFLURAMINE; FLUOROETHYLKETANSERIN; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; R 91150; R 93274; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SETOPERONE; TRACER; TRYPTOPHAN HYDROXYLASE; UNCLASSIFIED DRUG;

EID: 0032191771     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00185-1     Document Type: Review
Times cited : (123)

References (145)
  • 1
    • 0024471994 scopus 로고
    • 3H-Imipramine binding in the frontal cortex of suicides
    • 3H-Imipramine binding in the frontal cortex of suicides. Psychiatry Res 30:125-135.
    • (1989) Psychiatry Res , vol.30 , pp. 125-135
    • Arora, R.1    Meltzer, H.2
  • 2
    • 0024380268 scopus 로고
    • Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects
    • Arora R, Meltzer H (1989b): Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. Am J Psychiatry 146: 730-736.
    • (1989) Am J Psychiatry , vol.146 , pp. 730-736
    • Arora, R.1    Meltzer, H.2
  • 3
    • 0025922137 scopus 로고
    • 3H-imipramine binding" studies in the frontal cortex of normal controls and suicide victims
    • 3H-imipramine binding" studies in the frontal cortex of normal controls and suicide victims. Biol Psychiatry 29:1016-1022.
    • (1991) Biol Psychiatry , vol.29 , pp. 1016-1022
    • Arora, R.1    Meltzer, H.2
  • 4
    • 0017296144 scopus 로고
    • "Serotonin depression" - A biochemical subgroup within the affective disorders
    • Asberg M, Thoren P, Traskman L, Bertilsson L, Ringberger V (1976): "Serotonin depression" - A biochemical subgroup within the affective disorders. Science 191:478-480.
    • (1976) Science , vol.191 , pp. 478-480
    • Asberg, M.1    Thoren, P.2    Traskman, L.3    Bertilsson, L.4    Ringberger, V.5
  • 5
    • 0027335570 scopus 로고
    • Hypercortisolemia and hippocampal changes in depression
    • Axelson D, Doraiswamy P, McDonald W, et al (1993): Hypercortisolemia and hippocampal changes in depression. Psychiatry Res 47:163-173.
    • (1993) Psychiatry Res , vol.47 , pp. 163-173
    • Axelson, D.1    Doraiswamy, P.2    McDonald, W.3
  • 6
    • 0026320767 scopus 로고
    • Awakening the sleeping giant: Anatomy and plasticity of the brain serotonergic system
    • Azmitia E, Whitaker-Azmitia P (1991): Awakening the sleeping giant: Anatomy and plasticity of the brain serotonergic system. J Clin Psychiatry 52(suppl 12):4-16.
    • (1991) J Clin Psychiatry , vol.52 , Issue.SUPPL. 12 , pp. 4-16
    • Azmitia, E.1    Whitaker-Azmitia, P.2
  • 8
    • 0021815444 scopus 로고
    • Cerebral metabolic rates for glucose in mood disorders, studied with positron emission tomography (PET) and (F-18)-fluro-2-deoxyglucose (FDG)
    • Baxter L, Phelps M, Mazziottas J, et al (1985): Cerebral metabolic rates for glucose in mood disorders, studied with positron emission tomography (PET) and (F-18)-fluro-2-deoxyglucose (FDG). Arch Gen Psychiatry 42:441-447.
    • (1985) Arch Gen Psychiatry , vol.42 , pp. 441-447
    • Baxter, L.1    Phelps, M.2    Mazziottas, J.3
  • 9
    • 0024508732 scopus 로고
    • Reduction of prefrontal cortex glucose metabolism common to three types of depression
    • Baxter L, Schwartz J, Phelps M, et al (1989): Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry 46:243-250.
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 243-250
    • Baxter, L.1    Schwartz, J.2    Phelps, M.3
  • 10
    • 0026640757 scopus 로고
    • The anatomy of melancholia: Focal abnormalities of cerebral blood flow in major depression
    • Bench C, Fristen K, Brown R, Scott L, Frackowiak R, Dolan R (1992): The anatomy of melancholia: Focal abnormalities of cerebral blood flow in major depression. Psychol Med 22: 607-615.
    • (1992) Psychol Med , vol.22 , pp. 607-615
    • Bench, C.1    Fristen, K.2    Brown, R.3    Scott, L.4    Frackowiak, R.5    Dolan, R.6
  • 11
    • 0027326614 scopus 로고
    • Regional cerebral blood flow in depression measured by positron emission tomography: The relationship with clinical dimensions
    • Bench C, Friston K, Brown R, Frackowiak R, Dolan R (1993): Regional cerebral blood flow in depression measured by positron emission tomography: The relationship with clinical dimensions. Psychol Med 23:579-590.
    • (1993) Psychol Med , vol.23 , pp. 579-590
    • Bench, C.1    Friston, K.2    Brown, R.3    Frackowiak, R.4    Dolan, R.5
  • 12
    • 0030764452 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of nor-β-CIT: A potential radioligand for visualization of the serotonin transporter in the brain
    • Bergstrom K, Halldin C, Hall H, et al (1997): In vitro and in vivo characterization of nor-β-CIT: A potential radioligand for visualization of the serotonin transporter in the brain. Eur J Nucl Med 24:596-601.
    • (1997) Eur J Nucl Med , vol.24 , pp. 596-601
    • Bergstrom, K.1    Halldin, C.2    Hall, H.3
  • 13
    • 0030003744 scopus 로고    scopus 로고
    • 18F]RP62203: A selection 5-HT2A receptor radioligand for positron emission tomography
    • 18F]RP62203: A selection 5-HT2A receptor radioligand for positron emission tomography. Nucl Med Biol 23:169-171.
