Increased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorder

Journal of Neurochemistry

Volumn 73, Issue 4, 1999, Pages 1704-1710

  Fields, Anat ^a,b   Li, Peter P ^a,b   Kish, Stephen J ^a,b   Warsh, Jerry J ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bipolar disorder; Cyclic AMP; Cyclic AMP dependent protein kinase; Postmortem brain

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; LITHIUM;

ADULT; AGED; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BRAIN LEVEL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MANIC DEPRESSIVE PSYCHOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TEMPORAL CORTEX;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; AUTOPSY; BIPOLAR DISORDER; BRAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSOL; ENZYME INHIBITORS; FEMALE; HUMANS; KINETICS; LITHIUM; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDES; REFERENCE VALUES; TEMPORAL LOBE;

EID: 0032844695     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.731704.x     Document Type: Article

References (32)

1. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edit., revised. American Psychiatric Press, Washington, D.C.
2. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-252.
3. Chen G., Manji H. K., Wright C. B., Hawver D. B., and Potter W. Z. (1996a) Effects of valproic acid on β-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells. Neuropsychopharmacology 15, 271-280.
4. Chen G., Pan B. S., Hawver D. B., Wright C. B., Potter W. Z., and Manji H. K. (1996b) Attenuation of cyclic AMP production by carbamazepine. J. Neurochem. 67, 2079-2086.
5. i-protein a subunit in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 88, 10634-10637.
6. Dicken R. F., Weiner M. W., and Fein G. (1995) Decreased temporal lobe phosphomonoesters in bipolar disorder. J. Affect. Disord. 33, 195-199.
7. Dubovsky S. L., Thomas M., Hijaz A., and Murphy J. (1994) Intracellular calcium signaling in peripheral cells of patients with bipolar affective disorder. Eur. Arch. Psychiatry Clin. Neurosci. 243, 229-234.
8. Emamghoreishi M., Schlichter L., Li P. P., Parikh S., Sen J., Kamble A., and Warsh J. J. (1997) Elevated intracellular calcium concentration in transformed B-lymphoblasts. Am. J. Psychiatry 145, 976-982.
9. Greenberg S. N., Castellucci V. F., Bayley H., and Schwartz J. H. (1987) A molecular mechanism for long-term sensitization in Aplysia. Nature 329, 62-65.
10. Guitart X. and Nestler E. J. (1992) Chronic administration of lithium or other antidepressants increases levels of DARPP-32 in rat frontal cortex. J. Neurochem. 59, 1164-1167.
11. Gyulai L., Alavi A., Broich K., Reilley J., Ball W. B., and Whybrow P. C. (1997) 1-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: a clinical study. Biol. Psychiatry 41, 152-161.
12. Hudson C. J., Young L. T., Li P. P., and Warsh J. J. (1993) CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorder and schizophrenia. Synapse 13, 278-293.
13. Jensen J. B. and Mork A. (1997) Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatment. Eur. Neuropsychopharmacol. 7, 173-179.
14. Jope R. S., Song L., Li P. P., Young T., Kish S. J., Pacheco M., and Warsh J. J. (1996) The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. J. Neurochem. 66, 2402-2409.
15. Manji H. K. (1992) G-proteins: implications for psychiatry. Am. J. Psychiatry 149, 746-760.
16. Mori S., Zanardi R., Popoli M., Smeraldi E., Racagni G., and Perez J. (1996) Inhibitory effects of lithium on cAMP dependent phosphorylation system, life Sci. 59, PL99-PL104.
17. Mori S., Tradito D., Dorigo A., Zanardi R., Smeraldi E., Racagni G., and Perez J. (1998) Effects of lithium on cAMP-dependent protein kinase in rat brain. Neuropsychopharmacology 19, 233-240.
18. Palmer G. C., Jones D. J., Medina M. A., and Stavinoha W. B. (1979) Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in mouse brain. Epilepsia 20, 95-104.
19. Perez J., Zanardi R., Mori S., Gasperini M., Smeraldi E., and Racagni G. (1995) Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder. Am. J. Psychiatry 152, 1204-1206.
20. Post R. M., Ballenger J. C., Uhde T. W., Smith C., Rubinow D. R., and Bunney W. E. Jr. (1982) Effect of carbamazepine on cyclic nucleotides in CSF of patients with affective illness. Biol. Psychiatry 17, 1037-1045.
21. 3H]cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder. J. Neurochem. 68, 297-304.
22. Roskoski R. Jr. (1983) Assay of protein kinase. Methods Enzymol. 99, 3-6.
23. Schwechheimer K. and Hofmann F. (1977) Properties of regulatory subunit of cyclic AMP-dependent protein kinase (peak I) from rabbit skeletal muscle prepared by urea treatment of the holoenzyme. J. Biol. Chem. 252, 7690-7696.
24. Shimon H., Agam D., Belmaker R. H., Hyde T. M., and Kleinman J. E. (1997) Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder. Am. J. Psychiatry 154, 1148-1150.
25. Siegel S. (1956) Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill, New York.
26. Spaulding S. W. (1993) The ways in which hormones change cyclic adenosine 3′,5′-monophosphate-dependent protein kinase subunits, and how such changes affect cell behavior. Endocr. Rev. 14, 632-650.
27. Takahashi M., Terwilliger R., Lana C., Mezes P. S., Conti M., and Dumas R. S. (1999) Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms. J. Neurosci. 19, 610-618.
28. Tasken K., Skalhegg B. S., Tasken K. A., Solberg R., Knutsen H. K., Levy F. O., Sandberg M., Orstavik S., Larsen T., Johansen A. K., Vang T., Schrader H. P., Reinton N. T. K., Torgersen K. M., Hansson V., and Jahnsen T. (1997) Structure, function and regulation of human cAMP-dependent protein kinases. Adv. Second Messenger Phosphoprotein Res. 31, 191-204.
29. Taylor S. S., Buechler J. A., and Yonemoto W. (1990) cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem. 59, 971-1005.
30. α protein levels and forskolin-stimulated cAMP formation are increased in bipolar affective disorder. J. Neurochem. 61, 890-898.
31. Young L. T., Li P. P., Kamble A., Siu K. P., and Warsh J. J. (1994) Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am. J. Psychiatry 151, 594-596.
32. Zanardi R., Racagni G., Smeraldi E., and Perez J. (1997) Differential effect of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects. Psychopharmacology (Berl.) 129, 44-47.