Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 751-757

  Guéry, Jean Charles ^a,b   Ria, Francesco ^a,c   Adorini, Luciano ^a  

^a ROCHE MILANO RICERCHE   (Italy)

^b CHU PURPAN   (France)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADJUVANT THERAPY; ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; COMPLEX FORMATION; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN-PRESENTING CELLS; B-LYMPHOCYTES; CELLS, CULTURED; CHICKENS; DENDRITIC CELLS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; HYBRIDOMAS; INFLAMMATION; KINETICS; LYMPH NODES; LYSOSOMES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; SPECIES SPECIFICITY; T-LYMPHOCYTES;

EID: 0029978795     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.751     Document Type: Article

References (35)

1. Germain, R.N., and D.H. Margulies. 1993. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11:403-450.
2. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
3. + T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176: 1431-1437.
4. Bhardwaj, N., S M. Friedman, B.C. Cole, and A.J. Nisanian. 1992. Dendritic cells are potent antigen-presenting cells for microbial superantigens. J. Exp. Med. 175:267-273.
5. Inaba, K., J.P. Metlay, M.T. Crowley, and R.M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172:631-640.
6. Agger, R., M.T. Crowley, and M.D. Witmer-Pack. 1990. The surface of dendritic cells in the mouse as studied with monoclonal antibodies. Int. Hev. Immunol. 6:89-101.
7. Larsen, C.P., S.C. Ritchie, T.C. Pearson, P.S. Linsley, and R.P. Lowry. 1992. Functional expression of the costimulatory molecule B7/BB1, on murine dendritic cell populations. J. Exp. Med. 176:1215-1220.
8. Bhardwaj, N., J.W. Young, A.J. Nisanian, J. Baggers, and R.M. Steinman. 1993. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp. Med. 178:633-642.
9. Guéry, J.-C., and L. Adorini. 1995. Dendritic cells are the most efficient in presenting endogenous naturally processed self epitopes to class II-restricted T cells. J. Immunol. 154: 536-544.
10. Eynon, E.E., and D.C. Parker. 1992. Small B cells is antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175:131-138.
11. Ronchese, F., and B. Hausmann. 1993. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes. J. Exp. Med. 177:679-690.
12. Epstein, M.M., F. Di Rosa, D. Jankovic, A Sher, and P. Matzinger. 1995. Successful T cell priming in B cell-deficient mice. J. Exp. Med. 182:915-922.
13. Ron, Y., P. DeBaetselier, J. Gordon, M. Feldman, and S. Segal. 1981. Defective induction of antigen-reactive proliferating T cells in B cell-deprived mice. Eur. J. Immunol. 11:964-970.
14. Janeway, C.A., Y. Ron, and M.E. Katz. 1987. The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J. Immunol. 138:1051-1055.
15. Ron, Y., and J. Sprent. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138:2848-2856.
16. Kurt-Jones, E.A., D. Liano, K.A. Hayglass, B. Benacerraf, and M.-S. Sy. 1988. The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice. J. Immunol. 140:3773-3778.
17. Mamula, M.J., and C.A. Janeway. 1993. Do B cells drive the diversification of immune responses? Immunol. Today. 14: 151-152.
18. Crowley, M.T., K. Inaba, and R.M. Steinman. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172: 383-386.
19. Guéry, J.-C., A. Sette, J. Leighton, A. Dragomir, and L. Adorini. 1992. Selective immunosuppression by administration of MHC class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation. J. Exp. Med. 175:1345-1352.
20. Guéry, J.-C., M. Neagu, G. Rodriguez-Tarduchy, and L. Adorini. 1993. Selective immunosuppression by administration of major histocompatibility complex class II-binding peptides. II. Preventive inhibition of primary and secondary antibody responses. J. Exp. Med. 177:1461-1468.
21. Guéry, J.-C., A. Sette, E. Appella, and L. Adorini. 1995. Constitutive presentation of dominant epitopes from endogenous naturally processed self β2 microglobulin to class II-restricted T cells leads to self tolerance. J. Immunol. 154:545-554.
22. Adorini, L., J.C. Guéry, S. Fuchs, V. Ortiz-Navarrete, G.J. Hämmerling, and F. Momburg. 1993. Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells. J. Immunol. 151:3576-3586.
23. Adorini, L., A. Sette, S. Buus, H.M. Grey, M. Darsley, P.V. Lehmann, G. Dona, Z.A. Nagy, and E. Appella. 1988. Interaction of an immunodominant epitope with Ia molecules in T-cell activation. Proc. Natl. Acad. Sci. USA. 85:5181-5185.
24. Meday, J.P., M.D. Witmer-Pack, R. Agger, M.T. Crowley, D. Lawless, and R.M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171: 1753-1772.
25. Crowley, M.T., K. Inaba, M.D. Witmer-Pack, S. Gezelter, and R.M. Steinman. 1990. Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen. J. Immunol. Methods. 133:55-66.
26. Romani, N., and G. Schuler. 1992. The immunological properties of epidermal Langerhans cells as a part of the dendritic cell system. Springer Semin. Immunopathol. 13:265-279.
27. Ibrahim, M.A.A., B.M. Chain, and D.R. Katz. 1995. The injured cell: the role of the dendritic cell system as a sentinel receptor pathway. Immunol. Today. 16:181-186.
28. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109-1118.
29. Trinchieri, G. 1995. Interleukin 12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
30. Lassila, O., O. Vainio, and P. Matzinger. 1988. Can B cells turn on virgin T cells? Nature (Lond.). 334:253-255.
31. Fuchs, E.F., and P. Matzinger. 1992. B cells turn off virgin but not memory T cells. Science (Wash. DC). 258:1156-1159.
32. Goldman, M., P. Druet, and E. Gleichmann. 1991. Th2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today. 12: 223-227.
33. Guéry, J.-C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of Th2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient mice. J. Exp. Med. 183:485-497.
34. Trembleau, S., G. Penna, E. Bosi, A. Mortara, M.K. Gately, and L. Adorini. 1995. IL-12 administration induces Th1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:817-821.
35. + T cells. J. Immunol. 154:5071-5079.