Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression

Progress in Brain Research

Volumn 126, Issue , 2000, Pages 369-396

  Swaab, D F ^a   Fliers, E ^b   Hoogendijk, W J G ^c   Veltman, D J ^c   Zhou, J N ^d  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; FLUORODEOXYGLUCOSE F 18; GLUCOCORTICOID; NEUROPEPTIDE; OXYTOCIN; PROTIRELIN; VASOPRESSIN;

BIOLOGICAL RHYTHM; BRAIN FUNCTION; CIRCADIAN RHYTHM; CIRCANNUAL RHYTHM; CONFERENCE PAPER; DEPRESSION; DIAGNOSTIC IMAGING; ELECTROPHYSIOLOGY; HUMAN; HYPERCORTISOLISM; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; MOOD DISORDER; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PHOTOTHERAPY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEASONAL AFFECTIVE DISORDER; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUICIDE;

EID: 0034589405     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(00)26025-1     Document Type: Conference Paper

References (240)

1. Altamura, C., Van Gastel, A., Piolo, R., Mannu, P. and Maes, M. (1999) Seasonal and circadian rhythms in suicide in Calgiari, Italy. J. Aff. Dis., 53: 77-85.
2. Anderson, J.L., Vasile, R.G., Mooney, J.J., Bloomingdale, K.L., Samson, J.A. and Schildkraut, J.J. (1992) Changes in norepinephrine output following light therapy for fall/winter seasonal depression. Biol. Psychiatry, 32: 700-704.
3. Andreasen, N.C. (1997) Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology. Science, 275: 1586-1592.
4. Arborelius, L., Owens, M.J., Plotsky, P.M. and Nemeroff, C.B. (1999) The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol., 160: 1-12.
5. Aronson, R., Offman, H.J., Joffe, R.T. and Naylor, D. (1996) Triiodothyronine augmentation in the treatment of refractory depression. Arch. Gen. Psychiatry, 53: 842-848.
6. Arranz, B., Blennow, K., Eriksson, A., J-E. Månsson and Marcusson, J. (1997) Serotonergic, noradrenergic, and dopaminergic measures in suicide brains. Biol. Psychiatry, 41: 1000-1009.
7. Åström, M., Olsson, T. and Asplund, K. (1993) Different linkage of depression to hypercortisolism early vs. late after stroke. A 3-year longitudinal study. Stroke, 24: 52-57.
8. Awata, S., Ito, H., Konno, M., Ono, S., Kawashima, R., Fukuda, H. and Sato, M. (1998) Regional cerebral blood flow abnormalities in late-life depression: Relation to refractoriness and chronification. Psych. Clin. Neurosci., 52: 97-105
9. Banki, C.M., Karmacsi, L., Bissette, G. and Nemeroff, C.B. (1992) Cerebrospinal fluid neuropeptides in mood disorder and dementia. J. Aff. Dis., 25: 39-46.
10. Barden, N., Reul, J.M.H.M. and Holsboer, F. (1995) Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? TINS, 18: 6-11.
11. Baumann, B., Danos, P., Krell, D., Diekmann, S., Leschinger, A., Stauch, R., Wurthmann, C., Bernstein, H.G. and Bogerts, B. (1999) Reduced volume of limbic system-affiliated basal ganglia in mood disorders: Preliminary data from a postmortem study. J. Neuropsych. Clin. Neurosci., 11: 71-78.
12. Berman, K.F., Doran, A.R., Pickar, D. and Weinberger, D.R. (1993) Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? Br. J. Psychiatry, 162, 183-192
13. Bernstein, H.-G., Stanarius, A., Baumann, B., Henning, H., Krell, D., Danos, P., Falkai, P. and Bogerts, B. (1998) Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience, 83: 867-875.
14. Birkenhäger, T.K., Vegt, M. and Nolen, W.A. (1997) An open study of triiodothyronine augmentation of tricyclic antidepressants in inpatients with refractory depression. Pharmacopsychiatry, 30: 23-26.
15. Blouin, A., Blouin, J., Aubin, P., Carter, J., Goldstein, C., Boyer, H. and Perez, E. (1992) Seasonal patterns of bulimia nervosa. Am. J. Psychiatry, 149: 73-81.
16. Boivin, D.B., Czeisler, C.A., Dijk, D.J., Duffy, J.F., Folkard, S., Minors, D.S., Totterdell, P. and Waterhouse, J.M. (1997) Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch. Gen. Psychiatry, 54: 145-152.
17. Borson-Chazot, F., Jordan, D., Fèvre-Montange, M., Kopp, N., Tourniaire, J., Rouzioux, J.M., Veisseire, M. and Mornex, R. (1986) TRH and LH-RH distribution in discrete nuclei of the human hypothalamus: Evidence for a left predominance of TRH. Brain Res., 382: 433-436.
18. Brady, L.S., Whitfield, H.J., jr., Fox, R.J., Gold, P.W. and Herkenham, M. (1991) Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralcorticoid receptor gene expression in rat brain. J. Clin. Invest., 87: 831-837
19. Brady, L.S., Gold, P.W., Herkenham, M., Lynn, A.B. and Whitfield, H.J., Jr. (1992) The antidepressants fluoxetine, idazoxan and phenylzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: Therapeutic implication. Brain Res., 572: 117-125.
20. Bremner, J.D., Innis, R.B., Salomon, R.M., Staib, L.H., Ng, C.K., Miller, H.L., Bronen, R.A., Krystal, J.H., Duncan, J., Rich, D., Price, L.H., Malison, R., Dey, H., Soufer, H. and Charney, D.S. (1997) Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Arch. Gen. Psych., 54: 364-374.
21. Brönnegård, M., Stierna, P. and Marcus, C. (1996) Glucocorticoid resistant syndromes - Molecular basis and clinical presentations. J. Neuroendocrinol., 8: 405-415.
22. Brown, G.M. (1996) Pineal function in psychiatric disorders. In: P.L. Tang, S.F. Pang and R.J. Reiter, (Eds), Melatonin: A Universal Photoperiodic Signal With Diverse Actions. Front. Horm. Res., 21, Karger, Basel, pp. 174-179.
23. Brunetti, A., Fulham, M.J., Aloj, L., De Souza, B., Nieman, L., Oldfield, E.H. and Di Chiro, G. (1998) Decreased brain glucose utilization in patients with Cushing's disease. J. Nucl. Med., 39: 786-790.
24. Buijs, R.M., Wortel, J., Van Heerikhuize, J.J., Feenstra, M.G.P., Ter Horst, G.J., Romijn, H.J. and Kalsbeek, A. (1999) Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur. J. Neurosci., 11: 1535-1544.
25. Bunevičius, R., Kažanavičius, G., Žalinkevičius, R. and Prange, A.J. (1999) Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. New Engl. J. Med., 340: 424-429.