    • (1996) Nucl Med Biol , vol.23 , pp. 169-171
    • Besret, L.1    Dauphin, F.2    Huard, C.3
  • 14
    • 0030852548 scopus 로고
    • Dexfenfluramine hydrochloride: An anorexigenic agent
    • Bever K, Perry P (1976): Dexfenfluramine hydrochloride: An anorexigenic agent. Am J Health Syst Pharm 54:2059-2072.
    • (1976) Am J Health Syst Pharm , vol.54 , pp. 2059-2072
    • Bever, K.1    Perry, P.2
  • 15
    • 0028070883 scopus 로고
    • 2 receptors in humans using positron emission tomography
    • 2 receptors in humans using positron emission tomography. Eur J Nucl Med 21:937-946.
    • (1994) Eur J Nucl Med , vol.21 , pp. 937-946
    • Biver, F.1    Goldman, S.2    Luxen, A.3
  • 17
    • 0023820533 scopus 로고
    • 18F]setoperone: A new high-affinity ligand for positron emission tomography study of the serotonin-2 receptors in baboon brain in vivo
    • 18F]Setoperone: A new high-affinity ligand for positron emission tomography study of the serotonin-2 receptors in baboon brain in vivo. Eur J Pharmacol 147:73-82.
    • (1988) Eur J Pharmacol , vol.147 , pp. 73-82
    • Blin, J.1    Pappata, S.2    Kiyosawa, M.3    Crouzel, C.4    Baron, J.5
  • 19
    • 0026802919 scopus 로고
    • 125I]RTI-55 to dopamine and serotonin transporters in rat brain
    • 125I]RTI-55 to dopamine and serotonin transporters in rat brain. Synapse 12:27-36.
    • (1992) Synapse , vol.12 , pp. 27-36
    • Boja, J.1    Mitchell, W.2    Patel, A.3
  • 21
    • 0010316316 scopus 로고    scopus 로고
    • Serotonin and its receptors
    • Welch KMA, editor. New York: Academic Press
    • Bonvento G, MacKenzie E (1997): Serotonin and its receptors. In: Welch KMA, editor. Primer on Cerebrovascular Diseases. New York: Academic Press, pp 80-82.
    • (1997) Primer on Cerebrovascular Diseases , pp. 80-82
    • Bonvento, G.1    MacKenzie, E.2
  • 22
    • 0024408834 scopus 로고
    • Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of late life
    • Bowen D, Najlerahim A, Procter A, Francis P, Murphy E (1989): Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of late life. Proc Natl Acad Sci USA 86:9504-9508.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9504-9508
    • Bowen, D.1    Najlerahim, A.2    Procter, A.3    Francis, P.4    Murphy, E.5
  • 23
    • 0030944433 scopus 로고    scopus 로고
    • Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse
    • Bremner D, Innis R, Salomon R, et al (1997): Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Arch Gen Psychiatry 54:364-373.
    • (1997) Arch Gen Psychiatry , vol.54 , pp. 364-373
    • Bremner, D.1    Innis, R.2    Salomon, R.3
  • 24
    • 0019310944 scopus 로고
    • Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients
    • Briley M, Langer S, Raisman R, Sechter S, Zarifian E (1980): Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209:303-305.
    • (1980) Science , vol.209 , pp. 303-305
    • Briley, M.1    Langer, S.2    Raisman, R.3    Sechter, S.4    Zarifian, E.5
  • 25
    • 0022477071 scopus 로고
    • Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with F2-deoxyglucose in affective illness
    • Buchsbaum M, Wu J, DeLisi L, et al (1986): Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with F2-deoxyglucose in affective illness. J Affect Disorder 10:137-152.
    • (1986) J Affect Disorder , vol.10 , pp. 137-152
    • Buchsbaum, M.1    Wu, J.2    DeLisi, L.3
  • 26
    • 0029774787 scopus 로고    scopus 로고
    • Radioligands for brain 5-HT2 receptor imaging in vivo: Why do we need them?
    • Busatto G (1996): Radioligands for brain 5-HT2 receptor imaging in vivo: Why do we need them? Eur J Nucl Med 23:867-870.
    • (1996) Eur J Nucl Med , vol.23 , pp. 867-870
    • Busatto, G.1
  • 27
    • 0030614316 scopus 로고    scopus 로고
    • Initial evaluation of 123i-5-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects
    • Busatto G, Pilowsky L, Costa D, et al (1997): Initial evaluation of 123I-5-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects. Eur J Nuc Med 24:119-124.
    • (1997) Eur J Nuc Med , vol.24 , pp. 119-124
    • Busatto, G.1    Pilowsky, L.2    Costa, D.3
  • 28
    • 0023819531 scopus 로고
    • Brain 5-HT2 receptor binding sites in depressed suicide victims
    • Cheetham S, Crompton M, Katona C, Horton R (1988): Brain 5-HT2 receptor binding sites in depressed suicide victims. Brain Res 443:272-280.
    • (1988) Brain Res , vol.443 , pp. 272-280
    • Cheetham, S.1    Crompton, M.2    Katona, C.3    Horton, R.4
  • 30
    • 0027395531 scopus 로고
    • Quantitative cerebral anatomy of depression: A controlled magnetic resonance imaging study
    • Coffey C, Wilkinson W, Weiner R, et al (1993): Quantitative cerebral anatomy of depression: A controlled magnetic resonance imaging study. Arch Gen Psychiatry 50:7-16.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 7-16
    • Coffey, C.1    Wilkinson, W.2    Weiner, R.3
  • 31
    • 0030320649 scopus 로고    scopus 로고
    • A novel functional polymorphism within the promoter of the serotonin transporter gene: Possible role in susceptibility to affective disorders
    • Collier D, Stober G, Li T, et al (1996): A novel functional polymorphism within the promoter of the serotonin transporter gene: Possible role in susceptibility to affective disorders. Mol Psychiatry 1;453-460.
