Photogenotoxicity of Skin Phototumorigenic Fluoroquinolone Antibiotics Detected Using the Comet Assay

Photochemistry and Photobiology

Volumn 66, Issue 3, 1997, Pages 368-373

  Reavy, Helen J ^b   Traynor, Nicola J ^b   Gibbs, Neil K ^a,b  

^a NINEWELLS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; APHIDICOLIN; DNA; DNA DIRECTED DNA POLYMERASE; ENZYME INHIBITOR; MUTAGENIC AGENT; PHOTOSENSITIZING AGENT; QUINOLONE DERIVATIVE;

AGAR GEL ELECTROPHORESIS; ANIMAL; ARTICLE; CRICETULUS; DNA REPAIR; DRUG ANTAGONISM; HAMSTER; HUMAN; METHODOLOGY; MOUSE; RADIATION EXPOSURE; SKIN;

ANIMALS; ANTI-INFECTIVE AGENTS; APHIDICOLIN; CRICETINAE; CRICETULUS; DNA; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ELECTROPHORESIS, AGAR GEL; ENZYME INHIBITORS; FLUOROQUINOLONES; HUMANS; MICE; MUTAGENS; PHOTOSENSITIZING AGENTS; SKIN;

EID: 0031230566     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb03160.x     Document Type: Article

References (42)

