Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase

Biochemical Journal

Volumn 348, Issue 3, 2000, Pages 579-583

  Werner, Ernst R ^a   Habisch, Hans Jörg ^b   Gorren, Antonius C F ^b   Schmidt, Kurt ^b   Canevari, Laura ^c   Werner Felmayer, Gabriele ^a   Mayer, Bernd ^b  

^a Inst for Med C B of the U of I   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Biopterin; Inhibition; Reaction mechanism; Redox cycling; Stimulation

Indexed keywords

2,6 DICHLOROPHENOLINDOPHENOL; ACETIC ACID; DIHYDROPTERIDINE REDUCTASE; FORMIC ACID; METHYL GROUP; NITRIC OXIDE SYNTHASE; PHENYLALANINE 4 MONOOXYGENASE; RECOMBINANT ENZYME; TETRAHYDROBIOPTERIN; 5,6,7,8-TETRAHYDROBIOPTERIN; BIOPTERIN; DRUG DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; METHYLATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; METABOLISM; RAT;

ANIMALS; BIOPTERIN; DIHYDROPTERIDINE REDUCTASE; ENZYME ACTIVATION; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PHENYLALANINE HYDROXYLASE; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0034659806     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3480579     Document Type: Article

References (33)

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