In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(-)[11C]nicotine in Rhesus monkeys

Nuclear Medicine and Biology

Volumn 26, Issue 6, 1999, Pages 633-640

  Sihver, Wiebke ^a,b   Fasth, Karl Johan ^a   Ögren, Matthias ^a   Lundqvist, Hans ^a   Bergström, Mats ^a   Watanabe, Yasuyoshi ^a,b,c   Långström, Bengt ^a   Nordberg, Agneta ^d  

^a Subfemtomole Biorecognition Project   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

(S)( ) 11C nicotine; 11C ABT; 11C MPA; Nicotinic ligand; Positron emission tomography; Rhesus monkey

Indexed keywords

3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; AZETIDINE; NEW DRUG; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; TRACER;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RHESUS MONKEY; TEMPORAL CORTEX; THALAMUS;

ANIMALS; AZETIDINES; BRAIN; CARBON RADIOISOTOPES; CEREBELLUM; ISOXAZOLES; MACACA MULATTA; NICOTINE; ORGAN SPECIFICITY; PYRROLIDINES; RADIOPHARMACEUTICALS; TEMPORAL LOBE; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032855757     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(99)00034-7     Document Type: Article

References (63)

1. 3H]nicotine to rat brain membranes. Neurochem. Res. 10:1985;259-267.
2. 3H-labeled azetidine analogue of nicotine. Biochem. Pharmacol. 36:1987;2337-2341.
3. Abreo M.A., Lin N.H., Garvey D.S., Gunn D.E., Hettinger A.M., Wasicak J.T., Pavlik P.A., Martin Y.C., Donnelly-Roberts D.L., Anderson D.J., Sullivan J.P., Williams M., Arneric S.P., Holladay M.W. Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J. Med. Chem. 39:1996;817-825.
4. Adem A., Nordberg A., Jossan S.S., Sara V., Gillberg P.G. Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres. Neurosci. Lett. 101:1989;247-252.
5. 3H]ABT-418 A novel cholinergic channel ligand . J. Pharmacol. Exp. Ther. 273:1995;1434-1441.
6. Arneric S.P., Sullivan J.P., Briggs C.A., Donnelly-Roberts D., Anderson D.J., Raszkiewicz J.L., Hughes M.L., Cadman E.D., Adams P., Garvey D.S., Wasicak J.T., Williams M. (S)-3-Methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT-418) A novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization . J. Pharmacol. Exp. Ther. 270:1994;310-318.
7. Ator N.A., Griffiths R.R. Nicotine self-administration in baboons. Pharmacol. Biochem. Behav. 19:1993;993-1003.
8. Caruncho H.J., Guidotti A., Lindstrom J., Costa E., Pesold C. Subcellular localization of the α7 nicotinic receptor in rat cerebellar granule cell layer. NeuroReport. 8:1997;1431-1433.
9. Cimino M., Marini P., Fornasari D., Cattabeni F., Clementi F. Distribution of nicotinic receptors in cynomolgus monkey brain and ganglia Localization of α3 subunit nRNA, α-bungarotoxin and nicotine binding sites . Neurosci. 51:1992;77-86.
10. Court J.A., Perry E.K., Spurden D., Griffiths M., Kerwin J.M., Morris C.M., Johnson M., Oakley A.E., Birdsall N.J., Clementi F., Perry R.H. The role of the cholinergic system in the development of the human cerebellum. Dev. Brain Res. 90:1995;159-167.
11. 125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors. J. Pharmacol. Exp. Ther. 282:1997;445-451.
12. Didier M., Berman S.A., Lindstrom J., Bursztajn S. Characterization of nicotinic acetylcholine receptors expressed in primary cultures of cerebellar granule cells. Mol. Brain Res. 30:1995;17-28.
13. 11C-labeling of two selective high affinity nicotinic cholinergic agonists for evaluation as a radioligand for PET studies. J. Labelled Compd. Radiopharm. 38:1996;1099-1112.
14. 18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine, a highly potent radioligand for in vivo imaging central nicotinic acetylcholine receptors. J. Labelled Compd. Radiopharm. 41:1998;451-463.
15. Flores C.M., DeCamp R.M., Kilo S., Rogers S.W., Hargreaves K.M. Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion Demonstration of alpha3beta4, a novel subtype in the mammalian nervous system . J. Neurosci. 16:1996;7892-7901.