    • (1996) Mol Psychiatry , vol.1 , pp. 453-460
    • Collier, D.1    Stober, G.2    Li, T.3
  • 33
    • 0028031254 scopus 로고
    • Fluoxetine effects on cerebral glucose metabolism
    • Cook E, Metz J, Leventhal B, et al (1994): Fluoxetine effects on cerebral glucose metabolism. Neuroreport 5:1745-1458.
    • (1994) Neuroreport , vol.5 , pp. 1745-11458
    • Cook, E.1    Metz, J.2    Leventhal, B.3
  • 35
    • 0001941221 scopus 로고
    • Post-mortem neurochemical findings in suicide victims and depression: A study of the serotonergic system and imipramine binding in suicide victims
    • Deakin J, editor. London: Gaskell Press
    • Cooper S, Owen F, Chambers D, Crow T, Johnston J, Poulter M (1986): Post-mortem neurochemical findings in suicide victims and depression: A study of the serotonergic system and imipramine binding in suicide victims. In: Deakin J, editor. The Biology of Depression. London: Gaskell Press, pp 53-71.
    • (1986) The Biology of Depression , pp. 53-71
    • Cooper, S.1    Owen, F.2    Chambers, D.3    Crow, T.4    Johnston, J.5    Poulter, M.6
  • 36
    • 0025899924 scopus 로고
    • Serotonin receptor subtypes: Implications for psychopharmacology
    • Cowen P (1991): Serotonin receptor subtypes: Implications for psychopharmacology. Br J Psychiatry 159(suppl 12):7-14.
    • (1991) Br J Psychiatry , vol.159 , Issue.SUPPL. 12 , pp. 7-14
    • Cowen, P.1
  • 37
    • 0021699781 scopus 로고
    • Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides
    • Crow T, Cross A, Cooper S, et al (1984): Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23:1561-1569.
    • (1984) Neuropharmacology , vol.23 , pp. 1561-1569
    • Crow, T.1    Cross, A.2    Cooper, S.3
  • 38
    • 0023952199 scopus 로고
    • Ketanserin binds to the monoamine transporter of chromaffin granules and of synaptic vesicles
    • Darchen F, Scherman D, Ladyrib P, Henry J (1988): Ketanserin binds to the monoamine transporter of chromaffin granules and of synaptic vesicles. Mol Pharmacol 33:672-677.
    • (1988) Mol Pharmacol , vol.33 , pp. 672-677
    • Darchen, F.1    Scherman, D.2    Ladyrib, P.3    Henry, J.4
  • 39
    • 0025318311 scopus 로고
    • Serotonin function and the mechanism of antidepressant action. Reversal of anti-depressant induced remission by rapid depletion of plasma tryptophan
    • Delgado P, Charney D, Price L, Aghajanian G, Andes H, Heninger G (1990): Serotonin function and the mechanism of antidepressant action. Reversal of anti-depressant induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47:411-418.
    • (1990) Arch Gen Psychiatry , vol.47 , pp. 411-418
    • Delgado, P.1    Charney, D.2    Price, L.3    Aghajanian, G.4    Andes, H.5    Heninger, G.6
  • 40
    • 0028847715 scopus 로고
    • Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis
    • Dewey S, Smith G, Logan J, et al (1995): Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis. J Neurosci 15:821-829.
    • (1995) J Neurosci , vol.15 , pp. 821-829
    • Dewey, S.1    Smith, G.2    Logan, J.3
  • 42
    • 0025057318 scopus 로고
    • A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model
    • Diksic M, Nagahiro S, Sourkes T, Yamamoto Y (1990): A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J Cereb Blood Flow Metab 10:1-12.
    • (1990) J Cereb Blood Flow Metab , vol.10 , pp. 1-12
    • Diksic, M.1    Nagahiro, S.2    Sourkes, T.3    Yamamoto, Y.4
  • 43
    • 0026067573 scopus 로고
    • Serotonin synthesis rate measured in living dog brain by positron emission tomography
    • Diksic M, Nagahiro S, Chaly T, Sourkes T, Yamamoto Y, Feindel W (1991): Serotonin synthesis rate measured in living dog brain by positron emission tomography. J Neurochem 56:153-162.
    • (1991) J Neurochem , vol.56 , pp. 153-162
    • Diksic, M.1    Nagahiro, S.2    Chaly, T.3    Sourkes, T.4    Yamamoto, Y.5    Feindel, W.6
  • 45
    • 0031969731 scopus 로고    scopus 로고
    • Functional neuroimaging studies of depression: The anatomy of melancholia
    • Drevets W (1998): Functional neuroimaging studies of depression: The anatomy of melancholia. Annu Rev Med 49:331-361.
    • (1998) Annu Rev Med , vol.49 , pp. 331-361
    • Drevets, W.1
  • 46
    • 0026490305 scopus 로고
    • Neuroanatomical circuits in depression: Implications for treatment mechanisms
    • Drevets W, Raichle M (1992a): Neuroanatomical circuits in depression: Implications for treatment mechanisms. Psychopharmacol Bull 128:261-274.
    • (1992) Psychopharmacol Bull , vol.128 , pp. 261-274
    • Drevets, W.1    Raichle, M.2
  • 48
    • 0030935403 scopus 로고    scopus 로고
    • Subgenual prefrontal cortex abnormalities in mood disorders
    • Drevets W, Price J, Simpson J, et al (1997): Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386;824-827.
