Strong association of dermatomyositis-specific Mi-2 autoantibodies with a tryptophan at position 9 of the HLA-DRβ chain

Arthritis and Rheumatism

Volumn 39, Issue 5, 1996, Pages 868-876

  Mierau, Rudolf ^a,d   Dick, Thomas ^a   Bartz Bazzanella, Peter ^b   Keller, Elisabeth ^c   Albert, Ekkehard D ^c   Genth, Ekkehard ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Clinic and Research Institute for Rheumatic Diseases   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d Rheumaklinik und Rheumaforschungsinstitut   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HLA DR ANTIGEN; TRYPTOPHAN;

ALLELE; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CYTOTOXICITY TEST; DERMATOMYOSITIS; HLA TYPING; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENETICS; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY;

ADENOSINE TRIPHOSPHATASES; ADULT; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; BASE SEQUENCE; DERMATOMYOSITIS; DNA HELICASES; EPITOPES; FEMALE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; TRYPTOPHAN;

EID: 0029877837     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390521     Document Type: Article

References (44)

1. Bohan A, Peter JB: Polymyositis and dermatomyositis. N Engl J Med 292:344-347, 1975
2. Love LA, Leff RL, Fraser DD, Targoff IN, Dalakas M, Plotz PH, Miller FW: A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine 70:360-374, 1991
3. Targoff IN: Humoral immunity in polymyositis/dermatomyositis. J Invest Dermatol 100:116S-123S, 1993
4. Reichlin M, Arnett FC Jr: Multiplicity of antibodies in myositis sera. Arthritis Rheum 27:1150-1156, 1984
5. Targoff IN: Immune manifestations of inflammatory muscle disease. Rheum Dis Clin North Am 20:857-880, 1994
6. Genth E, Mierau R: Diagnostische Bedeutung Sklerodermieund Myositis-assoziierter Autoantikörper. Z Rheumatol 54:39-49, 1995
7. Targoff IN: Autoantibodies in polymyositis. Rheum Dis Clin North Am 18:455-482, 1992
8. Garlepp MJ: Immunogenetics of inflammatory myopathies. Baillieres Clin Neurol 2:579-597, 1993
9. Reichlin M, Mattioli M: Description of a serological reaction characteristic of polymyositis. Clin Immunol Immunopathol 5:12-20, 1976
10. Targoff IN, Reichlin M: The association between Mi-2 antibodies and dermatomyositis. Arthritis Rheum 28:796-803, 1985
11. Nilasena DS, Trieu EP, Targoff IN: Analysis of the Mi-2 autoantigen of dermatomyositis. Arthritis Rheum 38:123-128, 1995
12. Ge Q, Nilasena DS, O'Brien CA, Frank MB, Targoff IN: Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. J Clin Invest 96:1730-1737, 1995
13. Seelig HP, Moosbrugger I, Ehrfeld H, Fink T, Renz M, Genth E: The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. Arthritis Rheum 38:1389-1399, 1995
14. Targoff IN, Nilasena DS, Trieu EP, Arnett FC, Pachmann LM, Callen JP, Miller FW: Clinical features and immunologic testing of patients with anti-Mi-2 antibodies (abstract). Arthritis Rheum 33(suppl 9):S72, 1990
15. Gurley RC, Love LA, Targoff IN, Leff RL, Plotz PH, Miller FW: Association among myositis-specific autoantibodies and HLA-DQA 1 alleles (abstract). Arthritis Rheum 34(suppl 9): S137, 1991
16. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23:581-590, 1980
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, MedsgerTA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324, 1988
18. Manthorpe R, Oxholm P, Prause JU, Schmidt M: The Copenhagen criteria for Sjögren's syndrome. Scand J Rheumatol (Suppl)61:19-21, 1986
19. Salerni R, Rodnan GP, Leon DF, Shavers J: Pulmonary hypertension in the CREST syndrome variant of progressive systemic sclerosis. Ann Intern Med 86:394-399, 1977
20. Stahl NI, Kippel JH, Decker JL: A cutaneous lesion associated with myositis. Ann Intern Med 91:577-579, 1979
21. Kohler PF, Winter ME: A quantitative test for xerostomia: the Saxon test, an oral equivalent of the Schirmer test. Arthritis Rheum 28:1128-1132, 1985
22. Dick T, Mierau R, Sternfeld R, Weiner E, Genth E: Clinical relevance and HLA association of autoantibodies against the nucleolus organizer region (NOR-90). J Rheumatol 22:67-72, 1994