16. Flores C.M., Rogers S.W., Pabreza L.A., Wolfe B.B., Kellar K.J. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol. 41:1992;31-37.
17. Gotti C., Fornasari D., Clementi F. Human neuronal nicotinic receptors. Prog. Neurobiol. 53:1997;199-237.
18. Grünwald F., Biersack H.J. Nicotine receptor mapping. Eur. J. Nucl. Med. 23:1996;1012-1013.
19. Grünwald F., Schröck H., Kuschinsky W. The influence of nicotine on local cerebral blood flow. Neurosci Lett. 124:1991;108-110.
20. 11C]cotinine. Preparation, metabolite studies and in vivo distribution in the human brain using PET. Int. J. Rad. Appl. Instrum. [B]. 19:1992;871-880.
21. Hans F.J., Wei L., Bereczki D., Acuff V., Demaro J., Chen J.L., Otsuka T., Patlak C., Fenstermacher J. Nicotine increases microvascular blood flow and flow velocity in three groups of brain areas. Am. J. Physiol. 265:1993;H2142-H2150.
22. Hellström-Lindahl E., Gorbounova O., Seiger Å., Mousavi M., Nordberg A. Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord. Dev. Brain Res. 108:1998;147-160.
23. Hironaka N., Miyata H., Ando K. Effects of psychoactive drugs on short-term memory in rats and Rhesus monkeys. Jpn. J. Pharmacol. 59:1992;113-120.
24. 18F]A-85380) . J. Labelled Compd. Radiopharm. 41:1998;309-318.
25. Horti A.G., Scheffel U., Stathis M., Finley P., Ravert H.T., London E.D., Dannals R.F. Fluorine-18-FPH for PET imaging of nicotinic acetylcholine receptors. J. Nucl. Med. 38:1997;1260-1265.
26. 3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain. Mol. Pharmacol. 48:1995;280-287.
27. Koren A.O., Horti A.G., Muhkin A.G., Gündisch D., Kimes A.S., Dannals R.F., London E.D. 2-, 5- and 6-Halo-3-(2(S)-azetidinylmethoxy)pyrinides Synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling . J. Med. Chem. 41:1998;3690-3698.
28. Levin E.D. Nicotinic systems and cognitive function. Psychopharmacology. 108:1992;417-431.
29. Linville D.G., Williams S., Raszkiewicz J.L., Arneric S.P. Nicotinic agonists modulate basal forebrain control of cortical blood flow in anesthetized rats. J. Pharmacol. Exp. Ther. 267:1993;440-448.
30. Liu C., Nordberg A. and Zhang X. (1996) Differential co-expression of nicotinic acetylcholine receptor α4 and β2 subunit genes in various regions of rat brain. NeuroReport 7, 1745-1649.
31. Loch C., Bottlaender M., Kassiou M., Musachio J.L., London E.D., Dannals R.F., Maziere B. Evaluation of a Br-76 analog of epibatidine for PET imaging of nicotinic acetylcholine receptors. Eur. J. Nucl. Med. 24:1997;913.
32. Lundqvist H., Långström B., Nordberg A. Use of carbon-11 nicotine in PET studies. Eur. J. Nucl. Med. 24:1997;825-827.
33. 11C]nicotine binding assessed by PET A dual tracer model evaluated in the Rhesus monkey brain . Alzheimer Dis. Assoc. Disord. 12:1998;238-246.
34. Maziere M., Berger G., Masse R., Plummer R., Comar D. The "in vivo" distribution of carbon-11 labeled (-)nicotine in animals A method suitable for use in man . Remond A., Izard C. Electrophysiological Effects of Nicotine. 1979;31-47 Elsevier, Amsterdam.
35. 11C]nicotine Historical aspects . Domino E.F. Brain Imaging of Nicotine and Tobacco Smoking. 1995;13-28 NPP Books, Ann Arbor, MI.
36. 125/123I]Iodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors. Life Sci. 62:1998;L351-PL357.
37. Musachio J.L., Villemange V.L., Scheffel U.A., Dannals R.F., Dogan A.S., Yokoi F., Wong D.F. Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon. Nucl. Med. Biol. 26:1999;201-207.
38. 125/123I)IPH A radioiodonated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors . Synapse. 26:1997;392-399.
39. Muzic R.F., Berridge M.S., Friedland R.P., Zhu N., Nelson A.D. PET quantification of specific binding of carbon-11-nicotine in human brain. J. Nucl. Med. 39:1998;2048-2054.
40. Nordberg A., Adem A., Nilsson L., Romanelli L., Zhang X. Heterogeneous cholinergic nicotinic receptors in the CNS. NATO ASI Series. H25:1988;331-349.