26. Cappiello, A., Malison, R.T., McDougle, C.J., Vegso, S.J., Charney, D.S., Heninger, G.R. and Price, L.H. (1996) Seasonal variation in neuroendocrine and mood responses to IV L-tryptophan in depressed patients and healthy subjects. Neuropsychopharmacology, 15: 475-483.
27. Carlsson, A., Svennerholm, L. and Winblad, B. (1980) Seasonal and circadian monoamine variations in human brains examined post mortem. Acta Psych. Scand., 61, 75-85.
28. Carmichael, S.T. and Price, J.L. (1995) Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys. J. Comp. Neurol., 363: 615-641.
29. Carroll, B.J., Curtis, G.C. and Mendels, J. (1976) Cerebrospinal fluid and plasma free cortisol concentration in depression. Psychol. Med., 6: 235-244.
30. Catalán, R., Gallart, J.M., Castellanos, J.M. and Galard, R. (1998) Plasma corticotropin-releasing factor in depressive disorders. Biol. Psychiatry, 44: 15-20.
31. Checkley, S. (1996) The neuroendocrinology of depression and chronic stress. Br. Med. Bull., 52: 597-617.
32. Clark, P.M., Hindmarsh, P.C., Shiell, A.W., Law, C.M., Honour, J.W. and Barker, D.J.P. (1996) Size at birth and adrenocortical function in childhood. Clin. Endocrinol., 45: 721-726.
33. Clark, P.M. (1998) Programming of the hypothalamo-pituitaryadrenal axis and the fetal origins of adult disease hypothesis. Eur. J. Pediatr., 157: S7-S10.
34. Coffey, C.E., Wilkinson, W.E., Weiner, R.D., Parashos, I.A., Djang, W.T., Webb, M.C., Figiel, G.S. and Spritzer, C.E. (1993) Quantitative cerebral anatomy in depression: A controlled magnetic resonance imaging study. Arch. Gen. Psychiatry, 50: 7-16.
35. Coffman, J.A., Bornstein, R.A., Olson, S.C., Schwarzkopf, S.B. and Nasrallah, H.A. (1990) Cognitive impairment and cerebral structure by MRI in bipolar disorder. Biol. Psychiatry, 27: 1188-96.
36. Coiro, V., Volpi, R., Marchesi, C., De Ferri, A., d'Amato, L., Caffari, G., Davolio, M., Rossi, E., Caffarra, P. and Chiodera, P. (1994) Lack of seasonal variation in abnormal TSH secretion in patients with seasonal affective disorder. Soc. Biol. Psychiatry, 35: 36-41.
37. Contarino, A., Dellu, F., Koob, G.F., Smith, G.W., Lee, K-F., Vale, W. and Gold, L.H. (1999) Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Res., 835: 1-9.
38. Corrigan, F.M. (1998) Depression: Immunological resignation of the will to live? Med. Hypoth., 50: 9-18.
39. Cratty, M.S., Ward, H., Johnson, E.A., Azzaro, A.J. and Birkle, D.L. (1995) Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces. Brain Res., 675: 297-302.
40. Dahl, R.E., Ryan, N.D., Puig-Antich, J., Nguyen, N.A., Al-Shabbout, M., Meyer, V.A. and Perel, J. (1991) 24-Hour cortisol measures in adolescents with major depression: A controlled study. Biol. Psychiatry, 30: 25-36.
41. Davidson, R.J., Abercrombie, H., Nitschke, J.B. and Putnam, K. (1999) Regional brain function, emotion and disorders of emotion. Curr. Op. Neurobiol., 9: 228-234.
42. Dawson, G., Panagiotides, H., Klinger, L.G. and Spieker, S. (1997) Infants of depressed and non-depressed mothers exhibit differences in frontal brain electrical activity during the expression of negative emotions. Dev. Psychology, 33: 650-656.
43. De Bellis, M.D., Gold, P.W., Geracioti, T.D., Listwak, S.J. and Kling, M.A. (1993) Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression. Am. J. Psych., 150: 656-657.
44. De Bellis, M.D., Baum, A.S., Birmaher, B., Keshavan, M.S., Eccard, C.H., Boring, A.M., Jenkins, F.J. and Ryan, N.D. (1999) Developmental traumatology part I: Biological stress systems. Biol. Psychiatry, 45: 1259-1270.
45. De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joëls, M. (1997) Glucocorticoid feedback resistance. Trends Endocrinol. Metab., 8: 26-33.
46. De Vries, M.W. and Peeters, F.P.M.L. (1997) Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression. J. Nerv. Ment. Dis., 185: 201-202.
47. Delbende, C., Contesse, V., Mocaër, E., Kamoun, A. and Vaudry, H. (1991) The novel antidepressant tianeptine reduces stress-evoked stimulation of the hypothalamo-pituitary-adrenal axis. Eur. J. Pharmacol., 202, 391-392.
48. Deuschle, M., Gotthardt, U., Schweiger, U., Weber, B., Körner, A., Schmider, J., Standhardt, H., Lammers, C.-H. and Heuser, I. (1997) With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens. Life Sci., 61: 2239-2246.
49. Dinan, T.G. (1994) Glucocorticoids and the genesis of depressive illness: A psychobiological model. Br. J. Psychiatry, 164: 365-371.
50. Dinan, T.G., Lavelle, E., Cooney, J., Burnett, F., Scott, L., Dash, A., Thakore and J., Berti, C. (1997) Dexamethasone augmentation in treatment-resistant depression. Acta Psychiatry Scand., 95: 58-61.
51. Diorio, D., Viau, V. and Meaney, M.J. (1993) The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J. Neurosci., 13: 3839-3847.
52. Dittmann, V., Elster, K., Graw, P. and Wirz-Justice, A. (1994) Seasonal affective disorder: Are the DSM-III-R criteria valid? Psychopathology, 27: 291-297.
53. Dolberg, O.T., Hirschmann, S. and Grunhaus, L. (1998) Melatonin for the treatment of sleep disturbances in major depressive disorder. Am. J. Psychiatry, 155: 1119-1121.
54. Dorn, L.D., Burgess, E.S., Dubbert, B., Simpson, S.-E., Friedman, T., Kling, M., Gold, P.W. and Chrousos, G.P. (1995) Psychopathology in patients with endogenous Cushing's syndrome: 'atypical' or melancholic features. Clin. Endocrinol., 43: 433-442.
55. Dorn, L.D., Burgess, E.S., Friedman, T.C., Dubbert, B., Gold, P.W. and Chrousos, G.P. (1997) The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism. J. Clin. Endocrinol. Metab., 82: 912-919.
56. Drevets, W.C. and Raichle, M.E. (1992) Neuroanatomical circuits in depression: Implications for treatment mechanisms. Psychopharmacol Bull., 28: 261-274.
57. Drevets, W.C., Price, J.L., Jr Simpson, J.R., Todd, R.D., Reich, T., Vannier, M. and Raichle, M.E. (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386: 824-827.