23. Genth E, Mierau R, Genetzky P, von Mühlen CA, Kaufmann S, von Wilmowsky H, Meurer M, Krieg T, Pollmann H-J, Hartl PW: Immunogenetic associations of scleroderma-related antinuclear antibodies. Arthritis Rheum 33:657-665, 1990
24. Genth E, Kaufmann S, Mierau R: Das Anti(Aminoacyl-tRNA-) Synthetase-Syndrom (Jo-1-Syndrom). Aktuelle Rheumatol 18: 113-119, 1993
25. Terasaki PI, Bernoco D, Park MS, Ozturk G, Iwaki Y: Microdroplet testing for HLA-A, -B, -C and -D antigens. Am J Clin Pathol 69:103-120, 1978
26. Werner CH, Klouda PT, Correa MC, Vassalli P, Jeannet M: Isolation of B and T lymphocytes by nylon fiber columns. Tissue Antigens 9:227-229, 1977
27. Kimura A, Sasazuki T: HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. Oxford, Oxford University Press, 1992
28. Nevinny-Stickel C, Bettinotti MP, Andreas A, Hinzpeter M, Mühlegger K, Schmitz G, Albert ED: Non-radioactive HLA class II typing using polymerase chain reaction and digoxigenin-11-2′-3′-dideoxyuridine-triphosphate labeled oligonucleotide probes. Hum Immunol 31:7-13, 1991
29. Nevinny-Stickel C, Hinzpeter M, Andreas A, Albert ED: Non-radioactive oligotyping for HLA-DR1-DR10 using polymerase chain reaction, digoxigenin-labeled oligonucleotides and chemiluminiscent detection. Eur J Immunogen 18:323-332, 1991
30. Marsh SGE, Bodmer JG: HLA Class II nucleotide sequences, 1992. Eur J Immunogen 20:47-79, 1993
31. Rider LG, Miller FW, Targoff IN, Sherry DD, Samayoa E, Lindahl M, Wener MH, Pachman LM, Plotz PH: A broadened spectrum of juvenile myositis: myositis-specific autoantibodies in children. Arthritis Rheum 37:1534-1538, 1994
32. Winkelman WJ, Billick RC, Srolovitz H: Dermatomyositis presenting as panniculitis. J Am Acad Dermatol 23:127-128, 1990
33. Marguerie C, Bunn CC, Copier J, Bernstein RM, Gilroy JM, Black CM, So AK, Walport MJ: The clinical and immunogenetic features of patients with autoantibodies to the nucleolar antigen PM-Scl. Medicine 71:327-336, 1992
34. Oddis CV, Okano Y, Rudert WA, Trucco M, Duquesnoy RJ, Medsger TA Jr: Serum autoantibody to the nucleolar antigen PM-Scl: clinical and immunogenetic associations. Arthritis Rheum 35:1211-1217, 1992
35. Goldstein R, Duvic M, Targoff IN, Reichlin M, McMenemy AM, Reveille JD, Warner NB, Pollack MS, Arnett FC: HLA-D region genes associated with autoantibody responses to histidyltransfer RNA synthetase (Jo-1) and other translation-related factors in myositis. Arthritis Rheum 33:1240-1248, 1990
36. Schwartz RH: T-Lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Ann Rev Immunol 3:237-261, 1985
37. Jorgensen JL, Reay PA, Ehrich EW, Davis MM: Molecular components of T-cell recognition. Ann Rev Immunol 10:835-873, 1992
38. Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC: Three-dimensional structure of the human class II histocompatibility antigen HLA-DR 1. Nature 364:33-39, 1993
39. Reveille JD, Owerbach D, Goldstein R, Moreda R, Isern RA, Arnett FC: Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma). J Clin Invest 89:1208-1213, 1992
40. McHugh NJ, Whyte J, Artlett C, Briggs DC, Stephens CO, Olsen NJ, Gusseva NG, Maddison PJ, Black CM, Welsh KI: Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study. Clin Exp Rheumatol 96:267-274, 1994
41. Reveille JD, Macleod MJ, Whittington K, Amett FC: Specific amino acid residues in the second hypervariable region of HLA-DQA1 and DQB1 chain genes promote the Ro (SS-A)/LA (SS-B) autoantibody responses. J Immunol 146:3871-3876, 1991
42. Reveille JD, Durban E, MacLeod-St. Clair MJ, Goldstein R, Moreda R, Altman RD, Arnett FC: Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis). J Clin Invest 90:973-980, 1992
43. Yaneva M, Arnett FC: Antibodies against Ku protein in sera from patients with autoimmune diseases. Clin Exp Immunol 76:366-372, 1989
44. Marshall KW, Liu AF, Canales J, Perahia B, Jorgensen B, Gantzes RD, Aguilar B, Devaux B, Rothbard JB: Role of polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands. J Immunol 152:4946-4957, 1994