41. Nordberg A., Adem A., Nilsson L., Winblad B. Nicotinic and muscarinic cholinergic receptor heterogeneity in the human brain at normal aging and dementia of Alzheimer type. New Trends Aging Res. 15:1988;27-36.
42. Nordberg A., Amberla K., Shigeta M., Lundqvist H., Viitanen M., Hellström-Lindahl E., Johansson M., Andersson J., Hartvig P., Lilja A., Långström B., Winblad B. Long-term tacrine treatment in three mild Alzheimer patients effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities . Alzheimer Dis. Assoc. Disord. 12:1998;228-237.
43. 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography. J. Neural Transm. [P-D-Sect]. 2:1990;215-224.
44. 11C-nicotine in the brains of Rhesus monkey - An attempt to study nicotinic receptors in vivo. J. Neural Transm. [P-D-Sect]. 1:1989;195-205.
45. Nordberg A., Lilja A., Lundqvist H., Amberla K., Viitanen M., Warpman U., Johansson M., Hellström-Lindahl E., Bjurling P., Fasth K.J., Långström B., Winblad B. Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography. Neurobiol. Aging. 13:1992;747-758.
46. Nordberg A., Lundqvist H., Hartvig P., Andersson J., Johansson M., Hellström-Lindahl E., Långström B. Imaging of nicotinic and muscarinic receptors in Alzheimer's disease effect of tacrine treatment . Dement. Geriatr. Cogn. Disord. 8:1997;78-84.
47. 11C]nicotine in normal and Alzheimer brains - In vivo assessment using positron emission tomography. Alzheimer Dis. Assoc. Disord. 9:1995;21-27.
48. 3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci. Lett. 72:1986;115-119.
49. 11C]nicotine in the human brain Difficulties in visualizing specific receptor binding in vivo . Psychopharmacology. 115:1994;31-36.
50. 11C]nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient [case report]. J. Neural. Transm. [P-D-Sect]. 4:1992;79-95.
51. 11C]methylhomoepibatidine Radiosynthesis and biodistribution in mice . Eur. J. Nucl. Med. 24:1997;913.
52. 11C]MPA as nicotinic receptor ligands for positron emission tomography studies. J. Neurochem. 71:1998;1750-1760.
53. Slifer B.L., Balster R.L. Intravenous self-administration of nicotine With and without schedule-induction . Pharmacol. Biochem. Behav. 22:1985;61-69.
54. 2 fraction. Pharmacol. Bull. 19:1983;402-408.
55. Sorger D., Kämpfer I., Knapp W.H. Letter to the editor. Reply. Eur. J. Nucl. Med. 23:1996;1014.
56. Sullivan J.P., Donnelly-Roberts D., Briggs C.A., Anderson D.J., Gopalakrishnan M., Piattoni-Kaplan M., Campbell J.E., McKenna D.G., Molinari E., Hettinger A.M., Garvey D.S., Wasicak J.T., Holladay M.W., Williams M., Arneric S.P. A-85380 [3-(2(S)-azetidinylmethoxy)pyridine] In vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand . Neuropharmacology. 35:1996;725-734.
57. 11C]-methylcytisine. Nucl. Med. Commun. 18:1997;164-168.
58. 125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand. NeuroReport. 9:1998;2311-2317.
59. Villemange V.L., Horti A., Scheffel U., Ravert H.T., Finley P., Clough D.J., London E.D., Wagner H.N., Dannals R.F. Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an epibatidine analog. J. Nucl. Med. 38:1997;1737-1741.
60. Wada E., Wada K., Boulter J., Deneris E., Heinemann S., Patrick J., Swanson L.W. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system A hybridization histochemical study in the rat . J Comp. Neurol. 284:1989;314-335.
61. Warpman U., Nordberg A. Epibatidine and ABT-418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains. NeuroReport. 6:1995;2419-2423.
62. Whitehouse P.J., Martino A.M., Antuono P.G., Lowenstein P.R., Coyle J.T., Price D.L., Kellar K.J. Nicotinic acetycholine binding sites in Alzheimer's disease. Brain Res. 371:1986;146-151.
63. Zhang X., Gong Z.H., Fasth K.J., Långström B., Nordberg A. Interaction of the nicotinic agonist (R,S)-3-pyridyl-1-methyl-2-(3-pyridyl)-azetidine (MPA) with nicotinic acetylcholine receptor subtypes expressed in cell lines and rat cortex. Neurochem. Int. 32:1998;435-441.