1. Young, A. R., I. A. Magnus, A. C. Davies and N. P. Smith (1983) A comparison of the phototumorigenic potential of 8-MOP and 5-MOP in hairless albino mice exposed to solar simulated radiation. Br. J. Dermatol. 108, 507-518.
2. Kelly, G. E., W. D. Meikle and D. E. Moore (1989) Enhancement of UV-induced skin carcinogenesis by azathioprine: role of photochemical sensitization. Photochem. Photobiol. 49, 59-65.
3. Parrish, J. A., T. B. Fitzpatrick, L. Tanenbaum and M. A. Pathak (1974) Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light. N. Engl. J. Med. 291, 1207-1211.
4. Gihbs, N. K., A. R. Young and I. A. Magnus (1985) Failure of UVR dose reciprocity for skin tumorigenesis in hairless mice treated with 8-methoxypsoralen. Photochem. Photobiol. 42, 39-42.
5. Stern, R. S., N. Laird, J. Melski, J. A. Parrish, T. B. Fitzpatrick and H. L. Bleich (1984) Cutaneous squamous-cell carcinoma in patients treated with PUVA. N. Engl. J. Med. 310, 1156-1161.
6. Stern, R. S. and N. Laird (1994) The carcinogenic risk of treatments for severe psoriasis. Cancer 73, 2759-2764.
7. Wagai, N. and K. Tawara (1991) Important role of oxygen metabolites in quinolone antibacterial agent-induced cutaneous phototoxicity in mice. Arch. Toxicol. 65, 495-499.
8. Wagai, N. and K. Tawara (1991) Quinolone antibacterial agent-induced cutaneous phototoxicity: ear swelling reactions in Balb/c mice. Toxicol. Lett. 58, 215-223.
9. Ferguson, J. and B. E. Johnson (1992) Recently developed photosensitising agents. In Biological Responses to Ultraviolet A Radiation (Edited by F. Urbach), pp. 107-119. Valdenmar, Overland Park, KS.
10. Young, A. R., T. D. Fakouhi, G. I. Harrison, B. Roniker, E. A. Swabb and J. L. M. Hawk (1996) The UVR wavelength dependence for lomefloxacin photosensitisation of human skin. J. Photochem. Photobiol. B Biol. 32, 165-170.
11. Kimura, M., A. Kawada, T. Kobayashi, M. Hiruma and A. Ishibashi (1996) Photosensitivity induced by fleroxacin. Clin. Exp. Dermatol. 21, 46-47.
12. Ferguson, J. (1995) Fluoroquinolone photosensitization: a review of clinical and laboratory studies. Photochem. Photobiol. 62, 954-958.
13. Johnson, B. E., N. K. Gibbs and J. Ferguson (1995) The initial investigations on quinolone photosensitised skin tumorigenesis. Photodermatol. Photoimmunol. Photomed. 11, 236.
14. Johnson, B. E., N. K. Gibbs and J. Ferguson (1997) A quinolone antibiotic with potential to photosensitise skin tumorigenesis. J. Photochem. Photobiol. B Biol. 37, 171-173.
15. Klecak, G., F. Urbach and H. Urwyler (1997) Fluoroquinolone antibacterials enhance UVA-induced skin tumors. J. Photochem. Photobiol. B Biol. 37, 174-181.
16. Makinen, M., P. D. Forbes and F. Stenback (1997) Quinolone antibacterials, a new class of photochemical carcinogens. J. Photochem. Photobiol. B Biol. 37, 182-187.
17. Osterberg, R. E. and A. Szarfman (1996) Assessment of risk for photocarcinogenesis: regulatory reviewer viewpoint. Photochem. Photobiol. 63, 362-365.
18. Forbes, P. D., C. P. Sambuco and R. E. Davies (1993) Photocarcinogenesis safety testing. J. Am. Coll. Toxicol. 12, 417-124.
19. Albertini, S., A. A. Chetelat, B. Miller, W. Muster, E. Pujadas, R. Strobel and E. Gocke (1995) Genotoxicity of 17 gyrase and 4 mammalian topoisomerase - II. Poisons in prokaryotic and eukaryotic test systems. Mutagenesis 10, 343-351.
20. Gedik, C. M., S. W. B. Ewen and A. R. Collins (1992) Single-cell gel electrophoresis applied to the analysis of UVC damage and its repair in human cells. Int. J. Radiat. Biol. 62, 313-320.
21. Collins, A. R., M. Ai-guo and S. J. Duthie (1995) The kinetics and repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat. Res. 336, 69-77.
22. Ostling, O. and K. J. Johanson (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 123, 291-298.
23. Singh, N. P., M. T. McCoy, R. R. Tice and E. L. Schneider (1988) A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191.
24. McKelvey-Martin, V. J., M. H. L. Green, P. Schmezer, B. L. Pool-Zobel, M. P. De Méo and A. Collins (1993) The single cell gel electrophoresis assay (comet assay): a European review. Mitat. Res. 288, 47-63.
25. Fairbairn, D. W., P. L. Olive and K. L. O'Neill (1995) The comet assay: a comprehensive review. Mutat. Res. 339, 37-59.
26. Borenfreund, E., H. Babich and N. Martin-Alguacil (1988) Comparisons of two in vitro cytotoxicity assays - the neutral red (NR) and tetrazolium MTT tests. Toxicol. In Vitro 2, 1-6.
27. Tokura, Y., T. Nishijima, H. Yagi, F. Furukawa and M. Takigawa (1996) Photohaptenic properties of fluoroquinolones. Photochem. Photobiol. 64, 838-844.
28. Ziegler, A., A. S. Jonason, D. J. Leffell, J. A. Simon, H. W. Sharma, J. Kimmelman, L. Remington, T. Jacks and D. E. Brash (1994) Sunburn and p53 in the onset of skin cancer. Nature 372, 773-776.
29. Bredberg, A., M. Brant, K. Riesbeck, Y. Azou and A. Forsgren (1989) 4-Quinolone antibiotics: positive genotoxic screening tests despite an apparent lack of mutation induction. Mutat. Res. 211, 171-180.
30. Bredberg, A., M. Brant and M. Jaszyk (1991) Ciprofloxacin-induced inhibition of topoisomerase II in human lymphoblastoid cells. Antimicrob. Agents Chemother. 35, 448-450.
31. Rosenstein, B. S. and J. M. Ducore (1983) Induction of DNA strand breaks in normal human fibroblasts exposed to monochromatic ultraviolet and visible wavelengths in the 240-546 nm range. Photochem. Photobiol. 38, 51-55.
32. Chetelat, A.-A., S. Albertini and E. Gocke (1996) The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (comet assay). Mutagenesis 11, 497-504.
33. Iwamoto, Y., A. Kurita, T. Shimizu, T. Masuzawa, K. Uno, M. Yagi, T. Kitagawa, T. Oku and Y. Yanagihara (1994) DNA strand-breaking activities of quinolone antimicrobial agents under visible light irradiation. Biol. Pharm. Bull. 17, 654-657.
34. Paillous, N. and P. Vicendo (1993) Mechanisms of photosensitized DNA cleavage. J. Photochem. Photobiol. B Biol 20, 203-209.
35. Wagai, N. and K. Tawara (1992) Possible direct role of reactive oxygens in the cause of cutaneous phototoxicity induced by five quinolones in mice. Arch. Toxicol. 66, 392-397.
36. Gihbs, N. K. and T. G. Truscott (1995) Triplet state properties of skin photosensitising fluoroquinolone antibiotics (abstract). Presented to the 6th Congress of the European Society for Photobiology, Cambridge, England.
37. -) yields do not correlate with fluoroquinolone phototoxicity. Photochem. Photobiol. 63, 29S. [Abstract]
38. Dayhaw-Barker, P. and T. G. Truscott (1988) Direct detection of singlet oxygen sensitized by nalidixic acid: the effect of pH and melanin. Photochem. Photobiol. 47, 765-767.
39. Roza, L., G. P. van der Schans and P. H. M. Lohman (1985) The induction and repair of DNA damage and its influence on cell death in primary human tibroblasts exposed to UVA or UVC irradiation. Mutat. Res. 146, 89-98.
40. Sapora, O., F. Barone, M. Belli, A. Maggi, M. Quintiliani and M. A. Tabocchini (1991) Relationships between cell killing, mutation induction and DNA damage in X-irradiated V79 cells: the influence of oxygen and DMSO. Int. J. Radiat. Biol. 60, 467-482.
41. Gibbs, N. K., G. Torr and B. E. Johnson (1996) Evidence that certain phototoxic drugs photosensitize urocanic acid isomerisation. J. Photochem Photobiol. B Biol 34, 63-66.
42. Collins, A. R., M. Dusinska, C. M. Gedik and R. Stetina (1996) Oxidative damage to DNA - do we have a reliable biomarker? Environ. Health Perspect. 104, 465-469.