Tumor-induced apoptosis of T cells: Amplification by a mitochondrial cascade

Cancer Research

Volumn 60, Issue 24, 2000, Pages 6811-6817

  Gastman, B R ^a   Yin, X M ^a   Johnson, D E ^a   Wieckowski, E ^a   Wang, G Q ^a   Watkins, S C ^a   Rabinowich, H ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIOXIDANT; BONGKREKIC ACID; CARBOCYANINE; CASPASE 3; CASPASE 8; CYCLOSPORIN A; CYTOCHROME C; DNA FRAGMENT; ETOPOSIDE; FAS ANTIGEN; FAS LIGAND;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE;

ANTI-BACTERIAL AGENTS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BLOTTING, WESTERN; BONGKREKIC ACID; CARBOCYANINES; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CASPASE 9; CASPASES; COCULTURE TECHNIQUES; CYCLOSPORINE; CYTOCHROME C GROUP; CYTOSOL; DNA; ENZYME ACTIVATION; ENZYME INHIBITORS; ETOPOSIDE; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; HEAD AND NECK NEOPLASMS; HUMANS; JURKAT CELLS; LYMPHOCYTES; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; OLIGOPEPTIDES; PROTEIN TRANSPORT; SUBCELLULAR FRACTIONS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0034671560     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Mechanisms responsible for signaling and functional defects
2. Fas ligand expression by astrocytoma in vivo: Maintaining immune privilege in the brain?
3. Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells: Implications for altered expression of TcR in tumor-associated lymphocytes
4. The role of Fas/FasL in immunosuppression induced by human tumors
5. Capases: The proteases of the apoptotic pathway
6. Caspases: Enemies within
7. Prodomains-adaptors - Oligomerization: The pursuit of caspase activation in apoptosis
8. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death
9. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
11. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
12. Prevention of apoptosis by Bcl-2-release of cytochrome c from mitochondria blocked
13. The release of cytochrome c from mitochondria - A primary site for Bcl-2 regulation of apoptosis
14. L
15. Two CD95 (APO-1/Fas) signaling pathways
16. L prevents this release but not tumor necrosis factor-R1/Fas death
17. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
18. Caspase mediated degradation of TcR-ζ chain
19. Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes
20. BID: A novel BH3 domain-only death agonist
21. DiOC6 staining reveals organelle structure and dynamics in living yeast cells
22. The central executioner of apoptosis-multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
23. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
24. Redox regulation of the caspases during apoptosis
25. 2-terminal kinases
26. Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway
27. Mitochondrial permeability transition triggers lymphocyte apoptosis
28. Mitochondrial control of nuclear apoptosis
29. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
30. Apoptotic pathways: The roads to ruin
31. Bax directly induces release of cytochrome c from isolated mitochondria
32. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD- specific caspase activation and independently of mitochondrial transmembrane depolarization
33. Cytochrome c - Can't live with it - Can't live without it
34. Mitochondria and apoptosis
35. The Fas counterattack in vivo: Apoptotic depletion of tumor-infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma
36. The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
37. Mechanisms of apoptosis in T cells from patients with renal cell carcinoma
38. Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells
39. Fas ligand mediates activation-induced cell death in human T lymphocytes
40. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCASI
41. Tumor expression of Fas ligand (CD95L) and the consequences
42. "Stealth effect": Adenocarcinoma cells engineered to express trail elude tumor-specific and allogeneic T cell reactions
43. Neural apoptosis
44. The central executioners of apoptosis: Caspases or mitochondria?
45. Differential requirement for caspase 9 in apoptotic pathways in vivo
46. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium
47. Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells
48. Caspase-independent cell killing by Fas-associated protein with death domain
49. Cytochrome c is dispensable for Fas-induced caspase activation and apoptosis