The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay)

Mutagenesis

Volumn 11, Issue 5, 1996, Pages 497-504

  Chételat, Andrée Anne ^a   Albertini, Silvio ^a   Gocke, Elmar ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; FLEROXACIN; LOMEFLOXACIN; OXYGEN RADICAL; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; SCAVENGER;

AMES TEST; ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENE MUTATION; METAPHASE; MUTAGENICITY; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; EUKARYOTA; LETHRINIDAE; MAMMALIA; SACCHAROMYCES CEREVISIAE; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0029791978     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/11.5.497     Document Type: Article

References (30)

1. Albertini, S. and Gocke, E. (1988) Plasmid copy number and mutant frequencies in S.typhimurium TA102. Environ. Mol. Mutagen., 12, 353-363.
2. Albertini, S., Chételat, A.-A., Miller, B., Muster, W., Pudjadas, E., Strobel, R. and Gocke, E. (1995) Genotoxicity of 17 gyrase- and four mammalian topoisomerase II-poisons in prokaryotic and eukaryotic test systems. Mutagenesis, 10, 343-351.
3. Ames, B.N., Shigenaga, M.K. and Hagen, T.M. (1993) Oxidants, antioxidants, and the degenarative diseases of aging. Proc. Natl Acad. Sci. USA, 90, 7915-7922.
4. Ames, B.N., McCann, J. and Yamasaki, E. (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res., 31, 347-364.
5. Anderson, R.D. and Berger, N.A. (1994) Mutagenicity and carcinogenicity of topoisomerase-interactive agents. Mutat. Res., 309, 109-142.
6. Brennan, R.J., Swoboda, B.E.P. and Schiestl, R.H. (1994) Oxidative mutagens induce intrachromosomal recombination in yeast. Mutat. Res., 308, 159-167.
7. 2-sensitive and -resistent Chinese hamster ovary (CHO) cell variants. Toxicol. Lett., 73, 193-199.
8. Chételat, A., Albertini, S., Dresp, J.H., Strobel, R. and Gocke, E. (1993a) Photomutagenesis test development: I. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in bacteria and yeast assays. Mutat. Res., 292, 241-250.
9. Chételat, A., Dresp, J.H. and Gocke, E. (1993b) Photomutagenesis test development: II. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells. Mutat. Res., 292, 251-258.
10. Duell, T., Lengsfelder, E., Fink, R., Giesen, R. and Bauchinger, M. (1995) Effect of activated oxygen species in human lymphocytes. Mutat. Res., 336, 29-38.
11. Emerit, I. (1994) Reactive oxygen species, chromosome mutations, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radical Biol. Med., 16, 99-109.
12. Epe, B., Hegler, J. and Wild, D. (1989) Singlet oxygen as an ultimately reactive species in Salmonella typhimurium DNA damage induced by methylene blue/visible light. Carcinogenesis, 10, 2019-2024.
13. Ferguson, L.R. and Baguley, B.C. (1994) Topoisomerase II enzymes and mutagenicity. Environ. Mol. Mutagen., 24, 245-261.
14. Fort, F.L. (1992) Mutagenicity of quinolone antibacterials. Drug Safety, 7, 214-222.
15. Gocke, E. (1991) Mechanism of quinolone mutagenicity in bacteria. Mutat. Res., 248, 135-143.
16. Holden, H.E., Barett, J.F., Huntington, C.M., Muehlebauer, P.A. and Wahrenburg, M.G. (1989) Genetic profile of a nalidixic acid analogue: a model for the mechanism of sister chromatid exchange induction. Environ. Mol. Mutagen., 13, 238-252.
17. Johnson, B.E., Walker, E.M. and Ferguson, J. (1989) Quinolone-induced photosensitivity. Rev. Infect. Dis., 11, S1396-1397
18. Kaneko, M., Leadon, S.A. and Ito, T. (1988) Relationship between the induction of mitotic conversion and the formation of thymine glycols in yeast Saccharomyces treated with hydrogen peroxide. Mutat. Res., 207, 17-22.
19. Levin, D.E., Hollstein, M.C., Christman, M.F., Schwiers, E.A. and Ames, B.N. (1982) A new Salmonella tester strain (TA102) with A:T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl Acad. Sci. USA, 79, 7445-7449.
20. Maron, D.M. and Ames, B.N. (1983) Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113, 173-215.
21. McGarrity, G.J., Vanarran, V. and Sarama, J. (1984) Cytogenetic effects of mycoplasmal infection of cell cultures: a review. In Vitro, 20, 1-18.
22. Philips, B.J., Caroll, P.A., Tee, A.C. and Anderson, D. (1989) Microsome-mediated clastogenicity of butylaled hydroxyanisole (BHA) in cultured Chinese hamster ovary cells: the possible role of reactive oxygen species. Mutat. Res., 214, 105-114.
23. Richardson, C., Williams, D.A., Amphlett, G., Phillips, B., Allen, J.A. and Chanter, D.O. (1989) Analysis of data from in vitro cytogenetic assays. In Kirkland, D.J. (ed.), Statistical Evaluation of Mutagenicity Data. Cambridge University Press, Cambridge, pp. 141-154.
24. Stern, R. (1989) PUVA: its status in the United States. In Psoralens, T.B.F. (ed.). John Libbey Eurotext, Paris.
25. Studniberg, H.M. and Weller, P. (1993) Photosensitized lipid peroxidation by cinoxacin and its photoproducts. Involvment of a derived peroxide in its phototoxicity. J. Am. Acad. Dermatol., 29, 1013-1022.
26. Urbach, F. (1995) Drug photosensitized skin tumorigenesis. Abstract, 6th Congress of the European Society for Photobiology. Cambridge, UK, 3-8.9.1995.
27. Wagai, N., and Tawara, K. (1992) Possible direct role of reactive oxygens in the cause of cutaneous phototoxicity induced by five quinolones in mice. Arch. Toxicol., 66, 392-397.
28. Youssefi, A.A., Arutynyan, R. and Emerit, I. (1994) Chromosome damage in PUVA-treated human lymphocytes is related to active oxygen species and clastogenic factors. Mutat. Res., 309, 185-191.
29. Ysern, P., Clerch, B., Castano, M., Gilbert, I., Barbé, I. and Llagostern, M. (1990) Induction of SOS genes in Escherichia coli and mutagenesis in Salmonella typhimurium by fluoroquinolones. Mutagenesis 5, 63-66.
30. Zimmermann, F.K., Kern, R. and Rasenberger, H. (1975) A yeast strain for simultaneous detection of induced mitotic crossing over, mitotic gene conversion and reverse mutation. Mutat. Res., 28, 381-388.