The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells

Journal of Photochemistry and Photobiology B: Biology

Volumn 58, Issue 1, 2000, Pages 26-31

  Kidd, Samantha ^a   Meunier, Jean Roch ^b   Traynor, Nicola J ^a   Marrot, Laurent ^b   Agapakis Causse, Catherine ^b   Gibbs, Neil K ^a,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b L ORÉAL RECHERCHE   (France)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Fluoroquinolones; Lomefloxacin; P2(CIPI WAFI); P53; PARP; Photocarcinogenesis

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIBIOTIC AGENT; BETA GALACTOSIDASE; BINDING PROTEIN; CASPASE; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; HYDROGEN PEROXIDE; LOMEFLOXACIN; NALIDIXIC ACID; NAPHTHYRIDINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P21; PROTEIN P53; PYRIMIDINE DIMER; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; SODIUM CHLORIDE; TRANSCRIPTION FACTOR; TUMOR MARKER;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DNA TRANSCRIPTION; DRUG STRUCTURE; FIBROBLAST; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; KERATINOCYTE; MELANOMA CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; RADIATION EXPOSURE; RECEPTOR UPREGULATION; REPORTER GENE; SKIN CELL; TRANSACTIVATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET A RADIATION;

ANTI-INFECTIVE AGENTS; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA DAMAGE; FLUOROQUINOLONES; HUMANS; HYDROGEN PEROXIDE; MOLECULAR STRUCTURE; PHOTOSENSITIZING AGENTS; QUINOLONES; SKIN; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034535497     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(00)00099-3     Document Type: Article

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