58. Duval, F., Mokrani, M-C., Crocq, M-A., Jautz, M., Bailey, P., Diep, T-S. and Macher, J-P. (1996) Effect of antidepressant medication on morning and evening thyroid function tests during a major depressive episode. Arch. Gen. Psychiatry, 33: 833-840.
59. Eastman, C.I., Young, M.A., Fogg, L.F., Liu, L. and Meaden, P.M. (1998) Bright light treatment of winter depression: A placebo-controlled trial. Arch. Gen. Psychiatry, 55: 883-889.
60. Elliott, R, Baker, S.C., Rogers, R.D., O'Leary, D.A., Paykel, E.S., Frith, C.D., Dolan, R.J. and Sahakian, B.J. (1997) Prefrontal dysfunction in depressed patients performing a complex planning task: A study using positron emission tomography. Psychol. Med., 27: 931-942.
61. Elliott, R., Sahakian, B.J., Michael, A., Paykel, E.S. and Dolan, R.J. (1998) Abnormal response to feedback on planning and guessing tasks in patients with unipolar depression. Psychol. Med., 28, 559-571.
62. Escobar-Morreale, H.F., Obregón, M.J., Escober del Rey, F. and Morreale de Escobar, G. (1995) Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. J. Clin. Invest., 96: 2828-2838.
63. Fassbender, K., Schmidt, R., Mössner, R., Daffertshofer, M. and Hennerici, M. (1994) Pattern of activity of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome, Stroke, 25(6): 1105-1108.
64. Fava, G.A. (1994) Affective disorders and endocrine disease: New insights from psychosomatic studies. Psychosomatics, 35: 341-353.
65. Feibel, J.H., Hardy, P.M., Campbell, R.G., Goldstein, M.N. and Joynt, R.J. (1977) Prognostic value of the stress response following stroke. JAMA, 238(13): 1374-6.
66. Ferrier, I.N., McKeith, I.G., Cross, A.J., Perry, E.K., Candy, J.M. and Perry, R.H. (1986) Postmortem neurochemical studies in depression. Ann. NY Acad. Sci., 487: 128-42.
67. Fischer, P., Simanyi, M. and Danielczyk, W. (1990) Depression in dementia of the Alzheimer type and in multi-infarct dementia. Am. J. Psychiatry, 147: 1484-1487.
68. Fliers, E., Noppen, N.W.A.M., Wiersinga, W.M., Visser, T.J. and Swaab, D.F. (1994) Distribution of thyrotropin-releasing hormone (TRH)-containing cells and fibers in the human hypothalamus. J. Comp. Neurol., 350: 311-323.
69. Fujikawa, T., Yamawaki, S. and Touhouda, Y. (1993) Incidence of silent cerebral infarction in patients with major depression. Stroke, 24: 1631-1634.
70. Fujioka, T., Sakata, Y., Yamaguchi, K., Shibasaki, T., Kato, H., and Nakamura, S. (1999) The effects of prenatal stress on the development of hypothalamic paraventricular neurons in fetal rats. Neuroscience, 92: 1079-1088.
71. Fulham, M.J., Brunetti, A., Aloj, L., Raman, R., Dwyer, A.J. and Di Chiro, G. (1995) Decreased brain glucose metabolism in patients with brain tumors: An effect of cortico-steroids. J. Neurosurg., 83: 657-664.
72. Galynker, I.I., Cai, J., Ongseng, F., Finestone, H., Dutta, E. and Serseni, D. (1998) Hypofrontality and negative symptoms in major depressive disorder. J. Nucl. Med., 39: 608-612.
73. George, M.S., Ketter, T.A. and Post, R.M. (1993) SPECT and PET imaging in mood disorders. J. Clin. Psychiatry, 54: 6-13.
74. George, M.S., Wassermann, E.M. and Post, R.M. (1996) Transcranial magnetic stimulation; a neuropsychiatric tool for the 21st century. J. Neuropsych. Clin. Neurosci., 8: 373-382.
75. George, M.S., Wassermann, E.M., Kimbrell, T.A., Little, J.T., Williams, W.E., Danielson, A.L., Greenberg, B.D., Hallett, M. and Post, R.M. (1997) Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial. Am. J. Psych., 154: 1752-1756.
76. Gold, P.W., Licinio, J., Wong, M.L. and Chrousos, G.P. (1995) Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. Ann. NY Acad. Sci., 771: 716-729.
77. Gomez, F., Chapleur, M., Fernette, B., Burlet, C., Nicolas, J.-P. and Burlet, A. (1997) Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release. J. Neurosci. Res., 50: 565-574.
78. Goodyer, I.M., Herbert, J., Altham, P.M.E., Pearson, J., Secher, S.M. and Shiers, H.M. (1996) Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydro-epiandrosterone (DHEA) at presentation. Psychol. Med., 26: 245-256.
79. Goodyer, I.M., Herbert, J. and Altham, P.M.E. (1998) Adrenal steroid secretion and major depression in 8- to 16-year olds, III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression. Psychol. Med., 28: 265-273.
80. Gordijn, M.C.M., Beersma, D.G.M., Korte, H.J. and Van den Hoofdakker, R.H. (1998) Testing the hypothesis of a circadian phase disturbance underlying depressive mood in non-seasonal depression. J. Biol. Rhythm, 13: 132-147.
81. Gottfries, C.G., Frederiksen, S.O. and Heilig, M. (1995) Neuropeptides and Alzheimer's disease. Eur. Neuropsychopharm., 5: 491-500.
82. Grisaru, N., Chudakov, B.,Yaroslavsky, Y. and Belmaker, R.H. (1998) Transcranial magnetic stimulation in mania: A controlled study. Am. J. Psychiatry, 155:1608-1610.
83. Guillemette, J., Hébert, M., Paquet, J. and Dumont, M. (1998) Natural bright light exposure in the summer and winter in subjects with and without complaints of seasonal mood variations. Biol. Psych., 44: 622-628.
84. Healy, D. and Waterhouse, J.M. (1995) The circadian system and the therapeutics of the affective disorders. In: P.H. Redfern, and J. Waterhouse (Eds), Pharmacological Therapy, Vol. 65. Elsevier, Amsterdam, pp. 241-263.
85. Henley, W.N. and Koehnle, T.J. (1997) Thyroid hormones and the treatment of depression: an examination of basic hormonal actions in the mature mammalian brain. Synapse, 27: 36-44.
86. Heuser, I., Yasssouridis, A. and Holsboer, F. (1994) The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders. J. Psychiatry Res., 28: 341-356.
87. Heuser, I., Deuschle, M., Luppa, P., Schweiger, U., Standhardt, H. and Weber, B. (1998) Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients. J. Clin. Endocrinol. Metabol., 83: 3130-3133.
88. Hirano, N., Mori, E., Ishii, K., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, T., Yamashita, H. and Sasaki, M. (1998) Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology, 50: 380-383.