    • (1997) Nature , vol.386 , pp. 824-827
    • Drevets, W.1    Price, J.2    Simpson, J.3
  • 49
    • 0003103296 scopus 로고
    • Peripheral markers in affective disorders
    • Horton R, Katona C, editors. London: Academic Press
    • Elliott J (1991): Peripheral markers in affective disorders. In: Horton R, Katona C, editors. Biological Aspects of Affective Disorders, London: Academic Press, pp 95-144.
    • (1991) Biological Aspects of Affective Disorders , pp. 95-144
    • Elliott, J.1
  • 50
    • 0027958881 scopus 로고
    • Is platelet imipramine binding reduced in depression? A meta analysis
    • Ellis P, Salmond C (1994): Is platelet imipramine binding reduced in depression? A meta analysis. Biol Psychiatry 36:292-299.
    • (1994) Biol Psychiatry , vol.36 , pp. 292-299
    • Ellis, P.1    Salmond, C.2
  • 52
    • 0020644982 scopus 로고
    • Sleep suppressant action of fenfluramine in rats. I. Relation to postsynaptic serotonergic stimulation
    • Fornal C, Radulavacki M (1983): Sleep suppressant action of fenfluramine in rats. I. Relation to postsynaptic serotonergic stimulation. J Pharmacol Exp Ther 225:667-674.
    • (1983) J Pharmacol Exp Ther , vol.225 , pp. 667-674
    • Fornal, C.1    Radulavacki, M.2
  • 54
    • 0025581904 scopus 로고
    • Imaging the serotonergic system by positron emission tomography
    • Frost J (1990): Imaging the serotonergic system by positron emission tomography. Ann NY Acad Sci 600:273-280.
    • (1990) Ann NY Acad Sci , vol.600 , pp. 273-280
    • Frost, J.1
  • 55
    • 0022604786 scopus 로고
    • Biochemical pharmacology of the serotonin system
    • Fuller R (1986): Biochemical pharmacology of the serotonin system. Adv Neurol 43:469-480.
    • (1986) Adv Neurol , vol.43 , pp. 469-480
    • Fuller, R.1
  • 57
  • 58
    • 0028593855 scopus 로고
    • Prefrontal cortex dysfunction in clinical depression
    • George M, Ketter T, Post R (1994): Prefrontal cortex dysfunction in clinical depression. Depression 2:59-72.
    • (1994) Depression , vol.2 , pp. 59-72
    • George, M.1    Ketter, T.2    Post, R.3
  • 59
    • 0345108066 scopus 로고    scopus 로고
    • 11C]WAY-100635, in monkey and human plasma by HPLC: Comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET
    • 11C]WAY-100635, in monkey and human plasma by HPLC: Comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET. Nucl Med Biol 23:627-634.
    • (1996) Nucl Med Biol , vol.23 , pp. 627-634
    • Ginovart, N.1    Luthra, S.2    Bench, C.3
  • 60
    • 0030296740 scopus 로고    scopus 로고
    • The effects of age, gender, and season on serotonergic function in healthy subjects
    • Golden R, Gilmore J, Ekdsstrom R, et al (1996): The effects of age, gender, and season on serotonergic function in healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry 20: 1315-1323.
    • (1996) Prog Neuropsychopharmacol Biol Psychiatry , vol.20 , pp. 1315-1323
    • Golden, R.1    Gilmore, J.2    Ekdsstrom, R.3
  • 61
    • 0027145083 scopus 로고
    • 99mTC-exametazine with single photon emission tomography in major depression before and after treatment
    • 99mTC-exametazine with single photon emission tomography in major depression before and after treatment. J Affect Disord 29:243-253.
    • (1993) J Affect Disord , vol.29 , pp. 243-253
    • Goodwin, G.1    Austin, M.2    Dougall, N.3
  • 62
    • 0024556444 scopus 로고
    • Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: Effects of suicide
    • Gross-Isseroff R, Israeli M, Biegon A (1989): Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: Effects of suicide. Arch Gen Psychiatry 46: 237-241.
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 237-241
    • Gross-Isseroff, R.1    Israeli, M.2    Biegon, A.3
  • 65
    • 0026705830 scopus 로고
    • The neurochemistry of depression: Evidence derived from studies of post-mortem brain tissue
    • Horton R (1992): The neurochemistry of depression: Evidence derived from studies of post-mortem brain tissue. Mol Aspects Med 13:191-203.
    • (1992) Mol Aspects Med , vol.13 , pp. 191-203
    • Horton, R.1
  • 66
    • 44949283567 scopus 로고
    • Citalopram: Labelling with carbon-11 and evaluation in rats as a potential radioligand for in vivo PET studies of 5-HT re-uptake sites
    • Hume S, Pascali C, Pike V, et al (1991): Citalopram: Labelling with carbon-11 and evaluation in rats as a potential radioligand for in vivo PET studies of 5-HT re-uptake sites. Nucl Med Biol 18:339-351.
    • (1991) Nucl Med Biol , vol.18 , pp. 339-351
    • Hume, S.1    Pascali, C.2    Pike, V.3
  • 68
    • 0026515597 scopus 로고
    • Structure and function of the brain serotonergic system
    • Jacobs B, Azmitia E (1992): Structure and function of the brain serotonergic system. Physiol Rev 72:165-229.
    • (1992) Physiol Rev , vol.72 , pp. 165-229
    • Jacobs, B.1    Azmitia, E.2
  • 69
    • 10144229103 scopus 로고
    • Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter
    • Jagust W, Eberling J, Biegon A, et al (1995): Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter. J Nucl Med 37:1207-1214.
