Radioiodination of nicotine with specific activity high enough for mapping nicotinic acetylcholine receptors

European Journal of Nuclear Medicine

Volumn 23, Issue 2, 1996, Pages 157-162

  Kämpfer, Ingrid ^a   Sorger, Dietlind ^a   Schliebs, Reinhard ^a   Kärger, Wiebke ^a   Günther, Klaus ^a   Schulze, Klaus ^a   Knapp, Wolfram H ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Brain imaging; Neurotransmission; Nicotinic acetylcholine receptors; Radioiodination; Receptor autoradiography

Indexed keywords

NICOTINE; NICOTINIC RECEPTOR; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN CORTEX; CEREBELLUM; CORPUS STRIATUM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; RADIOIODINATION; RAT; THALAMUS;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; IODINE RADIOISOTOPES; ISOTOPE LABELING; NICOTINE; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; TISSUE DISTRIBUTION;

EID: 0030065860     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01731839     Document Type: Article

References (19)

1. 11C: synthesis and distribution kinetics in animals. Eur J Nucl Med 1976; 1: 255-258.
2. 11C-nicotine in brains of Alzheimer patients as visualized by positron emission tomography. J Neural Transm (P-D Sect) 1990; 2: 215-224.
3. Chan SM, Basmadjian GP, Marten DF, Sadek SA, Magarian RA, Grunder JR, Ice RD. Synthesis and biodistribution of radioiodinated 5-iodonicotine. J Labelled Compd Radiopharm 1983; 20: 1017-1026.
4. 123I-nicotinic acid diethylamide for potential brain studies. J Radioanalyt Nucl Chem. Articles 1985; 91/2: 285-289.
5. Dutschka K, Coenen HH, Gildehaus FJ, Brandau W. Effiziente Radioiodierung von Benzamiden durch Cu-(I)-katalysierten Nichtisolopen-Austausch. 1. Arbeitstagung der Arbeitsgemeinschaft Radiochemie/Radiopharmazie der DGN. 13-15 May 1993.
6. Moerlein SM. Regiospecific aromatic radioiodination via no-carrier-added copper(I) chloride-assisted iododebromination. Radiochim Acta 1990; 50: 55-61.
7. Lowry OH, Rosebrough NH, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
8. 3H]nicotine to a single class of high affinity sites in rat brain. Mol Pharmacol 1986; 29: 448-454.
9. 3H]methylcarbamylcholine in rat brain. Eur J Pharmacol 1994; 253: 261-267.
10. Marks MJ, Collins AC. Characterization of nicotine binding in mouse brain and comparison with the binding of α-bungarotoxin and quinuclidinyl benzilate. Mol Pharmacol 1982; 22: 554-564.
11. 3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 1991; 39: 9-12.
12. 3-H)-l-nicotine in the mouse brain. Life Sci 1989; 44: 1123-1132.
13. 11C]cotinine. Preparation, metabolite studies and in vivo distribution in the human brain using PET. Nucl Med Biol 1992; 19: 871-880.
14. Stöcklin G. Tracers for metabolic imaging of brain and heart. Eur J Nucl Med 1992; 19: 527-551.
15. 11C]nicotine in the human brain: difficulties in visualizing specific receptor binding in vivo. Psychopharmacology 1994; 115: 31-36.
16. 11C]nicotine in the brains of rhesus monkey. An attempt to study nicotine receptors in vivo. J Neural Transm (P-D Sect) 1989; 1: 195-205.
17. 11C]nicotine and its regional distribution in the mouse brain: a potential tracer for visualization of brain nicotinic receptors by positron emission tomography. Chem Pharm Bull 1992; 40: 734-736.
18. Saji H, Magata Y, Tajima K, Tanahashi K, Ohmomo Y, Iida Y, Yokoyama A. Radioiodinated (S)-5-iodonicotine: a new radiopharmaceutical for SPECT studies of brain nicotine receptors [abstract]. J Nucl Med 1993; 34: 234P
19. Maziere B, Maziere M. Where have we got to with neuroreceptor mapping of the human brain? Eur J Nucl Med 1990; 16: 817-835.