89. Ho, A.P., Gillin, J.C., Buchsbaum, M.S., Wu, J.C., Abel, L. and Bunney, W.E. Jr. (1996) Brain glucose metabolism during non-rapid eye movement sleep in major depression. A positron emission tomography study. Arch. Gen. Psychiatry, 53: 645-652.
90. Hofman, M.A. and Swaab, D.F. (1993a) Annual variations in the vasopressin neuron population of the human suprachiasmatic nucleus. Neuroscience, 53: 1103-1112.
91. Hofman, M.A. and Swaab, D.F. (1993b) Diurnal and seasonal rhythms of neuronal activity in the suprachiasmatic nucleus of humans. J. Biol. Rhythms, 8: 283-295.
92. Holsboer, F. and Barden, N. (1996) Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocrine Rev., 17: 187.
93. Holsboer, F., Lauer, C.J., Schreiber, W. and Krieg, J-C. (1995) Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology, 62: 340-347.
94. Holsboer, F., Spengler, D. and Heuser, I. (1992) The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. In: D.F. Swaab, M.A. Hofman, M. Mirmiran, R. Ravid, F.W. Van Leeuwen, (Eds), The Human Hypothalamus in Health and Disease. Progress in Brain Research, Vol. 93, pp. 385-417. Elsevier, Amsterdam.
95. Hucks, D., Lowther, S., Crompton, M.R., Katona, C.L.E. and Horton, R.W. (1997) Corticotropin-releasing factor binding sites in cortex of depressed suicides. Psychopharmacology, 134: 174-178.
96. Huizenga, N.A., Koper, J.W., de Lange, P., Pols, H.A., Stolk, R.P., Grobbee, D.E., de Jong, F.H. and Lamberts, S.W. (1998a) Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. J. Clin. Endocrinol. Metab., 83(1): 47-54.
97. Huizenga, N.A., Koper, J.W., de Lange, P., Pols, H.A., Stolk, R.P., Burger, H., Grobbee, D.E., Brinkmann, A.O., De Jong, F.H. and Lamberts, S.W. (1998b) A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J. Clin. Endocrinol. Metab., 83(1): 144-51.
98. Husain, M.M., McDonald, W.M., Doraiswamy, P.M., Figiel, G.S., Na, C., Escalona, P.R., Boyko, O.B., Nemeroff, C.B. and Krishnan, K.R. (1991) A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res., 40: 95-99.
99. Iacoboni, M., Padovani, A., Di Piero, V. and Lenzi, G.L. (1995) Post-stroke depression: Relationships with morphological damage and cognition over time. Ital. J. Neurol. Sci., 16: 209-216.
100. Inder, W.J., Donald, R.A., Prickett, T.C.R., Frampton, C.M., Sullivan, P.F., Mulder, R.T. and Joyce, P.R. (1997) Arginine vasopressin is associated with hypercortisolemia and suicide attempts in depression. Biol. Psychiatry, 42: 744-747.
101. Jackson, I.M.D. (1995) Thyrotropin-releasing hormone and corticotropin-releasing hormone - What's the message? Endocrinology, 136: 2793-2794.
102. Jackson, I.M.D. (1998) The thyroid axis and depression. Thyroid, 8: 951-956.
103. Jean-Louis, G., von Gizycki, H. and Zizi, F. (1998) Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J. Pineal Res., 25(3): 177-83.
104. Joffe, R.T. and Singer, W. (1990) A comparison of triiodothyronine and tyroxine in the potentiation of tricyclic antidepressants. Psychiatry Res., 32(3): 241-51.
105. Joffe, R.T., Singer, W., Levitt, A.J. and McDonald, C. (1993) A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression. Arch. Gen. Psychiatry, 50: 387-393.
106. Johansson, Å., Olsson, T., Carlberg, B., Karlsson, K. and Fagerlund, M. (1997) Hypercortisolism after stroke - Partly cytokine-mediated? J. Neurol. Sci., 147: 43-47.
107. Jordan, D., Borson-Chazot, F., Veisseire, M., Deluermoz, S., Malicier, D., Dalery, J. and Kopp, N. (1992) Disappearance of hypothalamic TRH asymmetry in suicide patients. J. Neural Transm., 89: 103-110.
108. Kalsbeek, A., Buijs, R.M., Van Heerikhuize, J.J., Arts, M. and Van der Woude, T.P. (1992) Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit cortico-sterone release. Brain Res., 580: 62-67.
109. Kellner, M., Yassouridis, A., Manz, B., Steiger, A., Holsboer, F. and Wiedemann, K. (1997) Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers - A potential link to low-melatonin syndrome in depression? Neuroendocrinology, 65: 284-290.
110. Kirkegaard, C. and Faber, J. (1998) The role of thyroid hormones in depression. Eur. J. Endocrinol., 138: 1-9.
111. Kitayama, T. Yaga, T. Kayahara, K. Nakano, S. Murase, M. Otani and Nomura, J. (1997) Long-term stress degenerates, but imipramine regenerates, noradrenergic axons in the rat cerebral cortex. Biol. Psychiatry, 42: 687-696.
112. Klein, E., Kreinin, I., Chistyakov, A., Koren, D., Mecz, L., Marmur, S., Ben-Shachar, D. and Feinsod, M. (1999) Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression: A double-blind controlled study. Arch. Gen. Psychiatry, 56: 315-320.
113. Kogan, A.O. and Guilford, P.M. (1998) Side effects of short-term 10,000 lux light therapy. Am. J. Psychiatry, 155: 293-294.
114. Kostoglou-Athanassiou, I., Treacher, D.F., Wheeler, M.J. and Forsling, M.L. (1998a) Bright light exposure and pituitary hormone secretion. Clin. Endocrinol., 48: 73-79.
115. Kostoglou-Athanassiou, I., Athanassiou, K., Treacher, D.F., Wheeler, M.J. and Forsling, M.L. (1998b) Neurohypophysial hormone and melatonin secretion over the natural and suppressed menstrual cycle in premenopausal women. Clin. Endocrinol., 49: 209-216.
116. Kripke, D.F. (1998) Light treatment for non-seasonal depression: Speed, efficacy, and combined treatment. J. Aff. Dis., 49: 109-117.
117. Krishnan, K.R., Hays, J.C. and Blazer, D.G. (1997) MRI-defined vascular depression. Am. J. Psychiatry, 154: 497-501.
118. Krishnan, K.R., Doraiswamy, P.M., Lurie, S.N., Figiel, G.S., Husain, M.M., Boyko, O.B., Ellinwood, E.H. and Nemeroff, C.B. (1991) Pituitary size in depression. J. Clin. Endocrinol. Metab., 72: 256-259.
119. Krishnan, K.R., McDonald, W.M., Escalona, P.R., Doraiswamy, P.M., Na, C., Husain, M.M., Figiel, G.S., Boyko, O.B., Ellinwood, E.H. and Nemeroff, C.B. (1992). Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Arch. Gen. Psychiatry, 49(7): 553-7.