    • (1995) J Nucl Med , vol.37 , pp. 1207-1214
    • Jagust, W.1    Eberling, J.2    Biegon, A.3
  • 70
    • 0026071638 scopus 로고
    • Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-F18)fluoroethylspiperone and positron emission tomography
    • Jovkar S, Wienhard K, Coenen H, Pawlik G, Heiss W (1991): Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-F18)fluoroethylspiperone and positron emission tomography. Eur J Nucl Med 18:158-163.
    • (1991) Eur J Nucl Med , vol.18 , pp. 158-163
    • Jovkar, S.1    Wienhard, K.2    Coenen, H.3    Pawlik, G.4    Heiss, W.5
  • 71
    • 0028285516 scopus 로고
    • Modulation of cortical neuronal activity by a serotonergic agent: A PET study in humans
    • Kapur S, Meyer J, Wilson A, Houle S, Brown G (1994): Modulation of cortical neuronal activity by a serotonergic agent: A PET study in humans. Brain Res 646:292-294.
    • (1994) Brain Res , vol.646 , pp. 292-294
    • Kapur, S.1    Meyer, J.2    Wilson, A.3    Houle, S.4    Brown, G.5
  • 72
    • 0028926033 scopus 로고
    • 1a receptor antagonist
    • 1A receptor antagonist. Brain Res 673:217-225.
    • (1995) Brain Res , vol.673 , pp. 217-225
    • Khawaja, X.1
  • 73
    • 0026780268 scopus 로고
    • Magnetic resonance imaging of the caudate nuclei in depression
    • Krishnan K, McDonald W, Escalona R, et al (1992): Magnetic resonance imaging of the caudate nuclei in depression. Arch Gen Psychiatry 49:553-557.
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 553-557
    • Krishnan, K.1    McDonald, W.2    Escalona, R.3
  • 74
    • 0028946905 scopus 로고
    • Imaging of serotonin and dopamine transporters in the living human brain
    • Kuikka J, Tihonen J, Bergstrom K, et al (1995): Imaging of serotonin and dopamine transporters in the living human brain. Eur J Nucl Med 22:346-350.
    • (1995) Eur J Nucl Med , vol.22 , pp. 346-350
    • Kuikka, J.1    Tihonen, J.2    Bergstrom, K.3
  • 76
    • 17144434961 scopus 로고
    • 123I] β-CIT: Pharmacological characterization of brain uptake in nonhuman primates
    • 123I] β-CIT: Pharmacological characterization of brain uptake in nonhuman primates. Synapse 13:295-309.
    • (1993) Synapse , vol.13 , pp. 295-309
    • Laruelle, M.1    Baldwin, R.2    Malison, R.3
  • 77
    • 0031030271 scopus 로고    scopus 로고
    • Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates
    • Laruelle M, Iyer R, Al-Tikriti M, et al (1997): Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates. Synapse 25:1-14.
    • (1997) Synapse , vol.25 , pp. 1-14
    • Laruelle, M.1    Iyer, R.2    Al-Tikriti, M.3
  • 80
    • 0026355999 scopus 로고
    • Fluorine-18-altanserin: A radioligand for the study of serotonin receptors with PET: Radiolabeling and in vivo biologic behavior in rats
    • Lemaire C, Cantineau R, Guillaume M, Plenevaux A, Christiaens L (1991): Fluorine-18-altanserin: A radioligand for the study of serotonin receptors with PET: Radiolabeling and in vivo biologic behavior in rats. J Nucl Med 32:2266-2272.
    • (1991) J Nucl Med , vol.32 , pp. 2266-2272
    • Lemaire, C.1    Cantineau, R.2    Guillaume, M.3    Plenevaux, A.4    Christiaens, L.5
  • 81
    • 0027212698 scopus 로고
    • Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter
    • Lesch K, Wolozin B, Murphy D, Reiderer P (1993): Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter. J Neurochem 60:2319-2322.
    • (1993) J Neurochem , vol.60 , pp. 2319-2322
    • Lesch, K.1    Wolozin, B.2    Murphy, D.3    Reiderer, P.4
  • 83
    • 0001310771 scopus 로고
    • Use of 5-HT receptor agonists and antagonists for the characterization of their respective receptor sites
    • Boulton A, Baker G, Jurio A, editors. Clifton, NJ: The Humana Press
    • Leysen J (1989): Use of 5-HT receptor agonists and antagonists for the characterization of their respective receptor sites. In: Boulton A, Baker G, Jurio A, editors. Drugs as Tools in Neurotransmitter Research. Clifton, NJ: The Humana Press, pp 299-350.
    • (1989) Drugs As Tools in Neurotransmitter Research , pp. 299-350
    • Leysen, J.1
  • 84
    • 0027332645 scopus 로고
    • 125I]RTi-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain
    • 125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain. J Neurochem 61:1996-2006.
    • (1993) J Neurochem , vol.61 , pp. 1996-2006
    • Little, K.1    Kirkman, J.2    Carroll, F.3    Breese, G.4    Duncan, G.5
  • 85
    • 0030914419 scopus 로고    scopus 로고
    • Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide
    • Little K, McLaughlin D, Ranc J, et al (1997): Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide. Biol Psychiatry 41:1156-1164.
    • (1997) Biol Psychiatry , vol.41 , pp. 1156-1164
    • Little, K.1    McLaughlin, D.2    Ranc, J.3
  • 86
    • 0028174631 scopus 로고
    • 11C]dapoxetine HCl, a serotonin reuptake inhibitor: Biodistribution in rat and preliminary PET imaging in the monkey
    • 11C]dapoxetine HCl, a serotonin reuptake inhibitor: Biodistribution in rat and preliminary PET imaging in the monkey. Nucl Med Biol 21:669-675.
    • (1994) Nucl Med Biol , vol.21 , pp. 669-675
    • Livini, E.1    Satterlee, W.2    Robey, R.3
  • 87
  • 88
    • 0029869731 scopus 로고    scopus 로고
    • [11C]MDL 100907, a radioligand for selective imaging of 5-HT2A receptor with positron emission tomography
    • Lundkvist C, Halldin C, Ginovart N, et al (1996): [11C]MDL 100907, a radioligand for selective imaging of 5-HT2A receptor with positron emission tomography. Life Sci 58:187-192.
    • (1996) Life Sci , vol.58 , pp. 187-192
    • Lundkvist, C.1    Halldin, C.2    Ginovart, N.3
  • 89
    • 0000587671 scopus 로고
    • The serotonin hypothesis of major depression
    • Bloom F, Kupfer D, editors. New York: Raven Press
    • Maes M, Meltzer H (1995): The serotonin hypothesis of major depression. In: Bloom F, Kupfer D, editors. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press, pp 933-944.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 933-944
    • Maes, M.1    Meltzer, H.2
  • 91
    • 0030853808 scopus 로고    scopus 로고
    • Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo
    • Malizia A, Melichar J, Brown D, et al (1997): Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo. J Psychopharmacol 11:279-281.
    • (1997) J Psychopharmacol , vol.11 , pp. 279-281
    • Malizia, A.1    Melichar, J.2    Brown, D.3
  • 92
    • 0022930193 scopus 로고
    • Increased serotonin2 and beta receptor in the frontal cortices of suicide victims
    • Mann J, Stanley P, McBride P, McEwen B (1986): Increased serotonin2 and beta receptor in the frontal cortices of suicide victims. Arch Gen Psychiatry 43:954.
    • (1986) Arch Gen Psychiatry , vol.43 , pp. 954
    • Mann, J.1    Stanley, P.2    McBride, P.3    McEwen, B.4
  • 93
    • 0022952669 scopus 로고
    • Postmortem monoamine receptor and enzyme studies in suicide
    • Mann J, McBride P, Stanley M (1990): Postmortem monoamine receptor and enzyme studies in suicide. Ann NY Acad Sci 487:114-121.
    • (1990) Ann NY Acad Sci , vol.487 , pp. 114-121
    • Mann, J.1    McBride, P.2    Stanley, M.3
  • 94
    • 0030048176 scopus 로고    scopus 로고
    • Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients
    • Mann J, Malone K, Diehl D, Perel J, Cooper T, Mintun M (1996): Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am J Psychiatry 153:174-182.
    • (1996) Am J Psychiatry , vol.153 , pp. 174-182
    • Mann, J.1    Malone, K.2    Diehl, D.3    Perel, J.4    Cooper, T.5    Mintun, M.6
  • 95
    • 0025053032 scopus 로고
    • Left prefrontal glucose hypometabolism in the depressed state: A confirmation
    • Martinet J, Hardy P, Feline A, et al (1990): Left prefrontal glucose hypometabolism in the depressed state: A confirmation. Am J Psychiatry 147:1313-1317.
    • (1990) Am J Psychiatry , vol.147 , pp. 1313-1317
    • Martinet, J.1    Hardy, P.2    Feline, A.3
  • 96
    • 0030611828 scopus 로고    scopus 로고
    • Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors
    • Massou J, Trichard C, Attar-Leny D, et al (1997): Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors. Psychopharmacology (Berl) 133:99-101.
    • (1997) Psychopharmacology (Berl) , vol.133 , pp. 99-101
    • Massou, J.1    Trichard, C.2    Attar-Leny, D.3
  • 97
    • 0027970120 scopus 로고
    • Frontal lobe dysfunction in secondary depression
    • Mayberg H (1994): Frontal lobe dysfunction in secondary depression. J Neuropsychiatry Clin Neurosci 6:428-442.
    • (1994) J Neuropsychiatry Clin Neurosci , vol.6 , pp. 428-442
    • Mayberg, H.1
  • 98
    • 0023759527 scopus 로고
    • PET imaging of the cortical S2 serotonin receptor after stroke: Lateralized changes and relationship to depression
    • Mayberg H, Robinson R, Wong D, et al (1988): PET imaging of the cortical S2 serotonin receptor after stroke: Lateralized changes and relationship to depression. Am J Psychiatry 145:937-943.
    • (1988) Am J Psychiatry , vol.145 , pp. 937-943
    • Mayberg, H.1    Robinson, R.2    Wong, D.3
  • 99
    • 0025980246 scopus 로고
    • Spontaneous remission of post-stroke depression and temporal changes in cortical S2-serotonin receptors
    • Mayberg H, Parikh R, Morris P, Robinson R (1991): Spontaneous remission of post-stroke depression and temporal changes in cortical S2-serotonin receptors. J Neuropsychiatry Clin Neurosci 3:80-83.
    • (1991) J Neuropsychiatry Clin Neurosci , vol.3 , pp. 80-83
    • Mayberg, H.1    Parikh, R.2    Morris, P.3    Robinson, R.4
  • 100
    • 0028264040 scopus 로고
    • Paralimbic hypoperfusion in unipolar depression
    • Mayberg H, Lewis P, Regenold W, Wagner H (1994): Paralimbic hypoperfusion in unipolar depression. J Nucl Med 35:929-934.
    • (1994) J Nucl Med , vol.35 , pp. 929-934
    • Mayberg, H.1    Lewis, P.2    Regenold, W.3    Wagner, H.4
  • 101
    • 8244256653 scopus 로고    scopus 로고
    • Cingulate function in depression: A potential predictor of treatment response
    • Mayberg H, Brannan S, Mahurin RK, et al (1997): Cingulate function in depression: A potential predictor of treatment response. Neuroreport 8:1057-1061.
    • (1997) Neuroreport , vol.8 , pp. 1057-1061
    • Mayberg, H.1    Brannan, S.2    Mahurin, R.K.3
  • 102
    • 0025321507 scopus 로고
    • Effects of age and gender on CNS serotonergic responsivity in normal adults
    • McBride P, Tierney H, DeMeo M, Chen J, Mann J (1990): Effects of age and gender on CNS serotonergic responsivity in normal adults. Biol Psychiatry 27:1143-1155.
    • (1990) Biol Psychiatry , vol.27 , pp. 1143-1155
    • McBride, P.1    Tierney, H.2    DeMeo, M.3    Chen, J.4    Mann, J.5
  • 103
    • 0023199181 scopus 로고
    • 5-HT receptor binding in post-mortem brains from patients with affective disorder
    • McKeith I, Marshall E, Ferrier I, et al (1987): 5-HT receptor binding in post-mortem brains from patients with affective disorder. J Affect Disord 13:67-74.
    • (1987) J Affect Disord , vol.13 , pp. 67-74
    • McKeith, I.1    Marshall, E.2    Ferrier, I.3
  • 104
    • 0024990739 scopus 로고
    • Why some depressed patients may have low platelet 3H-imipramine binding
    • Mellerup E, Plenge P (1990): Why some depressed patients may have low platelet 3H-imipramine binding. Acta Psychiatr Scand 82:330:334.
    • (1990) Acta Psychiatr Scand , vol.82 , pp. 330
    • Mellerup, E.1    Plenge, P.2
  • 105
    • 0025697462 scopus 로고
    • Role of serotonin in depression
    • Meltzer H (1990): Role of serotonin in depression. Ann NY Acad Sci 487:486-500.
    • (1990) Ann NY Acad Sci , vol.487 , pp. 486-500
    • Meltzer, H.1
  • 110
    • 0025156927 scopus 로고
    • A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium treated rats
    • Nagahiro S, Takada A, Diksic M, Sourkes T, Missala K, Yamamoto Y (1990): A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium treated rats. J Cereb Blood Flow Metab 10:13-21.
    • (1990) J Cereb Blood Flow Metab , vol.10 , pp. 13-21
    • Nagahiro, S.1    Takada, A.2    Diksic, M.3    Sourkes, T.4    Missala, K.5    Yamamoto, Y.6
  • 111
  • 112
    • 0030924948 scopus 로고    scopus 로고
    • Differences between males and females in rates of serotonin synthesis in human brain
    • Nishizawa S, Benkelfat C, Young S, et al (1997): Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 94:5308-5313.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5308-5313
    • Nishizawa, S.1    Benkelfat, C.2    Young, S.3
  • 113
    • 0029939169 scopus 로고    scopus 로고
    • Polymorphism in serotonin transporter gene associated with susceptibility to major depression
    • Ogilvie A, Battersby S, Bubb V, et al (1996): Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347:731-737.
    • (1996) Lancet , vol.347 , pp. 731-737
    • Ogilvie, A.1    Battersby, S.2    Bubb, V.3
  • 115
    • 0021055518 scopus 로고
    • Brain 5-HT2 receptors and suicide
    • Owen F, Cross A, Crow T, et al (1983): Brain 5-HT2 receptors and suicide. Lancet 11:1256.
    • (1983) Lancet , vol.11 , pp. 1256
    • Owen, F.1    Cross, A.2    Crow, T.3
  • 117
    • 0028265462 scopus 로고
    • Role of serotonin in the pathophysiology of depression
    • Owens M, Nemeroff C (1994): Role of serotonin in the pathophysiology of depression. Clin Chem 40:288-295.
    • (1994) Clin Chem , vol.40 , pp. 288-295
    • Owens, M.1    Nemeroff, C.2
  • 118
    • 0031456987 scopus 로고    scopus 로고
    • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites
    • Owens M, Morgan W, Plott S, Nemeroff C (1997): Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1305-1322
    • Owens, M.1    Morgan, W.2    Plott, S.3    Nemeroff, C.4
  • 120
    • 0000548551 scopus 로고
    • High affinity binding of antidepressants to a biogenic amine transport site in human brain and platelet: Studies in depression
    • Post RM, Bellinger JC, editors. Baltimore: Williams and Wilkins
    • Paul S, Rehavi M, Skolnick P, Goodwin F (1984): High affinity binding of antidepressants to a biogenic amine transport site in human brain and platelet: Studies in depression. In: Post RM, Bellinger JC, editors. Neurobiology of Mood Disorders. Baltimore: Williams and Wilkins, pp 845-853.
    • (1984) Neurobiology of Mood Disorders , pp. 845-853
    • Paul, S.1    Rehavi, M.2    Skolnick, P.3    Goodwin, F.4
  • 121
    • 0025933902 scopus 로고
    • Non-steady-state measurement of in vivo radioligand binding with positron emission tomography: Specificity analysis and comparison with in vitro binding
    • Perlmutter J, Moerlein S, Hwang D, Todd R (1991): Non-steady-state measurement of in vivo radioligand binding with positron emission tomography: Specificity analysis and comparison with in vitro binding. J Neurosci 11:1381-1389.
    • (1991) J Neurosci , vol.11 , pp. 1381-1389
    • Perlmutter, J.1    Moerlein, S.2    Hwang, D.3    Todd, R.4
  • 122
    • 0020656803 scopus 로고
    • Decreased imipramine binding in the brains of patients with depressive illness
    • Perry E, Marshall E, Blessed G, Tomlinson B, Perry R (1983): Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry 142:188-192.
    • (1983) Br J Psychiatry , vol.142 , pp. 188-192
    • Perry, E.1    Marshall, E.2    Blessed, G.3    Tomlinson, B.4    Perry, R.5
  • 123
    • 0030004584 scopus 로고    scopus 로고
    • Estimation of neocortical serotonin-2 receptor binding potential by single-dose fluorine-18-setoperone kinetic PET data analysis
    • Petit-Taboue M, Landeau B, Osmont A, Tillet I, Barre L, Baron J (1996): Estimation of neocortical serotonin-2 receptor binding potential by single-dose fluorine-18-setoperone kinetic PET data analysis. J Nucl Med 37:95-104.
    • (1996) J Nucl Med , vol.37 , pp. 95-104
    • Petit-Taboue, M.1    Landeau, B.2    Osmont, A.3    Tillet, I.4    Barre, L.5    Baron, J.6
  • 127
    • 0028980784 scopus 로고
    • β-CIT SPECT demonstrates blockade of 5-HT-uptake site by citalopram in the human brain in vivo
    • Pirker W, Asenbaum S, Kasper S, et al (1995): β-CIT SPECT demonstrates blockade of 5-HT-uptake site by citalopram in the human brain in vivo. J Neural Transm Gen Sect 100:247-256.
    • (1995) J Neural Transm Gen Sect , vol.100 , pp. 247-256
    • Pirker, W.1    Asenbaum, S.2    Kasper, S.3
  • 128
    • 0023259775 scopus 로고
    • Glucose utilization in the temporal cortex of affectively ill patients: Positron emission tomography
    • Post R, Lisi LD, Holcomb H, Uhde T, Cohen R, Buchsbaum M (1987): Glucose utilization in the temporal cortex of affectively ill patients: Positron emission tomography. Biol Psychiatry 22:545-553.
    • (1987) Biol Psychiatry , vol.22 , pp. 545-553
    • Post, R.1    Lisi, L.D.2    Holcomb, H.3    Uhde, T.4    Cohen, R.5    Buchsbaum, M.6
  • 131
    • 0001054498 scopus 로고
    • 11-fluoxetine as in vivo ligands for the serotonin uptake site
    • 11-fluoxetine as in vivo ligands for the serotonin uptake site. [Abstract]. J Nucl Med 31:883.
    • (1990) J Nucl Med , vol.31 , pp. 883
    • Scheffel, U.1    Dannals, R.2    Suehiro, M.3
  • 132
    • 0026749051 scopus 로고
    • Posterior fossa abnormalities in major depression: A controlled magnetic resonance imaging study
    • Shah S, Doraiswamy P, Husain M, et al (1992): Posterior fossa abnormalities in major depression: A controlled magnetic resonance imaging study. Acta Psychiatr Scand 85:474-479.
    • (1992) Acta Psychiatr Scand , vol.85 , pp. 474-479
    • Shah, S.1    Doraiswamy, P.2    Husain, M.3
  • 133
    • 0028809066 scopus 로고
    • Effect of pharmacologic treatment on the sleep of depressed patients
    • Sharpley A, Cowen P (1995): Effect of pharmacologic treatment on the sleep of depressed patients. Biol Psychiatry 37:85-98.
    • (1995) Biol Psychiatry , vol.37 , pp. 85-98
    • Sharpley, A.1    Cowen, P.2
  • 137
    • 0020660428 scopus 로고
    • Increased serotonin-2 binding sites in frontal cortex of suicide victims
    • Stanley M, Mann J (1983): Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet i:214-216.
    • (1983) Lancet , vol.1 , pp. 214-216
    • Stanley, M.1    Mann, J.2
  • 138
    • 0020264328 scopus 로고
    • Tritiated imipramine binding sites are decreased in the frontal cortex of suicides
    • Stanley M, Virgilio J, Gershon S (1982): Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216:1337-1339.
    • (1982) Science , vol.216 , pp. 1337-1339
    • Stanley, M.1    Virgilio, J.2    Gershon, S.3
  • 139
    • 0023030475 scopus 로고
    • Serotonin and serotonergic receptors in suicide
    • Stanley M, Mann J, Cohen L (1986): Serotonin and serotonergic receptors in suicide. Ann NY Acad Sci 487:122-127.
    • (1986) Ann NY Acad Sci , vol.487 , pp. 122-127
    • Stanley, M.1    Mann, J.2    Cohen, L.3
  • 142
    • 0010315748 scopus 로고
    • PET imaging of central serotonin re-uptake sites in the baboon brain with [C-11]-N-Me paroxetine (C-11-MPx)
    • Villemangne V, Dannals R, Sanchez R, et al (1989): PET imaging of central serotonin re-uptake sites in the baboon brain with [C-11]-N-Me paroxetine (C-11-MPx) [abstract]. J Nucl Med 30:1160.
    • (1989) J Nucl Med , vol.30 , pp. 1160
    • Villemangne, V.1    Dannals, R.2    Sanchez, R.3
  • 145
    • 0022182551 scopus 로고
    • Tryptophan depletion causes a rapid lowering of mood in normal subjects
    • Young S, Smith S, Pihl R, Ervin F (1985): Tryptophan depletion causes a rapid lowering of mood in normal subjects. Psychopharmacology (Berl) 87:173-177.
    • (1985) Psychopharmacology (Berl) , vol.87 , pp. 173-177
    • Young, S.1    Smith, S.2    Pihl, R.3    Ervin, F.4


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