Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 67, Issue 1, 1996, Pages 103-105

  Inayama, Yasuhiro ^a   Yoneda, Hiroshi ^a   Sakai, Toshiaki ^a   Ishida, Toru ^a   Nonomura, Yasuhiro ^a   Kono, Yoshihiro ^a   Takahata, Ryu Ichi ^a   Koh, Jun ^a   Sakai, Jun ^a   Takai, Akiko ^a   Inada, Yasushi ^a   Asaba, Hiroyuki ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Association study; Chromosome 13; Schizophrenia; Serotonin 1A receptor; Serotonin 2A receptor

Indexed keywords

DNA MARKER; SEROTONIN 2A RECEPTOR;

ARTICLE; CHROMOSOME 13Q; CONTROLLED STUDY; DNA SEQUENCE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN EXPERIMENT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA;

ADULT; BASE SEQUENCE; DNA; DNA PRIMERS; FEMALE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SCHIZOPHRENIA;

EID: 0029988749     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19960216)67:1<103::AID-AJMG18>3.0.CO;2-S     Document Type: Article

References (15)

1. Chen K, Yang W, Grimsby J, Shih JC (1992): The human 5HT2 receptor is encoded by a multiple intron-Exon gene. Mol Brain Res 14:20-26.
2. Curtis D, Brynjolfsson J, Petursson H, Holmes S, Sherrington R, Brett P, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD (1993): Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). Ann Hum Genet 57:27-39.
3. Fujiwara Y, Tomita H, Hikiji M, Kashihara K, Otsuki S, Ohnuki T, Hamagishi Y, Oki T, Sora I, Roeske WR, Yamamura HI (1992). Characterization of a cloned rat serotonin 5HT1A receptor expressed in the HeLa cell line. Life Sci 52:949-958.
4. Gelders Y, Vanden Bussche G, Reyntjens A, Janssen P (1986): Serotonin S2 receptor blocker in the treatment of chronic schizophrenia. Clin Neurophamacol 9:325-327.
5. Gerlach J (1991): New antipsychotics; classification, efficacy, and adverse effects. Schizophr Bull 17:289-304.
6. Hallmayer J, Kennedy JL, Wetterberg L, Sjögren B, Kidd KK, Cavalli-Sforza LL (1992): Exclusion of linkage between the serotonin 2 receptor and schizophrenia in a large Swedish kindred. Arch Gen Psychiatry 49:216-219.
7. Hsieh CL, Bowcock AM, Farrer LA, Hebert JM, Huang KN, Cavalli-Sforza LL, Julius D, Francke U (1990): The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma and on mouse chromosome 14. Somat Cell Genet 16:567-574.
8. Kobilka BK, Frielle T, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, Carrion MG (1987): An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329:75-79.
9. Leysen JE, Jansssen PMF, Gommeren W, Wynants J, Pauwels PJ, Janssen PAJ (1992): In vitro and vivo receptor binding and effects on monoamine turnover in rat brain region of the novel antipsychoties risperidone and ocaperidone. Mol Pharmacol 41:494-508.
10. Meltzer HY, Bastani B, Young Kwon K, Ramirez LF, Burnett S, Sharpe J (1989): A prospective study of clozapine in treatment-resistant schizophrenic patients. Psychopharmacology 99:68-72.
11. Mita T, Hanada S, Nishino N, Kuno T, Nakai H, Yamadori T, Mizoi Y, Tanaka T (1986): Decreased serotonin S2 and increased dopamone D2 receptor in chronic schizophrenia. Biol Psychiatry 21:1407-1414.
12. Saltzman AG, Morse B, Whitman MM, Ivanshchenko Y, Jaye M, Felder S (1991): Cloning of the human serotonin 5-HT2 and 5HT1C receptor subtypes. Biochem Biophys Res Commun 181: 1469-1478.
13. Warren Jr JT, Peacock ML, Fink JK (1992): A Rsal polymorphism in the human serotonin receptor gene (HTR1A); detection by DGGE and RFLP analysis. Hum Mol Genet 1 778.
14. Warren Jr JT, Peacock ML, Rodrigues LC, Fink JK (1993): An MspI polymorphism in the human serotonin receptor gene (HTR2); detection by DGGE and RFLP analysis. Hum Mol Genet 2:338.
15. Woolf B (1995): On estimating the relation between blood group and disease. Ann Hum Genet 19:251-253.