120. Kumar, A., Jin, Z., Bilker, W., Udupa, J. and Gottlieb, G. (1998). Late-onset minor and major depression: Early evidence for common neuroanatomical substrates detected by using MRI. Proc. Natl. Acad. Sci. USA, 95: 7654-7658.
121. Kusumi, I., Ohmori, T., Kohsaka, M., Ito, M., Honma, H. and Koyama, T. (1995) Chronobiological approach for treatment-resistant rapid cycling affective disorders. Soc. Biol. Psych., 37: 553-559.
122. Lam, R.W., Goldner, E.M., Solyom, L. and Remick, R.A. (1994) A controlled study of light therapy for bulimia nervosa. Am. J. Psychiatry, 151: 744-750.
123. Lam, R.W., Zis, A.P., Grewal, A., Delgado, P.L., Charney, D.S. and Krystal, J.H. (1996b) Effects of rapid tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Arch. Gen. Psych., 53: 41-44.
124. Legros, J.J. and Ansseau, M. (1992) Neurohypophyseal peptides and psychopathology. In: D.F. Swaab, M.A. Hofman, M. Mirmiran, R. Ravid and F.W. Van Leeuwen (Eds), The Human Hypothalamus in Health and Disease, Progress in Brain Research, Vol. 93, pp. 455-461, Elsevier, Amsterdam.
125. Leibenluft, E., Albert, P.S., Rosenthal, N.E. and Wehr, T.A. (1996) Relationship between sleep and mood in patients with rapid-cycling bipolar disorder. Psych. Res., 63: 161-168.
126. Leuchter, A.F., Dunkin, J.J., Lufkin, R.B., Anzai, Y., Cook, I.A. and Newton, T.F. (1994) Effect of white matter disease on functional connections in the aging brain. J. Neurol. Neurosurg. Psychiatry, 57: 1347-1354.
127. Levitan, R.D., Parikh, S.V., Lesage, A.D., Hegadoren, K.M., Adams, M., Kennedy, S.H. and Goering, P.N. (1998) Major depression in individuals with a history of childhood physical or sexual abuse: Relationship to neurovegetative features, mania, and gender. Am. J. Psychiatry, 155(12): 1746-52.
128. Lewy, A.J. and Sack, R.L. (1996) The role of melatonin and light in the human circadian system. In: R.M. Buijs, A. Kalsbeek, H.J. Romijn, C.M.A. Pennartz, M. Mirmiran, (Eds), Hypothalamic Integration of Circadian Rhythms. Progress in Brain Research, Vol. III, Elsevier, Amsterdam, pp. 205-216.
129. Lewy, A.J., Bauer, V.K., Cutler, N.L. and Sack, R.L. (1998) Melatonin treatment of winter depression: A pilot study. Psychiatry Res., 77: 57-61.
130. Lingjaerde, O., Føreland, A.R. and Dankertsen, J. (1998) Dawn simulation vs. lightbox treatment in winter depression: A comparative study. Acta Psychiatry Scand., 98: 73-80.
131. Linkowski, P., Mendlewicz, J., Kerkhofs, M., Leclercq, R., Golstein, J., Brasseur, M., Copinschi, G. and Van Cauter, E. (1987) 24-Hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: Effect of antidepressant treatment. J. Clin. Endocrinol. Metab., 65: 141-152
132. Loo, C., Mitchell, P., Sachdev, P., McDarmont, B., Parker, G. and Gandevia, S. (1999) Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression. Am. J. Psychiatry, 156: 946-948.
133. Loosen, P.T. and Prange, A.J. (1982) Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: A review. Am. J. Psychiatry, 139: 405-416.
134. Madden, P.A.F., Heath, A.C., Rosenthal, N.E. and Martin, N.G. (1996) Seasonal changes in mood and behavior: The role of genetic factors. Arch. Gen. Psych., 53: 47-55.
135. Madjirova, N.P., Tashev, T.G., Delchev, N.N. and Bakalova, R.G. (1995) Interrelationship between cortisol levels in plasma and the circadian rhythm of temperature, pulse and blood pressure in depressed patients with good and disturbed sleep. Int. J. Psychophysiol., 20: 145-154.
136. Maes, M., Meltzer, H.Y., Cosyns, P., Suy, E. and Schotte, C. (1993) An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: Results of a large-scaled and controlled study. Psychoneuroendocrinology, 18: 607-620.
137. Maes, M., Lin, A., Bonaccorso, S., Van Hunsel, F., Van Gastel, A., Delmeire, L., Biondi, M., Bosmans, E., Kenis, G. and Scharpe, S. (1998) Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatry Scand., 98: 328-335.
138. Mann, J.J., Malone, K.M., Diehl, D.J., Perel, J., Cooper, T.B. and Mintun, K.A. (1996) Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am. J. Psychiatry, 153: 174-182.
139. Mann, J.J., Oquendo, M., Underwood, M.D. and Arango, V. (1999). The neurobiology of suicide risk: A review for the clinician. J. Clin. Psychiatry, 60: suppl. 2, pp. 7-11, discussions pp. 18-20, 113-116.
140. Marangell, L.B., Ketter, T.A., George, M.S., Pazzaglia, P.J., Callahan, A.M., Parekh, P., Andreason, P.J., Horwitz, B., Herscovitch, P. and Post, R.M. (1997a) Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. Am. J. Psychiatry, 154: 224-230.
141. Marangell, L.B., George, M.S., Callahan, A.M., Ketter, T.A., Pazzaglia, P.J., L'Herrou, T.A., Leverich, G.S. and Post, R.M. (1997b) Effects of intrathecal thyrotropin-releasing hormone (protirelin) in refractory depressed patients. Arch. Gen. Psychiatry, 54: 214-222.
142. Mayberg, H.S., Liotti, M., Brannan, S.K., McGinnis, S., Mahurin, R.K., Jerabek, P.A., Silva, J.A., Tekell, J.L., Martin, C.C., Lancaster, J.L. and Fox, P.T. (1999) Reciprocal limbiccortical function and negative mood: Converging PET findings in depression and normal sadness. Am. J. Psychiatry, 156: 675-682.
143. McCann, U.D., Kimbrell, T.A., Morgan, C.M., Anderson, T., Geraci, M., Benson, B.E., Wassermann, E.M., Willis, M.W. and Post, R.M. (1998) Repetitive transcranial magnetic stimulation for post-traumatic stress disorder. Arch. Gen. Psychiatry, 55: 276-279.
144. Meana, J.J., Barturen, F. and Garca-Sevilla, J.A. (1992) α2adrenoceptors in the brain of suicide victims: Increased receptor density associated with major depression. Biol. Psychiatry, 31: 471-490.
145. Meesters, Y., Beersma, D.G.M., Bouhuys, A.L. and Van den Hoofdakker, R.H. (1999) Prophylactic treatment of seasonal affective disorder (SAD) by using light visors: Bright white or infrared light? Biol. Psychiatry, 46: 239-246.
