Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain

Acta Neurologica Scandinavica, Supplement

Volumn 102, Issue 176, 2000, Pages 27-33

  Sihver, W ^a   Langstrom B ^b   Nordberg, A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Alzheimer's disease; Brain imaging; Nicotinic receptor ligands; Positron emission tomography

Indexed keywords

3 (2 AZETIDINYLMETHOXY)PYRIDINE; EPIBATIDINE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; AZETIDINE DERIVATIVE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DIAGNOSTIC AGENT; FUSED HETEROCYCLIC RINGS; LIGAND; PYRIDINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN RADIOGRAPHY; COGNITION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC VALUE; HUMAN; ISOTOPE LABELING; MEMORY; PATHOGENESIS; PATIENT MONITORING; RECEPTOR BINDING; RECEPTOR DENSITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; PATHOPHYSIOLOGY; PRIMATE; RAT; REVIEW;

ALZHEIMER DISEASE; ANIMALS; AZETIDINES; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOOD-BRAIN BARRIER; CHOLINERGIC AGENTS; HUMANS; LIGANDS; PRIMATES; PYRIDINES; RATS; RECEPTORS, NICOTINIC; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034576476     PISSN: 00651427     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (74)

1. Neuronal nicotinic acetylcholine receptors
2. Neuronal nicotinic receptors in the human brain
3. Neuronal nicotinic acetylcholine receptors as targets for drug discovery
4. Neuronal nicotinic receptor subtypes
5. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment
6. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX
7. Homomers of α8 and α7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties
8. Heterogeneous cholinergic nicotinic receptors in the CNS
9. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia
10. 3H-labeled azetidine analogue of nicotine
11. 3H]cytisine
12. 3H]ABT-418: A novel cholinergic channel ligand
13. 3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain
14. 3H]-nicotine in the mouse brain
15. 3H]cytisine
16. 3H]epibatidine
17. Radioiodination of nicotine with specific activity high enough for mapping nicotinic acetylcholine receptors
18. PET quantification of specific binding of carbon-11-nicotine in human brain
19. 11C]nicotine in the human brain. Difficulties in visualizing specific receptor binding in vivo
20. Long-term tacrine treatment in three mild Alzheimer patients: Effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities
21. 11C]nicotine: Historical aspects
22. Nicotine receptor mapping
23. 11C]nicotine in normal and Alzheimer brains - In vivo assessment using positron emission tomography
24. 11C]Nicotine binding assessed by PET: A dual tracer model evaluated in the Rhesus monkey brain
25. 3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains
26. Nicotinic acetylcholine binding sites in Alzheimer's disease
27. Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology
28. 3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease
29. Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains
30. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease
31. Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain
32. Intravenous nicotine in Alzheimer's disease: A pilot study
33. The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type
34. Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease
35. Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography
36. 3H]nicotine binding sites in human brain
37. Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies
38. 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography
39. Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography
40. Imaging of nicotinic and muscarinic receptors in Alzheimer's disease: Effect of tacrine treatment
41. 11C]nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report)
42. (S)-3-Methyl-5(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): A nove cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization
43. (S)-3-Methyl-5(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): A novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization
44. 11C-labeled (S)(-)nicotine, (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, and (R,S)-1-methyl-2-(3-pyridyl)azetidine as nicotinic receptor ligands for positron emission tomography studies
45. 76Br]bromo-3-[[2(S)-azetidinyl]methoxy]pyridine, a novel nicotinic acetylcholine receptor ligand, in rat brain
46. 125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors
47. 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors
48. A85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand
49. Epibatidine binds with unique site and state selectivity to muscle nicotinic acetylcholine receptors
50. Comparative pharmacology of epibatidine: A potent agonist for neuronal nicotinic acetylcholine receptors
51. Fluoro-norchloroepibatidine: Preclinical assessment of acute toxicity
52. Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function
53. Interaction of the nicotinic agonist (R,S)-3-pyridyl-1-methyl2-(3-pyridyl)-azetidine (MPA) with nicotinic acetylcholine receptor subtypes expressed in cell lines and rat cortex
54. [125I]α-bungarotoxin
55. 3H]nicotine
56. 3H]Epibatidine labels nicotinic receptors in rat brain: An autoradiographic study
57. 125I]5-I-A-85,380, a nicotinic acetylcholine receptor radioligand
58. 18F]Fluoro-A85380, an in vivo tracer for the nicotinic acetylcholine receptors
59. Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro3-[2(S)-2-azetidinylmethoxy]pyridine: A new positron emission tomography ligand for nicotinic receptors
60. 18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo
61. 18F]fluoroA-85380
62. 18F]Fluoro-A85380: An in vivo tracer for the nicotinic acetylcholine receptor
63. 125/123I]Iodo3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors
64. Fluorine-18-FPH for PET-imaging of nicotinic acetylcholine receptors
65. 12S/123I)IPH: A radioiodonated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors
66. 11C]N-Methylepibatidine: Comparison of the stereoisomers
67. 18F]N-methylNFEP: Kinetics, nicotine effect, and toxicity
68. 11C]-methylcytisine
69. 11C]nicotine in Rhesus monkeys
70. Neuronal nicotinic acetylcholine receptor modulation by general anesthetics
71. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics
72. Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon