Electronic structure of tetrahydropteridine derivatives

Pteridines

Volumn 10, Issue 3, 1999, Pages 91-94

  Reibnegger, Gilbert ^a,c   Pauschenwein, Jutta ^a   Werner, Ernst R ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Ab initio; Nitric oxide synthase; Pteridines; Quantum chemistry; Visualization

Indexed keywords

LUMAZINE; NITRIC OXIDE SYNTHASE; PTERIDINE DERIVATIVE; PTERIN DERIVATIVE; TETRAHYDROBIOPTERIN;

CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR INTERACTION; PRIORITY JOURNAL; QUANTUM CHEMISTRY; REVIEW;

EID: 0032719403     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pteridines.1999.10.3.91     Document Type: Article

References (5)

1. Werner ER, Pitters E, Schmidt K, Wachter H, Werner-Felmayer G, Mayer B. Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synrhase. Biochem J 1996; 320: 193-196.
2. Presta A, Siddhanta U, Wu CQ, Sennequier N, Huang LX, Abusoud HM, Erzrum S, Stuehr DJ. Comparative functioning of dihydro-and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase. Biochemistry 1998; 37: 298-310.
3. Riethmüller C, Gorren ACF, Fitters E, Hemmens B, Habisch H-J, Heales SJR, Schmidt K, Werner ER, Mayer B. Activation of neuronal nitric oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor. J Biol Chem 1999; 274: 16047-16051.
4. Pfeiffer S, Gorren ACF, Pitters E, Schmidt K, Werner ER, Mayer B. Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-amino tetrahydrobiopterin. Biochem J 1997; 328: 349-352.
5. Mayer B, Wu C, Gorren ACF, Pfeiffer S, Schmidt K, Clark P, Stuehr DJ, Werner ER. Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase expressed in E. coli. Heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino tetrahydrobiopterin. Biochemistry 1997; 36: 8422-8427.