146. Meesters, Y. and Letsch, M.C. (1998) The dark side of light treatment for seasonal affective disorders. Int. J. Risk Safety Med., 11: 115-120.
147. Menkes, D.L., Bodnar, P., Ballesteros, R.A. and Swenson, M.R. (1999) Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) is an effective treatment for depression: A case-control pilot study of safety and efficacy. J. Neurol. Neurosurg. Psychiatry, 67:113-115.
148. Meyer, U., Kruhøffer, M., Flügge, G. and Fuchs, E. (1998) Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri). Mol. Brain Res., 55: 243-253.
149. Mitchell, A.J. (1998) The role of corticotropin releasing factor in depressive illness: A critical review. Neurosci. Biobehav. Rev., 22: 635-651.
150. Mitchell, A. and O'Keane, V. (1998) Steroids and depression: Glucocorticoid steroids affect behaviour and mood. BMJ, 316: 244-245.
151. Modell, S., Yassouridis, A., Huber, J. and Holsboer, F. (1997) Corticosteroid receptor function is decreased in depressed patients. Neuroendocrinology, 65: 216-222.
152. Mokrani, M.-C., Duval, E, Crocq, M.A., Bailey, B. and Macher, J.P. (1997) HPA axis dysfunction in depression: Correlation with monoamine system abnormalities. Psychoneuroendocrinology, 22, suppl. 1: S63-S68.
153. Morimoto, M., Morita, N., Ozawa, H., Yokoyama, K. and Kawata, M. (1996) Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: An immunohistochemical and in situ hybridization study. Neurosci. Res., 26: 235-269.
154. Morris, P.L.P., Robinson, R.G., Raphael, B. and Hopwood, M.J. (1996) Lesion location and poststroke depression. J. Neuropsych., 8: 399-403.
155. Morris, J.S., Smith, K.A., Cowen, P.J., Friston, K.J. and Dolan, R.J. (1999) Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion. NeuroImage, 10: 163-172.
156. Moses, S.G. and Robins, E. (1975) Regional distribution of norepinephrine and dopamine in brains of depressive suicides and alcoholic suicides. Psychopharmacol. Comm., 1: 327-337.
157. Murphy, B.E.P. (1997) Antiglucocorticoid therapies in major depression: A review. Psychoneuroendocrinology, 22: S125-S132.
158. Murros, K., Fogelholm, R., Kettunen, S. and Vuorela, A.L. (1993) Serum cortisol and outcome of ischemic brain infarction. J. Neurol. Sci., 116(1): 12-7.
159. Musselman, D.L. and Nemeroff, C.B. (1996) Depression and endocrine disorders: Focus on the thyroid and adrenal system. Brit. J. Psychiatry, 168: 123-128.
160. Nemeroff, C.B., Owens, M.J., Bissette, G., Andorn, A.C. and Stanley, M. (1988) Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch. Gen. Psychiatry, 45: 577-579.
161. Nemeroff, C.B. (1996) The corticotropin-releasing factor (CRF) hypothesis of depression: New findings and new directions. Mol. Psychiatry, 1: 336-342.
162. Neumeister, A., Praschak-Rieder, N., Heßelmann, B., Rao, ML., Glück, J. and Kasper, S. (1997) Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy. Arch. Gen. Psychiatry, 54: 133-138.
163. Neumeister, A., Turner, E.J., Matthews, J.R., Postolache, T.T., Barnett, R.L., Rauh, M., Vetticad, R.G. and Kasper, S., Rosenthal, N.E. (1998) Effects of tryptophan depletion vs. catecholamine depletion in patients with seasonal affective disorder in remission with light therapy. Arch. Gen. Psychiatry, 55: 524-530.
164. O'Brien, J.T., Ames, D., Schweitzer, I., Colman, P., Desmond, P. and Tress, B. (1996) Clinical and magnetic resonance imaging correlates of hypothalamic-pituitary-adrenal axis function in depression and Alzheimer's disease. Brit. J. Psychiatry, 168: 679-687.
165. Oka, M. (1956) Effect of cerebral vascular accident on the level of 17-Hydroxycorticosteroids in plasma. Acta Med. Scand., 156: 220-226
166. Ogura, A., Morinobu, S., Kawakatsu, S., Totsuka, S. and Komatani, A. (1998) Changes in regional brain activity in major depression after successful treatment with antidepressant drugs. Acta Psychiatry Scand., 98:54-59.
167. Olsson, T. (1990) Urinary free cortisol excretion shortly after ischaemic stroke. J. Internal Med., 228: 177-181.
168. Olsson, T., Marklund, N., Gustafson, Y. and Näsman, B. (1992) Abnormalities at different levels of the hypothalamicpituitary-adrenocortical axis early after stroke. Stroke, 23: 1573-1576.
169. Öngür, D., Drevets, W.C. and Price, J.L. (1998a) Glial reduction in the subgenual. Proc. Natl. Acad. Sci. USA, 95: 13290-13295.
170. Öngür, D., An, X. and Price, J.L. (1998b) Prefrontal cortical projections to the hypothalamus in Macaque monkeys. J. Comp. Neurol., 401: 480-505.
171. Oren, D.A., Levendosky, A.A., Kasper, S., Duncon, C.C. and Rosenthal, N.E. (1996) Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder. Biol. Psychiatry, 39: 157-170.
172. Owens, M.J. and Nemeroff, C.B (1999) Therapeutic potential in the treatment of affective disorders. CNS Drugs, 12: 85-92.
173. Palchikov, V.E., Zolotarev, D.Y., Danilenko, K.V. and Putilov, A.A. (1997) Effects of the seasons and of bright light administered at different times of day on sleep EEG and mood in patients with seasonal affective disorder. Biol. Rhythm Res., 28: 166-184.
174. Pardo, J.V., Pardo, P.J. and Raichle, M.E. (1993) Neural correlates of self-induced dysphoria. Am. J. Psychiatry, 150: 713-719.
175. Partonen, T. and Lönnqvist, J. (1996) Seasonal variation in bipolar disorder. Br. J. Psychiatry, 169: 641-646.
176. Pascual-Leone, A., Rubio, B., Pallardo, F. and Catala, M.D. (1996) Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet, 348: 233-237.
177. Penev, P. and Zee, P.C. (1997) Melatonin: A clinical perspective. Ann. Neurol., 42: 545-553.
178. Pfeffer, C.R., Stokes, P., Weiner, A., Shindledecker, R., Faughnan, L., Mintz, M., Stoll, P.M., Heiligenstein, E. (1989) Psychopathology and plasma cortisol responses to dexamethasone in prepubertal psychiatric inpatients. Biol. Psychiatry, 26(7): 677-89.
179. Pihoker, C., Owens, C., Kuhn, C.M., Schanberg, S.M. and Nemeroff, C.B. (1993) Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor. Psychoneuroendocrinology, 18: 485-493.
180. Plotsky, P.M., Owens, M.J. and Nemeroff, C.B. (1998) Psychoneuroendocrinology of depression. Psychoneuroendocrinology, 21: 293-307
181. Pop, V.J., Maartens, L.H., Leusink, G., Van Son, M.J., Knottnerus, A.A., Ward, A.M., Metcalfe, R. and Weetman, A.P. (1998) Are autoimmune thyroid dysfunction and depression related? J. Clin. Endocrinol. Metabol., 83: 3194-3197.
182. Purba, J.S., Hoogendijk, W.J.G., Hofman, M.A. and Swaab, D.F. (1996) Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch. Gen. Psychiatry, 53: 137-143.
183. Putilov, A.A. (1998) Multi-component physiological response mediates therapeutic benefits of bright light in winter seasonal affective disorder. Biol. Rhythm Res., 29: 367-386.
184. Raadsheer. F.C., Hoogendijk, W.J.G., Stam, F.C., Tilders, F.J.H. and Swaab, D.F. (1994) Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology, 60: 436-444.
185. Raadsheer, F.C., Van Heerikhuize, J.J., Lucassen, P.J., Hoogendijk, W.J.G., Tilders, F.J.H. and Swaab, D.F. (1995) Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am. J. Psychiatry, 152: 1372-1376.
186. Raitiere, M.N. (1992) Clinical evidence for thyroid dysfunction in patients with seasonal affective disorder. Psychoneuroendocrinology, 17: 231-241.
187. Regestein, Q.R. and Monk, T.H. (1995) Delayed sleep phase syndrome: A review of its clinical aspects. Am. J. Psychiatry, 152: 602-608.
188. Remé, C.E., Rol, P., Grothmann, K., Kaase, H. and Terman, M. (1996) Bright light therapy in focus: Lamp emission spectra and ocular safety. Technol. Health Care, 4: 403-413.
189. Rempel-Clower, N.L. and Barbas, H. (1998) Topographic organization of connections between the hypothalamus and prefrontal cortex in the rhesus monkey. J. Comp. Neurol., 398(3): 393-419.
190. Reul, M.H.M., Stec, I., Söder, M. and Holsboer, F. (1993) Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamo-pituitary-adrenocortical system. Endocrinology, 133: 312-320.
191. Reus, V.I., Wolkowitz, O.M. and Frederick, S. (1997) Antiglucocorticoid treatments in psychiatry. Psychoneuroendocrinology, 22: S121-S124.
192. Ring, H.A., Bench, C.J., Trimble, M.R., Brooks, D.J., Frackowiak, S.R. and Dolan, R.J. (1994) Depression in Parkinson's disease: A positron emission study. Br. J. Psychiatry, 165: 333-339.
193. Robinson, R.G., Kubos, K.L., Book Star, L., Rao, K. and Price, T.R. (1984) Mood disorders in stroke patients. Brain, 107: 81-93.
194. Rogers, M.A., Bradshaw, J.L., Pantelis, C. and Phillips, J.G. (1998) Frontostriatal deficits in unipolar major depression. Brain Res. Bull., 47: 297-310.
195. Roy, A., Wolkowitz, O.M., Bissette, G. and Nemeroff, C.B. (1994) Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects: Negative findings. Am. J. Psychiatry, 151: 600-602.
196. Rubin, R.T., Phillips, J.J., McCracken, J.T. and Sadow, T.F. (1996) Adrenal gland volume in major depression: Relationship to basal and stimulated pituitary-adrenal cortical axis function. Biol. Psychiatry, 40: 89-97.
197. Sackheim, H.A., Luber, B., Katzman, G.P., Moeller, J.R., Prudic, J., Devanand, D.P. and Nobler, M.S. (1996) The effects of electroconvulsive therapy on quantitative electroencephalograms: Relationship to clinical outcome. Arch. Gen. Psychiatry, 53: 814-824.
198. Saper, C.B. (2000) Hypothalamic connections with the cerebral cortex. Progress in Brain Research, this volume.
199. Satoh, J., Takeshige, H., Hara, H. and Fukuyama, Y. (1982) Brain shrinkage and subdural effusion associated with ACTH administration. Brain Dev., 4: 13-20.
200. Scott, L.V. and Dinan, T.G. (1998) Vasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: Implications for the pathophysiology of depression. Life Sci., 62: 1985-1998.
201. Shafti, M., MacMillan, D.R., Key, M.P., McCue Derrick, A., Kaufman, N. and Nahinsky, I.D. (1996) Nocturnal serum melatonin profile in major depression in children and adolescents. Arch. Gen. Psychiatry, 53: 1009-1013.
202. Sher, L., Goldman, D., Ozaki, N. and Rosenthal, N.E. (1999) The role of genetic factors in the etiology of seasonal affective disorder and seasonality. J. Affect. Disord., 53: 203-210.
203. Smith, G.S., Reynolds, C.F. 3rd, Pollock, B., Derbyshire, S., Nofzinger, E., Dew, M.A., Houck, P.R., Milko, D., Meltzer, C.C. and Kupfer, D.J. (1999a) Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression. Am. J. Psychiatry, 156: 683-689.
204. Smith, K.A., Morris, J.S., Friston, K.J., Cowen, P.J. and Dolan, R.J. (1999b) Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion. Br. J. Psychiatry, 174: 525-529.
205. Soares, J.C. and Mann, J.J. (1997a) The anatomy of mood disorders - Review of structural neuroimaging studies. Biol. Psychiatry, 41: 86-106.
206. Soares, J.C. and Mann J.J. (1997b). The functional neuroanatomy of mood disorders. J. Psychiatry Res., 31: 393-432.
207. Souêtre, E., Salvati, E., Belugou, J-L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J-L. and Darcourt, G. (1989) Circadian rhythms in depression and recovery: Evidence for blunted amplitude as the main chronobiological abnormality. Psychiatric Res., 28: 263-278.
208. Stanley, M. and Mann, J.J. (1983) Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet, 29: 214-216.
209. Stein, D. and Avni, J. (1988) Thyroid hormones in the treatment of affective disorders. Acta Psychiatry Scand., 77: 623-636.
210. Steingard, R.J., Renshaw, P.F., Yurgelun-Todd, D., Appelmans, K.E., Lyoo, I.K., Shorrock, K.L., Bucci, J.P., Cesena, M., Abebe, D., Zurakowski, D., Poussaint, T.Y. and Barnes, P. (1996) Structural abnormalities in brain magnetic resonance images of depressed children. J. Am. Acad. Child Adolesc., Psychiatry, 35: 307-311.
211. Stenzel-Poore, M.P., Heinrichs, S.C., Rivest, S., Koob, G.F. and Vale, W.W. (1994) Overproduction of corticotropin-releasing factor in transgenic mouse: A genetic model of anxiogenic behavior. J. Neurosci., 14: 2579-2584.
212. Styra, R., Joffe, R. and Singer, W. (1991) Hyperthyroxinemia in major affective disorders. Arch. Psychiatry Scand., 83: 61-63.
213. Sullivan, P.F., Wilson, D.A., Mulder, R.T. and Joyce, P.R. (1997) The hypothalamic-pituitary-thyroid axis in major depression. Acta Psychiatry Scand., 95: 370-378.
214. Sullivan, G.M., Hatterer, J.A., Herbert, J., Chen, X., Roose, S.P., Attia, E., Mann, J.J., Marangell, L.B., Goetz, R.R. and Gorman, J.M. (1999) Low levels of transthyretin in the CSF of depressed patients. Am. J. Psychiatry, 156: 710-715.
215. Swaab, D.F. (1995) Aging of the human hypothalamus. Horm. Res., 43: 8-11.
216. Swayze, V.W. 2d, Andreasen, N.C., Alliger, R.J., Yuh, W.T. and Ehrhardt, J.C. (1992) Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biol. Psychiatry, 31: 221-240.
217. Szigethy, E., Conwell, Y., Forbes, N.T., Cox, C. and Caine, E.D. (1994) Adrenal weight and morphology in victims of completed suicide. Biol. Psychiatry, 36: 374-380.
218. Teicher, M.H., Glod, C.A., Magnus, E., Harper, D., Benson, G., Krueger, K. and McGreenery, C.E. (1997) Circadian restactivity disturbances in seasonal affective disorder. Arch. Gen. Psychiatry, 54: 124-130.
219. Thal6n, B.E., Mørkrid, L., Kjellman, B.F. and Wetterberg, L. (1997) Cortisol in light treatment of seasonal and nonseasonal depression: Relationship between melatonin and cortisol. Acta Psychiatry Scand., 96: 385-394.
220. Thase, M.E., Buysse, D.J., Frank, E., Cherry, C.R., Comes, C.L., Mallinger, A.G. and Kupfer, D.J. (1997) Which depressed patients will respond to interpersonal psychotherapy? The role of abnormal EEG sleep profiles. Am. J. Psychiatry, 154: 502-509.
221. Thind, K.K. and Goldsmith, P.C. (1989) Corticotropin-releasing factor neurons innervate dopamine neurons in the periventricular hypothalamus of juvenile macaques. Neuroendocrinology, 50: 351-358.
222. Träskman, L., Tybring, G., Åsberg, M., Bertilsson, L., Lantto, O. and Schalling, D. (1980) Cortisol in the CSF of depressed and suicidal patients. Arch. Gen. Psychiatry, 37: 761-767.
223. Trichard, C., Martinot, J.L., Alagille, M., Masure, M.C., Hardy, P., Ginestet, D. and Feline, A. (1995) Time course of prefrontal lobe dysfunction in severely depressed in-patients: A longitudinal neuropsychological study. Psychol. Med., 25: 79-85.
224. Uvnäs-Moberg, K., Björkstrand, E., Hillegaart, V. and Ahlenius, S. (1999) Oxytocin as a possible mediator of SSRI-induced antidepressant effects. Psychopharmacology, 142: 95-101.
225. Van den Hoofdakker, R.H. (1994) Chronobiological theories of non-seasonal affective disorders and their implications for treatment. J. Biol. Rhythms, 9: 157-183.
226. Van Londen, L., Goekoop, J.G., Van Kempen, G.M.J., Frankhuijsen-Sierevogel, A.C., Wiegant, V.M., Van der Velde, E.A. and De Wied, D. (1997) Plasma levels of arginine vasopressin elevated in patients with major depression. Neuropsychopharmacology, 17: 284-292.
227. Van Londen, L., Goekoop, J.G., Zwinderman, A.H., Lanser, J.B.K., Wiegant, V.M. and De Wied, D. (1998a) Neuropsychol. Med., 28: 275-284.
228. Van Londen, L., Kerkhof, G.A., Van den Berg, F., Goekoop, J.G., Zwinderman, K.H., Frankhuijzen-Sierevogel, A.C., Wiegant, V.M. and De Wied, D. (1998b) Plasma arginine vasopressin and motor activity in major depression. Biol. Psychiatry, 43: 196-204.
229. Veith, R.C., Lewis, N., Langohr, J.I., Murburg, M.M., Ashleigh, E.A., Castillo, S., Peskind, E.R., Pascualy, M., Bissette, G., Nemeroff, C.B. and Raskind, M.A. (1993) Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects. Psychiatry Res., 46: 1-8.
230. Videbech, P. (1997) MRI findings in patients with affective disorder: A meta-analysis. Acta Psychiatry Scand., 96: 157-168.
231. Voderholzer, U., Laakmann, G., Becker, U., Haag, C., Baghai, T., Riemann, D., and Demisch, L. (1997) Circadian profiles of melatonin in melancholic depressed patients and healthy subjects in relation to cortisol secretion and sleep. Psychiatry Res., 71: 151-161.
232. Von Bardeleben, U., and Holsboer, F. (1989) Corticol response to a combined dexamethasone-human corticotrophin-releasing hormone challenge in patients with depression. J. Neuroendocrinol., 1: 485-488.
233. Von Gizycki, H. and Zizi, F. (1998) Melatonin effects on sleep, mood, and cognition in the elderly with mild cognitive impairment. J. Pineal Res., 25: 177-183.
234. Wang, R.H., Dillon, J., Reme, C., Whitt, R. and Roberts, J.E. (1992) The potential ocular phototoxicity of antidepressant drugs. Lens Eye Toxicity Res., 9: 483-491.
235. Weiss, E.L., Longhurst, J.G, and Mazure, C.M. (1999) Childhood sexual abuse as a risk factor for depression in women: Psychosocial and neurobiological correlates. Am. J. Psychiatry, 156: 816-828.
236. Wicki, W., Angst, J. and Merikangas, K.R. (1992) Epidemiology of seasonal depression. Arch. Psychiatry Clin. Neurosci., 241: 301-306.
237. Wirz-Justice, A. (1995) Biological rhythms in mood disorders. In: F.E. Bloom, and D.J. Kupfer, (Eds), Psychopharmacology: The Fourth Generation of Progress. Raven Press, NY, pp. 999-1017.
238. Wolkowitz, O.M., Reus, V.I., Roberts, E., Manfredi, F., Chan, T., Raum, W.J., Ormiston, S., Johnson, R., Canick, J., Brizendine, L. and Weingartner, H. (1997) Dehydroepiandrosterone (DHEA) treatment of depression. Biol. Psychiatry, 41: 311-318.
239. Yamada, N., Martin-Iverson, M.T., Daimon, K., Tsujimoto, T. and Takahashi, S. (1995) Clinical and chronobiological effects of light therapy on nonseasonal affective disorders. Biol. Psychiatry, 37: 866-873.
240. Yehuda, R., Teicher, M.H., Trestman, R.L., Levengood, R.A. and Siever, L.J. (1996) Cortisol regulation in post-traumatic stress disorder and major depression: A chronobiological analysis. Biol. Psychiatry, 40: 79-88.